JP5303458B2 - β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法 - Google Patents

β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法 Download PDF

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JP5303458B2
JP5303458B2 JP2009518489A JP2009518489A JP5303458B2 JP 5303458 B2 JP5303458 B2 JP 5303458B2 JP 2009518489 A JP2009518489 A JP 2009518489A JP 2009518489 A JP2009518489 A JP 2009518489A JP 5303458 B2 JP5303458 B2 JP 5303458B2
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ブランドン ウストマン
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アミークス セラピューティックス インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
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JP2009518489A 2006-06-23 2007-06-25 β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法 Active JP5303458B2 (ja)

Applications Claiming Priority (3)

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US81595206P 2006-06-23 2006-06-23
US60/815,952 2006-06-23
PCT/US2007/072016 WO2007150064A2 (en) 2006-06-23 2007-06-25 METHOD FOR THE TREATMENT OF NEUROLOGICAL DISORDERS BY ENHANCING THE ACTIVITY OF β-GLUCOCEREBROSIDASE

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JP2009541489A JP2009541489A (ja) 2009-11-26
JP2009541489A5 JP2009541489A5 (enExample) 2010-08-12
JP5303458B2 true JP5303458B2 (ja) 2013-10-02

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US (4) US7829579B2 (enExample)
EP (1) EP2040548B1 (enExample)
JP (1) JP5303458B2 (enExample)
KR (1) KR101402554B1 (enExample)
AT (1) ATE555788T1 (enExample)
AU (1) AU2007260812B2 (enExample)
BR (1) BRPI0713442A2 (enExample)
CA (1) CA2656643C (enExample)
DK (1) DK2040548T3 (enExample)
ES (1) ES2387845T3 (enExample)
IL (1) IL196151A (enExample)
MX (1) MX2009000032A (enExample)
PT (1) PT2040548E (enExample)
WO (1) WO2007150064A2 (enExample)
ZA (1) ZA200900270B (enExample)

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US9206457B2 (en) * 2009-05-26 2015-12-08 Amicus Therapeutics, Inc. Utilization of pharmacological chaperones to improve manufacturing and purification of biologics
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EP2490533B1 (en) 2009-10-19 2015-09-16 Amicus Therapeutics, Inc. Novel compositions for preventing and/or treating lysosomal storage disorders
RU2015147509A (ru) 2009-10-19 2019-01-14 Амикус Терапьютикс, Инк. Новые композиции для предупреждения и/или лечения дегенеративных расстройств центральной нервной системы
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KR20250069686A (ko) 2014-09-15 2025-05-19 제브라 덴마크 에이/에스 아리모클로몰 제제
PT3215511T (pt) 2014-11-06 2024-05-22 Bial R&D Invest S A Pirazolo(1,5-a)pirimidinas substituídas e a sua utilização no tratamento de distúrbios médicos
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BRPI0713442A2 (pt) 2012-03-06
PT2040548E (pt) 2012-08-02
AU2007260812A1 (en) 2007-12-27
CA2656643A1 (en) 2007-12-27
KR101402554B1 (ko) 2014-06-19
ZA200900270B (en) 2011-02-23
US20170027919A1 (en) 2017-02-02
US20110052613A1 (en) 2011-03-03
DK2040548T3 (da) 2012-08-13
WO2007150064A2 (en) 2007-12-27
US7829579B2 (en) 2010-11-09
EP2040548A4 (en) 2009-12-23
CA2656643C (en) 2015-08-25
US20080009516A1 (en) 2008-01-10
WO2007150064A3 (en) 2008-02-21
KR20090021393A (ko) 2009-03-03
ATE555788T1 (de) 2012-05-15
US20150025109A1 (en) 2015-01-22
AU2007260812B2 (en) 2012-08-16
ES2387845T3 (es) 2012-10-02
JP2009541489A (ja) 2009-11-26
US10064851B2 (en) 2018-09-04
EP2040548A2 (en) 2009-04-01
IL196151A (en) 2015-08-31
US9119845B2 (en) 2015-09-01
MX2009000032A (es) 2009-01-23
US9402837B2 (en) 2016-08-02
EP2040548B1 (en) 2012-05-02
IL196151A0 (en) 2009-11-18

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