JP2006521308A - ベンゾフロ−１，４−ジアゼピン−２−オン誘導体 - Google Patents

ベンゾフロ−１，４−ジアゼピン−２−オン誘導体 Download PDF

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Publication number
JP2006521308A
JP2006521308A JP2006504663A JP2006504663A JP2006521308A JP 2006521308 A JP2006521308 A JP 2006521308A JP 2006504663 A JP2006504663 A JP 2006504663A JP 2006504663 A JP2006504663 A JP 2006504663A JP 2006521308 A JP2006521308 A JP 2006521308A
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JP
Japan
Prior art keywords
formula
hydrogen
bromine
chlorine
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006504663A
Other languages
English (en)
Japanese (ja)
Inventor
リューディガー・フィッシャー
ベルント・カルトホーフ
ルディ・グリュッツマン
エリーザベト・ヴォルテリング
ベアトリクス・シュテルテ−ルートヴィッヒ
マルティナ・ヴットケ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of JP2006521308A publication Critical patent/JP2006521308A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006504663A 2003-03-24 2004-03-12 ベンゾフロ−１，４−ジアゼピン−２−オン誘導体 Pending JP2006521308A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10312969A DE10312969A1 (de) 2003-03-24 2003-03-24 Benzofuro-1,4-diazepin-2-on-Derivate
PCT/EP2004/002580 WO2004085440A1 (de) 2003-03-24 2004-03-12 Benzofuro-1,4-diazepin-2-on-derivate

Publications (1)

Publication Number Publication Date
JP2006521308A true JP2006521308A (ja) 2006-09-21

Family

ID=32946087

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006504663A Pending JP2006521308A (ja) 2003-03-24 2004-03-12 ベンゾフロ−１，４−ジアゼピン−２−オン誘導体

Country Status (5)

Country Link
EP (1) EP1608659A1 (de)
JP (1) JP2006521308A (de)
CA (1) CA2519987A1 (de)
DE (1) DE10312969A1 (de)
WO (1) WO2004085440A1 (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093061A1 (ja) * 2009-02-16 2010-08-19 日本ケミファ株式会社 ジアゼピンジオン誘導体
WO2012161301A1 (ja) * 2011-05-25 2012-11-29 国立大学法人九州大学 ギラン・バレー症候群に伴う神経因性疼痛の予防又は治療剤
WO2013105608A1 (ja) * 2012-01-13 2013-07-18 日本ケミファ株式会社 Ｐ２ｘ４受容体拮抗剤
WO2017188365A1 (ja) * 2016-04-28 2017-11-02 日本ケミファ株式会社 多発性硬化症の治療のための医薬

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009057281A (ja) * 2005-12-19 2009-03-19 Nippon Chemiphar Co Ltd Ｐ２ｘ４受容体拮抗剤
JP2009062278A (ja) * 2005-12-29 2009-03-26 Nippon Chemiphar Co Ltd Ｐ２ｘ４受容体拮抗剤
JPWO2008020651A1 (ja) * 2006-08-17 2010-01-07 国立大学法人九州大学 Ｐ２ｘ４受容体アンタゴニスト
KR20090055001A (ko) * 2006-08-25 2009-06-01 닛뽕 케미파 가부시키가이샤 Ｐ2ｘ4 수용체 길항제
WO2009022731A1 (ja) 2007-08-10 2009-02-19 Nippon Chemiphar Co., Ltd. Ｐ２ｘ４受容体拮抗剤
WO2012008478A1 (ja) 2010-07-13 2012-01-19 日本ケミファ株式会社 Ｐ２ｘ４受容体拮抗剤
WO2012014910A1 (ja) 2010-07-29 2012-02-02 日本ケミファ株式会社 Ｐ２ｘ４受容体拮抗剤
KR101890443B1 (ko) 2010-08-03 2018-09-28 닛뽕 케미파 가부시키가이샤 Ｐ2ｘ4 수용체 길항제
CA2819997C (en) 2010-11-05 2019-06-25 Kyushu University Preventive or therapeutic agent for pain associated with herpes zoster in acute phase
WO2013122778A1 (en) 2012-02-15 2013-08-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating and preventing diseases and disorders of the central nervous system
JP6357475B2 (ja) 2013-07-12 2018-07-11 日本ケミファ株式会社 Ｐ２ｘ４受容体拮抗剤
ES2753422T3 (es) 2013-07-12 2020-04-08 Nippon Chemiphar Co Antagonista de receptor P2X4
WO2015088565A1 (en) * 2013-12-13 2015-06-18 Sunovion Pharmaceuticals Inc. P2x4 receptor modulating compounds and methods of use thereof
US10695355B2 (en) 2017-03-30 2020-06-30 University Of Connecticut Methods for pharmacologic treatment of stroke
KR20230041650A (ko) * 2020-03-30 2023-03-24 유니베르시타＇ 디 피사 과민성 장 증후군 또는 염증성 장 질환의 예방 또는 치료를 위한 의약
WO2023239767A2 (en) * 2022-06-07 2023-12-14 University Of Connecticut Compositions and methods for pharmacologic treatment of stroke and myocardial ischemia reperfusion injury

