JP2007515433A5 - - Google Patents
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- Publication number
- JP2007515433A5 JP2007515433A5 JP2006545811A JP2006545811A JP2007515433A5 JP 2007515433 A5 JP2007515433 A5 JP 2007515433A5 JP 2006545811 A JP2006545811 A JP 2006545811A JP 2006545811 A JP2006545811 A JP 2006545811A JP 2007515433 A5 JP2007515433 A5 JP 2007515433A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- cycloalkyl
- cyc
- alkenyl
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 125000000753 cycloalkyl group Chemical group 0.000 claims 17
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 239000003112 inhibitor Substances 0.000 claims 14
- 125000001188 haloalkyl group Chemical group 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 12
- 125000000304 alkynyl group Chemical group 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 150000004492 retinoid derivatives Chemical class 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 8
- 150000001408 amides Chemical class 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 208000017520 skin disease Diseases 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000013521 Visual disease Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 208000029257 vision disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53060103P | 2003-12-17 | 2003-12-17 | |
| PCT/US2004/041889 WO2005058301A1 (en) | 2003-12-17 | 2004-12-13 | Methods for treating retinoid responsive disorders using selective inhibitors of cyp26a and cyp26b |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007515433A JP2007515433A (ja) | 2007-06-14 |
| JP2007515433A5 true JP2007515433A5 (enExample) | 2008-02-07 |
Family
ID=34700149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545811A Pending JP2007515433A (ja) | 2003-12-17 | 2004-12-13 | Ｃｙｐ２６ａおよびｃｙｐ２６ｂの選択的阻害剤を使用するレチノイド反応性障害の処置方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7468391B2 (enExample) |
| EP (1) | EP1696899A1 (enExample) |
| JP (1) | JP2007515433A (enExample) |
| CA (1) | CA2550010A1 (enExample) |
| WO (1) | WO2005058301A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| AU2006202209B2 (en) * | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| EP1888123B1 (en) | 2005-06-08 | 2013-01-09 | Janssen Biotech, Inc. | A cellular therapy for ocular degeneration |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| KR101057546B1 (ko) * | 2007-06-05 | 2011-08-17 | 주식회사 엘지화학 | 광학 이방성 화합물 및 이를 포함하는 수지 조성물 |
| CN103664637B (zh) | 2007-06-29 | 2016-02-03 | 奥克塞拉有限公司 | 用于治疗眼科疾病和紊乱的炔基苯基衍生化合物 |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| US9096832B2 (en) | 2007-07-31 | 2015-08-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| JP2009108036A (ja) * | 2007-09-28 | 2009-05-21 | Fujifilm Corp | 新規アセチレン化合物、その製造方法、それを構成単位として含むポリマー、該化合物及び／又は該ポリマーを含む組成物、該組成物を硬化させてなる硬化物 |
| ATE523585T1 (de) | 2007-11-27 | 2011-09-15 | Lifescan Inc | Differenzierung menschlicher embryonaler stammzellen |
| CA2959401C (en) | 2008-02-21 | 2021-12-07 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| EP2318516A1 (en) * | 2008-06-30 | 2011-05-11 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| KR101651661B1 (ko) | 2008-06-30 | 2016-08-26 | 얀센 바이오테크 인코포레이티드 | 만능 줄기 세포의 분화 |
| US20100028307A1 (en) * | 2008-07-31 | 2010-02-04 | O'neil John J | Pluripotent stem cell differentiation |
| CN102272291B (zh) * | 2008-10-31 | 2018-01-16 | 詹森生物科技公司 | 人胚胎干细胞向胰腺内分泌谱系的分化 |
| MX2011004563A (es) | 2008-10-31 | 2011-06-01 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| PL2366021T3 (pl) | 2008-11-20 | 2017-12-29 | Janssen Biotech, Inc. | Hodowla pluripotencjalnych komórek macierzystych na mikronośnikach |
| PL2366022T3 (pl) | 2008-11-20 | 2016-11-30 | Sposoby i kompozycje do przyłączania i hodowli komórek na podłożach planarnych | |
| ES2693088T3 (es) * | 2009-07-20 | 2018-12-07 | Janssen Biotech, Inc. | Diferenciación de células madre embriónicas humanas |
| AU2010276402B2 (en) | 2009-07-20 | 2014-07-03 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| KR20170118969A (ko) | 2009-07-20 | 2017-10-25 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| US20120190716A1 (en) * | 2009-08-05 | 2012-07-26 | Oehlen Lambertus J W M | Methods and uses of cytochrome p450 inhibitors |
| AU2010333839C1 (en) * | 2009-12-23 | 2016-07-21 | Janssen Biotech Inc. | Differentiation of human embryonic stem cells |
| MX339669B (es) | 2009-12-23 | 2016-06-02 | Janssen Biotech Inc | Diferenciacion de celulas madres embrionarias humanas. |
| CN107189979B (zh) * | 2010-03-01 | 2021-05-04 | 詹森生物科技公司 | 纯化衍生自多能干细胞的细胞的方法 |
