JP2009541489A5 - - Google Patents
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- Publication number
- JP2009541489A5 JP2009541489A5 JP2009518489A JP2009518489A JP2009541489A5 JP 2009541489 A5 JP2009541489 A5 JP 2009541489A5 JP 2009518489 A JP2009518489 A JP 2009518489A JP 2009518489 A JP2009518489 A JP 2009518489A JP 2009541489 A5 JP2009541489 A5 JP 2009541489A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmacological chaperone
- glucocerebrosidase
- isophagomine
- disease
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81595206P | 2006-06-23 | 2006-06-23 | |
| US60/815,952 | 2006-06-23 | ||
| PCT/US2007/072016 WO2007150064A2 (en) | 2006-06-23 | 2007-06-25 | METHOD FOR THE TREATMENT OF NEUROLOGICAL DISORDERS BY ENHANCING THE ACTIVITY OF β-GLUCOCEREBROSIDASE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009541489A JP2009541489A (ja) | 2009-11-26 |
| JP2009541489A5 true JP2009541489A5 (enExample) | 2010-08-12 |
| JP5303458B2 JP5303458B2 (ja) | 2013-10-02 |
Family
ID=38834440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518489A Expired - Fee Related JP5303458B2 (ja) | 2006-06-23 | 2007-06-25 | β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7829579B2 (enExample) |
| EP (1) | EP2040548B1 (enExample) |
| JP (1) | JP5303458B2 (enExample) |
| KR (1) | KR101402554B1 (enExample) |
| AT (1) | ATE555788T1 (enExample) |
| AU (1) | AU2007260812B2 (enExample) |
| BR (1) | BRPI0713442A2 (enExample) |
| CA (1) | CA2656643C (enExample) |
| DK (1) | DK2040548T3 (enExample) |
| ES (1) | ES2387845T3 (enExample) |
| IL (1) | IL196151A (enExample) |
| MX (1) | MX2009000032A (enExample) |
| PT (1) | PT2040548E (enExample) |
| WO (1) | WO2007150064A2 (enExample) |
| ZA (1) | ZA200900270B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
| DK2040548T3 (da) | 2006-06-23 | 2012-08-13 | Amicus Therapeutics Inc | Fremgangsmåde til behandling af neurologiske forstyrrelser ved forøgelse af aktiviteten af beta-glucocerebrosidase |
| GB0622702D0 (en) * | 2006-11-15 | 2006-12-27 | Univ Dundee | Selective glycosidase inhibitors |
| CN104383556B (zh) | 2007-05-16 | 2018-06-05 | 布里格姆妇女医院 | 突触核蛋白病的治疗 |
| JP5616336B2 (ja) * | 2008-06-26 | 2014-10-29 | オルファザイム エーピーエスＯｒｐｈａｚｙｍｅ Ａｐｓ | 酵素活性の調節因子としてのＨｓｐ７０の使用 |
| AU2009314447A1 (en) * | 2008-11-14 | 2010-05-20 | Neuraltus Pharmaceuticals, Inc. | Compositions and methods for the treatment of altered alpha-synuclein function |
| JP5645918B2 (ja) * | 2009-04-09 | 2014-12-24 | アミカス セラピューティックス インコーポレイテッド | リソソーム蓄積障害の予防および／または治療方法 |
| GB0906159D0 (en) * | 2009-04-09 | 2009-05-20 | Summit Corp Plc | Drug combination for the treatment of proteostatic diseases |
| CA2758187C (en) * | 2009-04-09 | 2017-03-07 | Robert Boyd | Methods for preventing and/or treating degenerative disorders of the central nervous system |
| US9206457B2 (en) * | 2009-05-26 | 2015-12-08 | Amicus Therapeutics, Inc. | Utilization of pharmacological chaperones to improve manufacturing and purification of biologics |
| EP2435459B1 (en) * | 2009-05-26 | 2016-05-04 | Amicus Therapeutics, Inc. | Utilization of pharmacological chaperones to improve manufacturing and purification of acid beta-glucosidase |
| AU2010281403B2 (en) * | 2009-07-28 | 2016-03-10 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating Gaucher disease |
