JP2007512027A5 - - Google Patents

Download PDF

Info

Publication number
JP2007512027A5
JP2007512027A5 JP2006541617A JP2006541617A JP2007512027A5 JP 2007512027 A5 JP2007512027 A5 JP 2007512027A5 JP 2006541617 A JP2006541617 A JP 2006541617A JP 2006541617 A JP2006541617 A JP 2006541617A JP 2007512027 A5 JP2007512027 A5 JP 2007512027A5
Authority
JP
Japan
Prior art keywords
irna
irna molecule
cell
molecule
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006541617A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007512027A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/039191 external-priority patent/WO2005081714A2/en
Publication of JP2007512027A publication Critical patent/JP2007512027A/ja
Publication of JP2007512027A5 publication Critical patent/JP2007512027A5/ja
Pending legal-status Critical Current

Links

JP2006541617A 2003-11-21 2004-11-22 トランスジェニック動物の産生における干渉rnaの使用 Pending JP2007512027A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52393803P 2003-11-21 2003-11-21
PCT/US2004/039191 WO2005081714A2 (en) 2003-11-21 2004-11-22 Use of interfering rna in the production of transgenic animals

Publications (2)

Publication Number Publication Date
JP2007512027A JP2007512027A (ja) 2007-05-17
JP2007512027A5 true JP2007512027A5 (https=) 2008-01-10

Family

ID=34910676

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006541617A Pending JP2007512027A (ja) 2003-11-21 2004-11-22 トランスジェニック動物の産生における干渉rnaの使用

Country Status (7)

