JP2006527776A - メラノコルチン−4レセプター結合化合物およびその使用方法 - Google Patents
メラノコルチン−4レセプター結合化合物およびその使用方法 Download PDFInfo
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- JP2006527776A JP2006527776A JP2006521070A JP2006521070A JP2006527776A JP 2006527776 A JP2006527776 A JP 2006527776A JP 2006521070 A JP2006521070 A JP 2006521070A JP 2006521070 A JP2006521070 A JP 2006521070A JP 2006527776 A JP2006527776 A JP 2006527776A
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- phenyl
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- 0 *N1ISCN=C1C(C(**C(*=CC=C)=I)=*)=C*=*P Chemical compound *N1ISCN=C1C(C(**C(*=CC=C)=I)=*)=C*=*P 0.000 description 16
- CEBDUCGPSOEIKN-UHFFFAOYSA-N BrC1C=C(CCC2=CCCC=C2C2=NCCCC2)C2OCOC2C1 Chemical compound BrC1C=C(CCC2=CCCC=C2C2=NCCCC2)C2OCOC2C1 CEBDUCGPSOEIKN-UHFFFAOYSA-N 0.000 description 1
- XYBOIZQGIVYRFV-UHFFFAOYSA-N CC(C)(C)NC(c1ncccc1C)=O Chemical compound CC(C)(C)NC(c1ncccc1C)=O XYBOIZQGIVYRFV-UHFFFAOYSA-N 0.000 description 1
- HIFUVSNEWAAPRI-UHFFFAOYSA-N CC1C(c2cccc(Cl)c2CCC2=CC(Br)=CCC2OCCN(C)C)NCCCC1 Chemical compound CC1C(c2cccc(Cl)c2CCC2=CC(Br)=CCC2OCCN(C)C)NCCCC1 HIFUVSNEWAAPRI-UHFFFAOYSA-N 0.000 description 1
- ZIVRFJGSQLCPHB-UHFFFAOYSA-N CCSC(c1cccc(Cl)c1CCc(cc(cc1)Br)c1OC)=N Chemical compound CCSC(c1cccc(Cl)c1CCc(cc(cc1)Br)c1OC)=N ZIVRFJGSQLCPHB-UHFFFAOYSA-N 0.000 description 1
- JHQSOHXOHPGCKG-UHFFFAOYSA-N COC(C1)CC(CCc(cccc2)c2C2=NCCN2)=CC1OC Chemical compound COC(C1)CC(CCc(cccc2)c2C2=NCCN2)=CC1OC JHQSOHXOHPGCKG-UHFFFAOYSA-N 0.000 description 1
- RWXDXLGCPMHKTB-SFGHEJKGSA-N C[O](C1)C1C(CC#N)C1C(C2C(CC[C@H]3C=CC=C4C=CCCC34)CCCC2)=NCC1 Chemical compound C[O](C1)C1C(CC#N)C1C(C2C(CC[C@H]3C=CC=C4C=CCCC34)CCCC2)=NCC1 RWXDXLGCPMHKTB-SFGHEJKGSA-N 0.000 description 1
- XMWGTKZEDLCVIG-UHFFFAOYSA-N ClCc1cccc2ccccc12 Chemical compound ClCc1cccc2ccccc12 XMWGTKZEDLCVIG-UHFFFAOYSA-N 0.000 description 1
- FXHACIKOGIFCDN-UHFFFAOYSA-N FC1=C(CCC2=CC=CC3SC=CC23)C(C2NCCN2)=CCC1 Chemical compound FC1=C(CCC2=CC=CC3SC=CC23)C(C2NCCN2)=CCC1 FXHACIKOGIFCDN-UHFFFAOYSA-N 0.000 description 1
- GCXBCGOSGSKQJS-UHFFFAOYSA-N N#Cc1ncccc1CCc1cccc2c1cccc2 Chemical compound N#Cc1ncccc1CCc1cccc2c1cccc2 GCXBCGOSGSKQJS-UHFFFAOYSA-N 0.000 description 1
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| PCT/US2004/019124 WO2005121100A1 (en) | 2003-06-16 | 2004-06-15 | Melanocortin-4 receptor binding compounds and methods of use thereof |
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| JP2006527776A true JP2006527776A (ja) | 2006-12-07 |
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| CA (1) | CA2529445A1 (OSRAM) |
| DE (1) | DE602004022168D1 (OSRAM) |
| WO (1) | WO2005121100A1 (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015500345A (ja) * | 2011-12-16 | 2015-01-05 | トランスポサジェン・バイオファーマシューティカルズ・インコーポレイテッドTransposagen Biopharmaceuticals, Inc. | 疼痛の治療または予防に使用されるtrpc4調節因子 |
| JP2015107948A (ja) * | 2013-12-06 | 2015-06-11 | 住友精化株式会社 | 芳香族チアゾール化合物の製造方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7375125B2 (en) * | 1999-08-04 | 2008-05-20 | Ore Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| CN103936690B (zh) | 2005-10-25 | 2016-06-08 | 盐野义制药株式会社 | 氨基二氢噻嗪衍生物 |
