JP2006528618A5 - - Google Patents

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Publication number
JP2006528618A5
JP2006528618A5 JP2006520907A JP2006520907A JP2006528618A5 JP 2006528618 A5 JP2006528618 A5 JP 2006528618A5 JP 2006520907 A JP2006520907 A JP 2006520907A JP 2006520907 A JP2006520907 A JP 2006520907A JP 2006528618 A5 JP2006528618 A5 JP 2006528618A5
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JP
Japan
Prior art keywords
use according
cancer
parp
nucleic acid
defective
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JP2006520907A
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English (en)
Japanese (ja)
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JP5519097B2 (ja
JP2006528618A (ja
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Priority claimed from GBGB0317466.1A external-priority patent/GB0317466D0/en
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Publication of JP2006528618A5 publication Critical patent/JP2006528618A5/ja
Application granted granted Critical
Publication of JP5519097B2 publication Critical patent/JP5519097B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2006520907A 2003-07-25 2004-07-23 癌を治療するための医薬の製造におけるPARP活性阻害性RNAiの使用 Expired - Lifetime JP5519097B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0317466.1A GB0317466D0 (en) 2003-07-25 2003-07-25 Use
GB0317466.1 2003-07-25
PCT/GB2004/003235 WO2005012524A1 (en) 2003-07-25 2004-07-23 Use of rnai inhibiting parp activtiy for the manufacture of a medicament for the treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011246988A Division JP5547164B2 (ja) 2003-07-25 2011-11-11 癌を治療するための医薬の製造におけるPARP活性阻害性RNAiの使用

Publications (3)

Publication Number Publication Date
JP2006528618A JP2006528618A (ja) 2006-12-21
JP2006528618A5 true JP2006528618A5 (enExample) 2007-08-02
JP5519097B2 JP5519097B2 (ja) 2014-06-11

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ID=27772701

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2006520907A Expired - Lifetime JP5519097B2 (ja) 2003-07-25 2004-07-23 癌を治療するための医薬の製造におけるPARP活性阻害性RNAiの使用
JP2011246988A Expired - Lifetime JP5547164B2 (ja) 2003-07-25 2011-11-11 癌を治療するための医薬の製造におけるPARP活性阻害性RNAiの使用
JP2013147532A Expired - Lifetime JP5848728B2 (ja) 2003-07-25 2013-07-16 癌を治療するための医薬の製造におけるPARP活性阻害性RNAiの使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2011246988A Expired - Lifetime JP5547164B2 (ja) 2003-07-25 2011-11-11 癌を治療するための医薬の製造におけるPARP活性阻害性RNAiの使用
JP2013147532A Expired - Lifetime JP5848728B2 (ja) 2003-07-25 2013-07-16 癌を治療するための医薬の製造におけるPARP活性阻害性RNAiの使用

Country Status (18)

