JP2007507553A5 - - Google Patents
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- Publication number
- JP2007507553A5 JP2007507553A5 JP2006534330A JP2006534330A JP2007507553A5 JP 2007507553 A5 JP2007507553 A5 JP 2007507553A5 JP 2006534330 A JP2006534330 A JP 2006534330A JP 2006534330 A JP2006534330 A JP 2006534330A JP 2007507553 A5 JP2007507553 A5 JP 2007507553A5
- Authority
- JP
- Japan
- Prior art keywords
- pantoprazole
- multiparticulates
- core
- multiparticulate
- seal coat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005019 pantoprazole Drugs 0.000 claims 63
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 claims 58
- 239000004094 surface-active agent Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 6
- YNWDKZIIWCEDEE-UHFFFAOYSA-N pantoprazole sodium Chemical compound [Na+].COC1=CC=NC(CS(=O)C=2[N-]C3=CC=C(OC(F)F)C=C3N=2)=C1OC YNWDKZIIWCEDEE-UHFFFAOYSA-N 0.000 claims 5
- 239000000725 suspension Substances 0.000 claims 5
- 239000011230 binding agent Substances 0.000 claims 4
- 239000002702 enteric coating Substances 0.000 claims 4
- 238000009505 enteric coating Methods 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 3
- 229960000913 crospovidone Drugs 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- 239000003002 pH adjusting agent Substances 0.000 claims 3
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 3
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 229960003943 hypromellose Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 239000000454 talc Substances 0.000 claims 2
- 229910052623 talc Inorganic materials 0.000 claims 2
- 229920003138 Eudragit® L 30 D-55 Polymers 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 claims 1
- 239000011888 foil Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 201000000052 gastrinoma Diseases 0.000 claims 1
- 229920003130 hypromellose 2208 Polymers 0.000 claims 1
- 229940031707 hypromellose 2208 Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- -1 pantoprazole compound Chemical class 0.000 claims 1
- 229960004048 pantoprazole sodium Drugs 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50781003P | 2003-10-01 | 2003-10-01 | |
| US60/507,810 | 2003-10-01 | ||
| PCT/US2004/033058 WO2005032513A2 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007507553A JP2007507553A (ja) | 2007-03-29 |
| JP2007507553A5 true JP2007507553A5 (https=) | 2007-11-15 |
| JP4789806B2 JP4789806B2 (ja) | 2011-10-12 |
Family
ID=34421667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534330A Expired - Fee Related JP4789806B2 (ja) | 2003-10-01 | 2004-09-30 | パントプラゾール多粒子処方 |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US7544370B2 (https=) |
| EP (1) | EP1667660B1 (https=) |
| JP (1) | JP4789806B2 (https=) |
| KR (1) | KR101141508B1 (https=) |
| CN (1) | CN1886119B (https=) |
| AR (1) | AR045956A1 (https=) |
| AU (1) | AU2004278037B2 (https=) |
| BR (1) | BRPI0415014A8 (https=) |
| CA (1) | CA2539982C (https=) |
| CO (1) | CO5690538A2 (https=) |
| CR (1) | CR8318A (https=) |
| EC (1) | ECSP066538A (https=) |
| ES (1) | ES2529570T3 (https=) |
| GT (1) | GT200400194A (https=) |
| IL (1) | IL174432A (https=) |
| MX (1) | MX266708B (https=) |
| MY (1) | MY147180A (https=) |
| NO (1) | NO339714B1 (https=) |
| NZ (1) | NZ581267A (https=) |
| PE (1) | PE20050960A1 (https=) |
| PL (1) | PL1667660T3 (https=) |
| RS (2) | RS20060238A (https=) |
| RU (1) | RU2361574C2 (https=) |
| SG (1) | SG146656A1 (https=) |
| TW (1) | TWI372066B (https=) |
| UA (1) | UA83255C2 (https=) |
| WO (1) | WO2005032513A2 (https=) |
| ZA (1) | ZA200602682B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2004000983A1 (es) | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
| PE20050150A1 (es) | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
| TWI372066B (en) * | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
| US8461187B2 (en) | 2004-06-16 | 2013-06-11 | Takeda Pharmaceuticals U.S.A., Inc. | Multiple PPI dosage form |
| KR101313702B1 (ko) | 2005-02-03 | 2013-10-04 | 와이어쓰 | 제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물 |
