JP2007504241A5 - - Google Patents
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- Publication number
- JP2007504241A5 JP2007504241A5 JP2006525449A JP2006525449A JP2007504241A5 JP 2007504241 A5 JP2007504241 A5 JP 2007504241A5 JP 2006525449 A JP2006525449 A JP 2006525449A JP 2006525449 A JP2006525449 A JP 2006525449A JP 2007504241 A5 JP2007504241 A5 JP 2007504241A5
- Authority
- JP
- Japan
- Prior art keywords
- heteroaryl
- aryl
- heterocyclyl
- alkyl
- arylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 135
- 125000001072 heteroaryl group Chemical group 0.000 claims 117
- 125000000217 alkyl group Chemical group 0.000 claims 104
- 125000003118 aryl group Chemical group 0.000 claims 102
- 125000003710 aryl alkyl group Chemical group 0.000 claims 87
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 65
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 57
- 150000001875 compounds Chemical class 0.000 claims 56
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 52
- 125000000753 cycloalkyl group Chemical group 0.000 claims 48
- 125000003342 alkenyl group Chemical group 0.000 claims 42
- 125000004093 cyano group Chemical group *C#N 0.000 claims 40
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 40
- 125000005843 halogen group Chemical group 0.000 claims 40
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 40
- BPXYEYJNCXITEY-UHFFFAOYSA-N diazonio(trifluoromethoxy)azanide Chemical compound FC(F)(F)ON=[N+]=[N-] BPXYEYJNCXITEY-UHFFFAOYSA-N 0.000 claims 37
- 229910052739 hydrogen Inorganic materials 0.000 claims 28
- 125000000304 alkynyl group Chemical group 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 150000002431 hydrogen Chemical class 0.000 claims 21
- 229920006395 saturated elastomer Polymers 0.000 claims 20
- 125000004043 oxo group Chemical group O=* 0.000 claims 18
- 125000004429 atom Chemical group 0.000 claims 16
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 14
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 12
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 12
- 239000000651 prodrug Substances 0.000 claims 12
- 229940002612 prodrug Drugs 0.000 claims 12
- 125000002837 carbocyclic group Chemical group 0.000 claims 10
- 125000000539 amino acid group Chemical group 0.000 claims 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 6
- -1 carbocycle Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 Cc1n[o]c2c1cc(C(O)=*)c(Nc(c(Cl)c1)ccc1Cl)c2F Chemical compound Cc1n[o]c2c1cc(C(O)=*)c(Nc(c(Cl)c1)ccc1Cl)c2F 0.000 description 3
- QPUQVLGZNFJHCD-UHFFFAOYSA-N Cc1c(cc(C(O)=O)c(Nc2ccccc2Cl)c2F)c2n[o]1 Chemical compound Cc1c(cc(C(O)=O)c(Nc2ccccc2Cl)c2F)c2n[o]1 QPUQVLGZNFJHCD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/654,580 US7144907B2 (en) | 2003-09-03 | 2003-09-03 | Heterocyclic inhibitors of MEK and methods of use thereof |
| US10/929,295 US7230099B2 (en) | 2003-09-03 | 2004-08-30 | Heterocyclic inhibitors of MEK and methods of use thereof |
| PCT/US2004/028649 WO2005023759A2 (en) | 2003-09-03 | 2004-09-01 | Heterocyclic inhibitors of mek and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007504241A JP2007504241A (ja) | 2007-03-01 |
| JP2007504241A5 true JP2007504241A5 (cg-RX-API-DMAC7.html) | 2007-07-12 |
| JP4131741B2 JP4131741B2 (ja) | 2008-08-13 |
Family
ID=34218110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525449A Expired - Fee Related JP4131741B2 (ja) | 2003-09-03 | 2004-09-01 | 複素環式ｍｅｋ阻害剤、及びその使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US7144907B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1673339B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4131741B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20060070558A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1874769A (cg-RX-API-DMAC7.html) |
| AR (1) | AR046081A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004270699B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0414111A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2537321A1 (cg-RX-API-DMAC7.html) |
| IL (4) | IL173936A (cg-RX-API-DMAC7.html) |
| IS (1) | IS8392A (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA06002466A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20061506L (cg-RX-API-DMAC7.html) |
| PT (1) | PT1673339E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2006109599A (cg-RX-API-DMAC7.html) |
| TW (1) | TW200526607A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005023759A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200602581B (cg-RX-API-DMAC7.html) |
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2003
- 2003-09-03 US US10/654,580 patent/US7144907B2/en not_active Expired - Fee Related
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2004
- 2004-08-30 US US10/929,295 patent/US7230099B2/en not_active Expired - Fee Related
- 2004-09-01 PT PT47830286T patent/PT1673339E/pt unknown
- 2004-09-01 BR BRPI0414111-3A patent/BRPI0414111A/pt not_active IP Right Cessation
- 2004-09-01 CN CNA2004800326551A patent/CN1874769A/zh active Pending
- 2004-09-01 EP EP04783028.6A patent/EP1673339B1/en not_active Expired - Lifetime
- 2004-09-01 CA CA002537321A patent/CA2537321A1/en not_active Abandoned
- 2004-09-01 AU AU2004270699A patent/AU2004270699B2/en not_active Ceased
- 2004-09-01 KR KR1020067004505A patent/KR20060070558A/ko not_active Withdrawn
- 2004-09-01 ZA ZA200602581A patent/ZA200602581B/en unknown
- 2004-09-01 MX MXPA06002466A patent/MXPA06002466A/es not_active Application Discontinuation
- 2004-09-01 RU RU2006109599/04A patent/RU2006109599A/ru not_active Application Discontinuation
- 2004-09-01 WO PCT/US2004/028649 patent/WO2005023759A2/en not_active Ceased
- 2004-09-01 JP JP2006525449A patent/JP4131741B2/ja not_active Expired - Fee Related
- 2004-09-02 AR ARP040103151A patent/AR046081A1/es not_active Application Discontinuation
- 2004-09-02 TW TW093126520A patent/TW200526607A/zh unknown
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2006
- 2006-02-26 IL IL173936A patent/IL173936A/en not_active IP Right Cessation
- 2006-03-31 IS IS8392A patent/IS8392A/is unknown
- 2006-04-03 NO NO20061506A patent/NO20061506L/no not_active Application Discontinuation
- 2006-04-24 US US11/410,344 patent/US20060189668A1/en not_active Abandoned
- 2006-04-24 US US11/410,343 patent/US7271178B2/en not_active Expired - Fee Related
- 2006-04-24 US US11/410,336 patent/US7511058B2/en not_active Expired - Fee Related
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2012
- 2012-05-08 IL IL219671A patent/IL219671A0/en unknown
- 2012-05-08 IL IL219670A patent/IL219670A/en not_active IP Right Cessation
- 2012-05-08 IL IL219669A patent/IL219669A0/en unknown