JP5001651B2 - うつ病の治療のためのロチゴチンの使用 - Google Patents
うつ病の治療のためのロチゴチンの使用 Download PDFInfo
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- JP5001651B2 JP5001651B2 JP2006521476A JP2006521476A JP5001651B2 JP 5001651 B2 JP5001651 B2 JP 5001651B2 JP 2006521476 A JP2006521476 A JP 2006521476A JP 2006521476 A JP2006521476 A JP 2006521476A JP 5001651 B2 JP5001651 B2 JP 5001651B2
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- depression
- rotigotine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Description
WHOの見積もりによれば、うつ病は2020年までに、疾病に関連した障害に対する2番目にもっとも多い原因となる(Murray,Lancet 349(1997)1498)。現在の薬理学的な治療の効率は、様々な理由から、例えばこの医薬品の遅延した作用開始、副作用又は不十分な効果のために制限されている。前記疾病の頻繁さ及び期間及び再発性のために、新規の、革新的な抗うつ薬に対する大きな需要が存在する。
I.内因性うつ病
内因性うつ病の際には、容易に認識可能な外因性原因がうつ病の誘因として同定されない。誘因は、脳の神経伝達系の障害のようである。内因性うつ病にとって典型的なのは、相のある経過であり、その際前記うつエピソードは繰り返して生じる可能性がある。内因性うつ病は通常は以下に分類される
・単極性うつ病(「大うつ病」)、この際うつ相のみが現れる
・双極性うつ病(「躁うつ障害」)、この際このうつエピソードは躁相と交代する。
II.体因性のうつ病
このうつ病の原因は、体の器質性障害である。一般的に、体因性のうつ病は、以下に分類される
・器質性うつ病、これは脳の疾病又は損傷に起因する。前記疾病又は損傷はしばしば変化した脳の物質代謝を伴い、例えば脳腫瘍、パーキンソン病、偏頭痛、てんかん、脳麻痺、脳の動脈硬化、脳外傷、髄膜炎、脳卒中、及び痴呆、例えばアルツハイマー病である;
・症候性うつ病、これはしばしば疾患の結果又は随伴症状として生じ、これは脳機能を非直接的にのみ影響する。これは例えば、循環疾患、甲状腺機能低下又はその他のホルモン障害、感染症、癌又は肝疾患であってよい;
・薬物性のうつ病、例えばアルコール乱用、薬物乱用又は麻薬乱用での薬物性のうつ病。
III.心因性うつ病
これはしばしば、1つ以上のトラウマ的な体験に対する過剰反応である。しばしば、消耗性うつ病、神経性うつ病、及び現在の葛藤又は出来事に対する反応性うつ病に分類される。
IV.特別な人生の場面でのうつ病
例えば、産褥性うつ病、老人性うつ病、幼年性うつ病、季節性うつ病並びに青春性うつ病である。
−選択的セロトニン再取り込み阻害剤、例えばセルトラリン、シタロプラム、パロキセチン、又はフルオキセチン、
−混合した、セロトニン再取り込み阻害剤、ノルアドレナリン再取り込み阻害剤、例えばベンラキサフィン、ミルナシプラム、ミルタザピン、及び三環系抗うつ薬、例えばアミトリプチリン、及びイミプラミン、
−選択的ノルアドレナリン再取り込み阻害剤、例えばレボキセチン、
−モノアミンオキシダーゼ阻害剤、例えばトラニルシプラミン、又はクロルジリン、
−アルファ2−レセプター及び/又はセロトニンレセプターの調節剤、例えばミルタザピン又はネファゾドンである。
実施例1:ロチゴチン−プラスター
ロチゴチン(遊離塩基)1.8gをエタノール2.4g中に溶かし、Kollidon 90F(エタノール1g中に溶かした)0.4gを添加した。この混合物を、シリコーンポリマー(BioPSA 7−4201 8.9g+BIO−PSA 7−4301 8.9g[Dow Corning])のヘプタン中の74%溶液に添加した。石油エーテル2.65gの添加の後に、この混合物を700rpmで1時間撹拌し、均質な分散液を得た。ポリエステル上にラミネートした後に、50℃で乾燥させた。このプラスター重量は、最終的に50g/cm2であった。
(a)Miglyol 812 1411.2gを、Duranフラスコ中に量り取った。Imwitor 312 14.4gを、前記Miglyolに添加し、引き続き30分間撹拌下で80℃に加熱した。この澄んだ溶液を、室温にまで冷却し、濾過した。
球切除試験を、Sprague−Dawley−ラットに対して実施した。対照群として、嗅球切除することなしに手術した偽手術した群を用いた。前記手術の14日後、前記ラットを媒体、ロチゴチン−デポー懸濁液(2日置き)又はイミプラミンで処置した。試験日に、前記ラットを試験領域で過ごさせ、かつ3分間放置した。この際この動物の移動運動活動性を、またいだラインの数をもとに測定した。
Claims (15)
