KR101203402B1 - 마이크로 유체 장치상에서의 가열, 냉각 및 열 순환 시스템및 방법 - Google Patents

마이크로 유체 장치상에서의 가열, 냉각 및 열 순환 시스템및 방법 Download PDF

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KR101203402B1
KR101203402B1 KR1020057023458A KR20057023458A KR101203402B1 KR 101203402 B1 KR101203402 B1 KR 101203402B1 KR 1020057023458 A KR1020057023458 A KR 1020057023458A KR 20057023458 A KR20057023458 A KR 20057023458A KR 101203402 B1 KR101203402 B1 KR 101203402B1
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heat
heat exchange
microfluidic
amplification chamber
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KR20060017850A (ko
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웨인 브라이드포드
크리스티 에이 랑캐스터
존 월리스 헤이옌가
로날드 엘 바델
제프리 에프 톤
베른하르트 하 바이글
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마이크로닉스 인코포레이티드.
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Assigned to 퍼킨엘머 헬스 사이언시즈, 아이엔씨. reassignment 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 권리의 전부이전등록 Assignors: 마이크로닉스 인코포레이티드.
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1877—Means for temperature control using chemical reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
KR1020057023458A 2003-06-06 2004-06-07 마이크로 유체 장치상에서의 가열, 냉각 및 열 순환 시스템및 방법 Expired - Lifetime KR101203402B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47635203P 2003-06-06 2003-06-06
US60/476,352 2003-06-06
PCT/US2004/017943 WO2004108287A1 (en) 2003-06-06 2004-06-07 System and method for heating, cooling and heat cycling on microfluidic device

Publications (2)

Publication Number Publication Date
KR20060017850A KR20060017850A (ko) 2006-02-27
KR101203402B1 true KR101203402B1 (ko) 2012-11-23

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KR1020057023458A Expired - Lifetime KR101203402B1 (ko) 2003-06-06 2004-06-07 마이크로 유체 장치상에서의 가열, 냉각 및 열 순환 시스템및 방법

Country Status (9)