| KR20080058435A (ko) * | 2005-10-27 | 2008-06-25 | 데이진 화-마 가부시키가이샤 | 벤조[b]티오펜 유도체 및 그 제조 방법 |
| BRPI0709612A2 (pt) | 2006-03-15 | 2011-07-19 | Wyeth Corp | composto de fórmula i; método para o tratamento de um distúrbio no sistema nervoso central relacionado ou afetado pelo receptor histamina-3 em um paciente que necessita deste tratamento; método para a inibição do receptor h3; composição farmacêutica; e processo para a preparação de um composto de fórmula i |
| EP1974729A1 (en) * | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
| WO2008133273A1 (ja) | 2007-04-24 | 2008-11-06 | Shionogi & Co., Ltd. | アルツハイマー症治療用医薬組成物 |
| RU2476430C2 (ru) | 2007-04-24 | 2013-02-27 | Сионоги Энд Ко., Лтд. | Производные аминодигидротиазина, замещенные циклической группой |
| US10125388B2 (en) | 2007-10-31 | 2018-11-13 | Akonni Biosystems, Inc. | Integrated sample processing system |
| CA2621950A1 (en) * | 2007-12-31 | 2009-06-30 | University Of Basel | Methods for diagnosing and treating obesity by modulating the activity of auto-antibodies against the melanocortin-4 receptor |
| ES2738123T3 (es) | 2008-06-13 | 2020-01-20 | Shionogi & Co | Derivado heterocíclico que contiene azufre que tiene actividad inhibitoria de ß-secretasa |
| WO2010047372A1 (ja) | 2008-10-22 | 2010-04-29 | 塩野義製薬株式会社 | Bace1阻害活性を有する2-アミノピリミジン-4-オンおよび2-アミノピリジン誘導体 |
| CA3041540C (en) * | 2009-09-21 | 2021-08-24 | Bio-Rad Laboratories, Inc. | Magnetic lysis method and device |
| WO2011071135A1 (ja) | 2009-12-11 | 2011-06-16 | 塩野義製薬株式会社 | オキサジン誘導体 |
| US8476251B2 (en) * | 2010-07-29 | 2013-07-02 | Conopco, Inc. | Skin care compositions comprising substituted diamines |
| US8293218B2 (en) | 2010-07-29 | 2012-10-23 | Conopco, Inc. | Skin care compositions comprising substituted monoamines |
| WO2012057247A1 (ja) | 2010-10-29 | 2012-05-03 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| US8927721B2 (en) | 2010-10-29 | 2015-01-06 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| JPWO2012147763A1 (ja) | 2011-04-26 | 2014-07-28 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
| US9562029B2 (en) | 2011-06-25 | 2017-02-07 | Xuanzhu Pharma Co., Ltd. | C-glycoside derivatives |
| KR20150065177A (ko) * | 2012-10-12 | 2015-06-12 | 에프. 호프만-라 로슈 아게 | 치환된 페닐카르바메이트 화합물 |
| EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
| KR20150079681A (ko) | 2012-11-08 | 2015-07-08 | 에프. 호프만-라 로슈 아게 | 호흡기 질환 치료용 trpa1 길항제로서의 [3-헤테로아릴-2-트라이플루오로메틸-프로필]-피페리딘-1-일 또는 -모폴린-4-일 화합물 |
| US10059671B2 (en) | 2013-02-04 | 2018-08-28 | Prexton Therapeutics Sa | Positive allosteric modulators of mGluR3 |
| US9315438B2 (en) | 2014-01-03 | 2016-04-19 | Xuanzhu Pharma Co., Ltd | Optically pure benzyl-4-chlorophenyl-C-glucoside derivative |
| WO2016056606A1 (ja) * | 2014-10-07 | 2016-04-14 | 国立大学法人京都大学 | ベンゾイソチアゾロピリミジン誘導体またはその塩、およびウイルス感染阻害剤ならびに医薬品 |
| CN114539273A (zh) | 2016-06-07 | 2022-05-27 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| HRP20241239T1 (hr) | 2017-03-23 | 2024-12-06 | Jacobio Pharmaceuticals Co., Ltd. | Novi heterociklički derivati korisni kao shp2 inhibitori |
| WO2020063760A1 (en) | 2018-09-26 | 2020-04-02 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| CN113423711B (zh) * | 2018-10-01 | 2024-03-15 | 建新公司 | 作为udp糖基转移酶抑制剂的噻吩并[3,2-b]吡啶衍生物及其使用方法 |