| RU2015147509A (ru) * | 2009-10-19 | 2019-01-14 | Амикус Терапьютикс, Инк. | Новые композиции для предупреждения и/или лечения дегенеративных расстройств центральной нервной системы |
| WO2011049737A1 (en) * | 2009-10-19 | 2011-04-28 | Amicus Therapeutics, Inc. | Novel compositions for preventing and/or treating lysosomal storage disorders |
| DK2490712T3 (en) * | 2009-10-19 | 2015-10-05 | Amicus Therapeutics Inc | PROCESS FOR THE TREATMENT OF ALZHEIMER'S DISEASE BY USING Pharmacological chaperones TO INCREASE ACTIVITY OF GANGLIOSIDASER |
| US9662375B2 (en) | 2010-11-30 | 2017-05-30 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
| TR201906779T4 (tr) | 2011-05-12 | 2019-05-21 | Proteostasis Therapeutics Inc | Proteostaz regülatörleri. |
| EP2533051A1 (en) | 2011-06-06 | 2012-12-12 | Centogene GmbH | Method for the diagnosis of Gaucher's disease |
| AU2012272815B2 (en) * | 2011-06-22 | 2017-09-07 | The General Hospital Corporation | Treatment of proteinopathies |
| WO2013112706A1 (en) | 2012-01-25 | 2013-08-01 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating compounds |
| HK1214521A1 (zh) * | 2012-11-05 | 2016-07-29 | Genzyme Corporation | 用於治療蛋白質病的組合物和方法 |
| WO2014089449A1 (en) * | 2012-12-07 | 2014-06-12 | Rush University Nedical Center | Composition and method for treating neuronal ceroid lipofuscinosis |
| JP2017502961A (ja) | 2013-12-23 | 2017-01-26 | アレクトス セラピューティックス インコーポレイテッド | グルコセレブロシダーゼモジュレーターおよびその使用 |
| US9675627B2 (en) | 2014-04-14 | 2017-06-13 | Amicus Therapeutics, Inc. | Dosing regimens for treating and/or preventing cerebral amyloidoses |
| US10709700B2 (en) | 2014-09-15 | 2020-07-14 | Orphazyme A/S | Arimoclomol formulation |
| EP3215511B1 (en) | 2014-11-06 | 2024-04-17 | Bial-R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
| CA2985235A1 (en) | 2015-05-07 | 2016-11-10 | Shire Human Genetic Therapies, Inc. | Glucocerebrosidase gene therapy for parkinson's disease |
| KR20180133461A (ko) | 2016-04-06 | 2018-12-14 | 리소소말 테라퓨틱스 인크. | 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물 및 의학적 장애의 치료에서의 그의 용도 |
| WO2017176961A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| MX388912B (es) | 2016-04-06 | 2025-03-20 | Lysosomal Therapeutics Inc | Compuestos de pirrol[1,2-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos |
| WO2017178029A1 (en) | 2016-04-13 | 2017-10-19 | Orphazyme Aps | Heat shock proteins and cholesterol homeostasis |
| ES2831764T3 (es) | 2016-04-29 | 2021-06-09 | Orphazyme As | Arimoclomol para el tratamiento de trastornos asociados a glucocerebrosidasa |
| WO2017192930A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| EP3264092A1 (en) * | 2016-07-01 | 2018-01-03 | Centogene AG | Use of lyso-gb1 as druggable target |
| EA202091032A1 (ru) * | 2017-10-26 | 2020-07-17 | Шайр Хьюман Дженетик Терапиз, Инк. | Составы, содержащие глюкоцереброзидазу и изофагомин |
| CN108428452B (zh) | 2018-03-14 | 2019-12-13 | 百度在线网络技术（北京）有限公司 | 终端支架和远场语音交互系统 |
| WO2020006296A1 (en) | 2018-06-27 | 2020-01-02 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| WO2020006269A1 (en) | 2018-06-27 | 2020-01-02 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| WO2020023390A1 (en) | 2018-07-25 | 2020-01-30 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
