JP2007501305A5 - - Google Patents
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- Publication number
- JP2007501305A5 JP2007501305A5 JP2006522341A JP2006522341A JP2007501305A5 JP 2007501305 A5 JP2007501305 A5 JP 2007501305A5 JP 2006522341 A JP2006522341 A JP 2006522341A JP 2006522341 A JP2006522341 A JP 2006522341A JP 2007501305 A5 JP2007501305 A5 JP 2007501305A5
- Authority
- JP
- Japan
- Prior art keywords
- acetylheparosan
- sulfation
- carried out
- modified
- partial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 39
- 150000004676 glycans Chemical class 0.000 claims description 7
- 229920001282 polysaccharide Polymers 0.000 claims description 7
- 239000005017 polysaccharide Substances 0.000 claims description 7
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 5
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 5
- 229960002442 glucosamine Drugs 0.000 claims description 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 4
- 229920000669 heparin Polymers 0.000 claims description 4
- 229960002897 heparin Drugs 0.000 claims description 4
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000005670 sulfation reaction Methods 0.000 claims 24
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 230000001180 sulfating effect Effects 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 7
- 230000019635 sulfation Effects 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 238000006345 epimerization reaction Methods 0.000 claims 5
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 239000002798 polar solvent Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- 229940088598 enzyme Drugs 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 206010002388 Angina unstable Diseases 0.000 claims 2
- 230000005526 G1 to G0 transition Effects 0.000 claims 2
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 208000007814 Unstable Angina Diseases 0.000 claims 2
- 206010047249 Venous thrombosis Diseases 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 claims 2
- 238000003381 deacetylation reaction Methods 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 230000002107 myocardial effect Effects 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000000053 physical method Methods 0.000 claims 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims 2
- 239000002994 raw material Substances 0.000 claims 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical group [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims 2
- MCHWWJLLPNDHGL-KVTDHHQDSA-N (2r,3s,4s,5r)-2,5-bis(hydroxymethyl)oxolane-3,4-diol Chemical group OC[C@H]1O[C@H](CO)[C@@H](O)[C@@H]1O MCHWWJLLPNDHGL-KVTDHHQDSA-N 0.000 claims 1
- WKFQMDFSDQFAIC-UHFFFAOYSA-N 2,4-dimethylthiolane 1,1-dioxide Chemical compound CC1CC(C)S(=O)(=O)C1 WKFQMDFSDQFAIC-UHFFFAOYSA-N 0.000 claims 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- 102000004411 Antithrombin III Human genes 0.000 claims 1
- 108090000935 Antithrombin III Proteins 0.000 claims 1
- 206010003178 Arterial thrombosis Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- 108010029144 Factor IIa Proteins 0.000 claims 1
- 108010074860 Factor Xa Proteins 0.000 claims 1
- 239000007995 HEPES buffer Substances 0.000 claims 1
- 108010022901 Heparin Lyase Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 101100450563 Mus musculus Serpind1 gene Proteins 0.000 claims 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 1
- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 108090000190 Thrombin Proteins 0.000 claims 1
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 238000003314 affinity selection Methods 0.000 claims 1
- 230000002744 anti-aggregatory effect Effects 0.000 claims 1
