HRP20050987B1 - Kvaterni derivati helidonina i alkaloida, postupak njihovog dobivanja i njihova upotreba u proizvodnji lijekova - Google Patents

Kvaterni derivati helidonina i alkaloida, postupak njihovog dobivanja i njihova upotreba u proizvodnji lijekova

Info

Publication number
HRP20050987B1
HRP20050987B1 HRP20050987AA HRP20050987A HRP20050987B1 HR P20050987 B1 HRP20050987 B1 HR P20050987B1 HR P20050987A A HRP20050987A A HR P20050987AA HR P20050987 A HRP20050987 A HR P20050987A HR P20050987 B1 HRP20050987 B1 HR P20050987B1
Authority
HR
Croatia
Prior art keywords
production
water
reaction products
helidonin
medicines
Prior art date
Application number
HRP20050987AA
Other languages
English (en)
Croatian (hr)
Inventor
Wassyl Nowicky
Original Assignee
Wassyl Nowicky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wassyl Nowicky filed Critical Wassyl Nowicky
Publication of HRP20050987A2 publication Critical patent/HRP20050987A2/xx
Publication of HRP20050987B1 publication Critical patent/HRP20050987B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
HRP20050987AA 2003-03-18 2004-03-12 Kvaterni derivati helidonina i alkaloida, postupak njihovog dobivanja i njihova upotreba u proizvodnji lijekova HRP20050987B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03006015A EP1459753A1 (en) 2003-03-18 2003-03-18 Quaternary chelidonine and alkaloid derivatives, process for their preparation and their use in the manufacture of medicaments
PCT/EP2004/002637 WO2004082698A1 (en) 2003-03-18 2004-03-12 Quaternary chelidonine and alkaloid derivatives, process for their preparation and their use in manufacture of medicaments

Publications (2)

Publication Number Publication Date
HRP20050987A2 HRP20050987A2 (en) 2007-07-31
HRP20050987B1 true HRP20050987B1 (hr) 2014-03-28

Family

ID=32798820

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20050987AA HRP20050987B1 (hr) 2003-03-18 2004-03-12 Kvaterni derivati helidonina i alkaloida, postupak njihovog dobivanja i njihova upotreba u proizvodnji lijekova

Country Status (36)

Country Link
US (1) US7795434B2 (enExample)
EP (2) EP1459753A1 (enExample)
JP (1) JP5303719B2 (enExample)
KR (1) KR101020680B1 (enExample)
CN (1) CN1532198A (enExample)
AR (1) AR043629A1 (enExample)
AT (1) ATE469651T1 (enExample)
AU (1) AU2004222661B2 (enExample)
BR (1) BRPI0408386A (enExample)
CA (1) CA2517769C (enExample)
CL (2) CL2004000552A1 (enExample)
CY (1) CY1112598T1 (enExample)
DE (1) DE602004027496D1 (enExample)
DK (1) DK1644012T3 (enExample)
EA (1) EA009049B1 (enExample)
ES (1) ES2346216T3 (enExample)
GE (1) GEP20084501B (enExample)
GT (1) GT200400046A (enExample)
HR (1) HRP20050987B1 (enExample)
IL (1) IL170505A (enExample)
MA (1) MA27833A1 (enExample)
MX (1) MXPA05009919A (enExample)
MY (1) MY141779A (enExample)
NO (1) NO333672B1 (enExample)
NZ (1) NZ542151A (enExample)
PA (1) PA8598201A1 (enExample)
PE (1) PE20050351A1 (enExample)
PL (1) PL1644012T3 (enExample)
PT (1) PT1644012E (enExample)
SG (1) SG158748A1 (enExample)
SI (1) SI1644012T1 (enExample)
TN (1) TNSN05230A1 (enExample)
TW (1) TWI347939B (enExample)
UA (1) UA89353C2 (enExample)
WO (1) WO2004082698A1 (enExample)
ZA (1) ZA200507020B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20080284A1 (it) * 2008-02-22 2009-08-23 Indena Spa Agenti antitumorali a struttura benzofenantridinica e formulazioni che li contengono
WO2009148623A2 (en) 2008-06-05 2009-12-10 Stc.Unm Methods and related compositions for the treatment of cancer
CN102552264A (zh) * 2012-02-28 2012-07-11 苏州大学 血根碱在制备电离辐射防护剂中的应用
WO2021073603A1 (en) * 2019-10-17 2021-04-22 Chengdu Anticancer Bioscience, Ltd. Benzophenanthridine alkaloids and their methods of use
CN113372355B (zh) * 2021-05-13 2023-02-17 山东大学 六氢苯并菲啶类生物碱及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865830A (en) 1969-06-16 1975-02-11 Nikolai Mikhailovich Turkevich Thiophosphamide derivatives of isoquinoline alkaloids, method of producing and application thereof
SU368254A1 (ru) 1969-06-16 1973-01-26 А. И. Потопальский , В. М. Новицкий Львовский государственный медицинский институт Способ получения соединений тиофосфамида с алкалоидами чистотела большого
AT354644B (de) 1975-12-19 1980-01-25 Nowicky Wassili Verfahren zur herstellung von neuen salzen von alkaloidderivaten von thiophosphorsaeure
AT377988B (de) 1976-06-28 1985-05-28 Nowicky Wassili Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden
DE3128018A1 (de) 1981-07-13 1983-04-07 Wassyl 1060 Wien Nowicky "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze"
US4970212A (en) 1982-05-18 1990-11-13 Nowicky Wassili Method of treating human illnesses which compromise the ability to mount an effective immunological response
AT407833B (de) 1995-06-01 2001-06-25 Nowicky Wassyl Dr Mittel zur behandlung von strahlenschäden
AT408719B (de) 2000-03-22 2002-02-25 Nowicky Wassili Mittel zur behandlung von hepatitis c
CH695417A5 (de) 2001-11-15 2006-05-15 Ddr Wassyl Nowicky Dipl Ing Verfahren zur Umsetzung von Alkaloiden.

