JP2006524699A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006524699A5 JP2006524699A5 JP2006513242A JP2006513242A JP2006524699A5 JP 2006524699 A5 JP2006524699 A5 JP 2006524699A5 JP 2006513242 A JP2006513242 A JP 2006513242A JP 2006513242 A JP2006513242 A JP 2006513242A JP 2006524699 A5 JP2006524699 A5 JP 2006524699A5
- Authority
- JP
- Japan
- Prior art keywords
- diuretic
- combination
- metabolite
- prodrug
- amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000001882 diuretic effect Effects 0.000 claims 104
- 239000002934 diuretic Substances 0.000 claims 100
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 50
- 150000001408 amides Chemical class 0.000 claims 37
- 150000002148 esters Chemical class 0.000 claims 37
- 239000002207 metabolite Substances 0.000 claims 37
- 239000000651 prodrug Substances 0.000 claims 37
- 229940002612 prodrug Drugs 0.000 claims 37
- 150000003839 salts Chemical class 0.000 claims 37
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 28
- 239000003814 drug Substances 0.000 claims 28
- 229940109239 creatinine Drugs 0.000 claims 25
- 229940079593 drug Drugs 0.000 claims 19
- 239000003795 chemical substances by application Substances 0.000 claims 18
- 230000003907 kidney function Effects 0.000 claims 17
- 230000008327 renal blood flow Effects 0.000 claims 15
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 14
- 229960005305 adenosine Drugs 0.000 claims 14
- 239000002171 loop diuretic Substances 0.000 claims 12
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 11
- 230000001939 inductive effect Effects 0.000 claims 9
- 208000017169 kidney disease Diseases 0.000 claims 9
- 210000002966 serum Anatomy 0.000 claims 8
- 229940030606 diuretics Drugs 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 claims 5
- 229960002576 amiloride Drugs 0.000 claims 5
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims 5
- 229960002256 spironolactone Drugs 0.000 claims 5
- 239000003451 thiazide diuretic agent Substances 0.000 claims 5
- 229960001288 triamterene Drugs 0.000 claims 5
- 208000004880 Polyuria Diseases 0.000 claims 4
- 206010061481 Renal injury Diseases 0.000 claims 4
- 230000003247 decreasing effect Effects 0.000 claims 4
- 229960003883 furosemide Drugs 0.000 claims 4
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 4
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 claims 3
- 238000011863 diuretic therapy Methods 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 230000001434 glomerular Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- UJEWTUDSLQGTOA-UHFFFAOYSA-N Piretanide Chemical compound C=1C=CC=CC=1OC=1C(S(=O)(=O)N)=CC(C(O)=O)=CC=1N1CCCC1 UJEWTUDSLQGTOA-UHFFFAOYSA-N 0.000 claims 2
- NGBFQHCMQULJNZ-UHFFFAOYSA-N Torsemide Chemical compound CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC1=CC=CC(C)=C1 NGBFQHCMQULJNZ-UHFFFAOYSA-N 0.000 claims 2
- -1 amiloride thiazide Chemical class 0.000 claims 2
- 229960004064 bumetanide Drugs 0.000 claims 2
- MAEIEVLCKWDQJH-UHFFFAOYSA-N bumetanide Chemical compound CCCCNC1=CC(C(O)=O)=CC(S(N)(=O)=O)=C1OC1=CC=CC=C1 MAEIEVLCKWDQJH-UHFFFAOYSA-N 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000035619 diuresis Effects 0.000 claims 2
- AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 claims 2
- 229960003199 etacrynic acid Drugs 0.000 claims 2
- 229960001085 piretanide Drugs 0.000 claims 2
- 229960005461 torasemide Drugs 0.000 claims 2
- 206010016803 Fluid overload Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000035433 tubuloglomerular feedback Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46600703P | 2003-04-25 | 2003-04-25 | |
| PCT/US2004/012518 WO2004096228A1 (en) | 2003-04-25 | 2004-04-23 | Method of improved diuresis in individuals with impaired renal function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006524699A JP2006524699A (ja) | 2006-11-02 |
| JP2006524699A5 true JP2006524699A5 (enExample) | 2006-12-14 |
Family
ID=33418325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006513242A Withdrawn JP2006524699A (ja) | 2003-04-25 | 2004-04-23 | 腎機能障害を持つ個体における利尿改善法 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7579331B2 (enExample) |
| EP (1) | EP1620107A1 (enExample) |
| JP (1) | JP2006524699A (enExample) |
| KR (1) | KR20060004959A (enExample) |
| CN (1) | CN1859913A (enExample) |
| AR (1) | AR044069A1 (enExample) |
