JP2007505042A5 - - Google Patents
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- JP2007505042A5 JP2007505042A5 JP2006525536A JP2006525536A JP2007505042A5 JP 2007505042 A5 JP2007505042 A5 JP 2007505042A5 JP 2006525536 A JP2006525536 A JP 2006525536A JP 2006525536 A JP2006525536 A JP 2006525536A JP 2007505042 A5 JP2007505042 A5 JP 2007505042A5
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- JP
- Japan
- Prior art keywords
- composition
- extract
- cancer
- group
- chemotherapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 65
- 239000000284 extract Substances 0.000 claims 47
- 239000002246 antineoplastic agent Substances 0.000 claims 15
- 229940127089 cytotoxic agent Drugs 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 201000011510 cancer Diseases 0.000 claims 11
- 230000003110 anti-inflammatory effect Effects 0.000 claims 8
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 6
- 229930012538 Paclitaxel Natural products 0.000 claims 6
- 244000269722 Thea sinensis Species 0.000 claims 6
- 229960001592 paclitaxel Drugs 0.000 claims 6
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 claims 4
- 108050003243 Prostaglandin G/H synthase 1 Proteins 0.000 claims 4
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 claims 4
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 claims 4
- 238000011394 anticancer treatment Methods 0.000 claims 4
- 230000004663 cell proliferation Effects 0.000 claims 4
- 239000002024 ethyl acetate extract Substances 0.000 claims 4
- 230000006698 induction Effects 0.000 claims 4
- 210000004698 lymphocyte Anatomy 0.000 claims 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 3
- WVKOPZMDOFGFAK-UHFFFAOYSA-N 4-hydroperoxycyclophosphamide Chemical compound OOC1=NP(O)(N(CCCl)CCCl)OCC1 WVKOPZMDOFGFAK-UHFFFAOYSA-N 0.000 claims 3
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 3
- 240000008397 Ganoderma lucidum Species 0.000 claims 3
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims 3
- 240000000950 Hippophae rhamnoides Species 0.000 claims 3
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 3
- 241000304195 Salvia miltiorrhiza Species 0.000 claims 3
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims 3
- 241000915604 Scutellaria barbata Species 0.000 claims 3
- 235000006468 Thea sinensis Nutrition 0.000 claims 3
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 229960004397 cyclophosphamide Drugs 0.000 claims 3
- 229960000975 daunorubicin Drugs 0.000 claims 3
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 3
- 229960003668 docetaxel Drugs 0.000 claims 3
- 229960004679 doxorubicin Drugs 0.000 claims 3
- 229960005420 etoposide Drugs 0.000 claims 3
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 3
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 3
- 229960005277 gemcitabine Drugs 0.000 claims 3
- 235000009569 green tea Nutrition 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 229960000485 methotrexate Drugs 0.000 claims 3
- 230000029115 microtubule polymerization Effects 0.000 claims 3
- 229960001196 thiotepa Drugs 0.000 claims 3
- 229960003048 vinblastine Drugs 0.000 claims 3
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 3
