JP2006527369A5 - - Google Patents

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JP2006527369A5
JP2006527369A5 JP2006515242A JP2006515242A JP2006527369A5 JP 2006527369 A5 JP2006527369 A5 JP 2006527369A5 JP 2006515242 A JP2006515242 A JP 2006515242A JP 2006515242 A JP2006515242 A JP 2006515242A JP 2006527369 A5 JP2006527369 A5 JP 2006527369A5
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heat exchange
fluid
plastic
exchange membrane
temperature
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JP2006515242A
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JP2006527369A (ja
JP4758891B2 (ja
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Priority claimed from PCT/US2004/017943 external-priority patent/WO2004108287A1/en
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JP2006515242A 2003-06-06 2004-06-07 微小流体デバイス上の加熱、冷却および熱サイクリングのためのシステムおよび方法 Expired - Lifetime JP4758891B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47635203P 2003-06-06 2003-06-06
US60/476,352 2003-06-06
PCT/US2004/017943 WO2004108287A1 (en) 2003-06-06 2004-06-07 System and method for heating, cooling and heat cycling on microfluidic device

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JP2006527369A JP2006527369A (ja) 2006-11-30
JP2006527369A5 true JP2006527369A5 (https=) 2011-06-02
JP4758891B2 JP4758891B2 (ja) 2011-08-31

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JP2006515242A Expired - Lifetime JP4758891B2 (ja) 2003-06-06 2004-06-07 微小流体デバイス上の加熱、冷却および熱サイクリングのためのシステムおよび方法

Country Status (9)

