JP2007500154A5 - - Google Patents
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- JP2007500154A5 JP2007500154A5 JP2006521476A JP2006521476A JP2007500154A5 JP 2007500154 A5 JP2007500154 A5 JP 2007500154A5 JP 2006521476 A JP2006521476 A JP 2006521476A JP 2006521476 A JP2006521476 A JP 2006521476A JP 2007500154 A5 JP2007500154 A5 JP 2007500154A5
- Authority
- JP
- Japan
- Prior art keywords
- depression
- use according
- pharmaceutical product
- rotigotine
- product according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010012378 Depression Diseases 0.000 claims 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims 6
- KFQYTPMOWPVWEJ-INIZCTEOSA-N (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 claims 5
- 229960003179 Rotigotine Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 206010061536 Parkinson's disease Diseases 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrugs Drugs 0.000 claims 4
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 206010004938 Bipolar disease Diseases 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate dianion Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 2
- 206010057840 Major depression Diseases 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-L Sulphite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 201000003104 endogenous depression Diseases 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- NJRWNWYFPOFDFN-UHFFFAOYSA-L phosphonate(2-) Chemical compound [O-][P]([O-])=O NJRWNWYFPOFDFN-UHFFFAOYSA-L 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- 229940005513 ANTIDEPRESSANTS Drugs 0.000 claims 1
- 229940005529 ANTIPSYCHOTICS Drugs 0.000 claims 1
- 229940005530 ANXIOLYTICS Drugs 0.000 claims 1
- 206010027599 Migraine Diseases 0.000 claims 1
- 208000008085 Migraine Disorders Diseases 0.000 claims 1
- 230000001430 anti-depressive Effects 0.000 claims 1
- 230000000561 anti-psychotic Effects 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 239000000164 antipsychotic agent Substances 0.000 claims 1
- 230000000949 anxiolytic Effects 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 230000001624 sedative Effects 0.000 claims 1
- 239000000932 sedative agent Substances 0.000 claims 1
Claims (17)
- ロチゴチン[(−)−5,6,7,8−テトラヒドロ−6−[プロピル[2−(2−チエニル)エチル]アミノ]−1−ナフトール]又はそのプロドラッグ又は生理学的に許容可能な塩を含有する、うつ病の治療のための医薬品。
- 前記うつ病は、単極性うつ病[大うつ病]又は躁うつ障害のうつエピソードである、請求項1記載の医薬品。
- 前記うつ病は器質性うつ病である、請求項1記載の医薬品。
- 前記うつ病は、パーキンソン病に依存しない器質性うつ病である、請求項3記載の医薬品。
- 前記うつ病は、パーキンソン病に関連したうつ病である、請求項3記載の医薬品。
- 非経口投与、経皮投与又は粘膜投与のための医薬品が予定されている、請求項1から5までのいずれか1項記載の医薬品。
- ロチゴチンが、一日当たり0.5〜50mgの用量で投与される、請求項1から6までのいずれか1項記載の医薬品。
- 前記プロドラッグは、エステル、カルバマート、カルボナート、ケタール、アセタート、ホスファート、ホスホナート、スルファート、又はスルホナートである、請求項1から7までのいずれか1項記載の医薬品。
- ロチゴチン[(−)−5,6,7,8−テトラヒドロ−6−[プロピル[2−(2−チエニル)エチル]アミノ]−1−ナフトール]並びにそのプロドラッグ及び生理学的に許容可能な塩の、うつ病の治療のための医薬品の製造のための使用。
- 前記うつ病は、単極性うつ病[大うつ病]又は躁うつ障害のうつエピソードである、請求項9記載の使用。
- 前記うつ病は器質性うつ病である、請求項9記載の使用。
- 前記うつ病は、パーキンソン病に依存しない器質性うつ病である、請求項11記載の使用。
- 前記うつ病は、パーキンソン病に関連したうつ病である、請求項11記載の使用。
- 非経口投与、経皮投与又は粘膜投与のための医薬品が予定されている、請求項9から13までのいずれか1項記載の使用。
- ロチゴチンが、一日当たり0.5〜50mgの用量で投与される、請求項9から14までのいずれか1項記載の使用。
- 前記プロドラッグは、エステル、カルバマート、カルボナート、ケタール、アセタート、ホスファート、ホスホナート、スルファート、又はスルホナートである、請求項9から15までのいずれか1項記載の使用。
- ロチゴチンと、抗うつ薬、抗精神病薬、鎮静剤、抗不安薬、又は偏頭痛薬のグループからなる更なる作用物質1つとを含有する、うつ病の治療のための組み合わせ製剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10334188.9 | 2003-07-26 | ||
DE10334188A DE10334188B4 (de) | 2003-07-26 | 2003-07-26 | Verwendung von Rotigotin zur Behandlung von Depressionen |
PCT/EP2004/008168 WO2005009424A1 (de) | 2003-07-26 | 2004-07-22 | Verwendung von rotigotin zur behandlung von depressionen |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007500154A JP2007500154A (ja) | 2007-01-11 |