- 229960004528 vincristine Drugs 0.000 claims 3
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 3
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 3
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 3
- 229960002066 vinorelbine Drugs 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 238000009169 immunotherapy Methods 0.000 claims 2
- 238000002428 photodynamic therapy Methods 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 241001072909 Salvia Species 0.000 claims 1
- 235000017276 Salvia Nutrition 0.000 claims 1
- 239000008565 Scutellaria barbata extract Substances 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50145603P | 2003-09-08 | 2003-09-08 | |
| US60/501,456 | 2003-09-08 | ||
| PCT/US2004/029263 WO2005044182A2 (en) | 2003-09-08 | 2004-09-08 | Compositions of botanical extracts for cancer therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013004459A Division JP2013064021A (ja) | 2003-09-08 | 2013-01-15 | 癌治療のための植物性薬品抽出物の組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007505042A JP2007505042A (ja) | 2007-03-08 |
| JP2007505042A5 true JP2007505042A5 (https=) | 2007-10-25 |
| JP5300195B2 JP5300195B2 (ja) | 2013-09-25 |
Family
ID=34572738
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525536A Expired - Fee Related JP5300195B2 (ja) | 2003-09-08 | 2004-09-08 | 癌治療のための植物性薬品抽出物の組成物 |
| JP2013004459A Pending JP2013064021A (ja) | 2003-09-08 | 2013-01-15 | 癌治療のための植物性薬品抽出物の組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013004459A Pending JP2013064021A (ja) | 2003-09-08 | 2013-01-15 | 癌治療のための植物性薬品抽出物の組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8173177B2 (https=) |
| EP (1) | EP1663103B1 (https=) |
| JP (2) | JP5300195B2 (https=) |
| CN (1) | CN1874781B (https=) |
| AT (1) | ATE532525T1 (https=) |
| AU (1) | AU2004287358A1 (https=) |
| CA (1) | CA2538218C (https=) |
| DK (1) | DK1663103T3 (https=) |
| ES (1) | ES2373663T3 (https=) |
| PL (1) | PL1663103T3 (https=) |
| RU (1) | RU2006111441A (https=) |
| WO (1) | WO2005044182A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1663103T3 (pl) | 2003-09-08 | 2012-05-31 | Genyous Biomed Int Inc | Kompozycje roślinnych ekstraktów do leczenia nowotworu |
| RU2006113703A (ru) * | 2003-09-22 | 2007-11-10 | Джиниус Байомед Интернэшнл Инк. (Us) | Композиции hippophae rhamnoides для терапии рака |
| US20050196409A1 (en) * | 2003-09-24 | 2005-09-08 | James Dao | Compositions of botanical extracts for treating malignancy-associated changes |
| JP4789082B2 (ja) * | 2004-03-04 | 2011-10-05 | 学校法人日本大学 | 沙棘枝から抽出したエキス並びにそれを含む発ガン抑制剤及び健康食品 |
| US7514085B2 (en) | 2004-07-16 | 2009-04-07 | Medimush A/S | Immune modulating compounds from fungi |
| CA2574060C (en) * | 2004-07-16 | 2019-06-25 | Medimush A/S | Immune modulating compounds from fungi |
| US20060134243A1 (en) * | 2004-12-17 | 2006-06-22 | Bionovo, Inc. | Method of using extracts of epimedium species |
| US7482029B2 (en) | 2005-04-01 | 2009-01-27 | Bionovo, Inc. | Composition for treatment of menopause |
| US20080118589A1 (en) * | 2005-05-11 | 2008-05-22 | Sallie Smith Schneider | Pharmaceutical formulations of rhodiola crenulata and methods of use thereof |