Country Link
US (1) US7544506B2 (https=)
EP (1) EP1633481A1 (https=)
JP (1) JP4758891B2 (https=)
KR (1) KR101203402B1 (https=)
CN (1) CN1812839A (https=)
AU (1) AU2004245094A1 (https=)
CA (1) CA2528208A1 (https=)
RU (1) RU2005141456A (https=)
WO (1) WO2004108287A1 (https=)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2359689B1 (en) 2002-09-27 2015-08-26 The General Hospital Corporation Microfluidic device for cell separation and use thereof
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US7648835B2 (en) * 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US20050047967A1 (en) * 2003-09-03 2005-03-03 Industrial Technology Research Institute Microfluidic component providing multi-directional fluid movement
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
WO2006039293A2 (en) * 2004-09-29 2006-04-13 University Of Virginia Patent Foundation Localized control of thermal properties on microdevices and applications thereof
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7488596B2 (en) 2004-12-17 2009-02-10 Samsung Electronics Co., Ltd. Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
AU2006204858A1 (en) * 2005-01-13 2006-07-20 Perkinelmer Health Sciences, Inc. Microfluidic rare cell detection device
CN102929309A (zh) * 2005-01-25 2013-02-13 欧西里其有限责任公司 用于具有不同热容的少量流体样品的温度控制器
JP4756880B2 (ja) * 2005-03-02 2011-08-24 キヤノン株式会社 Ｐｃｒ反応液の温度制御装置
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
FR2897873B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Procede d'analyse microbiologique rapide.
FR2897941B1 (fr) * 2006-02-24 2009-01-16 Millipore Corp Dispositif et procede pour l'analyse microbiologique rapide.
FR2897783B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Dispositif pour le controle microbiologique, ensembles de controle et d'incubation le comportant et procede le mettant en oeuvre
FR2897872B1 (fr) * 2006-02-24 2008-08-15 Millipore Corp Procede d'analyse microbiologique rapide.
ES2393758T3 (es) * 2006-03-15 2012-12-27 Micronics, Inc. Ensayos integrados de ácidos nucleicos
US7569789B2 (en) * 2006-03-16 2009-08-04 Visiongate, Inc. Cantilevered coaxial flow injector apparatus and method for sorting particles
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530167A1 (en) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Microfluidic Devices
EP1878501A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Instrument for heating and cooling
EP1878502A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Instrument for heating and cooling
EP2077912B1 (en) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
CA2682761C (en) * 2007-04-04 2015-10-13 Network Biosystems, Inc. Methods for rapid multiplexed amplification of target nucleic acids
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
FR2915487B1 (fr) * 2007-04-26 2009-06-05 Millipore Corp Ensemble et procede pour analyse microbiologique
EP2153295B1 (en) * 2007-06-06 2014-11-05 Path Chemical temperature control
ES2453107T3 (es) * 2007-06-11 2014-04-04 Wako Pure Chemical Industries, Ltd. Procedimiento de amplificación de ácidos nucleicos usando una PCR sobre microchip con detección integrada de CE en tiempo real
US9458451B2 (en) 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
EP2171420A1 (en) * 2007-07-31 2010-04-07 Micronics, Inc. Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays
US9724695B2 (en) * 2008-06-23 2017-08-08 Canon U.S. Life Sciences, Inc. Systems and methods for amplifying nucleic acids
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US8304185B2 (en) * 2009-07-17 2012-11-06 Canon U.S. Life Sciences, Inc. Methods and systems for DNA isolation on a microfluidic device
US9540686B2 (en) * 2008-09-18 2017-01-10 Canon U.S. Life Sciences, Inc. Systems and methods for the amplification of DNA
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
EP2391883B1 (en) 2009-01-30 2018-03-07 Micronics, Inc. Portable high gain fluorescence detection system
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
EP2414504A4 (en) * 2009-04-03 2013-08-28 Illumina Inc DEVICES AND METHOD FOR HEATING BIOLOGICAL SAMPLES
KR101763119B1 (ko) * 2009-04-13 2017-07-31 마이크로닉스 인코포레이티드. 미세유체 임상 분석기
JP5721704B2 (ja) 2009-06-12 2015-05-20 マイクロニクス， インコーポレイテッド マイクロ流体デバイス内のｔａｑポリメラーゼを乾燥保存するための再水和可能なマトリックス
WO2010144683A2 (en) 2009-06-12 2010-12-16 Micronics, Inc. Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices
EP2443254A2 (en) 2009-06-15 2012-04-25 NetBio, Inc. Improved methods for forensic dna quantitation
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
KR101143461B1 (ko) * 2009-12-28 2012-05-23 주식회사 지앤시바이오 중합 효소 연쇄 반응 장치의 열전냉각기 제어장치 및 방법
CA2786569C (en) 2010-01-29 2019-04-09 Perkinelmer Health Sciences, Inc. Sample-to-answer microfluidic cartridge
EP4484577A3 (en) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP2542696B1 (en) 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
