MA38144A1 - Compositions et procédés pour le traitement de protéinopathies - Google Patents

Compositions et procédés pour le traitement de protéinopathies

Info

Publication number
MA38144A1
MA38144A1 MA38144A MA38144A MA38144A1 MA 38144 A1 MA38144 A1 MA 38144A1 MA 38144 A MA38144 A MA 38144A MA 38144 A MA38144 A MA 38144A MA 38144 A1 MA38144 A1 MA 38144A1
Authority
MA
Morocco
Prior art keywords
methods
mammal
proteinopathies
compositions
treatment
Prior art date
Application number
MA38144A
Other languages
English (en)
Inventor
Sergio Pablo Sardi
Lamya Shihabuddin
Seng Cheng
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49578599&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA38144(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MA38144A1 publication Critical patent/MA38144A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des procédés pour améliorer la fonction neuronale chez un mammifère atteint d'une protéinopathie comprenant l'administration d'une quantité thérapeutiquement efficace d'un agent qui augmente l'activité glucocérébrosidase chez le mammifère. La présente invention concerne en outre des procédés pour réduire les lipides toxiques, de manière à réduire la ?-synucléine, et/ou inhiber l'accumulation d'agrégats de protéines chez un mammifère atteint d'une protéinopathie comprenant l'administration d'une quantité thérapeutiquement efficace d'un agent qui augmente l'activité glucocérébrosidase.
MA38144A 2012-11-05 2013-11-04 Compositions et procédés pour le traitement de protéinopathies MA38144A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261722434P 2012-11-05 2012-11-05
PCT/US2013/068242 WO2014071282A1 (fr) 2012-11-05 2013-11-04 Compositions et procédés pour le traitement de protéinopathies

Publications (1)

Publication Number Publication Date
MA38144A1 true MA38144A1 (fr) 2018-08-31

Family

ID=49578599

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38144A MA38144A1 (fr) 2012-11-05 2013-11-04 Compositions et procédés pour le traitement de protéinopathies

Country Status (22)

Country Link
US (1) US20150284472A1 (fr)
EP (1) EP2914281A1 (fr)
JP (1) JP2016503405A (fr)
KR (1) KR20150079751A (fr)
CN (1) CN104902923A (fr)
AR (1) AR093355A1 (fr)
AU (1) AU2013337354A1 (fr)
BR (1) BR112015009746A2 (fr)
CA (1) CA2889990A1 (fr)
CL (1) CL2015001157A1 (fr)
CR (1) CR20150216A (fr)
EA (1) EA201590880A1 (fr)
HK (1) HK1214521A1 (fr)
IL (1) IL238416A0 (fr)
MA (1) MA38144A1 (fr)
MX (1) MX2015005722A (fr)
PH (1) PH12015500879A1 (fr)
SG (1) SG11201502989XA (fr)
TN (1) TN2015000171A1 (fr)
TW (1) TW201427695A (fr)
WO (1) WO2014071282A1 (fr)
ZA (1) ZA201502618B (fr)

Families Citing this family (23)