Country Link
US (1) US10793873B2 (https=)
EP (2) EP2514826A3 (https=)
JP (1) JP2007512027A (https=)
CN (2) CN1972593A (https=)
AU (1) AU2004316293A1 (https=)
CA (1) CA2546853C (https=)
WO (1) WO2005081714A2 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4948163B2 (ja) * 2003-05-23 2012-06-06 サーナ・セラピューティクス・インコーポレイテッド 化学修飾した低分子干渉核酸(siNA)を使用する遺伝子発現のRNA干渉仲介抑制
CA2533259C (en) * 2003-07-21 2014-01-28 Lifecell Corporation Acellular tissue matrices made from galactose .alpha.-1,3-galactose-deficient tissue
EP1582591A3 (en) * 2004-02-27 2005-12-21 Bundesrepublik Deutschland vertreten durch das Bundesminsterium für Gesundheit, dieses vertr. durch das Robert-Koch-Institut Sirna and their use for knock down expression of porcine endogenous retrovirus
US20070033666A1 (en) * 2005-06-24 2007-02-08 Harris Reuben S Using cytosine deaminases to diminish retroelement transfer from pigs to humans
JP2007104969A (ja) * 2005-10-13 2007-04-26 Bio Think Tank Co Ltd ショートヘアピン型RNA(shRNA)前駆体を産生するための核酸及びその利用
JP5832721B2 (ja) * 2007-03-14 2015-12-16 バイオンシル・エス.アール.エル.Bionsil S.R.L. 上皮腫瘍細胞における薬剤耐性のモジュレータ化合物
DK2164967T3 (en) 2007-05-31 2015-10-19 Univ Iowa Res Found Reduction of off-target rna interferenstoksicitet
JP5554231B2 (ja) * 2007-06-13 2014-07-23 コモンウェルス サイエンティフィック アンドインダストリアル リサーチ オーガナイゼーション トリの生産形質の改変
WO2010008562A2 (en) * 2008-07-16 2010-01-21 Recombinetics Methods and materials for producing transgenic animals
WO2010125117A2 (en) * 2009-04-29 2010-11-04 Ralph Wirtz A method to assess prognosis and to predict therapeutic success in cancer by determining hormone receptor expression levels
CN105911275B (zh) * 2009-08-14 2018-06-29 加利福尼亚大学董事会 诊断自闭症的试剂盒
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
JP2013534824A (ja) * 2010-06-24 2013-09-09 ジ・オハイオ・ステート・ユニバーシティ 標的化されたmiR−29発現によりマウスにおいてモデル化された慢性リンパ性白血病
WO2012109667A1 (en) 2011-02-12 2012-08-16 University Of Iowa Research Foundation Therapeutic compounds
EP2698379A4 (en) * 2011-03-18 2015-04-29 Shanghai Inst Biol Sciences INSECTROSIVE PREPARATION AND METHODS BASED ON RNAI TECHNOLOGY
WO2013188358A1 (en) * 2012-06-12 2013-12-19 The General Hospital Corporation Miniature swine transgenic for one or more coagulation factors
WO2015066668A1 (en) 2013-11-04 2015-05-07 Lifecell Corporation Methods of removing alpha-galactose
CN104677866A (zh) * 2014-03-25 2015-06-03 中国科学院大连化学物理研究所 测定CP装载siRNA体系中siRNA释放的方法
EP3146051B8 (en) 2014-05-20 2019-11-27 University of Iowa Research Foundation Huntington's disease therapeutic compounds
CN104232670A (zh) * 2014-08-25 2014-12-24 中国水产科学研究院黑龙江水产研究所 一种采用鱼类转基因方法构建的基于鲤鱼mstn干涉载体及其构建方法
HK1254818A1 (zh) 2015-06-26 2019-07-26 The Regents Of The University Of California 抗原肽及其用於诊断和治疗自闭症的用途
CN108513580A (zh) 2015-10-08 2018-09-07 哈佛学院董事及会员团体 多重基因组编辑
CN106918697B (zh) * 2017-02-15 2018-07-31 中国医学科学院北京协和医院 一种预测ra药物疗效的诊断标志物及其应用
KR102746223B1 (ko) 2017-04-20 2024-12-27 이제네시스, 인크. 유전자 변형 동물의 생성 방법
CN107760682B (zh) * 2017-10-18 2020-12-18 云南大学 一种可用于分子防治害虫的核酸序列及其应用
CN110628807B (zh) * 2018-05-30 2021-06-18 中国科学院植物研究所 盐角草SePSS蛋白及其编码基因与应用
US20210277421A1 (en) * 2018-08-06 2021-09-09 NemaMetrix, Inc Homologous Recombination Reporter Construct and Uses Thereof
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
MX2021003866A (es) 2018-10-05 2021-09-08 Xenotherapeutics Inc Productos y metodos de xenotransplante.
US20210395738A1 (en) 2018-11-08 2021-12-23 Greenlight Biosciences, Inc. Control of insect infestation
CN110055253A (zh) * 2019-04-28 2019-07-26 复旦大学附属金山医院 一种针对人半胱氨酸蛋白酶抑制剂B的siRNA分子及其应用
US20220012673A1 (en) * 2020-07-13 2022-01-13 ZenDesk, Inc. Maintaining status information for customer-support agents across multiple channels
EP4256061A1 (en) * 2020-12-01 2023-10-11 ETH Zurich Dna constructs comprising alternative promoters
WO2022235971A2 (en) * 2021-05-06 2022-11-10 Systems Oncology, Llc Compositions for inhibiting growth of targeted cells
WO2022256294A1 (en) * 2021-06-01 2022-12-08 University Of Massachusetts Cas9 nickase-mediated gene editing
WO2023004365A1 (en) * 2021-07-20 2023-01-26 Sio Gene Therapies Inc. Vector constructs for delivery of nucleic acids encoding therapeutic proteasome activator complex subunits and methods of using the same
CN115011601B (zh) * 2022-06-27 2023-07-21 山东大学齐鲁医院 一种干扰JUND表达的shRNA、重组腺相关病毒载体及其应用
CN118581151B (zh) * 2024-05-29 2024-12-06 中国农业科学院兰州兽医研究所(中国动物卫生与流行病学中心兰州分中心) 一种猪becn1基因敲除细胞的构建方法及其应用
CN120608104B (zh) * 2025-08-12 2025-11-25 中国科学院水生生物研究所 lasp1基因在鱼类抗病毒免疫调控中的功能和应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4517338A (en) 1983-06-20 1985-05-14 Chiron Corporation Multiple reactor system and method for polynucleotide synthesis
US4888274A (en) 1985-09-18 1989-12-19 Yale University RecA nucleoprotein filament and methods
FR2646438B1 (fr) 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
WO1999046388A1 (en) 1998-03-12 1999-09-16 Taisho Pharmaceutical Co., Ltd. Nucleic acid enzyme showing allosteric rna-cleaving activity on target rna
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CN101818145A (zh) 1998-03-20 2010-09-01 联邦科学和工业研究组织 控制基因表达
AU5682999A (en) 1998-08-18 2000-03-14 Biotransplant Incorporated Molecular sequence of swine retrovirus and methods of use
EP1272630A2 (en) * 2000-03-16 2003-01-08 Genetica, Inc. Methods and compositions for rna interference
US20030084471A1 (en) * 2000-03-16 2003-05-01 David Beach Methods and compositions for RNA interference
ES2336887T5 (es) 2000-03-30 2019-03-06 Whitehead Inst Biomedical Res Mediadores de interferencia por ARN específicos de secuencias de ARN
US20030143597A1 (en) * 2000-12-28 2003-07-31 Finney Robert E. Methods for making polynucleotide libraries, polynucleotide arrays, and cell libraries for high-throughput genomics analysis
EP1386004A4 (en) 2001-04-05 2005-02-16 Ribozyme Pharm Inc MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
KR20040023596A (ko) * 2001-05-01 2004-03-18 도꾸리쯔교세이호진 상교기쥬쯔 소고겡뀨죠 신규 맥시자임
IL159756A0 (en) * 2001-07-12 2004-06-20 Univ Massachusetts IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING
WO2003012052A2 (en) * 2001-07-30 2003-02-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Specific inhibition of gene expression by small double stranded rnas
JP4344858B2 (ja) * 2001-09-13 2009-10-14 カリフォルニア インスティチュート オブ テクノロジー 細胞内で抗ウイルス性小rna分子を発現させる方法
US20030148519A1 (en) 2001-11-14 2003-08-07 Engelke David R. Intracellular expression and delivery of siRNAs in mammalian cells
JP2005538685A (ja) 2001-12-21 2005-12-22 トランザイム, インコーポレイテッド レンチウイルスベクターを使用して遺伝的に改変された動物を生成するための方法および組成物
CN1620508A (zh) 2001-12-21 2005-05-25 牛津生物医学(英国)有限公司 转基因生物
GB0130955D0 (en) 2001-12-24 2002-02-13 Cancer Res Ventures Expression system
EP1572902B1 (en) 2002-02-01 2014-06-11 Life Technologies Corporation HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
US20030203868A1 (en) * 2002-02-06 2003-10-30 Bushman Frederic D. Inhibition of pathogen replication by RNA interference
US20040045043A1 (en) 2002-05-20 2004-03-04 Finney Robert E. Compositions and methods for generating conditional knockouts
DK1534819T3 (da) 2002-08-21 2010-04-19 Revivicor Inc Griselignende dyr, som mangler enhver ekspression af funktionel alfa-1,3-galactosyltransferase
US20040072769A1 (en) * 2002-09-16 2004-04-15 Yin James Qinwei Methods for design and selection of short double-stranded oligonucleotides, and compounds of gene drugs
CN1276976C (zh) * 2003-10-30 2006-09-27 封江南 单一载体编码多个发夹结构小干扰性rna表达系统及其构建方法
EP1582591A3 (en) * 2004-02-27 2005-12-21 Bundesrepublik Deutschland vertreten durch das Bundesminsterium für Gesundheit, dieses vertr. durch das Robert-Koch-Institut Sirna and their use for knock down expression of porcine endogenous retrovirus