| US20060269567A1 (en) * | 2005-05-16 | 2006-11-30 | Liu Yuen | Universal detoxifying composition |
| JP2006342103A (ja) * | 2005-06-09 | 2006-12-21 | National Cancer Center-Japan | ウーロン茶葉抽出物ｏｔａｃを有効成分とする発癌抑制剤 |
| EP1896600A2 (en) * | 2005-06-15 | 2008-03-12 | Medimush A/S | Anti-cancer combination treatment and kit-of-part |
| EP1945202A2 (en) * | 2005-11-11 | 2008-07-23 | Licentia OY | Mammalian hedgehog signaling inhiabitors |
| US7700136B2 (en) * | 2005-11-14 | 2010-04-20 | Bionovo, Inc. | Scutellaria barbata extract for the treatment of cancer |
| WO2007131034A1 (en) * | 2006-05-03 | 2007-11-15 | The Regents Of The University Of Michigan | Pyrimidone derivatives which are modulators of heat shock protein (hsp) 70 |
| US20110117121A1 (en) * | 2006-10-27 | 2011-05-19 | James Dao | Compositions for treatment and inhibition of pain |
| US20080319051A1 (en) * | 2007-06-22 | 2008-12-25 | Bionovo, Inc. | Liquiritigenin and derivatives as selective estrogen receptor beta agonists |
| US20090042818A1 (en) * | 2007-06-22 | 2009-02-12 | Bionovo, Inc. | Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists |
| US8221803B1 (en) | 2007-06-25 | 2012-07-17 | OncoNatural Solutions, Inc. | Composition for prostate health |
| WO2009021196A1 (en) * | 2007-08-08 | 2009-02-12 | Bionovo, Inc. | Extracts of ligustrum lucidum and uses thereof |
| JP2010539086A (ja) * | 2007-09-07 | 2010-12-16 | バイオノボ・インコーポレーテッド | マメ科ファミリーのクズのエストロゲン性抽出物およびその使用 |
| AU2008296176A1 (en) * | 2007-09-07 | 2009-03-12 | Bionovo, Inc. | Estrogenic extracts of Asparagus conchinchinensis (Lour.) Merr of the Liliaceae Family and uses thereof |
| EP2190292A4 (en) | 2007-09-07 | 2012-12-26 | Bionovo Inc | ESTROGENWIRKSAME EXTRACTS OF SCUTTELARIA BARBATA D. DON OF THE FAMILY LABIATAE AND ITS USES |
| AU2008296072A1 (en) | 2007-09-07 | 2009-03-12 | Bionovo, Inc. | Estrogenic extracts of Astragalus membranaceus Fisch.Bge.Var.mongolicus Bge. of the Leguminosae Family and uses thereof |
| EP2222323A4 (en) * | 2007-11-19 | 2012-07-25 | Bionovo Inc | PROCESS FOR PREPARING A CLEANED EXTRACT OF SCUTELLARIA BARBATA D. DON |
| US20090130101A1 (en) * | 2007-11-19 | 2009-05-21 | Bionovo, Inc. | Anti-cancer therapy with an extract of scutellaria barbata |
| US20090130118A1 (en) * | 2007-11-19 | 2009-05-21 | Bionovo, Inc. | Scutellaria barbata extract and combinations for the treatment of cancer |
| EP2219659A4 (en) | 2007-11-19 | 2010-11-17 | Bionovo Inc | METHODS OF DETECTION AND TREATMENT OF CANCERS USING BARBATA SCUTTELARIA EXTRACT |
| CA2721191A1 (en) * | 2008-04-14 | 2009-10-22 | Bionovo, Inc. | Calycosin and analogs thereof for the treatment of estrogen receptor beta-mediated diseases |
| WO2009137534A2 (en) * | 2008-05-06 | 2009-11-12 | Bionovo, Inc. | Estrogenic extracts for use in treating vaginal and vulvar atrophy |
| CA2726982A1 (en) * | 2008-06-05 | 2009-12-10 | Bionovo, Inc. | Method of quantification of multiple bioactives from botanical compositions |
| US20090312437A1 (en) * | 2008-06-06 | 2009-12-17 | Bionovo, Inc., A Delaware Corporation | Anthraquinones and Analogs from Rhuem palmatum for Treatment of Estrogen Receptor Beta-Mediated Conditions |
| EP2340027A4 (en) * | 2008-09-03 | 2012-04-04 | Bionovo Inc | METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