WO2011122216A1 (ja) * 2010-03-31 2011-10-06 コニカミノルタオプト株式会社 マイクロチップ
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
CA2821580A1 (en) * 2010-12-17 2012-06-21 Bjs Ip Limited Methods and systems for fast pcr heating
EP2673382B1 (en) * 2011-02-11 2020-05-06 Bio-Rad Laboratories, Inc. Thermocycling device for nucleic acid amplification and methods of use
EP3412778A1 (en) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
CN102250751B (zh) * 2011-03-22 2013-05-22 博奥生物有限公司 一种用于生物芯片的接口装置
WO2012166913A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
EP3216872B1 (en) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US20130137144A1 (en) * 2011-06-08 2013-05-30 Bio-Rad Laboratories, Inc. LSG - GXD Division Thermal block with built-in thermoelectric elements
CA2872378C (en) 2011-07-20 2016-01-12 University Of Washington Through Its Center For Commercialization Photonic blood typing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2773775A4 (en) * 2011-11-04 2015-05-27 Diagnostics For All Inc Low-cost, one-way diagnostics on MOLECULAR BASE
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
US9279151B2 (en) 2012-04-02 2016-03-08 David W. Wright Disposable thermal in-vitro diagnostic apparatus and method of conducting an in-vitro diagnostic test
HK1207597A1 (en) 2012-05-24 2016-02-05 Bjs Ip Limited Clamp for fast pcr heating
EP2883039A1 (en) 2012-08-10 2015-06-17 Streck Inc. Real-time optical system for polymerase chain reaction
US20140099636A1 (en) * 2012-10-10 2014-04-10 Baker Hughes Incorporated FIELD-BASED qPCR MICROBIAL MONITORING
EP4170031A1 (en) 2012-10-23 2023-04-26 Caris Science, Inc. Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
AU2013334189B2 (en) 2012-10-24 2018-08-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
DE202012104694U1 (de) 2012-12-03 2013-01-29 Bürkert Werke GmbH Mikrofluidisches System
AU2013361323B2 (en) 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
CN104919035B (zh) 2012-12-21 2017-08-11 精密公司 便携式荧光检测系统和微测定盒
JP6498125B2 (ja) 2012-12-21 2019-04-10 マイクロニクス， インコーポレイテッド 流体回路および関連する製造方法
KR20150096788A (ko) 2012-12-21 2015-08-25 마이크로닉스 인코포레이티드. 마이크로 유체공학 용도를 위한 저탄성 막
EP2946252B1 (en) * 2013-01-16 2020-08-26 Siemens Aktiengesellschaft Automated input simulation for simulated programmable logic controller
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
EP2994543B1 (en) 2013-05-07 2018-08-15 Micronics, Inc. Device for preparation and analysis of nucleic acids
CA2911303C (en) 2013-05-07 2021-02-16 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
EP3014251A1 (en) 2013-06-28 2016-05-04 Streck Inc. Devices for real-time polymerase chain reaction
CN105980615A (zh) 2013-08-28 2016-09-28 卡里斯生命科学瑞士控股有限公司 寡核苷酸探针及其用途
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
CN104267766B (zh) * 2014-10-13 2017-02-15 中国科学技术大学 实时温控微型样品室
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
WO2016145128A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Oligonucleotide probes and uses thereof
EP3314027A4 (en) 2015-06-29 2019-07-03 Caris Science, Inc. THERAPEUTIC OLIGONUCLEOTIDES
EP3325161B1 (en) 2015-07-23 2020-10-14 Cepheid Thermal control device and methods of use
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10731166B2 (en) 2016-03-18 2020-08-04 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2017205686A1 (en) 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
CN105954448B (zh) * 2016-06-22 2020-06-26 山东省计量科学研究院 一种恒温电导检测装置及检测方法
EP3305911A1 (en) * 2016-10-07 2018-04-11 Fraunhofer Gesellschaft zur Förderung der Angewand Chemical heating system for diagnostic devices
DE102017205286A1 (de) 2017-03-29 2018-10-04 Robert Bosch Gmbh Mikrofluidische Vorrichtung und Verfahren zur Temperaturregelung eines Arbeitsfluids
EP3610947B1 (en) * 2018-08-17 2021-04-21 F. Hoffmann-La Roche AG Microfluidic system for digital polymerase chain reaction of a biological sample, and respective method
EP3888021B1 (en) 2018-11-30 2024-02-21 Caris MPI, Inc. Next-generation molecular profiling
WO2020146324A1 (en) * 2019-01-09 2020-07-16 Precigenome, LLC A microfluidic device for deformable beads enrichment and self-regulated ordering and encapsulation in droplets
EP3996846A4 (en) 2019-07-09 2023-10-18 Kryptos Biotechnologies, Inc. Microfluidic reaction vessel array with patterned films
WO2021022151A1 (en) * 2019-08-01 2021-02-04 Georgia Tech Research Corporation Microfluidic platform for temperature induced liquid-liquid phase separation
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
CA3163319A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
EP4281218A1 (en) * 2021-01-19 2023-11-29 10X Genomics, Inc. Temperature control methods and devices
EP4405499A4 (en) * 2021-09-23 2025-08-06 N6 Tec Inc SAMPLE ANALYSIS METHODS AND SYSTEMS
EP4412812A4 (en) * 2021-10-04 2025-07-09 Univ Maryland POLYMER PROCESSING SYSTEMS AND METHODS USING PULSED HEATING
KR102759203B1 (ko) * 2023-10-26 2025-01-24 김현철 핵산의 추출 및 증폭장치