Also Published As

Publication number Publication date
KR20060010726A (ko) 2006-02-02
JP2006520763A (ja) 2006-09-14
PT1644012E (pt) 2010-07-29
ZA200507020B (en) 2006-11-29
NO20054130L (no) 2005-12-19
UA89353C2 (uk) 2010-01-25
CY1112598T1 (el) 2016-02-10
NO20054130D0 (no) 2005-09-06
MXPA05009919A (es) 2006-03-21
WO2004082698A1 (en) 2004-09-30
ES2346216T3 (es) 2010-10-13
PE20050351A1 (es) 2005-05-04
TW200505467A (en) 2005-02-16
CA2517769A1 (en) 2004-09-30
DE602004027496D1 (de) 2010-07-15
PA8598201A1 (es) 2004-11-26
AU2004222661A1 (en) 2004-09-30
TWI347939B (en) 2011-09-01
KR101020680B1 (ko) 2011-03-09
US7795434B2 (en) 2010-09-14
CL2004000552A1 (es) 2005-01-21
IL170505A (en) 2013-04-30
EP1459753A1 (en) 2004-09-22
AU2004222661B2 (en) 2008-10-02
EP1644012B1 (en) 2010-06-02
CN1532198A (zh) 2004-09-29
AR043629A1 (es) 2005-08-03
CL2008002345A1 (es) 2009-01-02
MY141779A (en) 2010-06-30
NO333672B1 (no) 2013-08-05
TNSN05230A1 (en) 2007-06-11
SG158748A1 (en) 2010-02-26
CA2517769C (en) 2012-09-25
EA200501473A1 (ru) 2006-02-24
GT200400046A (es) 2005-11-24
JP5303719B2 (ja) 2013-10-02
ATE469651T1 (de) 2010-06-15
NZ542151A (en) 2008-11-28
GEP20084501B (en) 2008-10-10
US20060154947A1 (en) 2006-07-13
BRPI0408386A (pt) 2006-03-21
DK1644012T3 (da) 2010-10-04
PL1644012T3 (pl) 2011-01-31
HRP20050987A2 (en) 2007-07-31
SI1644012T1 (sl) 2010-10-29
MA27833A1 (fr) 2006-04-03
EP1644012A1 (en) 2006-04-12
EA009049B1 (ru) 2007-10-26

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