CL2004000552A1 - Procedimiento para la obtencion de un producto de reaccion alcaloide que comprende al menos un derivado de alcaloide que tiene un nitrogeno cuaternario; un producto de reaccion alcaloide; un derivado de quelidonina; y su uso para el tratamiento de in - Google Patents
Procedimiento para la obtencion de un producto de reaccion alcaloide que comprende al menos un derivado de alcaloide que tiene un nitrogeno cuaternario; un producto de reaccion alcaloide; un derivado de quelidonina; y su uso para el tratamiento de inInfo
- Publication number
- CL2004000552A1 CL2004000552A1 CL200400552A CL2004000552A CL2004000552A1 CL 2004000552 A1 CL2004000552 A1 CL 2004000552A1 CL 200400552 A CL200400552 A CL 200400552A CL 2004000552 A CL2004000552 A CL 2004000552A CL 2004000552 A1 CL2004000552 A1 CL 2004000552A1
- Authority
- CL
- Chile
- Prior art keywords
- reaction product
- alkaloid
- derivative
- alcaloid
- procedure
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 150000003797 alkaloid derivatives Chemical class 0.000 title 2
- 239000007795 chemical reaction product Substances 0.000 title 2
- 229930013930 alkaloid Natural products 0.000 title 1
- GHKISGDRQRSCII-ZOCIIQOWSA-N chelidonine Chemical class C1=C2[C@H]3N(C)CC4=C(OCO5)C5=CC=C4[C@H]3[C@@H](O)CC2=CC2=C1OCO2 GHKISGDRQRSCII-ZOCIIQOWSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/564—Three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Medical Informatics (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03006015A EP1459753A1 (en) | 2003-03-18 | 2003-03-18 | Quaternary chelidonine and alkaloid derivatives, process for their preparation and their use in the manufacture of medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004000552A1 true CL2004000552A1 (es) | 2005-01-21 |
Family
ID=32798820
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200400552A CL2004000552A1 (es) | 2003-03-18 | 2004-03-17 | Procedimiento para la obtencion de un producto de reaccion alcaloide que comprende al menos un derivado de alcaloide que tiene un nitrogeno cuaternario; un producto de reaccion alcaloide; un derivado de quelidonina; y su uso para el tratamiento de in |
| CL2008002345A CL2008002345A1 (es) | 2003-03-18 | 2008-08-08 | Compuesto derivado de quelidonina cuaternaria; procedimiento de preparacion; y su uso en la profilaxis o el tratamiento de una infeccion viral, cancer, disfuncion inmunologica, disfuncion metabolica y daño por radiacion. (divisional de la sol.552-04) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2008002345A CL2008002345A1 (es) | 2003-03-18 | 2008-08-08 | Compuesto derivado de quelidonina cuaternaria; procedimiento de preparacion; y su uso en la profilaxis o el tratamiento de una infeccion viral, cancer, disfuncion inmunologica, disfuncion metabolica y daño por radiacion. (divisional de la sol.552-04) |
Country Status (36)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20080284A1 (it) * | 2008-02-22 | 2009-08-23 | Indena Spa | Agenti antitumorali a struttura benzofenantridinica e formulazioni che li contengono |
| WO2009148623A2 (en) | 2008-06-05 | 2009-12-10 | Stc.Unm | Methods and related compositions for the treatment of cancer |
| CN102552264A (zh) * | 2012-02-28 | 2012-07-11 | 苏州大学 | 血根碱在制备电离辐射防护剂中的应用 |
| WO2021073603A1 (en) * | 2019-10-17 | 2021-04-22 | Chengdu Anticancer Bioscience, Ltd. | Benzophenanthridine alkaloids and their methods of use |
| CN113372355B (zh) * | 2021-05-13 | 2023-02-17 | 山东大学 | 六氢苯并菲啶类生物碱及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3865830A (en) | 1969-06-16 | 1975-02-11 | Nikolai Mikhailovich Turkevich | Thiophosphamide derivatives of isoquinoline alkaloids, method of producing and application thereof |
