JP2007515429A5 - - Google Patents
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- Publication number
- JP2007515429A5 JP2007515429A5 JP2006545607A JP2006545607A JP2007515429A5 JP 2007515429 A5 JP2007515429 A5 JP 2007515429A5 JP 2006545607 A JP2006545607 A JP 2006545607A JP 2006545607 A JP2006545607 A JP 2006545607A JP 2007515429 A5 JP2007515429 A5 JP 2007515429A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- alkyl
- aryl
- cycloalkenyl
- aminocarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 cyano, nitro, amino Chemical group 0.000 claims 60
- 125000000217 alkyl group Chemical group 0.000 claims 49
- 125000003118 aryl group Chemical group 0.000 claims 44
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 44
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 34
- 125000003710 aryl alkyl group Chemical group 0.000 claims 33
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 31
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 31
- 125000001475 halogen functional group Chemical group 0.000 claims 30
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 29
- 229910052799 carbon Inorganic materials 0.000 claims 28
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 27
- 125000000623 heterocyclic group Chemical group 0.000 claims 26
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 25
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 24
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 24
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 24
- 125000005309 thioalkoxy group Chemical group 0.000 claims 23
- 125000002252 acyl group Chemical group 0.000 claims 22
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 20
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims 20
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 19
- 125000005296 thioaryloxy group Chemical group 0.000 claims 19
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 18
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 16
- 125000005404 thioheteroaryloxy group Chemical group 0.000 claims 15
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 14
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 14
- 150000001408 amides Chemical class 0.000 claims 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 14
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 14
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 13
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 13
- 229910019142 PO4 Inorganic materials 0.000 claims 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 13
- 239000010452 phosphate Substances 0.000 claims 13
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 12
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 11
- 125000004104 aryloxy group Chemical group 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004694 alkoxyaminocarbonyl group Chemical group 0.000 claims 6
- 125000000747 amidyl group Chemical group [H][N-]* 0.000 claims 6
- 125000004043 oxo group Chemical group O=* 0.000 claims 6
- 125000001831 (C6-C10) heteroaryl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000003368 amide group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910021653 sulphate ion Inorganic materials 0.000 claims 3
- SQERDRRMCKKWIL-UHFFFAOYSA-N 2-hydroperoxy-2-oxoacetic acid Chemical compound OOC(=O)C(O)=O SQERDRRMCKKWIL-UHFFFAOYSA-N 0.000 claims 2
- 208000002705 Glucose Intolerance Diseases 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 150000007942 carboxylates Chemical class 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 201000009104 prediabetes syndrome Diseases 0.000 claims 2
- SOGBOGBTIKMGFS-UHFFFAOYSA-N thiophene-2-carbohydrazide Chemical compound NNC(=O)C1=CC=CS1 SOGBOGBTIKMGFS-UHFFFAOYSA-N 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 102000011990 Sirtuin Human genes 0.000 claims 1
- 108050002485 Sirtuin Proteins 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 230000011759 adipose tissue development Effects 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 230000000923 atherogenic effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 235000001508 sulfur Nutrition 0.000 claims 1
- 0 *C1=C(*)C(*)=C(*)*1 Chemical compound *C1=C(*)C(*)=C(*)*1 0.000 description 4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53094503P | 2003-12-19 | 2003-12-19 | |
| PCT/US2004/043207 WO2005060711A2 (en) | 2003-12-19 | 2004-12-20 | Methods of treating a disorder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007515429A JP2007515429A (ja) | 2007-06-14 |
| JP2007515429A5 true JP2007515429A5 (enExample) | 2008-02-07 |
Family
ID=34710193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545607A Pending JP2007515429A (ja) | 2003-12-19 | 2004-12-20 | 障害を治療する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050250794A1 (enExample) |
| EP (1) | EP1694323A4 (enExample) |
| JP (1) | JP2007515429A (enExample) |
| CA (1) | CA2550091A1 (enExample) |
| MX (1) | MXPA06007054A (enExample) |
| WO (1) | WO2005060711A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060074124A1 (en) * | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
| DK1701940T3 (da) * | 2003-12-23 | 2008-09-08 | Lundbeck & Co As H | 2-(1H-indolylsulfanyl)-bensylaminderivater som SSRI |