| DE102005032806A1 (de) * | 2005-07-12 | 2007-01-18 | Röhm Gmbh | Verwendung eines teilneutralisierten, anionischen (Meth)acrylat-Copolymers als Überzug für die Herstellung einer Arzneiform mit einer Wirkstofffreisetzung bei erniedrigten pH-Werten |
| EP1747776A1 (en) * | 2005-07-29 | 2007-01-31 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising granular pantoprazole |
| EP1942937A1 (en) | 2005-11-04 | 2008-07-16 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
| CN101453996B (zh) * | 2006-04-03 | 2016-05-11 | 伊萨·奥迪迪 | 药物递送组合物 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| ITFI20070253A1 (it) * | 2007-11-09 | 2009-05-10 | Valpharma Internat S P A | Formulazioni farmaceutiche per la somministrazione di ipp. |
| BRPI0914790A2 (pt) | 2008-06-17 | 2015-10-20 | Wyeth Llc | uso de um composto de vinorelbina e um composto de hki-272, composição farmacêutica e produto e kit para o tratamento de neoplasma |
| US8669273B2 (en) | 2008-08-04 | 2014-03-11 | Wyeth Llc | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
| DK3000467T3 (da) | 2009-04-06 | 2023-03-27 | Wyeth Llc | Behandling med neratinib mod brystkræft |
| US20110066141A1 (en) * | 2009-09-11 | 2011-03-17 | Cook Incorporated | Implantable medical device having an anti-gastric distress agent |
| CA2780332C (en) * | 2009-11-09 | 2018-01-30 | Wyeth Llc | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
| KR101787481B1 (ko) | 2010-10-21 | 2017-10-18 | 롯데정밀화학 주식회사 | 장용성 경질 캡슐용 조성물 및 상기 조성물을 사용하여 제조된 장용성 경질 캡슐 |
| WO2012103411A2 (en) | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
| US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
| WO2012109216A1 (en) * | 2011-02-11 | 2012-08-16 | Zx Pharma, Llc | Multiparticulate l-menthol formulations and related methods |
| US8911780B2 (en) | 2011-02-11 | 2014-12-16 | Zx Pharma, Llc | Multiparticulate L-menthol formulations and related methods |
| US8808736B2 (en) | 2011-02-11 | 2014-08-19 | Zx Pharma, Llc | Enteric coated multiparticulate controlled release peppermint oil composition and related methods |
| CN102670528A (zh) * | 2012-05-29 | 2012-09-19 | 海南卫康制药(潜山)有限公司 | 注射用泮托拉唑钠冻干粉组合物及其制备方法 |
| WO2014016754A2 (en) * | 2012-07-26 | 2014-01-30 | Lupin Limited | Pharmaceutical compositions of proton pump inhibitor |
| RU2501549C1 (ru) | 2012-08-30 | 2013-12-20 | Авва Девелопмент Лтд | Фармацевтическая композиция для лечения гастроэзофагеальной рефлюксной болезни |
| CA2909591C (en) * | 2013-04-23 | 2017-03-28 | Zx Pharma, Llc | Enteric coated multiparticulate composition with proteinaceous subcoat |
| TWI649100B (zh) | 2013-06-17 | 2019-02-01 | 地平線罕見醫學製藥有限責任公司 | 延遲釋放型半胱胺珠粒調配物，以及其製備及使用方法 |
| US10143665B2 (en) | 2015-11-17 | 2018-12-04 | Horizon Orphan Llc | Methods for storing cysteamine formulations and related methods of treatment |
| WO2018065952A1 (en) * | 2016-10-06 | 2018-04-12 | Jubilant Generics Limited | Delayed release pharmaceutical composition of pantoprazole and process for preparation thereof |
| WO2020104955A1 (en) * | 2018-11-20 | 2020-05-28 | Dr. Reddy’S Laboratories Limited | Pharmaceutical compositions of acotiamide and proton pump inhibitor |
| CN113125583B (zh) * | 2019-12-30 | 2022-06-21 | 成都百裕制药股份有限公司 | 一种注射用泮托拉唑钠中基因毒性杂质含量的检测方法 |
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- 2004-09-30 MX MXPA06003602 patent/MX266708B/es active IP Right Grant
- 2004-09-30 RS YUP-2006/0238A patent/RS20060238A/sr unknown
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- 2004-09-30 SG SG200806912-2A patent/SG146656A1/en unknown
- 2004-09-30 JP JP2006534330A patent/JP4789806B2/ja not_active Expired - Fee Related
- 2004-09-30 KR KR1020067008414A patent/KR101141508B1/ko not_active Expired - Lifetime
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- 2004-09-30 PL PL04789540T patent/PL1667660T3/pl unknown
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- 2004-09-30 AU AU2004278037A patent/AU2004278037B2/en not_active Ceased
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