MA27833A1 - CHELIDONINE QUATERNAIRE ET DERIVES ALCALOiDES, PROCEDE POUR LEUR PREPARATION ET LEUR UTILISATION DANS LA FABRICATION DE MEDICAMENTS - Google Patents
CHELIDONINE QUATERNAIRE ET DERIVES ALCALOiDES, PROCEDE POUR LEUR PREPARATION ET LEUR UTILISATION DANS LA FABRICATION DE MEDICAMENTSInfo
- Publication number
- MA27833A1 MA27833A1 MA28556A MA28556A MA27833A1 MA 27833 A1 MA27833 A1 MA 27833A1 MA 28556 A MA28556 A MA 28556A MA 28556 A MA28556 A MA 28556A MA 27833 A1 MA27833 A1 MA 27833A1
- Authority
- MA
- Morocco
- Prior art keywords
- alkaloid
- medicaments
- quaternary
- water
- reaction products
- Prior art date
Links
- 150000003797 alkaloid derivatives Chemical group 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- GHKISGDRQRSCII-ZOCIIQOWSA-N chelidonine Chemical group C1=C2[C@H]3N(C)CC4=C(OCO5)C5=CC=C4[C@H]3[C@@H](O)CC2=CC2=C1OCO2 GHKISGDRQRSCII-ZOCIIQOWSA-N 0.000 title 2
- VINIVXVRXVXNTR-UHFFFAOYSA-N Chelidonin Natural products CN1Cc2c3OCOc3ccc2C4C(O)Cc5c6OCOc6ccc5C14 VINIVXVRXVXNTR-UHFFFAOYSA-N 0.000 title 1
- GHKISGDRQRSCII-UHFFFAOYSA-N chelidonine Natural products C1=C2C3N(C)CC4=C(OCO5)C5=CC=C4C3C(O)CC2=CC2=C1OCO2 GHKISGDRQRSCII-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229930013930 alkaloid Natural products 0.000 abstract 3
- 239000007795 chemical reaction product Substances 0.000 abstract 3
- 229940100198 alkylating agent Drugs 0.000 abstract 2
- 239000002168 alkylating agent Substances 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 230000003818 metabolic dysfunction Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960001196 thiotepa Drugs 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/564—Three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Toxicology (AREA)
Abstract
Extrait L'invention porte sur des produits de réaction alcaloïdes obtenus dans un procédé oé les alcaloïdes sont réagis avec un agent alkylant, de préférence thiotépa, oé ensuite l'agent alkylant non réagit et d'autres composés solubles dans l'eau sont éliminés du mélange de réaction par lavage avec de l'eau ou un solvant aqueux approprié, oé ensuite le mélange de réaction est soumis à un traitement avec de l'acide fort, de préférence du chlorure d'hydrogène (HCI), pour précipiter un sel soluble dans l'eau des produits de réaction. Les produits de réaction précipités comprennent au moins un dérivé alcaloïde quaternaire et sont appropriés comme médicaments pour l'application prophylactique ou thérapeutique, en particulier dans le traitement des dysfonctionnements immunologiques ou métaboliques, et le cancer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03006015A EP1459753A1 (fr) | 2003-03-18 | 2003-03-18 | Dérivés quaternaires de chelidonine et d'alkaloides, procédé pour leur préparation et leur utilisation dans la préparation de médicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27833A1 true MA27833A1 (fr) | 2006-04-03 |
Family