JP2007500154A5 true JP2007500154A5 (ja) | 2007-08-30 |
JP5001651B2 JP5001651B2 (ja) | 2012-08-15 |
Family
ID=34088862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006521476A Expired - Fee Related JP5001651B2 (ja) | 2003-07-26 | 2004-07-22 | うつ病の治療のためのロチゴチンの使用 |
Country Status (23)
Country | Link |
---|---|
US (1) | US8754119B2 (ja) |
EP (1) | EP1648432B1 (ja) |
JP (1) | JP5001651B2 (ja) |
KR (1) | KR101140510B1 (ja) |
CN (1) | CN100430050C (ja) |
AT (1) | ATE478660T1 (ja) |
AU (1) | AU2004258697B2 (ja) |
BR (1) | BRPI0413000A (ja) |
CA (1) | CA2532859C (ja) |
DE (2) | DE10334188B4 (ja) |
DK (1) | DK1648432T3 (ja) |
EA (1) | EA009784B1 (ja) |
ES (1) | ES2351190T3 (ja) |
HK (1) | HK1091131A1 (ja) |
IL (1) | IL173028A (ja) |
IS (1) | IS8229A (ja) |
MX (1) | MXPA06000782A (ja) |
NO (1) | NO335666B1 (ja) |
NZ (1) | NZ545063A (ja) |
PL (1) | PL1648432T3 (ja) |
UA (1) | UA83493C2 (ja) |
WO (1) | WO2005009424A1 (ja) |
ZA (1) | ZA200600341B (ja) |
Families Citing this family (42)
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DE10041479A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
US20040048779A1 (en) * | 2002-05-06 | 2004-03-11 | Erwin Schollmayer | Use of rotigotine for treating the restless leg syndrome |
US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
US8211462B2 (en) | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
DE10261696A1 (de) | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
DE10334188B4 (de) | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
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DE102012013421A1 (de) | 2012-07-03 | 2014-01-09 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System (TTS) mit Rotigotin |
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CN106456566B (zh) | 2014-05-20 | 2020-06-16 | Lts勒曼治疗系统股份公司 | 含罗替戈汀的经皮递送系统 |
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-
2003
- 2003-07-26 DE DE10334188A patent/DE10334188B4/de not_active Expired - Fee Related
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2004
- 2004-07-22 EA EA200600222A patent/EA009784B1/ru not_active IP Right Cessation
- 2004-07-22 KR KR1020067001785A patent/KR101140510B1/ko not_active IP Right Cessation
- 2004-07-22 CN CNB2004800217910A patent/CN100430050C/zh not_active Expired - Fee Related
- 2004-07-22 EP EP04741204A patent/EP1648432B1/de not_active Revoked
- 2004-07-22 JP JP2006521476A patent/JP5001651B2/ja not_active Expired - Fee Related
- 2004-07-22 WO PCT/EP2004/008168 patent/WO2005009424A1/de active Application Filing
- 2004-07-22 BR BRPI0413000-6A patent/BRPI0413000A/pt active Search and Examination
- 2004-07-22 DE DE502004011581T patent/DE502004011581D1/de active Active
- 2004-07-22 ES ES04741204T patent/ES2351190T3/es active Active
- 2004-07-22 CA CA2532859A patent/CA2532859C/en not_active Expired - Fee Related
- 2004-07-22 DK DK04741204.4T patent/DK1648432T3/da active
- 2004-07-22 US US10/565,699 patent/US8754119B2/en not_active Expired - Fee Related
- 2004-07-22 AU AU2004258697A patent/AU2004258697B2/en not_active Ceased
- 2004-07-22 MX MXPA06000782A patent/MXPA06000782A/es active IP Right Grant
- 2004-07-22 NZ NZ545063A patent/NZ545063A/en not_active IP Right Cessation
- 2004-07-22 PL PL04741204T patent/PL1648432T3/pl unknown
- 2004-07-22 AT AT04741204T patent/ATE478660T1/de active
- 2004-07-22 UA UAA200600333A patent/UA83493C2/uk unknown
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- 2006-02-21 NO NO20060846A patent/NO335666B1/no not_active IP Right Cessation
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