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| WO2001010842A2 (en) * | 1999-08-04 | 2001-02-15 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| WO2002062766A2 (en) * | 2001-02-07 | 2002-08-15 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
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| US3594380A (en) * | 1969-02-18 | 1971-07-20 | American Home Prod | Isoquinolin-1(2h)-ones |
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| US4122263A (en) * | 1973-04-11 | 1978-10-24 | Basf Aktiengesellschaft | Production of 2-(o-alkylthiophenyl)-1,3-diazocycloalkene hydrohalides |
| DE3046366A1 (de) * | 1980-12-09 | 1982-07-08 | Bayer Ag, 5090 Leverkusen | Tricyclische cytosinderivate zur verwendung in arzneimitteln und verfahren zu ihrer herstellung |
| JPS60130561A (ja) * | 1983-12-16 | 1985-07-12 | Torii Yakuhin Kk | アミジン誘導体およびそれを含む強心剤 |
| ZA923283B (en) * | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
| JPH05156475A (ja) | 1991-12-02 | 1993-06-22 | Hideaki Yamaguchi | 金属の表面処理方法 |
| US5731408A (en) * | 1995-04-10 | 1998-03-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Peptides having potent antagonist and agonist bioactivities at melanocortin receptors |
| US5932779A (en) | 1996-06-10 | 1999-08-03 | Millennium Pharmaceuticals, Inc. | Screening methods for compounds useful in the regulation of body weight |
| AU742425B2 (en) | 1998-06-11 | 2002-01-03 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| US7375125B2 (en) * | 1999-08-04 | 2008-05-20 | Ore Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| US6699873B1 (en) * | 1999-08-04 | 2004-03-02 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| CA2437594A1 (en) * | 2001-03-02 | 2002-09-12 | Graham S. Poindexter | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
| WO2003051359A1 (en) * | 2001-12-18 | 2003-06-26 | F.Hoffmann-La Roche Ag | Cis-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors |
| EP1590338B1 (en) * | 2002-12-04 | 2009-08-26 | Ore Pharmaceuticals Inc. | Modulators of melanocortin receptor |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2001010842A2 (en) * | 1999-08-04 | 2001-02-15 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| WO2002062766A2 (en) * | 2001-02-07 | 2002-08-15 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015500345A (ja) * | 2011-12-16 | 2015-01-05 | トランスポサジェン・バイオファーマシューティカルズ・インコーポレイテッドTransposagen Biopharmaceuticals, Inc. | 疼痛の治療または予防に使用されるtrpc4調節因子 |
| JP2019135271A (ja) * | 2011-12-16 | 2019-08-15 | トランスポサジェン・バイオファーマシューティカルズ・インコーポレイテッドTransposagen Biopharmaceuticals, Inc. | 疼痛の治療または予防に使用されるtrpc4調節因子 |
| JP2015107948A (ja) * | 2013-12-06 | 2015-06-11 | 住友精化株式会社 | 芳香族チアゾール化合物の製造方法 |
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| AU2004320025A1 (en) | 2006-01-19 |
| US7375125B2 (en) | 2008-05-20 |
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| US20040082779A1 (en) | 2004-04-29 |
| WO2005121100A1 (en) | 2005-12-22 |
| DE602004022168D1 (de) | 2009-09-03 |
| AU2004320025A8 (en) | 2008-12-11 |
| US20080269217A1 (en) | 2008-10-30 |
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