| AU (1) | AU2004233852A1 (enExample) |
| BR (1) | BRPI0409699A (enExample) |
| CA (1) | CA2522971A1 (enExample) |
| MX (1) | MXPA05011371A (enExample) |
| NO (1) | NO20055536L (enExample) |
| NZ (1) | NZ543109A (enExample) |
| RU (1) | RU2367442C2 (enExample) |
| TW (1) | TW200500070A (enExample) |
| WO (1) | WO2004096228A1 (enExample) |
| ZA (1) | ZA200509311B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| CA2522971A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| EP1668008A4 (en) * | 2003-08-28 | 2009-02-25 | Nitromed Inc | NITROSED AND NITROSYLATED DIETETIC COMPOUNDS, COMPOSITIONS AND APPLICATION METHODS |
| MXPA06011823A (es) * | 2004-04-16 | 2006-12-15 | Novacardia Inc | Terapia de combinacion, que comprende un antagonista del receptor de la adenosina a1 y un inhibidor de la aldosterona. |
| CA2597460A1 (en) * | 2005-02-24 | 2006-08-31 | Nitromed, Inc. | Nitric oxide enhancing diuretic compounds, compositions and methods of use |
| WO2006115690A2 (en) * | 2005-04-22 | 2006-11-02 | Novacardia, Inc. | Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions |
| US20100168140A1 (en) * | 2005-12-14 | 2010-07-01 | Kyowa Hakko Kogyo Co., Ltd. | Easily Absorbable Oral Preparations of Xanthine Derivatives |
| CA2648281A1 (en) * | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| JP2009539995A (ja) * | 2006-06-16 | 2009-11-19 | ノヴァカーディア，インク． | うっ血性心不全および急性体液過剰の患者において入院期間を短縮するための方法 |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| US20090197900A1 (en) * | 2007-03-29 | 2009-08-06 | Howard Dittrich | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE416810C (sv) | 1977-10-14 | 1982-07-19 | Draco Ab | Forfarande for framstellning av xantinderivat med antiallergisk aktivitet |
| FR2531085A1 (fr) | 1982-07-28 | 1984-02-03 | Adir | Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US4769377A (en) * | 1983-02-18 | 1988-09-06 | The Johns Hopkins University | Adenosine receptor antagonists |
| DE8817122U1 (de) * | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Xanthinderivate mit Adenosinantogenistischer Wirkung |
| US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| SE9000207L (sv) | 1990-01-22 | 1991-07-23 | Nobel Chemicals Ab | Laekemedel samt anvaendningen av detsamma |
| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| WO1993000081A1 (en) | 1991-06-28 | 1993-01-07 | Sepracor, Inc. | Optically pure s(-) nadolol for treatment of cardiovascular disorders |
| CA2093403C (en) | 1992-04-08 | 1999-08-10 | Fumio Suzuki | Therapeutic agent for parkinson's disease |
| TW252044B (enExample) | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| DE4238367A1 (de) * | 1992-11-13 | 1994-05-19 | Boehringer Ingelheim Kg | Diuretisches Mittel |
| US5395836A (en) | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
| US5736528A (en) * | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
| US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| CN1049117C (zh) | 1994-09-16 | 2000-02-09 | 赵明玉 | 预防和治疗偏头痛的偏头痛片 |
| PT784974E (pt) * | 1995-07-26 | 2003-09-30 | Kyowa Hakko Kogyo Kk | Preparacao de derivados de xantina numa dispersao solida |
| PT958821E (pt) | 1996-08-07 | 2005-02-28 | Kyowa Hakko Kogyo Kk | Emulsao gorda que contem um derivado da xantina |
| DE19816857A1 (de) | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US6187780B1 (en) * | 1998-04-16 | 2001-02-13 | Boehringer Ingelheim Pharma Kg | Assymetrically substituted xanthine derivatives having adenosine A1 antagonistic activity |
| US20020115687A1 (en) | 1998-04-24 | 2002-08-22 | Evan Beckman | Method and composition for restoring diuretic and renal function |
| CA2295101C (en) | 1998-04-24 | 2009-06-30 | Biogen, Inc. | Adenosine a1 receptor antagonist containing composition and method for restoring diuretic and renal function |
| EP0970696A1 (en) | 1998-05-05 | 2000-01-12 | Kyowa Hakko Kogyo Co., Ltd. | Combination of loop diuretics with adenosine A1-receptor antagonists |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| SK6622002A3 (en) | 1999-11-12 | 2003-02-04 | Biogen Inc | Adenosine receptor antagonists and methods of making and using the same |
| PT1230243E (pt) * | 1999-11-12 | 2009-06-12 | Biogen Idec Inc | Policicloalquilpurinas como antagonistas dos receptores da adenosina |