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US (1) US7544506B2 (https=)
EP (1) EP1633481A1 (https=)
JP (1) JP4758891B2 (https=)
KR (1) KR101203402B1 (https=)
CN (1) CN1812839A (https=)
AU (1) AU2004245094A1 (https=)
CA (1) CA2528208A1 (https=)
RU (1) RU2005141456A (https=)
WO (1) WO2004108287A1 (https=)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2500392C (en) 2002-09-27 2012-11-27 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US7648835B2 (en) * 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US20050047967A1 (en) * 2003-09-03 2005-03-03 Industrial Technology Research Institute Microfluidic component providing multi-directional fluid movement
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
WO2006039293A2 (en) * 2004-09-29 2006-04-13 University Of Virginia Patent Foundation Localized control of thermal properties on microdevices and applications thereof
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7488596B2 (en) 2004-12-17 2009-02-10 Samsung Electronics Co., Ltd. Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
JP2008526255A (ja) * 2005-01-13 2008-07-24 マイクロニクス， インコーポレイテッド 微量流体希薄細胞検出デバイス
CN102929309A (zh) * 2005-01-25 2013-02-13 欧西里其有限责任公司 用于具有不同热容的少量流体样品的温度控制器
JP4756880B2 (ja) * 2005-03-02 2011-08-24 キヤノン株式会社 Ｐｃｒ反応液の温度制御装置
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP2009536313A (ja) 2006-01-11 2009-10-08 レインダンス テクノロジーズ， インコーポレイテッド ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法
FR2897873B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Procede d'analyse microbiologique rapide.
FR2897941B1 (fr) * 2006-02-24 2009-01-16 Millipore Corp Dispositif et procede pour l'analyse microbiologique rapide.
FR2897783B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Dispositif pour le controle microbiologique, ensembles de controle et d'incubation le comportant et procede le mettant en oeuvre
FR2897872B1 (fr) * 2006-02-24 2008-08-15 Millipore Corp Procede d'analyse microbiologique rapide.
JP5254949B2 (ja) * 2006-03-15 2013-08-07 マイクロニクス， インコーポレイテッド 一体型の核酸アッセイ
US7569789B2 (en) * 2006-03-16 2009-08-04 Visiongate, Inc. Cantilevered coaxial flow injector apparatus and method for sorting particles
ATE540750T1 (de) 2006-05-11 2012-01-15 Raindance Technologies Inc Mikrofluidische vorrichtung und verfahren
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP1878502A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Instrument for heating and cooling
EP1878501A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Instrument for heating and cooling
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
CA2984820C (en) * 2007-04-04 2021-12-07 Ande Corporation Plastic microfluidic separation and detection platforms
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
FR2915487B1 (fr) 2007-04-26 2009-06-05 Millipore Corp Ensemble et procede pour analyse microbiologique
EP2153295B1 (en) * 2007-06-06 2014-11-05 Path Chemical temperature control
ES2453107T3 (es) * 2007-06-11 2014-04-04 Wako Pure Chemical Industries, Ltd. Procedimiento de amplificación de ácidos nucleicos usando una PCR sobre microchip con detección integrada de CE en tiempo real
CA2754884C (en) 2007-06-21 2013-04-30 Gen-Probe Incorporated Methods of concentrating an analyte
EP2171420A1 (en) * 2007-07-31 2010-04-07 Micronics, Inc. Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays
US9724695B2 (en) * 2008-06-23 2017-08-08 Canon U.S. Life Sciences, Inc. Systems and methods for amplifying nucleic acids
EP2315629B1 (en) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Droplet libraries
US8304185B2 (en) * 2009-07-17 2012-11-06 Canon U.S. Life Sciences, Inc. Methods and systems for DNA isolation on a microfluidic device
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US9540686B2 (en) * 2008-09-18 2017-01-10 Canon U.S. Life Sciences, Inc. Systems and methods for the amplification of DNA
GB2463401B (en) 2008-11-12 2014-01-29 Caris Life Sciences Luxembourg Holdings S A R L Characterizing prostate disorders by analysis of microvesicles
WO2011109440A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarkers for theranostics
EP2391883B1 (en) 2009-01-30 2018-03-07 Micronics, Inc. Portable high gain fluorescence detection system
EP3415235B1 (en) 2009-03-23 2025-11-12 Bio-Rad Laboratories, Inc. Manipulation of microfluidic droplets
WO2010115160A2 (en) * 2009-04-03 2010-10-07 Helixis, Inc. Devices and methods for heating biological samples
EP2419217B1 (en) * 2009-04-13 2014-11-12 Micronics, Inc. Microfluidic clinical analyzer
WO2010144682A1 (en) 2009-06-12 2010-12-16 Micronics, Inc. Rehydratable matrices for dry storage of taq polymerase in a microfluidic device
JP5953229B2 (ja) 2009-06-12 2016-07-20 マイクロニクス， インコーポレイテッド マイクロ流体デバイス内でオンボード試薬を脱水保存する組成物および方法
EP2443254A2 (en) 2009-06-15 2012-04-25 NetBio, Inc. Improved methods for forensic dna quantitation
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
KR101143461B1 (ko) * 2009-12-28 2012-05-23 주식회사 지앤시바이오 중합 효소 연쇄 반응 장치의 열전냉각기 제어장치 및 방법
EP2528687B1 (en) 2010-01-29 2018-08-22 Micronics, Inc. System comprising a host instrument and a microfluidic cartridge for assays
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
CA2789425C (en) 2010-02-12 2020-04-28 Raindance Technologies, Inc. Digital analyte analysis with polymerase error correction