ID=32798820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA28556A MA27833A1 (fr) | 2003-03-18 | 2005-10-17 | CHELIDONINE QUATERNAIRE ET DERIVES ALCALOiDES, PROCEDE POUR LEUR PREPARATION ET LEUR UTILISATION DANS LA FABRICATION DE MEDICAMENTS |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US7795434B2 (fr) |
| EP (2) | EP1459753A1 (fr) |
| JP (1) | JP5303719B2 (fr) |
| KR (1) | KR101020680B1 (fr) |
| CN (1) | CN1532198A (fr) |
| AR (1) | AR043629A1 (fr) |
| AT (1) | ATE469651T1 (fr) |
| AU (1) | AU2004222661B2 (fr) |
| BR (1) | BRPI0408386A (fr) |
| CA (1) | CA2517769C (fr) |
| CL (2) | CL2004000552A1 (fr) |
| CY (1) | CY1112598T1 (fr) |
| DE (1) | DE602004027496D1 (fr) |
| DK (1) | DK1644012T3 (fr) |
| EA (1) | EA009049B1 (fr) |
| ES (1) | ES2346216T3 (fr) |
| GE (1) | GEP20084501B (fr) |
| GT (1) | GT200400046A (fr) |
| HR (1) | HRP20050987B1 (fr) |
| IL (1) | IL170505A (fr) |
| MA (1) | MA27833A1 (fr) |
| MX (1) | MXPA05009919A (fr) |
| MY (1) | MY141779A (fr) |
| NO (1) | NO333672B1 (fr) |
| NZ (1) | NZ542151A (fr) |
| PA (1) | PA8598201A1 (fr) |
| PE (1) | PE20050351A1 (fr) |
| PL (1) | PL1644012T3 (fr) |
| PT (1) | PT1644012E (fr) |
| SG (1) | SG158748A1 (fr) |
| SI (1) | SI1644012T1 (fr) |
| TN (1) | TNSN05230A1 (fr) |
| TW (1) | TWI347939B (fr) |
| UA (1) | UA89353C2 (fr) |
| WO (1) | WO2004082698A1 (fr) |
| ZA (1) | ZA200507020B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20080284A1 (it) * | 2008-02-22 | 2009-08-23 | Indena Spa | Agenti antitumorali a struttura benzofenantridinica e formulazioni che li contengono |
| US8835506B2 (en) | 2008-06-05 | 2014-09-16 | Stc.Unm | Methods and related compositions for the treatment of cancer |
| CN102552264A (zh) * | 2012-02-28 | 2012-07-11 | 苏州大学 | 血根碱在制备电离辐射防护剂中的应用 |
| WO2021073603A1 (fr) * | 2019-10-17 | 2021-04-22 | Chengdu Anticancer Bioscience, Ltd. | Alcaloïdes de benzophénanthridine et leurs procédés d'utilisation |
| CN113372355B (zh) * | 2021-05-13 | 2023-02-17 | 山东大学 | 六氢苯并菲啶类生物碱及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU368254A1 (ru) | 1969-06-16 | 1973-01-26 | А. И. Потопальский , В. М. Новицкий Львовский государственный медицинский институт | Способ получения соединений тиофосфамида с алкалоидами чистотела большого |
| US3865830A (en) * | 1969-06-16 | 1975-02-11 | Nikolai Mikhailovich Turkevich | Thiophosphamide derivatives of isoquinoline alkaloids, method of producing and application thereof |
| AT354644B (de) | 1975-12-19 | 1980-01-25 | Nowicky Wassili | Verfahren zur herstellung von neuen salzen von alkaloidderivaten von thiophosphorsaeure |
| AT377988B (de) * | 1976-06-28 | 1985-05-28 | Nowicky Wassili | Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden |
| DE3128018A1 (de) | 1981-07-13 | 1983-04-07 | Wassyl 1060 Wien Nowicky | "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze" |
| US4970212A (en) | 1982-05-18 | 1990-11-13 | Nowicky Wassili | Method of treating human illnesses which compromise the ability to mount an effective immunological response |
| AT407833B (de) * | 1995-06-01 | 2001-06-25 | Nowicky Wassyl Dr | Mittel zur behandlung von strahlenschäden |
