JP2007515393A5 - - Google Patents
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- JP2007515393A5 JP2007515393A5 JP2006532504A JP2006532504A JP2007515393A5 JP 2007515393 A5 JP2007515393 A5 JP 2007515393A5 JP 2006532504 A JP2006532504 A JP 2006532504A JP 2006532504 A JP2006532504 A JP 2006532504A JP 2007515393 A5 JP2007515393 A5 JP 2007515393A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- adjuvant
- polypeptide
- enhanzyn
- quila
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000240 adjuvant Effects 0.000 claims 6
- 239000002671 adjuvant Substances 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 210000001744 T-Lymphocytes Anatomy 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002708 enhancing Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000036210 malignancy Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 1
- 230000004936 stimulating Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
Claims (8)
- 患者における免疫応答の増強または誘導における使用のための組成物であって、以下：
（ａ）配列番号４６１に示される短縮型ＷＴ１−Ｆポリペプチドを含むＷＴ１ポリペプチド；ならびに
（ｂ）Ｅｎｈａｎｚｙｎ、ＲＣ−５２９−ＳＥ、およびＲＣ−５２９−ＡＦとＱｕｉｌＡとの組み合わせからなる群より選択されるアジュバント；
を含有する、組成物。 - 前記アジュバントがＥｎｈａｎｚｙｎを含む、請求項１に記載の組成物。
- 前記アジュバントがＲＣ−５２９−ＳＥを含む、請求項１に記載の組成物。
- 前記アジュバントがＲＣ−５２９−ＡＦとＱｕｉｌＡとの組み合わせを含む、請求項１に記載の組成物。
- ＷＴ１に特異的なＴ細胞を刺激および／または増殖させるためのエキソビボにおける方法であって、以下：
（ａ）配列番号４６１に示される短縮型ＷＴ１−Ｆポリペプチドを含むＷＴ１ポリペプチド；ならびに
（ｂ）Ｅｎｈａｎｚｙｎ、ＲＣ−５２９−ＳＥ、およびＲＣ−５２９−ＡＦとＱｕｉｌＡとの組み合わせからなる群より選択されるアジュバント；
を含有する組成物とＴ細胞とを、Ｔ細胞の刺激および／または増殖を可能にするのに十分な条件および時間のもとで接触させる工程を包含する、方法。 - 患者におけるＷＴ１関連悪性疾患の治療における使用のための組成物であって、以下：
（ａ）配列番号４６１に示される短縮型ＷＴ１−Ｆポリペプチドを含むＷＴ１ポリペプチド；ならびに
（ｂ）Ｅｎｈａｎｚｙｎ、ＲＣ−５２９−ＳＥ、およびＲＣ−５２９−ＡＦとＱｕｉｌＡとの組み合わせからなる群より選択されるアジュバント；
を含有する、組成物。 - 患者における免疫応答を増強または誘導するための医薬の製造のための、請求項１〜４に記載の組成物の使用。
- 患者におけるＷＴ１関連悪性疾患の治療のための医薬の製造のための、請求項６に記載の組成物の使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/427,717 US7553494B2 (en) | 2001-08-24 | 2003-04-30 | WT1 fusion proteins |
| PCT/US2004/013240 WO2004100870A2 (en) | 2003-04-30 | 2004-04-29 | Compositions and methods for wt1 specific immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007515393A JP2007515393A (ja) | 2007-06-14 |
| JP2007515393A5 true JP2007515393A5 (ja) | 2007-07-26 |
Family
ID=33449619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532504A Pending JP2007515393A (ja) | 2003-04-30 | 2004-04-29 | Ｗｔ１特異的な免疫治療のための組成物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7553494B2 (ja) |
| EP (1) | EP1617863A4 (ja) |
| JP (1) | JP2007515393A (ja) |
| KR (1) | KR20060054176A (ja) |
| CN (1) | CN1816349A (ja) |
| AU (1) | AU2004238226A1 (ja) |
| BR (1) | BRPI0409879A (ja) |
| CA (1) | CA2523943A1 (ja) |
| CO (1) | CO5700788A2 (ja) |
| MA (1) | MA27873A1 (ja) |
| MX (1) | MXPA05011755A (ja) |
| NO (1) | NO20055347L (ja) |
| RU (1) | RU2005137167A (ja) |
| TW (1) | TW200509967A (ja) |
| WO (1) | WO2004100870A2 (ja) |
| ZA (1) | ZA200509609B (ja) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4422903B2 (ja) | 1998-07-31 | 2010-03-03 | 株式会社癌免疫研究所 | 癌抑制遺伝子ｗｔ１の産物に基づく癌抗原 |
| US7901693B2 (en) * | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7329410B1 (en) * | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
| ATE383375T1 (de) * | 2001-03-22 | 2008-01-15 | Int Inst Cancer Immunology Inc | Wti-modifiziertes peptid |
| US7553494B2 (en) * | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
| EP1720565A1 (en) * | 2004-03-04 | 2006-11-15 | Corixa Corporation | Co-encapsulated wt1 polypeptide and immunostimulant microsphere formulations and methods thereof |
| EP1951281B1 (en) | 2005-10-17 | 2015-04-15 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| US9265816B2 (en) * | 2006-04-10 | 2016-02-23 | Sloan Kettering Institute For Cancer Research | Immunogenic WT-1 peptides and methods of use thereof |