| WO2005118561A1 (en) * | 2004-05-27 | 2005-12-15 | Ucb, S.A. | Benzoxazolone derivatives, processes for preparing them and their uses |
| DK1753512T3 (da) | 2004-05-28 | 2008-11-17 | 4Sc Ag | Tetrahydropyridothiophener |
| US7517986B2 (en) | 2004-06-04 | 2009-04-14 | 4Sc Ag | Tetrahydropyridothiophenes for use in the treatment of cancer |
| CA2569623A1 (en) | 2004-06-11 | 2005-12-22 | Altana Pharma Ag | Novel compounds and use of tetrahydropyridothiophenes |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| CA2579089A1 (en) * | 2004-08-30 | 2006-03-09 | Government Of The United States Of America As Represented By The Secreta Ry Department Of Health And Human Services | Inhibition of viruses using rnase h inhibitors |
| JP2008529989A (ja) | 2005-02-09 | 2008-08-07 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン |
| US7741488B2 (en) | 2005-02-11 | 2010-06-22 | 4Sc Ag | Tetrahydropyridothiophenes as antiproliferative agents for the treatment of cancer |
| AU2006251169A1 (en) | 2005-05-25 | 2006-11-30 | 4Sc Ag | Tetrahydropyridothiophenes for use in the treatment of cancer |
| WO2006125813A2 (en) | 2005-05-25 | 2006-11-30 | Nycomed Gmbh | Tetrahydropyridothiophenes for use in the treatment of cancer |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7649098B2 (en) * | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
| TW200813018A (en) | 2006-06-09 | 2008-03-16 | Astrazeneca Ab | Novel compounds |
| US20080021063A1 (en) * | 2006-07-18 | 2008-01-24 | Kazantsev Aleksey G | Compositions and methods for modulating sirtuin activity |
| US8227603B2 (en) | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| DK2069352T5 (en) | 2006-08-02 | 2017-04-03 | Cytokinetics Inc | SPECIFIC CHEMICAL UNITS, COMPOSITIONS AND PROCEDURES |
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| WO2008060400A2 (en) * | 2006-11-15 | 2008-05-22 | Sirtris Pharmaceuticals, Inc. | Sirtuin polymorphisms and methods of use thereof |
| EP2139478A4 (en) * | 2007-03-30 | 2010-05-05 | Cytokinetics Inc | CHEMICAL ENTITIES, COMPOSITIONS AND METHODS |
| EP2152262A2 (en) * | 2007-04-27 | 2010-02-17 | UCB Pharma, S.A. | New heterocyclic derivatives useful for the treatment of cns disorders |
| TW200920355A (en) * | 2007-09-06 | 2009-05-16 | Lexicon Pharmaceuticals Inc | Compositions and methods for treating immunological and inflammatory diseases and disorders |
| US8119661B2 (en) | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| JP5099794B2 (ja) | 2007-11-27 | 2012-12-19 | アルデア バイオサイエンシーズ インク． | 新規化合物、組成物、及び使用方法 |
| US7998976B2 (en) * | 2008-02-04 | 2011-08-16 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
| JP2011510985A (ja) * | 2008-02-04 | 2011-04-07 | サイトキネティックス， インコーポレイテッド | 特定の化学的実体、組成物および方法 |
| US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| EP2367563A4 (en) | 2008-12-08 | 2012-12-19 | Univ Northwestern | PROCESS FOR HSF-1 MODULATION |
| JP2012076998A (ja) * | 2009-01-29 | 2012-04-19 | Sapporo Medical Univ | メラノーマの転移抑制剤 |
| WO2010098866A1 (en) * | 2009-02-27 | 2010-09-02 | Supergen, Inc. | Cyclopentathiophene/cyclohexathiophene dna methyltransferase inhibitors |
| SG176983A1 (en) | 2009-07-08 | 2012-02-28 | Dermira Canada Inc | Tofa analogs useful in treating dermatological disorders or conditions |
| EP2993236A1 (en) * | 2010-04-15 | 2016-03-09 | Glaxosmithkline LLC | Sirtuin activators and activation assays |
| WO2012119605A1 (en) * | 2011-03-10 | 2012-09-13 | Akar Yahya Ahmed Abdellhafeez Salem | New disperse dye with potent anticancer activity |
| EP2731611B1 (en) | 2011-07-13 | 2019-09-18 | Cytokinetics, Inc. | Combination therapie for als |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6414013B1 (en) * | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
| IL138825A (en) * | 2000-10-03 | 2006-06-11 | Neurim Pharma 1991 | Pharmaceutical preparations containing tryptamine derivatives and similar compounds, and such new compounds |
| AU2002211663A1 (en) * | 2000-10-12 | 2002-04-22 | Smith Kline Beecham Corporation | Nf-$g(k)b inhibitors |
| US20040005574A1 (en) * | 2002-07-08 | 2004-01-08 | Leonard Guarente | SIR2 activity |
| SK16052003A3 (en) * | 2001-06-07 | 2004-10-05 | Hoffmann La Roche | New indole derivatives with 5-HT6 receptor affinity |
| US7241743B2 (en) * | 2001-06-15 | 2007-07-10 | The Trustees Of Columbia University In The City Of New York | Sir2α-based therapeutic and prophylactic methods |
| DE60203529T2 (de) * | 2001-09-27 | 2006-03-16 | F. Hoffmann-La Roche Ag | Indolderivate als cox-ii-inhibitoren |
| CA2538759C (en) * | 2003-09-12 | 2015-11-03 | Elixir Pharmaceuticals, Inc. | Substituted heterocyclic compounds as sirtuin inhitibitors |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| EP1715855A4 (en) * | 2004-01-29 | 2010-06-16 | Elixir Pharmaceuticals Inc | ANTIVIRAL DRUGS |
-
2004
- 2004-12-20 US US11/018,018 patent/US20050250794A1/en not_active Abandoned
- 2004-12-20 JP JP2006545607A patent/JP2007515429A/ja active Pending
- 2004-12-20 WO PCT/US2004/043207 patent/WO2005060711A2/en not_active Ceased
- 2004-12-20 MX MXPA06007054A patent/MXPA06007054A/es active IP Right Grant
- 2004-12-20 CA CA002550091A patent/CA2550091A1/en not_active Abandoned
- 2004-12-20 EP EP04815304A patent/EP1694323A4/en not_active Withdrawn
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