Country Link
US (5) US8859562B2 (enExample)
EP (1) EP1649017B2 (enExample)
JP (3) JP5519097B2 (enExample)
KR (1) KR101136702B1 (enExample)
CN (3) CN1856313B (enExample)
AT (1) ATE516353T1 (enExample)
AU (1) AU2004261779B2 (enExample)
BR (1) BRPI0412909B1 (enExample)
CA (1) CA2533423C (enExample)
DK (1) DK1649017T4 (enExample)
ES (1) ES2367433T5 (enExample)
GB (2) GB0317466D0 (enExample)
NO (1) NO338398B1 (enExample)
NZ (1) NZ545307A (enExample)
PL (1) PL1649017T5 (enExample)
PT (1) PT1649017E (enExample)
WO (1) WO2005012524A1 (enExample)
ZA (1) ZA200601386B (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956035B2 (en) 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
BRPI0407757A (pt) 2003-02-28 2006-02-14 Inotek Pharmaceuticals Corp derivados de benzamida tetracìclica e métodos de uso dos mesmos
GB0317466D0 (en) * 2003-07-25 2003-08-27 Univ Sheffield Use
ES2339663T3 (es) 2003-07-25 2010-05-24 Cancer Research Technology Limited Inhibidores de parp triciclicos.
US8071579B2 (en) * 2003-12-01 2011-12-06 The Institute Of Cancer Research: Royal Cancer Hospital DNA damage repair inhibitors for the treatment of cancer
WO2006078503A2 (en) * 2005-01-07 2006-07-27 Arqule, Inc. Compositions for modulation of parp and methods for screening for same
US7820668B2 (en) 2005-01-19 2010-10-26 Eisai Inc. Diazabenzo[de]anthracen-3-one compounds and methods for inhibiting PARP
CA2598647A1 (en) 2005-02-25 2006-09-08 Inotek Pharmaceuticals Corporation Tetracyclic amino and carboxamido compounds and methods of use thereof
KR20080039508A (ko) 2005-08-24 2008-05-07 이노텍 파마슈티컬스 코포레이션 인데노이소퀴놀리논 유사체 및 이의 사용 방법
EP1962843B1 (en) * 2005-11-25 2011-02-23 Pharma Mar S.A., Sociedad Unipersonal Use of parp-1 inhibitors
US20090062196A1 (en) * 2006-10-20 2009-03-05 D Andrea Alan Compositions and methods of treating cancer
DK2099442T3 (en) * 2006-12-26 2015-02-16 Pharmacyclics Inc Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
US20100121049A1 (en) 2007-02-28 2010-05-13 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
GB0707556D0 (en) * 2007-04-19 2007-05-30 Isis Innovation Treatment for cancer
WO2008156172A1 (ja) 2007-06-20 2008-12-24 Saitama Medical University 子宮癌、乳癌、及び膀胱癌の予防乃至治療に好適な二本鎖核酸分子、癌細胞増殖抑制剤、並びに医薬
WO2009027650A1 (en) * 2007-08-24 2009-03-05 The Institute Of Cancer: Royal Cancer Hospital Materials and methods for exploiting synthetic lethality in brca-associated cancers
DK2209375T3 (da) 2007-10-03 2014-10-06 Eisai Inc Parp-inhibitorforbindelser, præparater og fremgangsmåder til anvendelse deraf
WO2009113579A1 (ja) 2008-03-11 2009-09-17 学校法人埼玉医科大学 癌の予防乃至治療に好適な二本鎖核酸分子、癌細胞増殖抑制剤、並びに医薬
US8501431B2 (en) * 2008-10-24 2013-08-06 Magnachem International Laboratories, Inc. Method for screening for compounds selectively interacting with RAD9
US8435961B2 (en) * 2009-06-26 2013-05-07 Massachusetts Institute Of Technology Methods and compositions for increasing the activity of inhibitory RNA
US20110097329A1 (en) 2009-06-26 2011-04-28 Massachusetts Institute Of Technology Compositions and methods for treating cancer and modulating stress granule formation
US8268550B2 (en) * 2009-06-26 2012-09-18 Massachusetts Institute Of Technology Compositions and methods for identification of PARP function, inhibitors, and activators
WO2011058367A2 (en) 2009-11-13 2011-05-19 Astrazeneca Ab Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor
