JP2007502817A5 - - Google Patents
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- JP2007502817A5 JP2007502817A5 JP2006523866A JP2006523866A JP2007502817A5 JP 2007502817 A5 JP2007502817 A5 JP 2007502817A5 JP 2006523866 A JP2006523866 A JP 2006523866A JP 2006523866 A JP2006523866 A JP 2006523866A JP 2007502817 A5 JP2007502817 A5 JP 2007502817A5
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- Prior art keywords
- alkyl
- formula
- compound
- pharmaceutical salt
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 125000005842 heteroatoms Chemical group 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- -1 CF 3 Chemical group 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102100003818 GCG Human genes 0.000 claims 1
- 101710042131 GCG Proteins 0.000 claims 1
- 101700071595 GRZ1 Proteins 0.000 claims 1
- 101700078733 ZGLP1 Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
Description
本発明は式I:
I;
[式中、
R1およびR2はそれぞれ独立してH、OH、シアノ、C1−C6アルキル、C1−C6アルコキシ、CF3、ハロまたはNR4R4'であり、
R3はH、C1−C6アルキルであり、
Xは、適宜C1−C4アルキルで置換される五員芳香族ヘテロ環であり、ここで前記ヘテロ環はN、SおよびOから選択された少なくとも2つまたは3つのヘテロ原子を含み、ここで少なくともひとつのヘテロ原子はNでなくてはならず、
YはS、CR5=NまたはN=CR5であり、
nは2、3、4、5、6または7であり、
R4はH、COR6、SO2R7またはC1−C6アルキルであり、
R4'はHまたはC1−C6アルキルであり、
R5はHであるか、またはXとの結合を形成し、
R6はHまたはC1−C6アルキルであり、
R7はHまたはC1−C6アルキルである]
で示される化合物、またはその医薬的な塩に関する。
[式中、
R1およびR2はそれぞれ独立してH、OH、シアノ、C1−C6アルキル、C1−C6アルコキシ、CF3、ハロまたはNR4R4'であり、
R3はH、C1−C6アルキルであり、
Xは、適宜C1−C4アルキルで置換される五員芳香族ヘテロ環であり、ここで前記ヘテロ環はN、SおよびOから選択された少なくとも2つまたは3つのヘテロ原子を含み、ここで少なくともひとつのヘテロ原子はNでなくてはならず、
YはS、CR5=NまたはN=CR5であり、
nは2、3、4、5、6または7であり、
R4はH、COR6、SO2R7またはC1−C6アルキルであり、
R4'はHまたはC1−C6アルキルであり、
R5はHであるか、またはXとの結合を形成し、
R6はHまたはC1−C6アルキルであり、
R7はHまたはC1−C6アルキルである]
で示される化合物、またはその医薬的な塩に関する。
Claims (5)
- 式I:
[式中、
R1およびR2はそれぞれ独立してH、OH、シアノ、C1−C6アルキル、C1−C6アルコキシ、CF3、ハロまたはNR4R4'であり;
R3はH、C1−C6アルキルであり;
Xは、適宜C1−C4アルキルで置換されていてもよい5員芳香族ヘテロ環であり;ここに、該ヘテロ環はN、SおよびOから選択された少なくとも2または3のヘテロ原子を含み、ここに、少なくとも一つのヘテロ原子はNでなくてはならず;
YはS、CR5=NまたはN=CR5であり;
nは2、3、4、5、6または7であり;
R4はH、COR6、SO2R7またはC1−C6アルキルであり;
R4'はHまたはC1−C6アルキルであり;
R5はHであるか、またはXとの結合を形成し;
R6はHまたはC1−C6アルキルであり;
R7はHまたはC1−C6アルキルであるが;但し、式Iの化合物は式:
で示される化合物、またはその医薬的な塩。 - R3がHである、請求項1記載の化合物。
- a)請求項2もしくは3記載の化合物またはその医薬的な塩;およびb)GLP−1化合物を含む、医薬組成物。
- a)請求項2もしくは3記載の化合物またはその医薬的な塩;およびb)MC4アゴニストペプチドを含む、医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49653703P | 2003-08-20 | 2003-08-20 | |
US60/496,537 | 2003-08-20 | ||
PCT/US2004/024387 WO2005019212A1 (en) | 2003-08-20 | 2004-08-18 | Compounds, methods and formulations for the oral delivery of a glucagon like peptide (glp)-1 compound or an melanocortin 4 receptor (mc4) agonist peptide |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007502817A JP2007502817A (ja) | 2007-02-15 |
JP2007502817A5 true JP2007502817A5 (ja) | 2007-05-31 |
JP4754487B2 JP4754487B2 (ja) | 2011-08-24 |
Family
ID=34216017
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006523866A Expired - Fee Related JP4754487B2 (ja) | 2003-08-20 | 2004-08-18 | グルカゴン様ペプチド(glp)−1化合物またはメラノコルチン4受容体(mc4)アゴニストペプチドの経口デリバリーのための化合物、方法および製剤 |
JP2011104435A Pending JP2011207886A (ja) | 2003-08-20 | 2011-05-09 | グルカゴン様ペプチド(glp)−1化合物またはメラノコルチン4受容体(mc4)アゴニストペプチドの経口デリバリーのための化合物、方法および製剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011104435A Pending JP2011207886A (ja) | 2003-08-20 | 2011-05-09 | グルカゴン様ペプチド(glp)−1化合物またはメラノコルチン4受容体(mc4)アゴニストペプチドの経口デリバリーのための化合物、方法および製剤 |
Country Status (12)
Country | Link |
---|---|
US (3) | US20070293423A1 (ja) |
EP (1) | EP1658285B1 (ja) |
JP (2) | JP4754487B2 (ja) |
CN (1) | CN100398536C (ja) |
AT (1) | ATE361294T1 (ja) |
AU (1) | AU2004267044B8 (ja) |
BR (1) | BRPI0413676B8 (ja) |
CA (1) | CA2530983C (ja) |
DE (1) | DE602004006279T2 (ja) |
ES (1) | ES2286679T3 (ja) |
