TWI393560B - 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合 - Google Patents
包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合 Download PDFInfo
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- TWI393560B TWI393560B TW093111373A TW93111373A TWI393560B TW I393560 B TWI393560 B TW I393560B TW 093111373 A TW093111373 A TW 093111373A TW 93111373 A TW93111373 A TW 93111373A TW I393560 B TWI393560 B TW I393560B
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| TW101105603A TWI494102B (zh) | 2003-05-02 | 2004-04-23 | 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合 |
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| US20060293266A1 (en) * | 2000-05-10 | 2006-12-28 | The Trustees Of Columbia | Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure |
| US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US7879840B2 (en) * | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US20040229781A1 (en) * | 2000-05-10 | 2004-11-18 | Marks Andrew Robert | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
| US6489125B1 (en) * | 2000-05-10 | 2002-12-03 | The Trustees Of Columbia University In The City Of New York | Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor |
| US20040048780A1 (en) * | 2000-05-10 | 2004-03-11 | The Trustees Of Columbia University In The City Of New York | Method for treating and preventing cardiac arrhythmia |
| US7393652B2 (en) * | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US7544678B2 (en) * | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
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2004
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- 2004-04-30 PE PE2004000438A patent/PE20050148A1/es not_active Application Discontinuation
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- 2004-04-30 EP EP04751157A patent/EP1638545A1/en not_active Withdrawn
- 2004-04-30 EP EP10011299.4A patent/EP2289502B1/en not_active Expired - Lifetime
- 2004-04-30 AR ARP040101498A patent/AR044155A1/es unknown
- 2004-04-30 JP JP2006514221A patent/JP2006525360A/ja active Pending
- 2004-04-30 WO PCT/US2004/013633 patent/WO2004098583A1/en not_active Ceased
- 2004-04-30 CN CN2011104212299A patent/CN102512679A/zh active Pending
- 2004-04-30 EP EP10011298A patent/EP2289501A1/en not_active Withdrawn
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| TW200507831A (en) | 2005-03-01 |
| US20050020668A1 (en) | 2005-01-27 |
| AR044155A1 (es) | 2005-08-24 |
| EP2289502B1 (en) | 2015-07-22 |
| HK1154780A1 (en) | 2012-05-04 |
| EP1638545A1 (en) | 2006-03-29 |
| EP2289501A1 (en) | 2011-03-02 |
| PE20050148A1 (es) | 2005-05-19 |
| JP2006525360A (ja) | 2006-11-09 |
| EP2289502A1 (en) | 2011-03-02 |
| TW201231043A (en) | 2012-08-01 |
| CN102512679A (zh) | 2012-06-27 |
| TWI494102B (zh) | 2015-08-01 |
| JP2012107018A (ja) | 2012-06-07 |
| US20140121229A1 (en) | 2014-05-01 |
| WO2004098583A1 (en) | 2004-11-18 |
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