DK3109325T3 (en) 2010-08-24 2019-01-28 Dana Farber Cancer Inst Inc Methods for predicting anticancer response
WO2013052006A1 (en) * 2010-10-07 2013-04-11 Agency For Science, Technology And Research (A*Star) Parp-1 inhibitors
CN110115768A (zh) 2011-07-22 2019-08-13 厄尔莱克斯制药公司 合成致死与癌症的治疗
CA3080441C (en) 2012-02-23 2026-01-06 The Technical University Of Denmark Methods for predicting anti-cancer response
ES2595240T3 (es) 2012-07-09 2016-12-28 Lupin Limited Derivados de tetrahidroquinazolinona como inhibidores de PARP
EP2986709A4 (en) * 2013-04-16 2017-03-15 University Of Washington Through Its Center For Commercialization Activating an alternative pathway for homology-directed repair to stimulate targeted gene correction and genome engineering
EP3049536B1 (en) * 2013-09-23 2019-05-22 The University of Chicago Methods and compositions relating to cancer therapy with dna damaging agents
WO2015118156A1 (en) * 2014-02-07 2015-08-13 Vib Vzw Inhibition of neat1 for treatment of solid tumors
US9889141B2 (en) * 2014-10-14 2018-02-13 Institute For Cancer Research Combined inhibition of the vitamin D receptor and poly(ADP) ribose polymerase (PARP) in the treatment of cancer
PT3277321T (pt) 2015-04-01 2024-09-17 Anaptysbio Inc Anticorpos dirigidos contra a proteína de imunoglobulina de células t e mucina 3 (tim-3)
ES2964607T3 (es) 2015-07-17 2024-04-08 Pacylex Pharmaceuticals Inc Silenciamiento epigenético de NMT2
WO2017054832A1 (en) * 2015-10-02 2017-04-06 University Of Copenhagen Small molecules blocking histone reader domains
ES2847252T3 (es) * 2016-02-22 2021-08-02 Caribou Biosciences Inc Procedimientos de modulación de resultados de reparación de ADN
CA3041685A1 (en) 2016-11-01 2018-05-11 Anaptysbio, Inc. Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
KR102671283B1 (ko) 2017-01-09 2024-06-03 테사로, 인코포레이티드 항tim-3 항체로 암을 치료하는 방법
CN107058233A (zh) * 2017-05-03 2017-08-18 上海长海医院 一种减小肿瘤细胞对抗肿瘤药物的耐药性的方法
CN108048465A (zh) * 2017-12-20 2018-05-18 李风玲 一种抑制PARP基因用于治疗乳腺癌的siRNA
WO2019133864A1 (en) 2017-12-29 2019-07-04 Accutar Biotechnology DUAL INHIBITORS OF PARP1 and CDK
TWI820077B (zh) 2018-01-05 2023-11-01 美商斯布雷克薩一號公司 治療涉及酸性或缺氧性患病組織之疾病之化合物、組合物及方法
CR20210281A (es) 2018-10-30 2021-10-25 Repare Therapeutics Inc Compuestos, composiciones farmacéuticas y métodos de preparación de compuestos y de uso como inhibidores de la cinasa atr
PH12021552205A1 (en) * 2019-03-25 2022-06-13 Cyteir Therapeutics Inc Combinations of rad51 and parp inhibitors
KR20220052918A (ko) 2019-07-10 2022-04-28 싸이브렉사 2, 인크. 치료제로서의 사이토톡신의 펩티드 접합체
KR20220051332A (ko) 2019-07-10 2022-04-26 싸이브렉사 3, 인크. 치료제로서의 미세소관 표적화제의 펩티드 접합체
CA3161892A1 (en) 2019-12-23 2021-07-01 Jie Fan Combinations of estrogen receptor degraders and cyclin-dependent kinase inhibitors for treating cancer
FI4143182T3 (fi) 2020-04-28 2025-03-04 Rhizen Pharmaceuticals Ag Poly(adp-riboosi)polymeraasin (parp) estäjinä käyttökelpoisia uusia yhdisteitä
WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
CN114836472A (zh) * 2021-02-01 2022-08-02 中国人民解放军军事科学院军事医学研究院 PARP-1shRNA重组慢病毒载体、该载体稳定转染HaCaT的细胞系及其应用
BR112023020615A2 (pt) 2021-04-08 2023-12-19 Incozen Therapeutics Pvt Ltd Inibidores de poli(adp-ribose) polimerase
JP2024518509A (ja) 2021-05-18 2024-05-01 オンコニック セラピューティクス インコーポレイテッド Parp阻害剤抵抗性癌治療剤
US20250019708A1 (en) * 2021-11-19 2025-01-16 Institut Curie Methods for the treatment of hrd cancer and brca-associated cancer
