JP2007502781A5 - - Google Patents
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- Publication number
- JP2007502781A5 JP2007502781A5 JP2006523498A JP2006523498A JP2007502781A5 JP 2007502781 A5 JP2007502781 A5 JP 2007502781A5 JP 2006523498 A JP2006523498 A JP 2006523498A JP 2006523498 A JP2006523498 A JP 2006523498A JP 2007502781 A5 JP2007502781 A5 JP 2007502781A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- alkyl
- group
- halo
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49682503P | 2003-08-21 | 2003-08-21 | |
| PCT/CA2004/001524 WO2005019161A1 (en) | 2003-08-21 | 2004-08-19 | Cathepsin cysteine protease inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007502781A JP2007502781A (ja) | 2007-02-15 |
| JP2007502781A5 true JP2007502781A5 (enExample) | 2007-10-04 |
| JP4553899B2 JP4553899B2 (ja) | 2010-09-29 |
Family
ID=34216040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006523498A Expired - Fee Related JP4553899B2 (ja) | 2003-08-21 | 2004-08-19 | カテプシンシステインプロテアーゼ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7312353B2 (enExample) |
| EP (1) | EP1673336B1 (enExample) |
| JP (1) | JP4553899B2 (enExample) |
| CN (1) | CN1839114A (enExample) |
| AU (1) | AU2004266740B2 (enExample) |
| CA (1) | CA2535359A1 (enExample) |
| WO (1) | WO2005019161A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1842515A (zh) * | 2003-08-27 | 2006-10-04 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶抑制剂 |
| WO2005056529A1 (en) * | 2003-12-12 | 2005-06-23 | Merck Frosst Canada Ltd. | Cathepsin cysteine protease inhibitors |
| US8013186B2 (en) * | 2004-12-01 | 2011-09-06 | Virobay, Inc. | Haloalkyl containing compounds as cysteine protease inhibitors |
| WO2006076797A1 (en) * | 2005-01-19 | 2006-07-27 | Merck Frosst Canada Ltd. | Cathepsin k inhibitors and atherosclerosis |
| WO2006076796A1 (en) * | 2005-01-19 | 2006-07-27 | Merck Frosst Canada Ltd. | Cathepsin k inhibitors and obesity |
| US20090291988A1 (en) * | 2005-06-14 | 2009-11-26 | Renata Oballa | Reversible Inhibitors of Monoamine Oxidase A and B |
| US20090264479A1 (en) * | 2005-07-26 | 2009-10-22 | Cameron Black | Papain Family Cysteine Protease Inhibitors for the Treatment of Parasitic Diseases |
| AU2006301896A1 (en) * | 2005-10-12 | 2007-04-19 | Merck Frosst Canada Ltd | Cathepsin cysteine protease inhibitors |
| EP2132173B1 (en) * | 2007-02-26 | 2015-10-07 | Merck Sharp & Dohme Corp. | Formulations for cathepsin k inhibitors |
| JP5364695B2 (ja) | 2007-04-02 | 2013-12-11 | メルク カナダ インコーポレイテッド | カテプシンｋインヒビターのアミド化調製方法 |
| WO2010023931A1 (ja) | 2008-08-29 | 2010-03-04 | 興和株式会社 | １－アダマンチルアゼチジン－２－オン誘導体及びこれを含有する医薬 |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| TWI519530B (zh) | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| WO2016027285A2 (en) * | 2014-08-22 | 2016-02-25 | Alkem Laboratories Ltd. | Bicyclic heteroaryl amides as cathepsin cysteine protease inhibitors |
| DK3302448T3 (da) | 2015-06-04 | 2024-02-05 | Aurigene Oncology Ltd | Erstattede heterocyclylafledninger som cdk-inhibitore |
| CN107922315B (zh) * | 2015-08-29 | 2021-03-26 | 广东东阳光药业有限公司 | 组织蛋白酶k抑制剂及其用途 |
| EP3946332A1 (en) | 2019-04-05 | 2022-02-09 | Université de Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
| CN115637275A (zh) * | 2022-10-14 | 2023-01-24 | 天津药明康德新药开发有限公司 | 一种(s)-2-(4-溴苯基)丙酸的制备方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA777769A (en) | 1963-03-18 | 1968-02-06 | H. Roy Clarence | Substituted methylene diphosphonic acid compounds and detergent compositions |
| US4294926A (en) | 1979-06-15 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4319039A (en) | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| JPS5889191A (ja) | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法 |