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Publication number Priority date Publication date Assignee Title
PL2659904T3 (pl) 2008-06-26 2016-01-29 Orphazyme Aps Zastosowanie Hsp70 jako regulatora aktywności enzymatycznej
PL2646044T3 (pl) 2010-11-30 2020-03-31 Orphazyme A/S Sposoby zwiększenia aktywności wewnątrzkomórkowej Hsp70
EP3922242A1 (fr) 2014-09-15 2021-12-15 Orphazyme A/S Formulation arimoclomol
CA2985235A1 (fr) * 2015-05-07 2016-11-10 Shire Human Genetic Therapies, Inc. Therapie genique par glucocerebrosidase pour la maladie de parkinson
WO2017015491A1 (fr) * 2015-07-21 2017-01-26 Thomas Jefferson University Thérapies géniques pour les troubles neurodégénératifs ciblant les voies de biosynthèse des gangliosides
US10898476B2 (en) 2016-04-13 2021-01-26 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
EP3782624A1 (fr) * 2016-04-29 2021-02-24 Orphazyme A/S Arimoclomol pour le traitement de troubles associés à la glucocérébrosidase
EP3264092A1 (fr) * 2016-07-01 2018-01-03 Centogene AG Utilisation de gb1 en tant que cible thérapeutique
AU2017306558B2 (en) * 2016-08-03 2024-09-19 University Of South Florida Reelin compositions for treatment of neurological disorders
US11802294B2 (en) * 2017-10-03 2023-10-31 Prevail Therapeutics, Inc. Gene therapies for lysosomal disorders
US11993790B2 (en) * 2017-10-03 2024-05-28 Prevail Therapeutics, Inc. Gene therapies for lysosomal disorders
CN111465691A (zh) 2017-10-03 2020-07-28 普利维尔治疗公司 用于溶酶体障碍的基因疗法
EP3701030A4 (fr) * 2017-10-23 2022-04-20 Prevail Therapeutics, Inc. Thérapies géniques pour maladie neurodégénérative
AU2018354318B2 (en) * 2017-10-26 2024-07-04 Takeda Pharmaceutical Company Limited Formulations comprising glucocerebrosidase and isofagomine
EP3765855A1 (fr) * 2018-03-14 2021-01-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Détection de phospho-sérine 129 alpha-synucléine dans des cellules sanguines en tant que biomarqueur pour synucléinopathies
US11999974B2 (en) 2019-04-10 2024-06-04 Prevail Therapeutics, Inc. Gene therapies for lysosomal disorders
CA3136117A1 (fr) * 2019-04-10 2020-10-15 Prevail Therapeutics, Inc. Therapies geniques pour troubles lysosomaux
EP3986412A4 (fr) * 2019-06-21 2023-11-15 The Broad Institute, Inc. Agents pour inverser des protéinopathies toxiques
TW202214864A (zh) 2020-08-06 2022-04-16 應用醫學研究基金會 用於藉基因療法治療諸如阿茲海默症之Ｔａｕ蛋白病變的病毒顆粒
EP4247792A1 (fr) 2020-11-19 2023-09-27 Zevra Denmark A/S Procédés de préparation de citrate d'arimoclomol et intermédiaires associés
CN112569354B (zh) * 2020-12-29 2022-06-10 四川大学华西医院 tau蛋白及其基因作为药物靶点在制备治疗糖尿病药物中的应用
WO2023111336A1 (fr) * 2021-12-17 2023-06-22 F. Hoffmann-La Roche Ag Agonistes oligonucleotidiques de gba
EP4448762A1 (fr) * 2021-12-17 2024-10-23 F. Hoffmann-La Roche AG Oligonucléotides capables d'augmenter l'expression de la glucocérébrosidase

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Also Published As

Publication number Publication date
ZA201502618B (en) 2016-01-27
JP2016503405A (ja) 2016-02-04
CA2889990A1 (fr) 2014-05-08
HK1214521A1 (zh) 2016-07-29
TN2015000171A1 (fr) 2016-10-03
MX2015005722A (es) 2016-01-12
BR112015009746A2 (pt) 2017-08-15
CL2015001157A1 (es) 2015-10-16
TW201427695A (zh) 2014-07-16
CR20150216A (es) 2015-05-29
US20150284472A1 (en) 2015-10-08
WO2014071282A1 (fr) 2014-05-08
IL238416A0 (en) 2015-06-30
SG11201502989XA (en) 2015-05-28
CN104902923A (zh) 2015-09-09
KR20150079751A (ko) 2015-07-08
EA201590880A1 (ru) 2015-09-30
PH12015500879A1 (en) 2015-06-29
AR093355A1 (es) 2015-06-03
EP2914281A1 (fr) 2015-09-09
AU2013337354A1 (en) 2015-05-21

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