JP2006525360A - Ｓ−［２−（［［１−（２−エチルブチル）シクロヘキシル］カルボニル］アミノ）フェニル］２−メチルプロパンチオエートおよびＨＭＧ−ＣｏＡ還元酵素阻害剤を含む併用 - Google Patents
Ｓ−［２−（［［１−（２−エチルブチル）シクロヘキシル］カルボニル］アミノ）フェニル］２−メチルプロパンチオエートおよびＨＭＧ−ＣｏＡ還元酵素阻害剤を含む併用 Download PDFInfo
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- JP2006525360A JP2006525360A JP2006514221A JP2006514221A JP2006525360A JP 2006525360 A JP2006525360 A JP 2006525360A JP 2006514221 A JP2006514221 A JP 2006514221A JP 2006514221 A JP2006514221 A JP 2006514221A JP 2006525360 A JP2006525360 A JP 2006525360A
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- hmg
- coa reductase
- reductase inhibitor
- ethylbutyl
- cyclohexyl
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Landscapes
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Applications Claiming Priority (5)
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| US46741803P | 2003-05-02 | 2003-05-02 | |
| US47149503P | 2003-05-16 | 2003-05-16 | |
| US47737203P | 2003-06-10 | 2003-06-10 | |
| US53485604P | 2004-01-08 | 2004-01-08 | |
| PCT/US2004/013633 WO2004098583A1 (en) | 2003-05-02 | 2004-04-30 | Combination comprising s-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]2-methylpropanethioate and an hmg coa reductase inhibitor |
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| JP2006525360A true JP2006525360A (ja) | 2006-11-09 |
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| JP2011284636A Pending JP2012107018A (ja) | 2003-05-02 | 2011-12-27 | Ｓ−［２−（［［１−（２−エチルブチル）シクロヘキシル］カルボニル］アミノ）フェニル］２−メチルプロパンチオエートおよびＨＭＧ−ＣｏＡ還元酵素阻害剤を含む併用 |
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| US (2) | US20050020668A1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP1638545A1 (cg-RX-API-DMAC7.html) |
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| JP2015515498A (ja) * | 2012-04-30 | 2015-05-28 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規製剤 |
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| US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US7879840B2 (en) * | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
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| US6489125B1 (en) * | 2000-05-10 | 2002-12-03 | The Trustees Of Columbia University In The City Of New York | Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor |
| US20040048780A1 (en) * | 2000-05-10 | 2004-03-11 | The Trustees Of Columbia University In The City Of New York | Method for treating and preventing cardiac arrhythmia |
| US7393652B2 (en) * | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US7544678B2 (en) * | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
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| US8710045B2 (en) * | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
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| US7704990B2 (en) * | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| EP3323818A1 (en) | 2010-09-22 | 2018-05-23 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| CN111073974B (zh) | 2013-03-27 | 2024-04-09 | 豪夫迈·罗氏有限公司 | 用于预测对于治疗的响应性的遗传标记 |
| JP6854752B2 (ja) | 2014-07-30 | 2021-04-07 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｈｄｌ上昇剤又はｈｄｌ模倣剤を用いた治療に対する応答性を予測するための遺伝マーカー |
| WO2016112075A1 (en) | 2015-01-06 | 2016-07-14 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| KR102603199B1 (ko) | 2015-06-22 | 2023-11-16 | 아레나 파마슈티칼스, 인크. | Ｓ1ｐ1 수용체-관련 장애에서의 사용을 위한 (ｒ)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[ｂ]인돌-3-일)아세트산 (화합물 1)의 결정성 ｌ-아르기닌 염 |
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- 2004-04-30 PE PE2004000438A patent/PE20050148A1/es not_active Application Discontinuation
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- 2004-04-30 EP EP04751157A patent/EP1638545A1/en not_active Withdrawn
- 2004-04-30 EP EP10011299.4A patent/EP2289502B1/en not_active Expired - Lifetime
- 2004-04-30 AR ARP040101498A patent/AR044155A1/es unknown
- 2004-04-30 JP JP2006514221A patent/JP2006525360A/ja active Pending
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Cited By (1)
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| JP2015515498A (ja) * | 2012-04-30 | 2015-05-28 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規製剤 |
Also Published As
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|---|---|
| TW200507831A (en) | 2005-03-01 |
| US20050020668A1 (en) | 2005-01-27 |
| AR044155A1 (es) | 2005-08-24 |
| EP2289502B1 (en) | 2015-07-22 |
| HK1154780A1 (en) | 2012-05-04 |
| EP1638545A1 (en) | 2006-03-29 |
| EP2289501A1 (en) | 2011-03-02 |
| PE20050148A1 (es) | 2005-05-19 |
| EP2289502A1 (en) | 2011-03-02 |
| TW201231043A (en) | 2012-08-01 |
| CN102512679A (zh) | 2012-06-27 |
| TWI494102B (zh) | 2015-08-01 |
| TWI393560B (zh) | 2013-04-21 |
| JP2012107018A (ja) | 2012-06-07 |
| US20140121229A1 (en) | 2014-05-01 |
| WO2004098583A1 (en) | 2004-11-18 |
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