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
WO2011122216A1 (ja) * 2010-03-31 2011-10-06 コニカミノルタオプト株式会社 マイクロチップ
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
US9168530B2 (en) 2010-12-17 2015-10-27 Bjs Ip Ltd. Methods and systems for fast PCR heating
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
EP2673382B1 (en) * 2011-02-11 2020-05-06 Bio-Rad Laboratories, Inc. Thermocycling device for nucleic acid amplification and methods of use
EP3736281A1 (en) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
CN102250751B (zh) * 2011-03-22 2013-05-22 博奥生物有限公司 一种用于生物芯片的接口装置
WO2012166913A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3709018A1 (en) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Microfluidic apparatus for identifying components of a chemical reaction
US20130137144A1 (en) * 2011-06-08 2013-05-30 Bio-Rad Laboratories, Inc. LSG - GXD Division Thermal block with built-in thermoelectric elements
WO2013013220A2 (en) 2011-07-20 2013-01-24 University Of Washington Through Its Center For Commercialization Photonic blood typing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2773775A4 (en) * 2011-11-04 2015-05-27 Diagnostics For All Inc Low-cost, one-way diagnostics on MOLECULAR BASE
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
US9279151B2 (en) 2012-04-02 2016-03-08 David W. Wright Disposable thermal in-vitro diagnostic apparatus and method of conducting an in-vitro diagnostic test
US9579657B2 (en) 2012-05-24 2017-02-28 Bjs Ip Ltd Clamp for fast PCR heating
CA2879638A1 (en) 2012-08-10 2014-02-13 Streck, Inc. Real-time optical system for polymerase chain reaction
US20140099636A1 (en) * 2012-10-10 2014-04-10 Baker Hughes Incorporated FIELD-BASED qPCR MICROBIAL MONITORING
AU2013340414B2 (en) 2012-10-23 2019-05-02 Caris Science, Inc. Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
JP1628115S (https=) 2012-10-24 2019-04-01
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
DE202012104694U1 (de) 2012-12-03 2013-01-29 Bürkert Werke GmbH Mikrofluidisches System
EP2935628B1 (en) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Compositions and methods for aptamer screening
EP3549674B1 (en) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Low elasticity films for microfluidic use
WO2014100732A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Fluidic circuits and related manufacturing methods
CN104919035B (zh) 2012-12-21 2017-08-11 精密公司 便携式荧光检测系统和微测定盒
WO2014112990A1 (en) * 2013-01-16 2014-07-24 Siemens Aktiengesellschaft Automated input simulation for simulated programmable logic controller
CN107866286A (zh) 2013-03-15 2018-04-03 金马克诊断股份有限公司 用于操纵可变形流体容器的系统、方法和设备
EP2994750B1 (en) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド 核酸の調製および分析のためのデバイス
JP6472788B2 (ja) 2013-05-07 2019-02-20 マイクロニクス， インコーポレイテッド 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法
US10006861B2 (en) 2013-06-28 2018-06-26 Streck, Inc. Devices for real-time polymerase chain reaction
AU2014312211A1 (en) 2013-08-28 2016-03-10 Caris Science, Inc. Oligonucleotide probes and uses thereof
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
CN104267766B (zh) * 2014-10-13 2017-02-15 中国科学技术大学 实时温控微型样品室
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
WO2016145128A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Oligonucleotide probes and uses thereof
CA2991045A1 (en) 2015-06-29 2017-01-05 Caris Science, Inc. Therapeutic oligonucleotides binding c1q
US10544966B2 (en) 2015-07-23 2020-01-28 Cepheid Thermal control device and methods of use
AU2016298317B2 (en) 2015-07-28 2021-02-18 Caris Science, Inc. Targeted oligonucleotides
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
EP4339288A3 (en) 2016-03-18 2024-06-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
CA3025486A1 (en) 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
CN105954448B (zh) * 2016-06-22 2020-06-26 山东省计量科学研究院 一种恒温电导检测装置及检测方法
EP3305911A1 (en) * 2016-10-07 2018-04-11 Fraunhofer Gesellschaft zur Förderung der Angewand Chemical heating system for diagnostic devices
DE102017205286A1 (de) 2017-03-29 2018-10-04 Robert Bosch Gmbh Mikrofluidische Vorrichtung und Verfahren zur Temperaturregelung eines Arbeitsfluids
EP3610947B1 (en) * 2018-08-17 2021-04-21 F. Hoffmann-La Roche AG Microfluidic system for digital polymerase chain reaction of a biological sample, and respective method
JP7462632B2 (ja) 2018-11-30 2024-04-05 カリス エムピーアイ インコーポレイテッド 次世代分子プロファイリング
WO2020146324A1 (en) * 2019-01-09 2020-07-16 Precigenome, LLC A microfluidic device for deformable beads enrichment and self-regulated ordering and encapsulation in droplets
US20210008550A1 (en) * 2019-07-09 2021-01-14 Kryptos Biotechnologies, Inc. Microfluidic reaction vessel array with patterned films
WO2021022151A1 (en) * 2019-08-01 2021-02-04 Georgia Tech Research Corporation Microfluidic platform for temperature induced liquid-liquid phase separation
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
CN116917042A (zh) * 2021-01-19 2023-10-20 10X基因组学有限公司 温度控制方法和装置
JP2024535381A (ja) * 2021-09-23 2024-09-30 エヌシックス・テック、インコーポレイテッド 試料分析のための方法およびシステム
EP4412812A4 (en) * 2021-10-04 2025-07-09 Univ Maryland POLYMER PROCESSING SYSTEMS AND METHODS USING PULSED HEATING
KR102759203B1 (ko) * 2023-10-26 2025-01-24 김현철 핵산의 추출 및 증폭장치