WO2023201338A1 (en) 2022-04-15 2023-10-19 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a parp inhibitor
JP2025521156A (ja) 2022-06-01 2025-07-08 イデアヤ、バイオサイエンシズ、インコーポレイテッド Dnaポリメラーゼシータ阻害剤としてのチアジアゾリル誘導体およびその使用
WO2024194401A1 (en) * 2023-03-21 2024-09-26 Institut Curie Vps4b inhibitor for use in methods for the treatment of hrd cancer
WO2024194402A1 (en) * 2023-03-21 2024-09-26 Institut Curie Farnesyl transferase inhibitor for use in methods for the treatment of hrd cancer
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025183523A1 (ko) * 2024-02-29 2025-09-04 아주대학교 산학협력단 Parp 억제제 감수성 증가 방법
WO2025217307A1 (en) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Methods for predicting response to a ras(on) inhibitor and combination therapies
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484951A (en) 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
US5098861A (en) 1991-01-08 1992-03-24 Unitrode Corporation Method of processing a semiconductor substrate including silicide bonding
US5464871A (en) 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
EP0600831A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Phthalazinonderivate
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
AU8784698A (en) * 1997-08-15 1999-03-08 Johns Hopkins University, The Method of using selective parp inhibitors to prevent or treat neurotoxicity
CA2360003C (en) 1999-01-11 2012-07-10 Agouron Pharmaceuticals, Inc. Tricyclic inhibitors of poly(adp-ribose) polymerases
US6635677B2 (en) 1999-08-13 2003-10-21 Case Western Reserve University Methoxyamine combinations in the treatment of cancer
ECSP003637A (es) * 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
DE10022925A1 (de) 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
KR20030020450A (ko) * 2000-08-08 2003-03-08 사노피-신델라보 벤지미다졸 유도체, 그의 제조 방법 및 치료적 용도
MXPA03003218A (es) 2000-10-30 2004-12-03 Kudos Pharm Ltd Derivados de ftalazinona.
DE60218458T2 (de) 2001-05-08 2007-11-15 Kudos Pharmaceuticals Ltd. Isochinolinon derivate als parp inhibitoren
US7072771B2 (en) * 2001-06-07 2006-07-04 University Of Kentucky Research Foundation Selective PARP-1 targeting for designing chemo/radio sensitizing agents
US20030073692A1 (en) 2001-08-07 2003-04-17 Pharmacia & Upjohn S.P.A. Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
AUPS019702A0 (en) 2002-01-29 2002-02-21 Fujisawa Pharmaceutical Co., Ltd. Condensed heterocyclic compounds
US20030229004A1 (en) 2002-03-20 2003-12-11 Pangene Corporation Modulation of tumor cells using BER inhibitors in combination with a sensitizing agent and DSBR inhibitors
JP4500161B2 (ja) 2002-04-30 2010-07-14 クドス ファーマシューティカルズ リミテッド フタラジノン誘導体
WO2004008976A1 (en) 2002-07-19 2004-01-29 Osteotech, Inc. Chisels and procedure for insertion of spinal implant in a spinal disc space
HRP20050895B1 (hr) * 2003-03-12 2014-06-06 Kudos Pharmaceuticals Limited Ftalazinon derivati
US7176188B2 (en) 2003-05-07 2007-02-13 UniversitéLaval Method of lethally sensitizing human and animal cells
ES2339663T3 (es) * 2003-07-25 2010-05-24 Cancer Research Technology Limited Inhibidores de parp triciclicos.
GB0317466D0 (en) * 2003-07-25 2003-08-27 Univ Sheffield Use
US8071579B2 (en) 2003-12-01 2011-12-06 The Institute Of Cancer Research: Royal Cancer Hospital DNA damage repair inhibitors for the treatment of cancer

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