| KR101986176B1 (ko) | 2010-05-12 | 2019-06-05 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| WO2012030539A2 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| AU2011296381B2 (en) | 2010-08-31 | 2016-03-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| WO2012030540A2 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| US9248120B2 (en) | 2011-08-23 | 2016-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Reversing intestinal inflammation by inhibiting retinoic acid metabolism |
| EP2910549A1 (en) | 2011-09-15 | 2015-08-26 | Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University | 1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene derivatives useful as rxr modulators for treating alzheimer's disease and cancer |
| US9388386B2 (en) | 2011-12-22 | 2016-07-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| CA2866590A1 (en) | 2012-03-07 | 2013-09-12 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
| WO2013184888A1 (en) | 2012-06-08 | 2013-12-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| RU2684215C2 (ru) | 2012-12-31 | 2019-04-04 | Янссен Байотек, Инк. | Способ получения панкреатических эндокринных клеток (варианты) и способ увеличения выхода бета-клеток |
| WO2014105543A1 (en) | 2012-12-31 | 2014-07-03 | Janssen Biotech, Inc. | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells |
| RU2687379C2 (ru) | 2012-12-31 | 2019-05-13 | Янссен Байотек, Инк. | Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки |
| US10328040B2 (en) | 2014-01-17 | 2019-06-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic methods |
| JP6588969B2 (ja) | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞内のｍａｆａ発現を強化するための小分子の使用 |
| US10759762B2 (en) * | 2014-10-10 | 2020-09-01 | High Force Research Limited | Fluorescent synthetic retinoids |
| CN105481723B (zh) * | 2015-04-29 | 2017-08-25 | 中国农业大学 | 一种非均相催化的烷基/苄基/芳基脲类化合物的制备方法 |
| PL3380086T3 (pl) | 2015-11-25 | 2022-02-21 | Io Therapeutics, Inc. | Oporne na cyp26 agonisty selektywne względem rar-alfa w leczeniu nowotworu |
| CN107176945B (zh) * | 2016-03-11 | 2021-06-08 | 中国科学院上海有机化学研究所 | 一种视黄酸类化合物、其制备方法、中间体及应用 |
| JP6705911B2 (ja) | 2016-04-14 | 2020-06-03 | ヤンセン バイオテツク，インコーポレーテツド | 多能性幹細胞の中腸内胚葉細胞への分化 |
| US10238626B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US10231947B2 (en) | 2017-01-23 | 2019-03-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Isochroman compounds and methods of use thereof |
| US10238655B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Dihydroindene and tetrahydronaphthalene compounds |
| WO2018224455A1 (en) | 2017-06-07 | 2018-12-13 | Basf Se | Substituted cyclopropyl derivatives |
| WO2019057946A1 (en) | 2017-09-25 | 2019-03-28 | F. Hoffmann-La Roche Ag | MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS |
| US11795148B2 (en) | 2017-12-12 | 2023-10-24 | Queen's University At Kingston | Compounds and methods for inhibiting CYP26 enzymes |
| WO2019121143A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Substituted cyclopropyl derivatives |
| TW202045491A (zh) * | 2019-02-20 | 2020-12-16 | 日商第一三共股份有限公司 | 唑衍生物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5599967A (en) | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| US5952345A (en) | 1995-09-01 | 1999-09-14 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5723666A (en) | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| US7537919B2 (en) * | 1999-12-16 | 2009-05-26 | Cytochroma Inc. | Cytochrome P450RAI-2 and related proteins |
| WO2002048334A2 (en) | 2000-12-15 | 2002-06-20 | Cytochroma Inc. | P450rai-2 (p450 cytochrome 26b), encoding nucleic acid molecules and methods and uses thereof |
| US6380256B1 (en) * | 2000-08-29 | 2002-04-30 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6387951B1 (en) * | 2000-08-29 | 2002-05-14 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6303785B1 (en) | 2000-08-29 | 2001-10-16 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6252090B1 (en) * | 2000-08-29 | 2001-06-26 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6313107B1 (en) * | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
| US20030166932A1 (en) | 2002-01-04 | 2003-09-04 | Beard Richard L. | Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
| GB0204735D0 (en) * | 2002-02-28 | 2002-04-17 | Inpharmatica Ltd | Protein |
| BRPI0412424A (pt) | 2003-07-10 | 2006-09-05 | Osi Pharm Inc | composto, composição farmacêutica, método para tratar doenças dermatológicas ou cancerosas em um mamìfero, composição, e, método para tratar doenças relacionadas com a pele ou cancerosas |
| US7226951B2 (en) * | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
-
2004
- 2004-12-13 CA CA002550010A patent/CA2550010A1/en not_active Abandoned
- 2004-12-13 EP EP04814113A patent/EP1696899A1/en not_active Withdrawn
- 2004-12-13 US US11/010,953 patent/US7468391B2/en not_active Expired - Fee Related
- 2004-12-13 WO PCT/US2004/041889 patent/WO2005058301A1/en not_active Ceased
- 2004-12-13 JP JP2006545811A patent/JP2007515433A/ja active Pending
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