WO2012119605A1 - New disperse dye with potent anticancer activity - Google Patents

New disperse dye with potent anticancer activity Download PDF

Info

Publication number
WO2012119605A1
WO2012119605A1 PCT/EG2011/000002 EG2011000002W WO2012119605A1 WO 2012119605 A1 WO2012119605 A1 WO 2012119605A1 EG 2011000002 W EG2011000002 W EG 2011000002W WO 2012119605 A1 WO2012119605 A1 WO 2012119605A1
Authority
WO
WIPO (PCT)
Prior art keywords
disperse dye
anticancer activity
potent anticancer
new
new disperse
Prior art date
Application number
PCT/EG2011/000002
Other languages
French (fr)
Inventor
Yahya Ahmed Abdellhafeez Salem AKAR
Original Assignee
Akar Yahya Ahmed Abdellhafeez Salem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akar Yahya Ahmed Abdellhafeez Salem filed Critical Akar Yahya Ahmed Abdellhafeez Salem
Priority to PCT/EG2011/000002 priority Critical patent/WO2012119605A1/en
Publication of WO2012119605A1 publication Critical patent/WO2012119605A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • 2-cinnamyl-5,6,7,8-tetrahydro[l ]benzothieno[2,3-d )pyrimidine- 4(3H)-one is a yellow powder of new synthesized disperse dye which synthesized by reacting2-amino-4,5,6,7-tetrahydrobenzo[bjthiophene-3- carboxamide with cinnamaldehyde in presence of HCL(few drops) and filtered after 5 hours and filtrate is recrystallized from methanol then the powder is subjected to anticancer activity at the national cancer institute at different cell lines showing a potent anticancer activity.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

New yellow disperse dye of 2-cinnamyl-5,6,7,8- tetrahydro[l]benzothieno[2,3-d]pyrimidine-4(3H)-one with a first medical application as anticancer showing potent activity against different cancer cell lines and low cytotoxicity to melanocytes (normal skin) which will be helpful in treatment of cancer specially melanoma due to dye stability on the skin.

Description

NEW DISPERSE DYE WITH POTENT
ANTICANCER ACTIVITY
Technical Field:
Treatment of cancer specially melanoma due to dye stability.
Background Art:
All disperse dyes was only used in polyester dyeing but no medical use.
Disclosure of Invention:
2-cinnamyl-5,6,7,8-tetrahydro[l ]benzothieno[2,3-d )pyrimidine- 4(3H)-one is a yellow powder of new synthesized disperse dye which synthesized by reacting2-amino-4,5,6,7-tetrahydrobenzo[bjthiophene-3- carboxamide with cinnamaldehyde in presence of HCL(few drops) and filtered after 5 hours and filtrate is recrystallized from methanol then the powder is subjected to anticancer activity at the national cancer institute at different cell lines showing a potent anticancer activity.

Claims

1. First medical application for disperse dye as anticancer.
2. New compound of yellow disperse dye.
PCT/EG2011/000002 2011-03-10 2011-03-10 New disperse dye with potent anticancer activity WO2012119605A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EG2011/000002 WO2012119605A1 (en) 2011-03-10 2011-03-10 New disperse dye with potent anticancer activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EG2011/000002 WO2012119605A1 (en) 2011-03-10 2011-03-10 New disperse dye with potent anticancer activity

Publications (1)

Publication Number Publication Date
WO2012119605A1 true WO2012119605A1 (en) 2012-09-13

Family

ID=44625918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EG2011/000002 WO2012119605A1 (en) 2011-03-10 2011-03-10 New disperse dye with potent anticancer activity

Country Status (1)

Country Link
WO (1) WO2012119605A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016191537A1 (en) * 2015-05-28 2016-12-01 The Regents Of The University Of California Tubulin-binding compounds, compositions and uses related thereto

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032778A1 (en) * 2003-06-10 2005-02-10 Solvay Pharmaceuticals B.V. Therapeutically active thiophenepyrimidinone compounds and their use
US20050038053A1 (en) * 2003-06-10 2005-02-17 Solvay Pharmaceuticals B.V. Novel compounds and their use in therapy
US20050250794A1 (en) * 2003-12-19 2005-11-10 Andrew Napper Methods of treating a disorder
WO2006044826A2 (en) * 2004-10-20 2006-04-27 Compass Pharmaceuticals Llc Thiophens and their use as anti-tumor agents
US20090030196A1 (en) * 2006-12-29 2009-01-29 Abbott Laboratories Pim kinase inhibitors as cancer chemotherapeutics

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032778A1 (en) * 2003-06-10 2005-02-10 Solvay Pharmaceuticals B.V. Therapeutically active thiophenepyrimidinone compounds and their use
US20050038053A1 (en) * 2003-06-10 2005-02-17 Solvay Pharmaceuticals B.V. Novel compounds and their use in therapy
US20050250794A1 (en) * 2003-12-19 2005-11-10 Andrew Napper Methods of treating a disorder
WO2006044826A2 (en) * 2004-10-20 2006-04-27 Compass Pharmaceuticals Llc Thiophens and their use as anti-tumor agents
US20090030196A1 (en) * 2006-12-29 2009-01-29 Abbott Laboratories Pim kinase inhibitors as cancer chemotherapeutics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PECH R ET AL: "UEBER THIENO-VERBINDUNGEN 7. MITTEILUNG: ZUR DARSTELLUNG VON 2-ARYLVINYL-3,4-DIHYDRO-4-OXOTHIENO Ä2,3-DÜPYRIMIDINEN//THIENO COMPOUNDS. PART 7. PREPARATION OF 2-(ARYLVINYL)-3,4-DIHYDRO-4-OXOTHI ENO Ä2,3-DÜPYRIMIDINES", DIE PHARMAZIE, GOVI VERLAG PHARMAZEUTISCHER VERLAG GMBH, ESCHBORN, DE, vol. 42, no. 2, 1 January 1987 (1987-01-01), pages 131, XP008047719, ISSN: 0031-7144 *
SHISHOO C J ET AL: "STUDIES ON THE SYNTHESIS OF 2-(2-ARYLVINYL)THIENO not 2,3-D 3/4 PYRIMIDINESAND 5-(2-ARYLVINYL)TRIAZOLOTHIENOL not 3,2-E 3/4 PYRIMIDINES", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 22, no. 3, 1 May 1985 (1985-05-01), pages 825 - 830, XP000983905, ISSN: 0022-152X, DOI: 10.1002/JHET.5570220343 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016191537A1 (en) * 2015-05-28 2016-12-01 The Regents Of The University Of California Tubulin-binding compounds, compositions and uses related thereto
US10913750B2 (en) 2015-05-28 2021-02-09 The Regents Of The University Of California Tubulin-binding compounds, compositions and uses related thereto

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