JP2006520763A5 - - Google Patents
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- JP2006520763A5 JP2006520763A5 JP2006504683A JP2006504683A JP2006520763A5 JP 2006520763 A5 JP2006520763 A5 JP 2006520763A5 JP 2006504683 A JP2006504683 A JP 2006504683A JP 2006504683 A JP2006504683 A JP 2006504683A JP 2006520763 A5 JP2006520763 A5 JP 2006520763A5
- Authority
- JP
- Japan
- Prior art keywords
- alkaloid
- krs
- reaction product
- water
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229930013930 alkaloid Natural products 0.000 claims description 67
- 239000007795 chemical reaction product Substances 0.000 claims description 55
- 238000000034 method Methods 0.000 claims description 54
- 150000003797 alkaloid derivatives Chemical class 0.000 claims description 50
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical group C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 claims description 40
- 239000000203 mixture Substances 0.000 claims description 33
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 27
- 229910052757 nitrogen Inorganic materials 0.000 claims description 26
- 229940100198 alkylating agent Drugs 0.000 claims description 23
- 239000002168 alkylating agent Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 22
- 238000006243 chemical reaction Methods 0.000 claims description 21
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 21
- 239000003960 organic solvent Substances 0.000 claims description 20
- 241001233914 Chelidonium majus Species 0.000 claims description 16
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 claims description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 15
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| SU368254A1 (ru) | 1969-06-16 | 1973-01-26 | А. И. Потопальский , В. М. Новицкий Львовский государственный медицинский институт | Способ получения соединений тиофосфамида с алкалоидами чистотела большого |
| AT354644B (de) | 1975-12-19 | 1980-01-25 | Nowicky Wassili | Verfahren zur herstellung von neuen salzen von alkaloidderivaten von thiophosphorsaeure |
| AT377988B (de) * | 1976-06-28 | 1985-05-28 | Nowicky Wassili | Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden |
| DE3128018A1 (de) | 1981-07-13 | 1983-04-07 | Wassyl 1060 Wien Nowicky | "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze" |
| US4970212A (en) | 1982-05-18 | 1990-11-13 | Nowicky Wassili | Method of treating human illnesses which compromise the ability to mount an effective immunological response |
| AT407833B (de) * | 1995-06-01 | 2001-06-25 | Nowicky Wassyl Dr | Mittel zur behandlung von strahlenschäden |
| AT408719B (de) | 2000-03-22 | 2002-02-25 | Nowicky Wassili | Mittel zur behandlung von hepatitis c |
| CH695417A5 (de) | 2001-11-15 | 2006-05-15 | Ddr Wassyl Nowicky Dipl Ing | Verfahren zur Umsetzung von Alkaloiden. |
-
2003
- 2003-03-18 EP EP03006015A patent/EP1459753A1/en not_active Withdrawn
- 2003-06-19 CN CNA031373550A patent/CN1532198A/zh active Pending
-
2004
- 2004-03-12 ES ES04719983T patent/ES2346216T3/es not_active Expired - Lifetime
- 2004-03-12 WO PCT/EP2004/002637 patent/WO2004082698A1/en not_active Ceased
- 2004-03-12 JP JP2006504683A patent/JP5303719B2/ja not_active Expired - Fee Related
- 2004-03-12 PL PL04719983T patent/PL1644012T3/pl unknown
- 2004-03-12 ZA ZA200507020A patent/ZA200507020B/en unknown
- 2004-03-12 CA CA2517769A patent/CA2517769C/en not_active Expired - Fee Related
- 2004-03-12 GE GEAP20048963A patent/GEP20084501B/en unknown
- 2004-03-12 AU AU2004222661A patent/AU2004222661B2/en not_active Ceased
- 2004-03-12 SG SG200706589-9A patent/SG158748A1/en unknown
- 2004-03-12 EA EA200501473A patent/EA009049B1/ru not_active IP Right Cessation
- 2004-03-12 PT PT04719983T patent/PT1644012E/pt unknown
- 2004-03-12 EP EP04719983A patent/EP1644012B1/en not_active Expired - Lifetime
- 2004-03-12 US US10/549,433 patent/US7795434B2/en not_active Expired - Fee Related
- 2004-03-12 AT AT04719983T patent/ATE469651T1/de active
- 2004-03-12 MX MXPA05009919A patent/MXPA05009919A/es active IP Right Grant
- 2004-03-12 SI SI200431489T patent/SI1644012T1/sl unknown
- 2004-03-12 HR HRP20050987AA patent/HRP20050987B1/hr not_active IP Right Cessation
- 2004-03-12 BR BRPI0408386-5A patent/BRPI0408386A/pt not_active IP Right Cessation
- 2004-03-12 DK DK04719983.1T patent/DK1644012T3/da active
- 2004-03-12 DE DE602004027496T patent/DE602004027496D1/de not_active Expired - Lifetime
- 2004-03-12 KR KR1020057017086A patent/KR101020680B1/ko not_active Expired - Fee Related
- 2004-03-12 NZ NZ542151A patent/NZ542151A/en not_active IP Right Cessation
- 2004-03-16 MY MYPI20040919A patent/MY141779A/en unknown
- 2004-03-17 AR ARP040100877A patent/AR043629A1/es not_active Application Discontinuation
- 2004-03-17 CL CL200400552A patent/CL2004000552A1/es unknown
- 2004-03-17 PE PE2004000281A patent/PE20050351A1/es not_active Application Discontinuation
- 2004-03-18 GT GT200400046A patent/GT200400046A/es unknown
- 2004-03-18 TW TW093107196A patent/TWI347939B/zh not_active IP Right Cessation
- 2004-03-18 PA PA20048598201A patent/PA8598201A1/es unknown
- 2004-12-03 UA UAA200509763A patent/UA89353C2/uk unknown
-
2005
- 2005-08-25 IL IL170505A patent/IL170505A/en not_active IP Right Cessation
- 2005-09-06 NO NO20054130A patent/NO333672B1/no not_active IP Right Cessation
- 2005-09-16 TN TNP2005000230A patent/TNSN05230A1/en unknown
- 2005-10-17 MA MA28556A patent/MA27833A1/fr unknown
-
2008
- 2008-08-08 CL CL2008002345A patent/CL2008002345A1/es unknown
-
2010
- 2010-08-20 CY CY20101100773T patent/CY1112598T1/el unknown
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