| FR2531088B1 (fr) | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| WO1984002131A1 (fr) | 1982-11-22 | 1984-06-07 | Sandoz Ag | Produits analogues de mevalolactone et leurs derives, leurs procedes de production, compositions pharmaceutiques les contenant ainsi que leur utilisation en tant que produits pharmaceutiques |
| US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
| US4911165A (en) | 1983-01-12 | 1990-03-27 | Ethicon, Inc. | Pliabilized polypropylene surgical filaments |
| US4761406A (en) | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
| US4681893A (en) | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| DE3623397A1 (de) | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4885314A (en) | 1987-06-29 | 1989-12-05 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US4782084A (en) | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
| US4820850A (en) | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| CA1339805C (en) | 1988-01-20 | 1998-04-07 | Yasuo Isomura | (cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active |
| US5030447A (en) | 1988-03-31 | 1991-07-09 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions having good stability |
| US5180589A (en) | 1988-03-31 | 1993-01-19 | E. R. Squibb & Sons, Inc. | Pravastatin pharmaceuatical compositions having good stability |
| US4916239A (en) | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
| US5118853A (en) | 1988-10-13 | 1992-06-02 | Sandoz Ltd. | Processes for the synthesis of 3-disubstituted aminoacroleins |
| US5290946A (en) | 1988-10-13 | 1994-03-01 | Sandoz Ltd. | Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes |
| US4929437A (en) | 1989-02-02 | 1990-05-29 | Merck & Co., Inc. | Coenzyme Q10 with HMG-CoA reductase inhibitors |
| US5189164A (en) | 1989-05-22 | 1993-02-23 | Sandoz Ltd. | Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof |
| US4922007A (en) | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| US5177080A (en) | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
| HU217629B (hu) | 1991-12-12 | 2000-03-28 | Novartis Ag. | Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására |
| US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5510517A (en) | 1993-08-25 | 1996-04-23 | Merck & Co., Inc. | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
| TW257765B (enExample) | 1993-08-25 | 1995-09-21 | Merck & Co Inc | |
| US6544767B1 (en) | 1994-10-27 | 2003-04-08 | Axys Pharmaceuticals, Inc. | Cathespin O2 protease |
| EA200100972A1 (ru) * | 1999-03-15 | 2002-02-28 | Аксис Фармасьютикалз, Инк. | Новые соединения и композиции как ингибиторы протеаз |
| GB9925264D0 (en) * | 1999-10-26 | 1999-12-29 | Zeneca Ltd | Chemical compounds |
| CA2400626C (en) | 2000-02-14 | 2010-06-01 | Merck & Co., Inc. | Estrogen receptor modulators |
| WO2001068645A2 (en) | 2000-03-15 | 2001-09-20 | Axys Pharmaceuticals, Inc. | N-cyanomethylcarboxamides and their use as protease inhibitors |
| AU2696502A (en) | 2000-11-27 | 2002-06-03 | Merck & Co Inc | Estrogen receptor modulators |
| US7012075B2 (en) * | 2001-03-02 | 2006-03-14 | Merck & Co., Inc. | Cathepsin cysteine protease inhibitors |
| EP1446115B1 (en) * | 2001-11-13 | 2008-02-27 | Merck Frosst Canada Ltd. | Cyanoalkylamino derivatives as protease inhibitors |
| ATE395911T1 (de) * | 2002-03-05 | 2008-06-15 | Merck Frosst Canada Ltd | Cathepsin-cystein-protease-hemmer |
-
2004
- 2004-08-19 AU AU2004266740A patent/AU2004266740B2/en not_active Ceased
- 2004-08-19 JP JP2006523498A patent/JP4553899B2/ja not_active Expired - Fee Related
- 2004-08-19 EP EP04761688.3A patent/EP1673336B1/en not_active Expired - Lifetime
- 2004-08-19 CN CNA2004800237609A patent/CN1839114A/zh active Pending
- 2004-08-19 WO PCT/CA2004/001524 patent/WO2005019161A1/en not_active Ceased
- 2004-08-19 CA CA002535359A patent/CA2535359A1/en not_active Abandoned
- 2004-08-19 US US10/568,495 patent/US7312353B2/en not_active Expired - Lifetime
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