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60185257U (ja) * 1984-05-18 1985-12-09 株式会社島津製作所 クロマトグラフ用恒温槽
JPS6273062A (ja) * 1985-09-25 1987-04-03 右近　村次郎 発熱または吸熱反応により飲料水または食品を自己加熱または自己冷却する罐
US6787338B2 (en) * 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
JPH0682444A (ja) * 1992-09-02 1994-03-22 Fuji Photo Film Co Ltd 電源を必要としない可搬型インキュベータ
US6613560B1 (en) * 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
DE19519015C1 (de) * 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
EP0871539B1 (en) * 1995-06-16 2002-02-20 University of Washington Tangential flow planar microfabricated fluid filter
US5932100A (en) 1995-06-16 1999-08-03 University Of Washington Microfabricated differential extraction device and method
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5724404A (en) * 1995-07-03 1998-03-03 Garcia; Max Integrated international telephone circuit monitoring system
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
UA22030C2 (uk) 1996-01-25 2002-04-15 Юнайтед Технолоджіз Корп. Пратт Енд Уітні Спосіб з'єдhаhhя титаhової деталі з другою металевою деталлю
US5741647A (en) * 1996-02-16 1998-04-21 Tam; Joseph Wing On Flow through nucleic acid hybridisation uses thereof and a device thereof
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6054277A (en) * 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
EP0910474B1 (en) * 1996-06-14 2004-03-24 University of Washington Absorption-enhanced differential extraction method
US5748827A (en) * 1996-10-23 1998-05-05 University Of Washington Two-stage kinematic mount
US5958349A (en) * 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
DE19717085C2 (de) * 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
WO1998050147A1 (en) * 1997-05-09 1998-11-12 The Regents Of The University Of California Peltier-assisted microfabricated reaction chambers for thermal cycling
US5974867A (en) * 1997-06-13 1999-11-02 University Of Washington Method for determining concentration of a laminar sample stream
WO1999012016A1 (en) 1997-09-02 1999-03-11 Caliper Technologies Corporation Microfluidic system with electrofluidic and electrothermal controls
US6126804A (en) * 1997-09-23 2000-10-03 The Regents Of The University Of California Integrated polymerase chain reaction/electrophoresis instrument
US6007775A (en) * 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
DK1179585T3 (da) * 1997-12-24 2008-11-10 Cepheid Indretning og fremgangsmåde til lysis
US6420143B1 (en) * 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US6018616A (en) * 1998-02-23 2000-01-25 Applied Materials, Inc. Thermal cycling module and process using radiant heat
US6572830B1 (en) * 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6261431B1 (en) * 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6171850B1 (en) * 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6192596B1 (en) * 1999-03-08 2001-02-27 Battelle Memorial Institute Active microchannel fluid processing unit and method of making
US6303343B1 (en) * 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
WO2001031053A1 (en) * 1999-10-22 2001-05-03 Aclara Biosciences, Inc. Microfluidic card thermal control
AU2082701A (en) 1999-12-09 2001-06-18 Motorola, Inc. Multilayered microfluidic devices for analyte reactions
US6699713B2 (en) * 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US6403037B1 (en) * 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
DE50107530D1 (de) * 2000-02-14 2006-02-09 Cpc Cellular Process Chemistry Mikroreaktor mit verbessertem Wärmetauscher
WO2001090614A2 (en) * 2000-05-24 2001-11-29 Micronics, Inc. Surface tension valves for microfluidic applications
JP2002018271A (ja) 2000-07-05 2002-01-22 Kawamura Inst Of Chem Res 微小ケミカルデバイス
JP2002090357A (ja) 2000-09-12 2002-03-27 Kawamura Inst Of Chem Res 温度調節機構を有する微小ケミカルデバイス
US6432695B1 (en) * 2001-02-16 2002-08-13 Institute Of Microelectronics Miniaturized thermal cycler
US6509186B1 (en) * 2001-02-16 2003-01-21 Institute Of Microelectronics Miniaturized thermal cycler
AU2002307152A1 (en) * 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
DE10217335A1 (de) * 2001-04-21 2002-10-24 Vodafone Pilotentwicklung Gmbh Vorrichtung zum Erzeugen und/oder Aufbereiten eines Brennstoffs für eine Brennstoffzelle
WO2003004162A1 (en) * 2001-07-02 2003-01-16 Gene Logic, Inc. Flow-thru chip cartridge, chip holder, system & method thereof
US6762049B2 (en) * 2001-07-05 2004-07-13 Institute Of Microelectronics Miniaturized multi-chamber thermal cycler for independent thermal multiplexing
US7338760B2 (en) * 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US7364897B2 (en) * 2002-04-11 2008-04-29 Sequenom, Inc. Methods and devices for performing chemical reactions on a solid support
US7338637B2 (en) * 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices

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