- 230000002785 anti-thrombosis Effects 0.000 claims 1
- 229960005348 antithrombin iii Drugs 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002009 diols Chemical group 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000003480 fibrinolytic effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 1
- AJFDBNQQDYLMJN-UHFFFAOYSA-N n,n-diethylacetamide Chemical compound CCN(CC)C(C)=O AJFDBNQQDYLMJN-UHFFFAOYSA-N 0.000 claims 1
- 230000014508 negative regulation of coagulation Effects 0.000 claims 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 235000010288 sodium nitrite Nutrition 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229960004072 thrombin Drugs 0.000 claims 1
- 230000001732 thrombotic effect Effects 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
- 239000002253 acid Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- CNPURSDMOWDNOQ-UHFFFAOYSA-N 4-methoxy-7h-pyrrolo[2,3-d]pyrimidin-2-amine Chemical compound COC1=NC(N)=NC2=C1C=CN2 CNPURSDMOWDNOQ-UHFFFAOYSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 150000002016 disaccharides Chemical group 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- AEMOLEFTQBMNLQ-CLQWQSTFSA-N l-iduronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O AEMOLEFTQBMNLQ-CLQWQSTFSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001618A ITMI20031618A1 (it) | 2003-08-06 | 2003-08-06 | Derivati polisaccaridici dotati di alta attivita' |
| PCT/EP2004/051391 WO2005014656A1 (en) | 2003-08-06 | 2004-07-07 | Polysaccharides derivatives with high antithrombotic activity in plasma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007501305A JP2007501305A (ja) | 2007-01-25 |
| JP2007501305A5 true JP2007501305A5 (https=) | 2007-09-06 |
Family
ID=34131211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006522341A Pending JP2007501305A (ja) | 2003-08-06 | 2004-07-07 | 血漿中で高度の抗血栓活性を有する多糖類誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7687249B2 (https=) |
| EP (1) | EP1654288B9 (https=) |
| JP (1) | JP2007501305A (https=) |
| KR (1) | KR20060063933A (https=) |
| CN (1) | CN1832966A (https=) |
| AT (1) | ATE458009T1 (https=) |
| AU (1) | AU2004262584A1 (https=) |
| BR (1) | BRPI0413346A (https=) |
| CA (1) | CA2534709A1 (https=) |
| DE (1) | DE602004025583D1 (https=) |
| DK (1) | DK1654288T3 (https=) |
| ES (1) | ES2341249T3 (https=) |
| IL (1) | IL173482A0 (https=) |
| IT (1) | ITMI20031618A1 (https=) |
| MX (1) | MXPA06001511A (https=) |
| RU (1) | RU2361881C2 (https=) |
| WO (1) | WO2005014656A1 (https=) |
| ZA (1) | ZA200601643B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007058592A1 (en) * | 2005-11-21 | 2007-05-24 | Ge Healthcare Bio-Sciences Ab | A method of chromatography using semi-synthetic heparin ligands |
| GB0818255D0 (en) | 2008-10-06 | 2008-11-12 | Agency Science Tech & Res | Isolation and identification of glycosaminoglycans |
| US9498494B2 (en) | 2008-09-11 | 2016-11-22 | Agency For Science, Technology And Research | Glycosaminoglycans |
| CN101698838B (zh) * | 2008-12-26 | 2012-05-23 | 北京大学 | 尿苷二磷酸葡萄糖醛酸异构酶及其编码基因与应用 |
| ITMI20091445A1 (it) * | 2009-08-07 | 2011-02-08 | Inalco S P A A Socio Unico | Derivati semi-sintetici del polisaccaride k5 per la prevenzione ed il trattamento del danno tissutale associato a ischemia e/o riperfusione |
| SG178349A1 (en) | 2009-09-01 | 2012-03-29 | Zhenyu Wang | K5 heparosan fermentation and purification |
| EP2598652A4 (en) | 2010-07-29 | 2014-04-30 | Shire Human Genetic Therapies | TESTS FOR THE DETECTION OF GLYCOSAMINOGLYCANES |
| EP2809796A4 (en) * | 2012-02-01 | 2016-08-17 | Shire Human Genetic Therapies | TESTS FOR THE DETECTION OF GLYCOSAMINOGLYCANES |
