JP2007509950A - Ｈｃｖ処置の組合せ剤 - Google Patents

Ｈｃｖ処置の組合せ剤 Download PDF

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Publication number
JP2007509950A
JP2007509950A JP2006538195A JP2006538195A JP2007509950A JP 2007509950 A JP2007509950 A JP 2007509950A JP 2006538195 A JP2006538195 A JP 2006538195A JP 2006538195 A JP2006538195 A JP 2006538195A JP 2007509950 A JP2007509950 A JP 2007509950A
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JP
Japan
Prior art keywords
inhibitor
hepatitis
virus
cytochrome
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006538195A
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English (en)
Japanese (ja)
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JP2007509950A5 (enExample
Inventor
ロジャー・ディ・トゥン
グルダット・チャンドルカル
ロバート・ビー・パーニ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2007509950A publication Critical patent/JP2007509950A/ja
Publication of JP2007509950A5 publication Critical patent/JP2007509950A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Catalysts (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2006538195A 2003-10-27 2004-10-27 Ｈｃｖ処置の組合せ剤 Pending JP2007509950A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51485303P 2003-10-27 2003-10-27
PCT/US2004/035549 WO2005042020A2 (en) 2003-10-27 2004-10-27 Combinations for hcv treatment

Publications (2)

Publication Number Publication Date
JP2007509950A true JP2007509950A (ja) 2007-04-19
JP2007509950A5 JP2007509950A5 (enExample) 2008-07-03

Family

ID=34549356

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006538195A Pending JP2007509950A (ja) 2003-10-27 2004-10-27 Ｈｃｖ処置の組合せ剤

Country Status (22)

Country Link
US (3) US20060003942A1 (enExample)
EP (1) EP1677827B1 (enExample)
JP (1) JP2007509950A (enExample)
KR (1) KR20060120162A (enExample)
CN (1) CN1893978A (enExample)
AT (1) ATE416789T1 (enExample)
AU (1) AU2004285503A1 (enExample)
BR (1) BRPI0415935A (enExample)
CA (1) CA2543696A1 (enExample)
CY (1) CY1110176T1 (enExample)
DE (1) DE602004018363D1 (enExample)
DK (1) DK1677827T3 (enExample)
ES (1) ES2319775T3 (enExample)
IL (1) IL175211A0 (enExample)
MX (1) MXPA06004723A (enExample)
NO (1) NO20062428L (enExample)
PL (1) PL1677827T3 (enExample)
PT (1) PT1677827E (enExample)
RU (1) RU2006118359A (enExample)
SI (1) SI1677827T1 (enExample)
WO (1) WO2005042020A2 (enExample)
ZA (1) ZA200603863B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010532755A (ja) * 2007-07-06 2010-10-14 ギリアード サイエンシーズ， インコーポレイテッド 治療剤の薬物動態特性の調整剤
JP2015078193A (ja) * 2008-02-28 2015-04-23 アッヴィ・インコーポレイテッド 錠剤およびその調製
JP2018519340A (ja) * 2015-06-30 2018-07-19 アイガー グループ インターナショナル インコーポレイテッド 炎症性状態および癌性状態を治療するための、クロロキン化合物およびクレミゾール化合物の使用

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US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
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RU2373923C2 (ru) * 2004-06-08 2009-11-27 Вертекс Фармасьютикалз Инкорпорейтед Фармацевтические композиции
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US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
CA2643688A1 (en) 2006-02-27 2007-08-30 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
CN101460166B (zh) * 2006-03-06 2014-11-19 Abbvie公司 用于治疗c型肝炎病毒的利托那韦组合物及其用途
US20070225297A1 (en) 2006-03-16 2007-09-27 Perni Robert B Deuterated hepatitis C protease inhibitors
US20070218138A1 (en) * 2006-03-20 2007-09-20 Bittorf Kevin J Pharmaceutical Compositions
WO2007111866A2 (en) * 2006-03-23 2007-10-04 Schering Corporation Combinations of hcv protease inhibitor(s) and cyp3a4 inhibitor(s), and methods of treatment related thereto
UA100666C2 (uk) 2006-04-11 2013-01-25 Новартіс Аг Інгібітори нсv/віл та їх застосування
WO2007149382A2 (en) * 2006-06-19 2007-12-27 The Cleveland Clinic Foundation Therapeutic compositions and methods useful in treating hepatitis
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EP2112925A4 (en) * 2006-11-15 2013-01-09 Abbott Lab SOLID PHARMACEUTICAL DOSAGE FORMULATIONS
EP2134717A2 (en) * 2007-02-27 2009-12-23 Vertex Pharmceuticals Incorporated Inhibitors of serine proteases
MX2009009182A (es) * 2007-02-27 2009-09-04 Vertex Pharma Co-cristales y composiciones farmaceuticas que los comprenden.
NZ583699A (en) * 2007-08-30 2012-04-27 Vertex Pharma Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same
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Cited By (5)

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Publication number Priority date Publication date Assignee Title
JP2010532755A (ja) * 2007-07-06 2010-10-14 ギリアード サイエンシーズ， インコーポレイテッド 治療剤の薬物動態特性の調整剤
JP2015078193A (ja) * 2008-02-28 2015-04-23 アッヴィ・インコーポレイテッド 錠剤およびその調製
JP2018519340A (ja) * 2015-06-30 2018-07-19 アイガー グループ インターナショナル インコーポレイテッド 炎症性状態および癌性状態を治療するための、クロロキン化合物およびクレミゾール化合物の使用
JP7068827B2 (ja) 2015-06-30 2022-05-17 アイガー グループ インターナショナル インコーポレイテッド 炎症性状態および癌性状態を治療するための、クロロキン化合物およびクレミゾール化合物の使用
US12090141B2 (en) 2015-06-30 2024-09-17 Eiger Group International, Inc. Use of clemizole compounds for treatment of inflammatory conditions

Also Published As

Publication number Publication date
PL1677827T3 (pl) 2009-06-30
CY1110176T1 (el) 2015-01-14
EP1677827A2 (en) 2006-07-12
CN1893978A (zh) 2007-01-10
MXPA06004723A (es) 2006-07-05
WO2005042020A3 (en) 2005-06-23
US20120114604A1 (en) 2012-05-10
PT1677827E (pt) 2009-03-13
AU2004285503A1 (en) 2005-05-12
KR20060120162A (ko) 2006-11-24
ATE416789T1 (de) 2008-12-15
ES2319775T3 (es) 2009-05-12
RU2006118359A (ru) 2007-12-10
CA2543696A1 (en) 2005-05-12
SI1677827T1 (sl) 2009-06-30
WO2005042020A2 (en) 2005-05-12
EP1677827B1 (en) 2008-12-10
NO20062428L (no) 2006-05-29
IL175211A0 (en) 2006-09-05
BRPI0415935A (pt) 2007-01-02
DK1677827T3 (da) 2009-03-30
US20060003942A1 (en) 2006-01-05
ZA200603863B (en) 2007-11-28
US20100015090A1 (en) 2010-01-21
DE602004018363D1 (de) 2009-01-22

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