JP2006523669A - Nima調節タンパク質(pin1)を阻害するための、リン酸/硫酸エステル化合物および医薬組成物 - Google Patents
Nima調節タンパク質(pin1)を阻害するための、リン酸/硫酸エステル化合物および医薬組成物 Download PDFInfo
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- JP2006523669A JP2006523669A JP2006506287A JP2006506287A JP2006523669A JP 2006523669 A JP2006523669 A JP 2006523669A JP 2006506287 A JP2006506287 A JP 2006506287A JP 2006506287 A JP2006506287 A JP 2006506287A JP 2006523669 A JP2006523669 A JP 2006523669A
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- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 10
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- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07C305/18—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings containing six-membered aromatic rings
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Applications Claiming Priority (2)
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US45316303P | 2003-03-10 | 2003-03-10 | |
PCT/IB2004/000574 WO2004087720A1 (en) | 2003-03-10 | 2004-02-23 | Phosphate/sulfate ester compounds and pharmaceutical compositions for inhibiting protein interacting nima (pin1) |
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JP2006523669A true JP2006523669A (ja) | 2006-10-19 |
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JP2006506287A Pending JP2006523669A (ja) | 2003-03-10 | 2004-02-23 | Nima調節タンパク質(pin1)を阻害するための、リン酸/硫酸エステル化合物および医薬組成物 |
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EP (1) | EP1603926A1 (de) |
JP (1) | JP2006523669A (de) |
BR (1) | BRPI0408477A (de) |
CA (1) | CA2517281A1 (de) |
MX (1) | MXPA05009241A (de) |
WO (1) | WO2004087720A1 (de) |
Cited By (3)
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WO2018101329A1 (ja) * | 2016-11-29 | 2018-06-07 | 国立大学法人広島大学 | 新規エステル体化合物並びにそれを用いたPin1阻害剤、炎症性疾患治療剤及び大腸癌治療剤 |
JP2020505411A (ja) * | 2017-01-31 | 2020-02-20 | ギリアード サイエンシーズ, インコーポレイテッド | テノホビルアラフェナミドの結晶形態 |
WO2022270628A1 (ja) * | 2021-06-25 | 2022-12-29 | 国立大学法人 大分大学 | Rsウイルス感染症の処置および/または予防用医薬としてのヘテロシクロアルキル置換ポリヘテロアゾール誘導体 |
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WO2005080406A2 (en) * | 2003-12-19 | 2005-09-01 | Jerini Ag | Compounds for the inhibition of undesired cell proliferation and use thereof |
US7795448B2 (en) | 2004-05-06 | 2010-09-14 | Cytokinetics, Incorporated | Imidazoyl-benzamide anti-cancer agents |
US7504413B2 (en) | 2004-05-06 | 2009-03-17 | Cytokinetics, Inc. | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases |
US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
WO2006040646A1 (en) * | 2004-10-14 | 2006-04-20 | Pfizer, Inc. | Benzimidazole or indole amides as inhibitors of pin1 |
EP2845588A1 (de) * | 2013-09-09 | 2015-03-11 | Centre National de la Recherche Scientifique (C.N.R.S.) | PIN1-Hemmer zur Verwendung bei der Vorbeugung und/oder Behandlung von Theileriose sowie zugehörige Anwendungen |
BR112017006669B1 (pt) | 2014-10-03 | 2023-04-18 | Ucb Biopharma Sprl | Derivados de imidazol pentacíclico fundido, composição farmacêutica compreendendo os mesmos e uso dos mesmos |
WO2017063757A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds |
WO2017063755A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds |
WO2017063756A1 (en) * | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds as pin1 modulators |
WO2017063754A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds as pin1 modulators |
US10793578B2 (en) | 2016-04-01 | 2020-10-06 | UCB Biopharma SRL | Fused pentacyclic imidazole derivatives as modulators of TNF activity |
EP3436460B1 (de) | 2016-04-01 | 2021-08-18 | UCB Biopharma SRL | Kondensierte pentacyclische imidazol-derivate als modulatoren der tnf-aktivität |
US10766906B2 (en) | 2016-04-01 | 2020-09-08 | UCB Biopharma SRL | Fused hexacyclic imidazole derivatives as modulators of TNF activity |
JP6968092B2 (ja) | 2016-04-01 | 2021-11-17 | ユーシービー バイオファルマ エスアールエル | Tnf活性のモジュレーターとしての縮合五環式イミダゾール誘導体 |
WO2018167176A1 (en) | 2017-03-15 | 2018-09-20 | Ucb Biopharma Sprl | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
CN111201215B (zh) | 2017-08-07 | 2024-01-26 | 国立大学法人广岛大学 | 新型酰胺系化合物、使用了该化合物的Pin1抑制剂、炎症性疾病的治疗剂及癌症的治疗剂 |
CN111183129B (zh) | 2017-08-07 | 2024-07-23 | 国立大学法人广岛大学 | 新型邻氨基苯甲酸系化合物、使用了该化合物的Pin1抑制剂、炎症性疾病及癌症的治疗剂 |
US11071738B2 (en) | 2017-08-07 | 2021-07-27 | Hiroshima University | Therapeutic agent for fatty liver diseases and therapeutic agent for adiposity |
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---|---|---|---|---|
US5508387A (en) * | 1993-08-04 | 1996-04-16 | Glycomed Incorporated | Selectin binding glycopeptides |
EP1521825A2 (de) * | 2002-07-09 | 2005-04-13 | Pfizer Inc. | Pin1 peptidyl-prolyl isomerase polypeptide, deren kristallstrukturen, und deren verwendungen frü den entwurf von arzneimitteln |
-
2004
- 2004-02-23 EP EP04713610A patent/EP1603926A1/de not_active Withdrawn
- 2004-02-23 BR BRPI0408477-2A patent/BRPI0408477A/pt not_active IP Right Cessation
- 2004-02-23 WO PCT/IB2004/000574 patent/WO2004087720A1/en not_active Application Discontinuation
- 2004-02-23 MX MXPA05009241A patent/MXPA05009241A/es unknown
- 2004-02-23 JP JP2006506287A patent/JP2006523669A/ja active Pending
- 2004-02-23 CA CA002517281A patent/CA2517281A1/en not_active Abandoned
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018101329A1 (ja) * | 2016-11-29 | 2018-06-07 | 国立大学法人広島大学 | 新規エステル体化合物並びにそれを用いたPin1阻害剤、炎症性疾患治療剤及び大腸癌治療剤 |
JPWO2018101329A1 (ja) * | 2016-11-29 | 2019-10-31 | 国立大学法人広島大学 | 新規エステル体化合物並びにそれを用いたPin1阻害剤、炎症性疾患治療剤及び大腸癌治療剤 |
US11203565B2 (en) | 2016-11-29 | 2021-12-21 | Hiroshima University | Ester compound and PIN1 inhibitor, inflammatory disease therapeutic, and colon cancer therapeutic in which said ester compound is used |
JP7048054B2 (ja) | 2016-11-29 | 2022-04-05 | 国立大学法人広島大学 | 新規エステル体化合物並びにそれを用いたPin1阻害剤、炎症性疾患治療剤及び大腸癌治療剤 |
JP2020505411A (ja) * | 2017-01-31 | 2020-02-20 | ギリアード サイエンシーズ, インコーポレイテッド | テノホビルアラフェナミドの結晶形態 |
WO2022270628A1 (ja) * | 2021-06-25 | 2022-12-29 | 国立大学法人 大分大学 | Rsウイルス感染症の処置および/または予防用医薬としてのヘテロシクロアルキル置換ポリヘテロアゾール誘導体 |
Also Published As
Publication number | Publication date |
---|---|
CA2517281A1 (en) | 2004-10-14 |
MXPA05009241A (es) | 2005-10-19 |
BRPI0408477A (pt) | 2006-04-04 |
WO2004087720A1 (en) | 2004-10-14 |
EP1603926A1 (de) | 2005-12-14 |
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