| TWI426269B (zh) * | 2006-08-14 | 2014-02-11 | Academia Sinica | 胃液蛋白分析於胃癌鑑定之方法 |
| DK2479275T3 (en) * | 2006-12-28 | 2015-12-14 | Int Inst Cancer Immunology Inc | HLA-A * 1101-restricted WT1 peptide or pharmaceutical composition comprising this |
| AU2012227350C1 (en) * | 2006-12-28 | 2015-11-12 | International Institute Of Cancer Immunology, Inc. | HLA-A*1101-Restricted WT1 peptide and pharmaceutical composition comprising the same |
| MX352947B (es) * | 2007-02-27 | 2017-12-14 | Int Inst Cancer Immunology Inc | Metodo para activacion de celula t auxiliar y composicion para usarse en el metodo. |
| US20090035360A1 (en) | 2007-05-24 | 2009-02-05 | Dominique Ingrid Lemoine | Lyophilised antigen composition |
| EP3539567A1 (en) | 2007-07-02 | 2019-09-18 | Etubics Corporation | Methods and compositions for producing an adenovirus vector for use with multiple vaccinations |
| UY32560A (es) | 2009-04-29 | 2010-11-30 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| AU2012230780B2 (en) * | 2011-03-23 | 2016-10-27 | Fred Hutchinson Cancer Center | Method and compositions for cellular immunotherapy |
| AU2012236068A1 (en) * | 2011-04-01 | 2013-10-17 | Eureka Therapeutics, Inc. | T cell receptor-like antibodies specific for a WT1 peptide presented by HLA-A2 |
| US20150104413A1 (en) | 2012-01-13 | 2015-04-16 | Memorial Sloan Kettering Cancer Center | Immunogenic wt-1 peptides and methods of use thereof |
| US9605276B2 (en) | 2012-08-24 | 2017-03-28 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
| KR102258021B1 (ko) * | 2012-12-13 | 2021-06-01 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Ｗｔ１ 백신 |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| HUE052541T2 (hu) | 2013-01-15 | 2021-05-28 | Memorial Sloan Kettering Cancer Center | Immunogén WT-1 peptidek és eljárások azok alkalmazására |
| CA2841016A1 (en) | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Wt1 peptide cancer vaccine composition for transdermal administration |
| RU2697443C2 (ru) * | 2013-02-05 | 2019-08-14 | Нитто Денко Корпорейшн | Препарат противораковой вакцины, содержащий пептид wt1, в форме ленты трансдермального введения |
| KR102045029B1 (ko) * | 2013-02-05 | 2019-11-14 | 닛토덴코 가부시키가이샤 | 점막 투여용 ｗｔ1 펩티드 암 백신 조성물 |
| US10253075B2 (en) | 2014-02-26 | 2019-04-09 | tella, Inc. | WT1 antigenic polypeptide, and anti-tumor agent containing said polypeptide |
| US10739344B2 (en) * | 2014-12-29 | 2020-08-11 | West Virginia University | Zinc finger linker (ZnFL) antibody |
| JP6770269B2 (ja) * | 2015-06-25 | 2020-10-14 | 国立大学法人神戸大学 | 経口腫瘍ワクチン |
| WO2017087857A1 (en) | 2015-11-20 | 2017-05-26 | Memorial Sloan Kettering Cancer Center | Methods and compositions for treating cancer |
| WO2017112944A1 (en) * | 2015-12-23 | 2017-06-29 | Fred Hutchinson Cancer Research Center | High affinity t cell receptors and uses thereof |
| CN105713874A (zh) * | 2016-01-29 | 2016-06-29 | 深圳市中美康士生物科技有限公司 | 一种抗肿瘤相关抗原wt1特异性ctl及其制备方法 |
| EP3549957A4 (en) | 2016-11-30 | 2020-08-05 | Sumitomo Dainippon Pharma Co., Ltd. | WT1-HELPER PEPTIDE AND COMBINATION OF THE SAYING PEPTIDE AND A CANCER ANTIGEN PEPTIDE CONJUGATE |
| US20210100886A1 (en) | 2017-03-30 | 2021-04-08 | Sumitomo Dainippon Pharma Co., Ltd. | Wt1 cancer antigen peptides and peptide conjugates comprising the peptides |
| WO2020067453A1 (ja) | 2018-09-28 | 2020-04-02 | 大日本住友製薬株式会社 | 注射用組成物 |
| MX2022014249A (es) * | 2020-05-12 | 2023-02-22 | Sumitomo Pharma Co Ltd | Composición farmacéutica para tratar el cáncer. |
| EP4385519A1 (en) | 2021-08-12 | 2024-06-19 | International Institute of Cancer Immunology, Inc. | Pharmaceutical composition and method for treatment or prevention of cancer |