| SU368254A1 (ru) | 1969-06-16 | 1973-01-26 | А. И. Потопальский , В. М. Новицкий Львовский государственный медицинский институт | Способ получения соединений тиофосфамида с алкалоидами чистотела большого |
| AT354644B (de) | 1975-12-19 | 1980-01-25 | Nowicky Wassili | Verfahren zur herstellung von neuen salzen von alkaloidderivaten von thiophosphorsaeure |
| AT377988B (de) | 1976-06-28 | 1985-05-28 | Nowicky Wassili | Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden |
| DE3128018A1 (de) | 1981-07-13 | 1983-04-07 | Wassyl 1060 Wien Nowicky | "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze" |
| US4970212A (en) | 1982-05-18 | 1990-11-13 | Nowicky Wassili | Method of treating human illnesses which compromise the ability to mount an effective immunological response |
| AT407833B (de) * | 1995-06-01 | 2001-06-25 | Nowicky Wassyl Dr | Mittel zur behandlung von strahlenschäden |
| AT408719B (de) | 2000-03-22 | 2002-02-25 | Nowicky Wassili | Mittel zur behandlung von hepatitis c |
| CH695417A5 (de) | 2001-11-15 | 2006-05-15 | Ddr Wassyl Nowicky Dipl Ing | Verfahren zur Umsetzung von Alkaloiden. |
-
2003
- 2003-03-18 EP EP03006015A patent/EP1459753A1/en not_active Withdrawn
- 2003-06-19 CN CNA031373550A patent/CN1532198A/zh active Pending
-
2004
- 2004-03-12 EP EP04719983A patent/EP1644012B1/en not_active Expired - Lifetime
- 2004-03-12 ZA ZA200507020A patent/ZA200507020B/en unknown
- 2004-03-12 WO PCT/EP2004/002637 patent/WO2004082698A1/en not_active Ceased
- 2004-03-12 KR KR1020057017086A patent/KR101020680B1/ko not_active Expired - Fee Related
- 2004-03-12 JP JP2006504683A patent/JP5303719B2/ja not_active Expired - Fee Related
- 2004-03-12 ES ES04719983T patent/ES2346216T3/es not_active Expired - Lifetime
- 2004-03-12 SG SG200706589-9A patent/SG158748A1/en unknown
- 2004-03-12 GE GEAP20048963A patent/GEP20084501B/en unknown
- 2004-03-12 MX MXPA05009919A patent/MXPA05009919A/es active IP Right Grant
- 2004-03-12 US US10/549,433 patent/US7795434B2/en not_active Expired - Fee Related
- 2004-03-12 PT PT04719983T patent/PT1644012E/pt unknown
- 2004-03-12 HR HRP20050987AA patent/HRP20050987B1/hr not_active IP Right Cessation
- 2004-03-12 NZ NZ542151A patent/NZ542151A/en not_active IP Right Cessation
- 2004-03-12 DE DE602004027496T patent/DE602004027496D1/de not_active Expired - Lifetime
- 2004-03-12 DK DK04719983.1T patent/DK1644012T3/da active
- 2004-03-12 EA EA200501473A patent/EA009049B1/ru not_active IP Right Cessation
- 2004-03-12 CA CA2517769A patent/CA2517769C/en not_active Expired - Fee Related
- 2004-03-12 BR BRPI0408386-5A patent/BRPI0408386A/pt not_active IP Right Cessation
- 2004-03-12 AU AU2004222661A patent/AU2004222661B2/en not_active Ceased
- 2004-03-12 PL PL04719983T patent/PL1644012T3/pl unknown
- 2004-03-12 SI SI200431489T patent/SI1644012T1/sl unknown
- 2004-03-12 AT AT04719983T patent/ATE469651T1/de active
- 2004-03-16 MY MYPI20040919A patent/MY141779A/en unknown
- 2004-03-17 PE PE2004000281A patent/PE20050351A1/es not_active Application Discontinuation
- 2004-03-17 AR ARP040100877A patent/AR043629A1/es not_active Application Discontinuation
- 2004-03-17 CL CL200400552A patent/CL2004000552A1/es unknown
- 2004-03-18 TW TW093107196A patent/TWI347939B/zh not_active IP Right Cessation
- 2004-03-18 PA PA20048598201A patent/PA8598201A1/es unknown
- 2004-03-18 GT GT200400046A patent/GT200400046A/es unknown
- 2004-12-03 UA UAA200509763A patent/UA89353C2/uk unknown
-
2005
- 2005-08-25 IL IL170505A patent/IL170505A/en not_active IP Right Cessation
- 2005-09-06 NO NO20054130A patent/NO333672B1/no not_active IP Right Cessation
- 2005-09-16 TN TNP2005000230A patent/TNSN05230A1/en unknown
- 2005-10-17 MA MA28556A patent/MA27833A1/fr unknown
-
2008
- 2008-08-08 CL CL2008002345A patent/CL2008002345A1/es unknown
-
2010
- 2010-08-20 CY CY20101100773T patent/CY1112598T1/el unknown
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