MX (1) | MXPA06001916A (ja) |
WO (1) | WO2005019212A1 (ja) |
Families Citing this family (20)
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EP2286825B1 (en) | 2005-07-08 | 2016-09-28 | Ipsen Pharma | Melanocortin receptor ligands |
WO2007008684A2 (en) | 2005-07-08 | 2007-01-18 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Ligands of melanocortin receptors |
CA2662853C (en) * | 2006-08-31 | 2016-07-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
TWI364290B (en) | 2007-05-25 | 2012-05-21 | Ipsen Pharma Sas | Melanocortin receptor ligands modifled with hydantoin |
JP5628796B2 (ja) | 2008-06-09 | 2014-11-19 | パラティン テクノロジーズ, インコーポレイテッドPalatin Technologies, Inc. | 性的不能の治療用のメラノコルチンレセプタ特異的ペプチド |
EP2440227B1 (en) | 2009-06-08 | 2017-10-18 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptides |
UY32690A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Péptidos específicos para receptores de melanocortina |
EP2440572B1 (en) | 2009-06-08 | 2017-04-05 | Palatin Technologies, Inc. | Lactam-bridged melanocortin receptor-specific peptides |
EP2504351A4 (en) | 2009-11-23 | 2013-10-30 | Palatin Technologies Inc | MELANOCORTIN-1 RECEPTOR-SPECIFIC LINEAR PEPTIDE |
CA2781402C (en) | 2009-11-23 | 2017-03-21 | Palatin Technologies, Inc. | Melanocortin-1 receptor-specific cyclic peptides |
US10357348B2 (en) * | 2013-08-19 | 2019-07-23 | Warren Matthew Leevy | Fluid manifold |
US20160244860A1 (en) * | 2015-02-20 | 2016-08-25 | Cytec Industries Inc. | Aliphatic-aromatic heterocyclic compounds and uses thereof in metal extractant compositions |
WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
CN105017136A (zh) * | 2015-07-24 | 2015-11-04 | 陈吉美 | 一种2-溴-3-甲氧基吡啶的制备方法 |
EA201991839A1 (ru) | 2017-02-08 | 2020-02-17 | Байер Акциенгезельшафт | Новые производные триазолтиона |
US20200017467A1 (en) | 2017-02-08 | 2020-01-16 | Bayer Cropscience Aktiengesellschaft | Novel triazole derivatives |
EP3580218A1 (en) | 2017-02-08 | 2019-12-18 | Bayer CropScience Aktiengesellschaft | Novel triazole derivatives |
JP2020507579A (ja) | 2017-02-10 | 2020-03-12 | バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft | 1−(フェノキシ−ピリジニル)−2−(1,2,4−トリアゾール−1−イル)−エタノール誘導体を含む有害微生物を制御するための組成物 |
WO2020020816A1 (en) | 2018-07-26 | 2020-01-30 | Bayer Aktiengesellschaft | Novel triazole derivatives |
CN111793038B (zh) * | 2019-04-08 | 2022-08-12 | 新发药业有限公司 | 一种取代噁唑化合物的环保制备方法 |
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-
2004
- 2004-08-18 EP EP04779447A patent/EP1658285B1/en not_active Not-in-force
- 2004-08-18 JP JP2006523866A patent/JP4754487B2/ja not_active Expired - Fee Related
- 2004-08-18 US US10/566,012 patent/US20070293423A1/en not_active Abandoned
- 2004-08-18 MX MXPA06001916A patent/MXPA06001916A/es active IP Right Grant
- 2004-08-18 CA CA2530983A patent/CA2530983C/en not_active Expired - Fee Related
- 2004-08-18 AU AU2004267044A patent/AU2004267044B8/en not_active Ceased
- 2004-08-18 AT AT04779447T patent/ATE361294T1/de not_active IP Right Cessation
- 2004-08-18 DE DE602004006279T patent/DE602004006279T2/de active Active
- 2004-08-18 WO PCT/US2004/024387 patent/WO2005019212A1/en active IP Right Grant
- 2004-08-18 ES ES04779447T patent/ES2286679T3/es active Active
- 2004-08-18 CN CNB2004800227912A patent/CN100398536C/zh not_active Expired - Fee Related
- 2004-08-18 BR BRPI0413676A patent/BRPI0413676B8/pt not_active IP Right Cessation
-
2008
- 2008-11-03 US US12/263,722 patent/US7947841B2/en not_active Expired - Fee Related
-
2011
- 2011-04-14 US US13/087,255 patent/US8546581B2/en active Active
- 2011-05-09 JP JP2011104435A patent/JP2011207886A/ja active Pending
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