Similar Documents

Publication Publication Date Title
JP2007512027A5 (https=)
CN101939446B (zh) 人类卵巢癌中的微小rna特征
CN101835902B (zh) 编码ncrna的超保守区域
EP2516647B1 (en) Molecule for treating an inflammatory disorder
JP5426383B2 (ja) 慢性リンパ球性白血病におけるmiR−29およびmiR−181によって制御されるTCL1発現
ES2739804T3 (es) Compuestos terapéuticos
JP2019512014A (ja) がん診断法および治療法におけるpiRNAを使用する組成物および方法
US20130323838A1 (en) TRIGGERED RNAi
JP2002272489A5 (https=)
CN103380215A (zh) 包含锁定核苷酸的微rna抑制剂
JP2008526213A (ja) 自己保護オリゴヌクレオチドを使用する、遺伝子発現を調節するための組成物および方法
EP3957751B1 (en) Short rna-primed xeno sensor module amplification-based short rna detection technique
CN102181517A (zh) 绵羊mstn基因启动子区两个新snp位点检测及其检测方法的建立
CN118541481A (zh) 用分化簇109(cd109)抑制剂治疗骨矿物质密度降低的方法
Lee et al. Lineage specific evolutionary events on SFTPB gene: Alu recombination-mediated deletion (ARMD), exonization, and alternative splicing events
CN1269962C (zh) 一种哺乳动物细胞siRNA表达载体
US11357853B2 (en) Inhibition of a lncRNA for treatment of neuroblastoma
EP4466357A2 (en) Methods of improving health with apolipoprotein e (apoe) inhibitors
AU2015203577A1 (en) Molecule for treating an inflammatory disorder
AU2014202073B2 (en) MicroRNA signatures in human ovarian cancer
CA3222828A1 (en) Treatment of hypertension with solute carrier family 9 isoform a3 regulatory factor 2 (slc9a3r2) inhibitors
TW201012927A (en) Type III promoter of RNA polymerase III