| US20050038017A1 (en) * | 1999-12-22 | 2005-02-17 | Wolff Andrew A. | Method and composition for restoring diuretic and renal function |
| AR035400A1 (es) | 2000-12-01 | 2004-05-26 | Biogen Inc | Un compuesto antagonista del receptor de adenosina a1, una composicion farmaceutica que lo comprende y un proceso para prepararlo |
| CN1461218A (zh) | 2000-12-18 | 2003-12-10 | 诺瓦提斯公司 | 阿洛地平和贝那普利的治疗组合 |
| UA80258C2 (en) * | 2001-09-06 | 2007-09-10 | Biogen Inc | Methods of treating pulmonary disease |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| CA2522971A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| WO2005000294A1 (en) * | 2003-06-06 | 2005-01-06 | Pharmacia Corporation | Selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders |
| MXPA06011823A (es) * | 2004-04-16 | 2006-12-15 | Novacardia Inc | Terapia de combinacion, que comprende un antagonista del receptor de la adenosina a1 y un inhibidor de la aldosterona. |
| EP1751159A2 (en) * | 2004-04-28 | 2007-02-14 | Cv Therapeutics, Inc. | Purine derivatives as a1 adenosine receptor antagonists |
| CA2648281A1 (en) | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| CN101466383A (zh) | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| JP2009539995A (ja) * | 2006-06-16 | 2009-11-19 | ノヴァカーディア，インク． | うっ血性心不全および急性体液過剰の患者において入院期間を短縮するための方法 |
| KR20090042330A (ko) * | 2006-08-22 | 2009-04-29 | 노바카르디아, 인코포레이션 | 혈액뇌장벽을 통과하지 않는 ｋｗ―３９０２ 컨쥬게이트 |
-
2004
- 2004-04-23 CA CA002522971A patent/CA2522971A1/en not_active Abandoned
- 2004-04-23 TW TW093111522A patent/TW200500070A/zh unknown
- 2004-04-23 US US10/830,617 patent/US7579331B2/en not_active Expired - Fee Related
- 2004-04-23 KR KR1020057020243A patent/KR20060004959A/ko not_active Ceased
- 2004-04-23 AR ARP040101381A patent/AR044069A1/es unknown
- 2004-04-23 JP JP2006513242A patent/JP2006524699A/ja not_active Withdrawn
- 2004-04-23 MX MXPA05011371A patent/MXPA05011371A/es not_active Application Discontinuation
- 2004-04-23 BR BRPI0409699-1A patent/BRPI0409699A/pt not_active IP Right Cessation
- 2004-04-23 CN CNA2004800105597A patent/CN1859913A/zh active Pending
- 2004-04-23 NZ NZ543109A patent/NZ543109A/en unknown
- 2004-04-23 EP EP04760339A patent/EP1620107A1/en not_active Withdrawn
- 2004-04-23 WO PCT/US2004/012518 patent/WO2004096228A1/en not_active Ceased
- 2004-04-23 AU AU2004233852A patent/AU2004233852A1/en not_active Abandoned
- 2004-04-23 RU RU2005131938/15A patent/RU2367442C2/ru not_active IP Right Cessation
-
2005
- 2005-10-11 US US11/248,905 patent/US20060035911A1/en not_active Abandoned
- 2005-10-11 US US11/248,479 patent/US20060030572A1/en not_active Abandoned
- 2005-11-17 ZA ZA200509311A patent/ZA200509311B/en unknown
- 2005-11-23 NO NO20055536A patent/NO20055536L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Fogel et al. | Diuresis in the ascitic patient: a randomized controlled trial of three regimens | |
| JP2022009125A5 (enExample) | ||
| JP2006524699A5 (enExample) | ||
| AU2018357775B2 (en) | New combination of active agents for the treatment of progressive fibrosing interstitial lung diseases (PF-ILD) | |
| JP2019517542A5 (enExample) | ||
| JP2020508339A5 (enExample) | ||
| Kim et al. | Ethacrynic acid and furosemide: Diuretic and hemodynamic effects and clinical uses | |
| JP2002522485A5 (enExample) | ||
| JP2002528502A5 (enExample) | ||
| HRP20210294T1 (hr) | Postupci liječenja akutnog bubrežnog oštećenja | |
| JP2013541583A (ja) | 組み合わせ組成物 | |
| Cruz et al. | Intradialytic hypotension: is midodrine beneficial in symptomatic hemodialysis patients? | |
| JP2017514911A5 (enExample) | ||
| JP2008509224A5 (enExample) | ||
| JP2019533660A5 (enExample) | ||
| JP2018531929A5 (enExample) | ||
| US20040235802A1 (en) | Combinations comprising cox-2-inhibitors and aspirin | |
| JP2020500864A5 (enExample) | ||
| JP2015522077A5 (enExample) | ||
| CN110974828A (zh) | 化合物Axitinib在制备治疗脑血管疾病的药物中的应用及其药物组合物 | |
| HRP20221185T1 (hr) | Beta-ukosnica peptidomimetik s inhibitorskom aktivnošću elastase i njegovi oblici doziranja aerosolom | |
| RU2005131938A (ru) | Способ нормализации мочеиспускания при нарушении функции почек | |
| SHAFAT et al. | Reversal of cardiovascular toxicity in severe organophosphate poisoning with 20% Intralipid emulsion therapy: case report and review of literature | |
| JP2020510043A5 (enExample) | ||
| RS64668B1 (sr) | Montelukast za lečenje erozivnog osteoartritisa šake |