| CN113730562B (zh) * | 2021-09-10 | 2024-06-04 | 中国人民解放军陆军军医大学 | 以壳聚糖修饰plga的wt1多肽纳米粒疫苗及其制备方法和应用 |
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| DE69033127T2 (de) * | 1989-11-13 | 1999-10-14 | Massachusetts Inst Technology | Lokalisation und charakterisierung des wilms-tumor-gens |
| ATE152915T1 (de) * | 1991-11-29 | 1997-05-15 | Viagene Inc | Immuntherapeutische vektorkonstrukte gegen krebs |
| WO1994001133A1 (en) * | 1992-07-08 | 1994-01-20 | Schering Corporation | Use of gm-csf as a vaccine adjuvant |
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| AU6363094A (en) | 1993-03-15 | 1994-10-11 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Peptide coated dendritic cells as immunogens |
| US5705159A (en) | 1993-08-31 | 1998-01-06 | John Wayne Cancer Institute | Immunoreactive peptide sequence from a 43 KD human cancer antigen |
| US5622835A (en) | 1994-04-28 | 1997-04-22 | The Wistar Institute Of Anatomy & Biology | WT1 monoclonal antibodies |
| US5670317A (en) | 1995-05-08 | 1997-09-23 | Sloan-Kettering Institute For Cancer Research | Diagnostic test for the desmoplastic small round cell tumor |
| DE69636339T2 (de) | 1995-06-01 | 2007-07-19 | Kishimoto, Tadamitsu, Tondabayashi | Wachstumsinhibitor gegen leukämische zellen, der antisense-oligonukleotidderivate gegen das wilms-tumorgen enthält |
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| US7329410B1 (en) | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
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| RU2237674C2 (ru) | 1998-09-30 | 2004-10-10 | Корикса Корпорейшн | Композиции и способы wt1-специфичной иммунотерапии |
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| US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| NZ521430A (en) | 2000-02-22 | 2004-04-30 | Corixa Corp | Compositions comprising 1-4 antigenic peptide fragments of the Wilms' tumour gene product for treatment or prevention of malignant mesothelioma |
| CN1314359A (zh) | 2000-03-17 | 2001-09-26 | 上海博德基因开发有限公司 | 一种新的多肽——肿瘤抑制因子63和编码这种多肽的多核苷酸 |
| JP2004509612A (ja) | 2000-06-05 | 2004-04-02 | アバロン ファーマシューティカルズ | ガン遺伝子決定および特徴的な遺伝子群を用いた治療用スクリーニング |
| AU2001266787A1 (en) | 2000-06-07 | 2002-01-08 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
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| US7553494B2 (en) * | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
-
2003
- 2003-04-30 US US10/427,717 patent/US7553494B2/en not_active Expired - Fee Related
-
2004
- 2004-04-29 CA CA002523943A patent/CA2523943A1/en not_active Abandoned
- 2004-04-29 MX MXPA05011755A patent/MXPA05011755A/es unknown
- 2004-04-29 JP JP2006532504A patent/JP2007515393A/ja active Pending
- 2004-04-29 BR BRPI0409879-0A patent/BRPI0409879A/pt not_active IP Right Cessation
- 2004-04-29 KR KR1020057020608A patent/KR20060054176A/ko not_active Application Discontinuation
- 2004-04-29 EP EP04750910A patent/EP1617863A4/en not_active Withdrawn
- 2004-04-29 AU AU2004238226A patent/AU2004238226A1/en not_active Abandoned
- 2004-04-29 RU RU2005137167/15A patent/RU2005137167A/ru not_active Application Discontinuation
- 2004-04-29 CN CNA2004800184705A patent/CN1816349A/zh active Pending
- 2004-04-29 WO PCT/US2004/013240 patent/WO2004100870A2/en active Application Filing
- 2004-04-30 TW TW093112333A patent/TW200509967A/zh unknown
-
2005
- 2005-11-11 MA MA28598A patent/MA27873A1/fr unknown
- 2005-11-11 NO NO20055347A patent/NO20055347L/no not_active Application Discontinuation
- 2005-11-28 ZA ZA200509609A patent/ZA200509609B/xx unknown
- 2005-11-30 CO CO05121536A patent/CO5700788A2/es not_active Application Discontinuation
-
2009
- 2009-05-21 US US12/470,408 patent/US7915393B2/en not_active Expired - Fee Related
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