JP2007505902A - 好中球エラスターゼ阻害剤としての２−ピリドン誘導体およびその使用 - Google Patents

好中球エラスターゼ阻害剤としての２−ピリドン誘導体およびその使用 Download PDF

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Publication number
JP2007505902A
JP2007505902A JP2006526856A JP2006526856A JP2007505902A JP 2007505902 A JP2007505902 A JP 2007505902A JP 2006526856 A JP2006526856 A JP 2006526856A JP 2006526856 A JP2006526856 A JP 2006526856A JP 2007505902 A JP2007505902 A JP 2007505902A
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JP
Japan
Prior art keywords
phenyl
oxo
trifluoromethyl
methyl
alkyl
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Pending
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JP2006526856A
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English (en)
Japanese (ja)
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JP2007505902A5 (OSRAM
Inventor
ペーター・ハンセン
カロリナ・ラヴィッツ
ハンス・レン
アントニオス・ニキティディス
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AstraZeneca AB
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AstraZeneca AB
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Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of JP2007505902A publication Critical patent/JP2007505902A/ja
Publication of JP2007505902A5 publication Critical patent/JP2007505902A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2006526856A 2003-09-18 2004-09-15 好中球エラスターゼ阻害剤としての２−ピリドン誘導体およびその使用 Pending JP2007505902A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0302487A SE0302487D0 (sv) 2003-09-18 2003-09-18 Novel compounds
PCT/SE2004/001336 WO2005026124A1 (en) 2003-09-18 2004-09-15 2-pyridone derivatives as netrophil elastase inhibitors and their use

Publications (2)

Publication Number Publication Date
JP2007505902A true JP2007505902A (ja) 2007-03-15
JP2007505902A5 JP2007505902A5 (OSRAM) 2007-11-01

Family

ID=29212489

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006526856A Pending JP2007505902A (ja) 2003-09-18 2004-09-15 好中球エラスターゼ阻害剤としての２−ピリドン誘導体およびその使用

Country Status (25)

Country Link
US (1) US20070043036A1 (OSRAM)
EP (1) EP1663974B1 (OSRAM)
JP (1) JP2007505902A (OSRAM)
KR (1) KR20060096995A (OSRAM)
CN (1) CN100439339C (OSRAM)
AR (1) AR046083A1 (OSRAM)
AT (1) ATE420861T1 (OSRAM)
AU (1) AU2004272485B2 (OSRAM)
BR (1) BRPI0414570A (OSRAM)
CA (1) CA2538410A1 (OSRAM)
CO (1) CO5670357A2 (OSRAM)
DE (1) DE602004019110D1 (OSRAM)
ES (1) ES2319300T3 (OSRAM)
IL (1) IL173986A0 (OSRAM)
IS (1) IS8394A (OSRAM)
MX (1) MXPA06002723A (OSRAM)
NO (1) NO20061700L (OSRAM)
RU (1) RU2348617C2 (OSRAM)
SA (1) SA04250300B1 (OSRAM)
SE (1) SE0302487D0 (OSRAM)
TW (1) TW200526579A (OSRAM)
UA (1) UA84878C2 (OSRAM)
UY (1) UY28513A1 (OSRAM)
WO (1) WO2005026124A1 (OSRAM)
ZA (1) ZA200602262B (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013512954A (ja) * 2009-12-08 2013-04-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換インダゾール及びアザインダゾール化合物の生成に有効な中間体の合成方法
JP2017509611A (ja) * 2014-02-21 2017-04-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリドン及びピラジノン、並びに好中球エラスターゼ活性の阻害剤としてのその使用