| CN102796723A (zh) * | 2012-09-11 | 2012-11-28 | 深圳市海普瑞药业股份有限公司 | 肝素酶i的固定化方法 |
| CN102888390B (zh) * | 2012-10-30 | 2014-09-03 | 深圳市海普瑞药业股份有限公司 | 肝素酶ⅲ的固定化方法 |
| CN103059165B (zh) * | 2012-12-26 | 2015-04-29 | 安徽丰原药业股份有限公司 | 一种多糖酰化物及其制备方法 |
| JP6879216B2 (ja) * | 2015-12-28 | 2021-06-02 | 味の素株式会社 | 抗凝固活性を有するヘパラン硫酸の製造法 |
| JP6225321B1 (ja) | 2016-08-31 | 2017-11-08 | 王子ホールディングス株式会社 | ポリ硫酸ペントサンの製造方法 |
| WO2018043666A1 (ja) | 2016-08-31 | 2018-03-08 | 王子ホールディングス株式会社 | 酸性キシロオリゴ糖の製造方法 |
| JP6281659B1 (ja) | 2017-02-28 | 2018-02-21 | 王子ホールディングス株式会社 | ポリ硫酸ペントサン、医薬組成物及び抗凝固剤 |
| EP3632451A4 (en) | 2017-05-31 | 2021-03-10 | Oji Holdings Corporation | MOISTURIZING TOPICAL PREPARATION |
| WO2019054344A1 (ja) | 2017-09-12 | 2019-03-21 | 王子ホールディングス株式会社 | ポリ硫酸ペントサン及びポリ硫酸ペントサンの製造方法 |
| AU2018387999B2 (en) | 2017-12-20 | 2021-06-17 | Oji Holdings Corporation | Pentosan polysulfate and medicine containing pentosan polysulfate |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1214609B (it) * | 1985-05-17 | 1990-01-18 | Opocrin Spa | Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. |
| FR2669932B1 (fr) | 1990-12-03 | 1994-07-01 | Sanofi Sa | Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent. |
| IT1271057B (it) | 1994-11-04 | 1997-05-26 | Inalco Spa | Polisaccaridi aventi un elevato contenuto di acido iduronico |
| IT1282994B1 (it) * | 1996-05-10 | 1998-04-03 | Inalco Spa | Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante |
| IT1290814B1 (it) | 1997-03-24 | 1998-12-11 | Istituto Scient Di Chimica E B | Glicosaminoglicani aventi elevata attivita' antitrombotica |
| SE9701454D0 (sv) | 1997-04-18 | 1997-04-18 | Ulf Lindahl | new DNA sequences and a process for enzyme manufacture |
| US20020062019A1 (en) | 2000-03-30 | 2002-05-23 | Pasqua Oreste | Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation |
| IT1318432B1 (it) * | 2000-03-30 | 2003-08-25 | Inalco Spa | Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro |
| ITMI20011633A1 (it) * | 2001-07-27 | 2003-01-27 | San Raffaele Centro Fond | Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv |
| PL375088A1 (en) * | 2002-06-18 | 2005-11-14 | Glycores 2000 S.R.L. | Epimerized derivatives of k5 polysaccharide with a very high degree of sulfation |
-
2003
- 2003-08-06 IT IT001618A patent/ITMI20031618A1/it unknown
-
2004
- 2004-07-07 CA CA002534709A patent/CA2534709A1/en not_active Abandoned
- 2004-07-07 WO PCT/EP2004/051391 patent/WO2005014656A1/en not_active Ceased
- 2004-07-07 EP EP04766148A patent/EP1654288B9/en not_active Expired - Lifetime
- 2004-07-07 MX MXPA06001511A patent/MXPA06001511A/es active IP Right Grant
- 2004-07-07 ES ES04766148T patent/ES2341249T3/es not_active Expired - Lifetime
- 2004-07-07 RU RU2006106790/04A patent/RU2361881C2/ru not_active IP Right Cessation
- 2004-07-07 JP JP2006522341A patent/JP2007501305A/ja active Pending
- 2004-07-07 AT AT04766148T patent/ATE458009T1/de not_active IP Right Cessation
- 2004-07-07 DE DE602004025583T patent/DE602004025583D1/de not_active Expired - Fee Related
- 2004-07-07 US US10/557,584 patent/US7687249B2/en not_active Expired - Fee Related
- 2004-07-07 CN CNA2004800223076A patent/CN1832966A/zh active Pending
- 2004-07-07 BR BRPI0413346-3A patent/BRPI0413346A/pt not_active IP Right Cessation
- 2004-07-07 KR KR1020067002532A patent/KR20060063933A/ko not_active Withdrawn
- 2004-07-07 AU AU2004262584A patent/AU2004262584A1/en not_active Abandoned
- 2004-07-07 DK DK04766148.3T patent/DK1654288T3/da active
-
2006
- 2006-01-31 IL IL173482A patent/IL173482A0/en unknown
- 2006-02-24 ZA ZA200601643A patent/ZA200601643B/en unknown
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