| CA2759671A1 (en) * | 2009-04-28 | 2010-11-11 | Bionovo, Inc. | Method of reducing fat accumulation and inducing weight loss |
| TWI606835B (zh) * | 2010-04-23 | 2017-12-01 | 中央研究院 | 基於靈芝多醣之組合物及治療癌症之方法 |
| EP2635127B1 (en) * | 2010-11-04 | 2018-10-17 | Genyous Biomed International | Combination therapy for prostate cancer using botanical compositions and bicalutamide |
| US8858953B2 (en) * | 2011-05-09 | 2014-10-14 | Yu-Hwa Peter Sheng | Herbal composition for treating cancer |
| US8765193B2 (en) * | 2012-02-24 | 2014-07-01 | Santé International, Inc. | Methods for radiation protection |
| JP6093238B2 (ja) * | 2013-05-13 | 2017-03-08 | 株式会社リンクス | 放射線障害に対する造血前駆細胞回復剤 |
| WO2014197520A1 (en) * | 2013-06-03 | 2014-12-11 | Genyous Biomed International | Novel formulations of botanical extracts for cancer therapy |
| SG11201510802QA (en) | 2013-06-03 | 2016-02-26 | Genyous Biomed Internat | Combination therapy for prostate cancer using botanical compositions and docetaxel |
| US9789153B2 (en) | 2014-07-02 | 2017-10-17 | Hsiu-Hsien Tsai | Composition for preventing cancer and treating cancer and intensifying the effects of other anticancer drugs |
| US20170035789A1 (en) * | 2015-08-05 | 2017-02-09 | Bill H. McAnalley | Composition Of Dietary Supplements Based On Apoptosis that Support Optimal Health |
| KR101951203B1 (ko) * | 2015-09-24 | 2019-02-25 | 주식회사 씨엔에이치코퍼레이션 | 생약 성분을 포함하는 호흡기암 예방 또는 치료용 조성물 |
| CN110122232B (zh) * | 2018-02-09 | 2022-08-05 | 紫云自治县长萌农业科技开发有限责任公司 | 一种提高山豆根种子坐果率和产量的栽培方法 |
| JP7763509B2 (ja) * | 2020-11-09 | 2025-11-04 | ユニバーシティ－インダストリー コーオペレイション グループ オブ キョンヒ ユニバーシティ | タンジンおよびダイオウの複合抽出物を含む悪液質予防または治療用組成物の製造方法 |
| CN113759031A (zh) * | 2021-05-08 | 2021-12-07 | 北京康仁堂药业有限公司 | 半枝莲及半枝莲组方制剂的薄层鉴定方法 |
| CN113633732A (zh) * | 2021-09-28 | 2021-11-12 | 山东大学 | 一种治疗肺癌的中药组合物及其制备方法和应用 |
| CN119386498A (zh) * | 2024-11-05 | 2025-02-07 | 中国农业大学 | 用于提取荷叶多酚的深共晶溶剂及荷叶多酚提取方法 |
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-
2004
- 2004-09-08 PL PL04816850T patent/PL1663103T3/pl unknown
- 2004-09-08 RU RU2006111441/14A patent/RU2006111441A/ru not_active Application Discontinuation
- 2004-09-08 US US10/937,707 patent/US8173177B2/en not_active Expired - Lifetime
- 2004-09-08 CN CN2004800317919A patent/CN1874781B/zh not_active Expired - Fee Related
- 2004-09-08 EP EP04816850A patent/EP1663103B1/en not_active Expired - Lifetime
- 2004-09-08 AT AT04816850T patent/ATE532525T1/de active
- 2004-09-08 ES ES04816850T patent/ES2373663T3/es not_active Expired - Lifetime
- 2004-09-08 DK DK04816850.4T patent/DK1663103T3/da active
- 2004-09-08 CA CA2538218A patent/CA2538218C/en not_active Expired - Fee Related
- 2004-09-08 WO PCT/US2004/029263 patent/WO2005044182A2/en not_active Ceased
- 2004-09-08 JP JP2006525536A patent/JP5300195B2/ja not_active Expired - Fee Related
- 2004-09-08 AU AU2004287358A patent/AU2004287358A1/en not_active Abandoned
-
2012
- 2012-04-12 US US13/445,812 patent/US20130101616A1/en not_active Abandoned
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2013
- 2013-01-15 JP JP2013004459A patent/JP2013064021A/ja active Pending
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