- ロチゴチン[(−)−5,6,7,8−テトラヒドロ−6−[プロピル[2−(2−チエニル)エチル]アミノ]−1−ナフトール]又は生理学的に許容可能な塩を含有する、うつ病の治療のための医薬品。
- 前記うつ病は、単極性うつ病[大うつ病]又は躁うつ障害のうつエピソードである、請求項1記載の医薬品。
- 前記うつ病は器質性うつ病である、請求項1記載の医薬品。
- 前記うつ病は、パーキンソン病に依存しない器質性うつ病である、請求項3記載の医薬品。
- 前記うつ病は、パーキンソン病に関連したうつ病である、請求項3記載の医薬品。
- 非経口投与、経皮投与又は粘膜投与のための医薬品が予定されている、請求項1から5までのいずれか1項記載の医薬品。
- ロチゴチンが、一日当たり0.5〜50mgの用量で投与される、請求項1から6までのいずれか1項記載の医薬品。
- ロチゴチン[(−)−5,6,7,8−テトラヒドロ−6−[プロピル[2−(2−チエニル)エチル]アミノ]−1−ナフトール]及び生理学的に許容可能な塩の、うつ病の治療のための医薬品の製造のための使用。
- 前記うつ病は、単極性うつ病[大うつ病]又は躁うつ障害のうつエピソードである、請求項8記載の使用。
- 前記うつ病は器質性うつ病である、請求項8記載の使用。
- 前記うつ病は、パーキンソン病に依存しない器質性うつ病である、請求項10記載の使用。
- 前記うつ病は、パーキンソン病に関連したうつ病である、請求項10記載の使用。
- 非経口投与、経皮投与又は粘膜投与のための医薬品が予定されている、請求項8から12までのいずれか1項記載の使用。
- ロチゴチンが、一日当たり0.5〜50mgの用量で投与される、請求項8から13までのいずれか1項記載の使用。
- ロチゴチンと、抗うつ薬、抗精神病薬、鎮静剤、抗不安薬、又は偏頭痛薬のグループからなる更なる作用物質1つとを含有する、うつ病の治療のための組み合わせ製剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10334188A DE10334188B4 (de) | 2003-07-26 | 2003-07-26 | Verwendung von Rotigotin zur Behandlung von Depressionen |
DE10334188.9 | 2003-07-26 | ||
PCT/EP2004/008168 WO2005009424A1 (de) | 2003-07-26 | 2004-07-22 | Verwendung von rotigotin zur behandlung von depressionen |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007500154A JP2007500154A (ja) | 2007-01-11 |
JP2007500154A5 JP2007500154A5 (ja) | 2007-08-30 |
JP5001651B2 true JP5001651B2 (ja) | 2012-08-15 |
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Application Number | Title | Priority Date | Filing Date |
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JP2006521476A Expired - Fee Related JP5001651B2 (ja) | 2003-07-26 | 2004-07-22 | うつ病の治療のためのロチゴチンの使用 |
Country Status (23)
Country | Link |
---|---|
US (1) | US8754119B2 (ja) |
EP (1) | EP1648432B1 (ja) |
JP (1) | JP5001651B2 (ja) |
KR (1) | KR101140510B1 (ja) |
CN (1) | CN100430050C (ja) |
AT (1) | ATE478660T1 (ja) |
AU (1) | AU2004258697B2 (ja) |
BR (1) | BRPI0413000A (ja) |
CA (1) | CA2532859C (ja) |
DE (2) | DE10334188B4 (ja) |
DK (1) | DK1648432T3 (ja) |
EA (1) | EA009784B1 (ja) |
ES (1) | ES2351190T3 (ja) |
HK (1) | HK1091131A1 (ja) |
IL (1) | IL173028A (ja) |
IS (1) | IS8229A (ja) |
MX (1) | MXPA06000782A (ja) |
NO (1) | NO335666B1 (ja) |
NZ (1) | NZ545063A (ja) |
PL (1) | PL1648432T3 (ja) |
UA (1) | UA83493C2 (ja) |
WO (1) | WO2005009424A1 (ja) |
ZA (1) | ZA200600341B (ja) |
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