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TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
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US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US20050288290A1 (en) 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
TW200700392A (en) * 2005-03-16 2007-01-01 Astrazeneca Ab Novel compounds
PT1928454E (pt) * 2005-05-10 2014-12-04 Intermune Inc Derivativos da piridona para modulação do sistema de proteína quinase ativada pelo stress
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
RU2442771C2 (ru) 2005-08-08 2012-02-20 Арджента Дискавери Лтд Производные бицикло[2,2,1]гепт-7-иламина и их применения
EP1940458A4 (en) * 2005-09-29 2010-03-03 Univ Alberta COMPOSITIONS AND METHODS OF INHIBITING GRANZYME B
GB0605469D0 (en) * 2006-03-17 2006-04-26 Argenta Discovery Ltd Multimers of heterocyclic compounds and their use
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
EP2535330A3 (en) 2006-10-23 2012-12-26 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
CA2669266C (en) 2006-11-08 2014-04-29 Bristol-Myers Squibb Company Pyridinone compounds
BRPI0819258A2 (pt) 2007-11-06 2017-05-02 Astrazeneca Ab alguns derivados de 2-pirazinona e seu uso como inibidores da elastase neutrófila
DK2327693T3 (da) 2007-12-14 2012-08-13 Pulmagen Therapeutics Asthma Ltd Indoler og terapeutisk anvendelse deraf
HRP20130040T1 (hr) 2008-01-23 2013-02-28 Bristol-Myers Squibb Company 4-piridinon spojevi i njihova uporaba kod karcinoma
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
AU2010215261A1 (en) 2009-02-17 2011-09-08 Chiesi Farmaceutici S.P.A. Triazolopyridine derivatives as p38 MAP kinase inhibitors
GB0902648D0 (en) 2009-02-17 2009-04-01 Argenta Discovery Ltd Pharmaceutical compounds and compositions
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
MX2012003644A (es) * 2009-10-02 2012-04-30 Astrazeneca Ab Compuestos de 2-piridona empleados como inhibidores de la elastasa neutrofila.
GB0918923D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminothiazole derivatives
GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
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GB201009731D0 (en) 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
CN104024241B (zh) 2011-08-01 2016-01-20 大日本住友制药株式会社 尿嘧啶衍生物和其用于医学目的的用途
RU2586333C1 (ru) 2011-12-09 2016-06-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные 4-гидрокси-1,2,3,4-тетрагидронафталин-1-ил-мочевины и их применение в лечении, среди прочего, заболеваний дыхательного тракта
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MA44131A (fr) 2015-12-23 2021-05-26 Chiesi Farm Spa Dérivés de 1-(3-tert-butyl-2h-pyrazol-5-yl or 5-tert-butyl-isoxaol-3-yl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro-naphthalenyl) urée et leur utlisation en tant qu'inhibiteurs de p38 mapk
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JP7339263B2 (ja) 2018-01-15 2023-09-05 エフ． ホフマン－ラ ロシュ アーゲー Ｊａｋ阻害剤としてのピラゾロピリミジン化合物
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JP7682110B2 (ja) 2019-06-18 2025-05-23 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｊａｋキナーゼのテトラゾール置換ピラゾロピリミジン阻害剤及びその使用
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WO2002053543A1 (en) * 2000-12-28 2002-07-11 Shionogi & Co., Ltd. Pyridone derivative having affinity for cannabinoid 2-type receptor
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WO2003053930A1 (en) * 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
JP2006513261A (ja) * 2002-11-12 2006-04-20 アストラゼネカ・アクチエボラーグ 好中球エラスターゼの阻害剤としての２−ピリドン誘導体
JP4515455B2 (ja) * 2003-09-18 2010-07-28 アストラゼネカ・アクチエボラーグ 好中球エラスターゼ阻害剤としての２−ピリドン誘導体およびそれらの使用

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JPH0656785A (ja) * 1991-04-18 1994-03-01 Imperial Chem Ind Plc <Ici> 複素環アミド類
WO2002053543A1 (en) * 2000-12-28 2002-07-11 Shionogi & Co., Ltd. Pyridone derivative having affinity for cannabinoid 2-type receptor
WO2003047577A2 (en) * 2001-12-06 2003-06-12 Eisai Co Ltd Pharmaceutical compositions comprising dihydropyridinone compounds and an immunoregulatory or an antiinflammatory agent and their uses
WO2003053930A1 (en) * 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
JP2006513261A (ja) * 2002-11-12 2006-04-20 アストラゼネカ・アクチエボラーグ 好中球エラスターゼの阻害剤としての２−ピリドン誘導体
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013512954A (ja) * 2009-12-08 2013-04-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換インダゾール及びアザインダゾール化合物の生成に有効な中間体の合成方法
JP2017509611A (ja) * 2014-02-21 2017-04-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリドン及びピラジノン、並びに好中球エラスターゼ活性の阻害剤としてのその使用

Also Published As

Publication number Publication date
BRPI0414570A (pt) 2006-11-07
IL173986A0 (en) 2006-07-05
UA84878C2 (ru) 2008-12-10
TW200526579A (en) 2005-08-16
EP1663974B1 (en) 2009-01-14
RU2348617C2 (ru) 2009-03-10
NO20061700L (no) 2006-04-18
CO5670357A2 (es) 2006-08-31
ATE420861T1 (de) 2009-01-15
MXPA06002723A (es) 2006-06-06
UY28513A1 (es) 2005-04-29
AR046083A1 (es) 2005-11-23
HK1089167A1 (en) 2006-11-24
SE0302487D0 (sv) 2003-09-18
IS8394A (is) 2006-03-31
WO2005026124A1 (en) 2005-03-24
DE602004019110D1 (de) 2009-03-05
RU2006112427A (ru) 2007-11-10
SA04250300B1 (ar) 2008-09-07
ZA200602262B (en) 2007-07-25
ES2319300T3 (es) 2009-05-06
AU2004272485A1 (en) 2005-03-24
CN100439339C (zh) 2008-12-03
US20070043036A1 (en) 2007-02-22
AU2004272485B2 (en) 2008-03-13
KR20060096995A (ko) 2006-09-13
CA2538410A1 (en) 2005-03-24
EP1663974A1 (en) 2006-06-07
CN1856467A (zh) 2006-11-01

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