JP2002508326A5 - - Google Patents
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- Publication number
- JP2002508326A5 JP2002508326A5 JP2000538696A JP2000538696A JP2002508326A5 JP 2002508326 A5 JP2002508326 A5 JP 2002508326A5 JP 2000538696 A JP2000538696 A JP 2000538696A JP 2000538696 A JP2000538696 A JP 2000538696A JP 2002508326 A5 JP2002508326 A5 JP 2002508326A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- aminocarbonyl
- amino
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- HBWCJMBLUCNJIS-UHFFFAOYSA-N Cc1nc(NCCC2)c2cc1 Chemical compound Cc1nc(NCCC2)c2cc1 HBWCJMBLUCNJIS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6990997P | 1997-12-17 | 1997-12-17 | |
| GB9807384.4 | 1998-04-06 | ||
| GBGB9807384.4A GB9807384D0 (en) | 1998-04-06 | 1998-04-06 | Vitronectin receptor antagonists |
| US8325098P | 1998-04-27 | 1998-04-27 | |
| US9263098P | 1998-07-13 | 1998-07-13 | |
| GB60/083,250 | 1998-07-21 | ||
| GB60/069,909 | 1998-07-21 | ||
| GBGB9815803.3A GB9815803D0 (en) | 1998-07-21 | 1998-07-21 | Vitronectin receptor antagonists |
| GB9815803.3 | 1998-07-21 | ||
| GB60/092,630 | 1998-07-21 | ||
| PCT/US1998/026485 WO1999030713A1 (en) | 1997-12-17 | 1998-12-14 | Integrin receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508326A JP2002508326A (ja) | 2002-03-19 |
| JP2002508326A5 true JP2002508326A5 (https=) | 2006-02-02 |
Family
ID=27517454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000538696A Withdrawn JP2002508326A (ja) | 1997-12-17 | 1998-12-14 | インテグリン受容体拮抗薬 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1044001B1 (https=) |
| JP (1) | JP2002508326A (https=) |
| AT (1) | ATE299023T1 (https=) |
| AU (1) | AU738452B2 (https=) |
| CA (1) | CA2315232A1 (https=) |
| DE (1) | DE69830806T2 (https=) |
| ES (1) | ES2243015T3 (https=) |
| WO (1) | WO1999030713A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000006169A1 (en) * | 1998-07-29 | 2000-02-10 | Merck & Co., Inc. | Integrin receptor antagonists |
| AU748621B2 (en) * | 1998-08-13 | 2002-06-06 | Merck & Co., Inc. | Integrin receptor antagonists |
| CA2360305A1 (en) | 1999-02-09 | 2000-08-17 | Bristol-Myers Squibb Company | Lactam inhibitors of fxa and method |
| US7125883B1 (en) | 1999-04-13 | 2006-10-24 | Abbott Gmbh & Co. Kg | Integrin receptor ligands |
| CN1589145A (zh) | 1999-06-02 | 2005-03-02 | 麦克公司 | αv整联蛋白受体拮抗剂 |
| US6514964B1 (en) | 1999-09-27 | 2003-02-04 | Amgen Inc. | Fused cycloheptane and fused azacycloheptane compounds and their methods of use |
| EP1229910A4 (en) | 1999-10-04 | 2003-10-01 | Merck & Co Inc | integrin |
| US6849639B2 (en) | 1999-12-14 | 2005-02-01 | Amgen Inc. | Integrin inhibitors and their methods of use |
| CA2397194C (en) | 2000-01-20 | 2011-05-17 | Mark E. Duggan | Alpha v integrin receptor antagonists |
| US7119098B2 (en) | 2000-06-15 | 2006-10-10 | Pharmacia Corporation | Heteroarylakanoic acids as intergrin receptor antagonists |
| US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
| WO2002022615A1 (en) | 2000-09-14 | 2002-03-21 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
| CA2436130A1 (en) | 2001-01-29 | 2002-08-08 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted indoles and their use as integrin antagonists |
| JP4660067B2 (ja) | 2001-04-24 | 2011-03-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗血管新生剤とＴＮＦαとを用いる組合せ療法 |
| US6872730B2 (en) | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
| AU2003259891A1 (en) * | 2002-08-16 | 2004-03-19 | Janssen Pharmaceutica N.V. | Piperidinyl compounds that selectively bind integrins |
| JP2006516144A (ja) | 2002-12-20 | 2006-06-22 | ファルマシア・コーポレーション | インテグリン受容体アンタゴニスト誘導体としてのチアゾール化合物 |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| BRPI0706540A2 (pt) | 2006-01-18 | 2011-03-29 | Merck Patent Gmbh | terapia especìfica usando ligantes de integrina para tratar cáncer |
| EP2441464B1 (en) | 2007-01-18 | 2014-04-09 | Merck Patent GmbH | Integrin ligands for use in treating colon cancer |
| CN102448497A (zh) | 2009-05-25 | 2012-05-09 | 默克专利有限公司 | 在癌症治疗中的西仑吉肽的持续给药 |
| SI3050878T1 (sl) | 2013-09-24 | 2022-01-31 | Fujifilm Corporation | Nova dušik-vsebujoča spojina ali njena sol ali kovinski kompleks le-te |
| ES2864079T3 (es) | 2014-05-30 | 2021-10-13 | Pfizer | Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos |
| MX394210B (es) | 2017-02-28 | 2025-03-04 | Morphic Therapeutic Inc | INHIBIDORES DE INTEGRINA AVß6. |
| MA52117A (fr) | 2017-02-28 | 2022-04-06 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| WO2020047239A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | INHIBITING αV β6 INTEGRIN |
| SI3844162T1 (sl) | 2018-08-29 | 2025-06-30 | Morphic Therapeutic, Inc. | Zaviralci integrina alfa v beta6 |
| EP3873605B1 (en) | 2018-10-30 | 2024-10-23 | Gilead Sciences, Inc. | Compounds for inhibition of alpha4beta7 integrin |
| ES3013256T3 (en) | 2018-10-30 | 2025-04-11 | Gilead Sciences Inc | Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases |
| FI3873884T3 (fi) | 2018-10-30 | 2025-02-24 | Gilead Sciences Inc | 3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa |
| JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリンの阻害のための化合物 |
| WO2021030438A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4929618A (en) * | 1988-03-25 | 1990-05-29 | Ube Industries, Ltd. | Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same |
-
1998
- 1998-12-14 CA CA002315232A patent/CA2315232A1/en not_active Abandoned
- 1998-12-14 JP JP2000538696A patent/JP2002508326A/ja not_active Withdrawn
- 1998-12-14 AT AT98963893T patent/ATE299023T1/de not_active IP Right Cessation
- 1998-12-14 WO PCT/US1998/026485 patent/WO1999030713A1/en not_active Ceased
- 1998-12-14 ES ES98963893T patent/ES2243015T3/es not_active Expired - Lifetime
- 1998-12-14 DE DE69830806T patent/DE69830806T2/de not_active Expired - Fee Related
- 1998-12-14 AU AU19128/99A patent/AU738452B2/en not_active Ceased
- 1998-12-14 EP EP98963893A patent/EP1044001B1/en not_active Expired - Lifetime
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