| KR20210113606A (ko) * | 2018-12-05 | 2021-09-16 | 워싱턴 유니버시티 | 신경 질환을 검출, 예방, 회복 및 치료하는 방법 |
| CN113906012A (zh) * | 2019-04-25 | 2022-01-07 | 武田药品工业有限公司 | 异法戈明盐、使用方法和调配物 |
| CN111450306B (zh) * | 2020-03-06 | 2021-11-19 | 大连理工大学 | 外用纳米羟基磷灰石/聚多巴胺湿黏附型止血粉及其制备方法 |
| EP4247792A1 (en) | 2020-11-19 | 2023-09-27 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
| CA3218259A1 (en) * | 2021-04-30 | 2022-11-03 | Vanqua Bio, Inc. | Small molecule modulators of glucocerebrosidase activity and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0934531B1 (en) * | 1996-10-15 | 2004-08-04 | D-Gen Limited | Diagnosis of spongiform encephalopathy |
| GB2355074A (en) * | 1996-10-15 | 2001-04-11 | Imperial College | Method for predicting susceptibility to bovine spongiform encephalopathy |
| US6274597B1 (en) * | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
| JP5589165B2 (ja) | 2003-01-31 | 2014-09-17 | マウント シナイ スクール オブ メディシン オブ ニューヨーク ユニバーシティー | タンパク質欠損性障害の治療のための併用療法 |
| US20050137223A1 (en) | 2003-11-12 | 2005-06-23 | Amicus Therapeutics, Inc. | Glucoimidazole and polyhydroxycyclohexenyl amine derivatives to treat gaucher disease |
| ES2485369T3 (es) * | 2005-06-08 | 2014-08-13 | Amicus Therapeutics, Inc. | Tratamiento de trastornos del SNC asociados con mutaciones en genes que codifican enzimas lisosómicas |
| WO2007140212A2 (en) * | 2006-05-24 | 2007-12-06 | Amicus Therapeutics, Inc. | Tartrate salt of isofagomine and methods of use |
| DK2040548T3 (da) | 2006-06-23 | 2012-08-13 | Amicus Therapeutics Inc | Fremgangsmåde til behandling af neurologiske forstyrrelser ved forøgelse af aktiviteten af beta-glucocerebrosidase |
| KR101789000B1 (ko) * | 2007-05-22 | 2017-10-20 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 이소파고민과 이의 유도체를 제조하는 새로운 방법 |
-
2007
- 2007-06-25 DK DK07812295T patent/DK2040548T3/da active
- 2007-06-25 JP JP2009518489A patent/JP5303458B2/ja not_active Expired - Fee Related
- 2007-06-25 PT PT07812295T patent/PT2040548E/pt unknown
- 2007-06-25 AU AU2007260812A patent/AU2007260812B2/en not_active Ceased
- 2007-06-25 MX MX2009000032A patent/MX2009000032A/es active IP Right Grant
- 2007-06-25 ES ES07812295T patent/ES2387845T3/es active Active
- 2007-06-25 US US11/768,043 patent/US7829579B2/en active Active
- 2007-06-25 KR KR1020097001465A patent/KR101402554B1/ko not_active Expired - Fee Related
- 2007-06-25 EP EP20070812295 patent/EP2040548B1/en active Active
- 2007-06-25 BR BRPI0713442-8A patent/BRPI0713442A2/pt not_active Application Discontinuation
- 2007-06-25 AT AT07812295T patent/ATE555788T1/de active
- 2007-06-25 WO PCT/US2007/072016 patent/WO2007150064A2/en not_active Ceased
- 2007-06-25 CA CA2656643A patent/CA2656643C/en not_active Expired - Fee Related
-
2008
- 2008-12-23 IL IL196151A patent/IL196151A/en active IP Right Grant
-
2009
- 2009-01-13 ZA ZA2009/00270A patent/ZA200900270B/en unknown
-
2010
- 2010-11-08 US US12/941,468 patent/US9119845B2/en active Active
-
2014
- 2014-08-26 US US14/469,008 patent/US9402837B2/en active Active
-
2016
- 2016-08-01 US US15/225,029 patent/US10064851B2/en active Active
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