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002018271A (ja) 2000-07-05 2002-01-22 Kawamura Inst Of Chem Res 微小ケミカルデバイス
JP2002090357A (ja) 2000-09-12 2002-03-27 Kawamura Inst Of Chem Res 温度調節機構を有する微小ケミカルデバイス

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60185257U (ja) * 1984-05-18 1985-12-09 株式会社島津製作所 クロマトグラフ用恒温槽
JPS6273062A (ja) * 1985-09-25 1987-04-03 右近　村次郎 発熱または吸熱反応により飲料水または食品を自己加熱または自己冷却する罐
US6787338B2 (en) * 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
JPH0682444A (ja) * 1992-09-02 1994-03-22 Fuji Photo Film Co Ltd 電源を必要としない可搬型インキュベータ
US6613560B1 (en) * 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
DE19519015C1 (de) * 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
US5932100A (en) 1995-06-16 1999-08-03 University Of Washington Microfabricated differential extraction device and method
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5922210A (en) * 1995-06-16 1999-07-13 University Of Washington Tangential flow planar microfabricated fluid filter and method of using thereof
US5724404A (en) * 1995-07-03 1998-03-03 Garcia; Max Integrated international telephone circuit monitoring system
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
UA22030C2 (uk) 1996-01-25 2002-04-15 Юнайтед Технолоджіз Корп. Пратт Енд Уітні Спосіб з'єдhаhhя титаhової деталі з другою металевою деталлю
US5741647A (en) * 1996-02-16 1998-04-21 Tam; Joseph Wing On Flow through nucleic acid hybridisation uses thereof and a device thereof
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6054277A (en) * 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
DE69728269T2 (de) * 1996-06-14 2005-03-10 University Of Washington, Seattle Absorbtionsverbessertes differentielles extraktionsverfahren
US5748827A (en) * 1996-10-23 1998-05-05 University Of Washington Two-stage kinematic mount
US5958349A (en) * 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
DE19717085C2 (de) * 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
AU7477398A (en) 1997-05-09 1998-11-27 Regents Of The University Of California, The Peltier-assisted microfabricated reaction chambers for thermal cycling
US5974867A (en) * 1997-06-13 1999-11-02 University Of Washington Method for determining concentration of a laminar sample stream
JP2001515204A (ja) 1997-09-02 2001-09-18 カリパー テクノロジーズ コーポレイション 電気流体制御および電気熱制御を有するマイクロ流体システム
US6126804A (en) * 1997-09-23 2000-10-03 The Regents Of The University Of California Integrated polymerase chain reaction/electrophoresis instrument
US6007775A (en) * 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
EP1179585B1 (en) * 1997-12-24 2008-07-09 Cepheid Device and method for lysis
US6420143B1 (en) * 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US6018616A (en) * 1998-02-23 2000-01-25 Applied Materials, Inc. Thermal cycling module and process using radiant heat
US6572830B1 (en) * 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6261431B1 (en) * 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6171850B1 (en) * 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6192596B1 (en) * 1999-03-08 2001-02-27 Battelle Memorial Institute Active microchannel fluid processing unit and method of making
US6303343B1 (en) * 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
WO2001031053A1 (en) * 1999-10-22 2001-05-03 Aclara Biosciences, Inc. Microfluidic card thermal control
AU2082701A (en) 1999-12-09 2001-06-18 Motorola, Inc. Multilayered microfluidic devices for analyte reactions
US6699713B2 (en) * 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US6403037B1 (en) * 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
DE50107530D1 (de) * 2000-02-14 2006-02-09 Cpc Cellular Process Chemistry Mikroreaktor mit verbessertem Wärmetauscher
CA2408574A1 (en) * 2000-05-24 2001-11-29 Micronics, Inc. Microfluidic concentration gradient loop
US6432695B1 (en) * 2001-02-16 2002-08-13 Institute Of Microelectronics Miniaturized thermal cycler
US6509186B1 (en) * 2001-02-16 2003-01-21 Institute Of Microelectronics Miniaturized thermal cycler
EP1384022A4 (en) * 2001-04-06 2004-08-04 California Inst Of Techn NUCLEIC ACID AMPLIFICATION USING MICROFLUID DEVICES
DE10217335A1 (de) * 2001-04-21 2002-10-24 Vodafone Pilotentwicklung Gmbh Vorrichtung zum Erzeugen und/oder Aufbereiten eines Brennstoffs für eine Brennstoffzelle
CA2468260A1 (en) * 2001-07-02 2003-01-16 Matthew Torres Flow-thru chip cartridge, chip holder, system & method thereof
US6762049B2 (en) * 2001-07-05 2004-07-13 Institute Of Microelectronics Miniaturized multi-chamber thermal cycler for independent thermal multiplexing
US7338760B2 (en) * 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
CA2480990A1 (en) * 2002-04-11 2003-10-23 Sequenom, Inc. Methods and devices for performing chemical reactions on a solid support
US7338637B2 (en) * 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002018271A (ja) 2000-07-05 2002-01-22 Kawamura Inst Of Chem Res 微小ケミカルデバイス
JP2002090357A (ja) 2000-09-12 2002-03-27 Kawamura Inst Of Chem Res 温度調節機構を有する微小ケミカルデバイス

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