| AT408719B (de) | 2000-03-22 | 2002-02-25 | Nowicky Wassili | Mittel zur behandlung von hepatitis c |
| CH695417A5 (de) | 2001-11-15 | 2006-05-15 | Ddr Wassyl Nowicky Dipl Ing | Verfahren zur Umsetzung von Alkaloiden. |
-
2003
- 2003-03-18 EP EP03006015A patent/EP1459753A1/fr not_active Withdrawn
- 2003-06-19 CN CNA031373550A patent/CN1532198A/zh active Pending
-
2004
- 2004-03-12 CA CA2517769A patent/CA2517769C/fr not_active Expired - Fee Related
- 2004-03-12 PL PL04719983T patent/PL1644012T3/pl unknown
- 2004-03-12 BR BRPI0408386-5A patent/BRPI0408386A/pt not_active IP Right Cessation
- 2004-03-12 EA EA200501473A patent/EA009049B1/ru not_active IP Right Cessation
- 2004-03-12 NZ NZ542151A patent/NZ542151A/en not_active IP Right Cessation
- 2004-03-12 DE DE602004027496T patent/DE602004027496D1/de not_active Expired - Lifetime
- 2004-03-12 PT PT04719983T patent/PT1644012E/pt unknown
- 2004-03-12 MX MXPA05009919A patent/MXPA05009919A/es active IP Right Grant
- 2004-03-12 AT AT04719983T patent/ATE469651T1/de active
- 2004-03-12 AU AU2004222661A patent/AU2004222661B2/en not_active Ceased
- 2004-03-12 JP JP2006504683A patent/JP5303719B2/ja not_active Expired - Fee Related
- 2004-03-12 SI SI200431489T patent/SI1644012T1/sl unknown
- 2004-03-12 GE GEAP20048963A patent/GEP20084501B/en unknown
- 2004-03-12 DK DK04719983.1T patent/DK1644012T3/da active
- 2004-03-12 KR KR1020057017086A patent/KR101020680B1/ko not_active IP Right Cessation
- 2004-03-12 ZA ZA200507020A patent/ZA200507020B/en unknown
- 2004-03-12 US US10/549,433 patent/US7795434B2/en not_active Expired - Fee Related
- 2004-03-12 WO PCT/EP2004/002637 patent/WO2004082698A1/fr active Search and Examination
- 2004-03-12 SG SG200706589-9A patent/SG158748A1/en unknown
- 2004-03-12 EP EP04719983A patent/EP1644012B1/fr not_active Expired - Lifetime
- 2004-03-12 ES ES04719983T patent/ES2346216T3/es not_active Expired - Lifetime
- 2004-03-16 MY MYPI20040919A patent/MY141779A/en unknown
- 2004-03-17 AR ARP040100877A patent/AR043629A1/es not_active Application Discontinuation
- 2004-03-17 CL CL200400552A patent/CL2004000552A1/es unknown
- 2004-03-17 PE PE2004000281A patent/PE20050351A1/es not_active Application Discontinuation
- 2004-03-18 GT GT200400046A patent/GT200400046A/es unknown
- 2004-03-18 PA PA20048598201A patent/PA8598201A1/es unknown
- 2004-03-18 TW TW093107196A patent/TWI347939B/zh not_active IP Right Cessation
- 2004-12-03 UA UAA200509763A patent/UA89353C2/uk unknown
-
2005
- 2005-08-25 IL IL170505A patent/IL170505A/en not_active IP Right Cessation
- 2005-09-06 NO NO20054130A patent/NO333672B1/no not_active IP Right Cessation
- 2005-09-16 TN TNP2005000230A patent/TNSN05230A1/en unknown
- 2005-10-17 MA MA28556A patent/MA27833A1/fr unknown
- 2005-12-08 HR HRP20050987AA patent/HRP20050987B1/hr not_active IP Right Cessation
-
2008
- 2008-08-08 CL CL2008002345A patent/CL2008002345A1/es unknown
-
2010
- 2010-08-20 CY CY20101100773T patent/CY1112598T1/el unknown
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