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW219896B (de) * 1988-07-07 1994-02-01 Duphar Int Res
WO2001051490A1 (en) * 2000-01-14 2001-07-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5592278B2 (ja) * 2009-02-16 2014-09-17 日本ケミファ株式会社 ジアゼピンジオン誘導体
WO2010093061A1 (ja) * 2009-02-16 2010-08-19 日本ケミファ株式会社 ジアゼピンジオン誘導体
KR101727761B1 (ko) 2009-02-16 2017-04-17 닛뽕 케미파 가부시키가이샤 디아제핀디온 유도체
JP2017119702A (ja) * 2011-05-25 2017-07-06 国立大学法人九州大学 ギラン・バレー症候群に伴う神経因性疼痛の予防又は治療剤
WO2012161301A1 (ja) * 2011-05-25 2012-11-29 国立大学法人九州大学 ギラン・バレー症候群に伴う神経因性疼痛の予防又は治療剤
JPWO2012161301A1 (ja) * 2011-05-25 2014-07-31 国立大学法人九州大学 ギラン・バレー症候群に伴う神経因性疼痛の予防又は治療剤
US9969700B2 (en) 2012-01-13 2018-05-15 Nippon Chemiphar Co., Ltd. P2X4 receptor antagonist
WO2013105608A1 (ja) * 2012-01-13 2013-07-18 日本ケミファ株式会社 Ｐ２ｘ４受容体拮抗剤
US9382236B2 (en) 2012-01-13 2016-07-05 Nippon Chemiphar Co., Ltd P2X4 receptor antagonist
JPWO2013105608A1 (ja) * 2012-01-13 2015-05-11 日本ケミファ株式会社 Ｐ２ｘ４受容体拮抗剤
US10633349B2 (en) 2012-01-13 2020-04-28 Nippon Chemiphar Co., Ltd P2X4 receptor antagonist
US11434207B2 (en) 2012-01-13 2022-09-06 Nippon Chemiphar Co., Ltd P2X4 receptor antagonist
WO2017188365A1 (ja) * 2016-04-28 2017-11-02 日本ケミファ株式会社 多発性硬化症の治療のための医薬
KR20190019062A (ko) * 2016-04-28 2019-02-26 닛뽕 케미파 가부시키가이샤 다발성 경화증의 치료를 위한 의약
JPWO2017188365A1 (ja) * 2016-04-28 2019-04-04 日本ケミファ株式会社 多発性硬化症の治療のための医薬
JP7116679B2 (ja) 2016-04-28 2022-08-10 日本ケミファ株式会社 多発性硬化症の治療のための医薬
KR102535907B1 (ko) * 2016-04-28 2023-05-23 닛뽕 케미파 가부시키가이샤 다발성 경화증의 치료를 위한 의약
US11918589B2 (en) 2016-04-28 2024-03-05 Nippon Chemiphar Co., Ltd. Medicament for treatment of multiple sclerosis

Also Published As

Publication number Publication date
EP1608659A1 (de) 2005-12-28
CA2519987A1 (en) 2004-10-07
DE10312969A1 (de) 2004-10-07
WO2004085440A1 (de) 2004-10-07

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