JP2006519023A5 - - Google Patents
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- Publication number
- JP2006519023A5 JP2006519023A5 JP2006504501A JP2006504501A JP2006519023A5 JP 2006519023 A5 JP2006519023 A5 JP 2006519023A5 JP 2006504501 A JP2006504501 A JP 2006504501A JP 2006504501 A JP2006504501 A JP 2006504501A JP 2006519023 A5 JP2006519023 A5 JP 2006519023A5
- Authority
- JP
- Japan
- Prior art keywords
- medium
- virus
- culture medium
- fresh
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 241001465754 Metazoa Species 0.000 claims 11
- 241000700605 Viruses Species 0.000 claims 10
- 239000004365 Protease Substances 0.000 claims 9
- 239000006143 cell culture medium Substances 0.000 claims 9
- 102000035195 Peptidases Human genes 0.000 claims 7
- 108091005804 Peptidases Proteins 0.000 claims 7
- 239000003636 conditioned culture medium Substances 0.000 claims 7
- 235000019419 proteases Nutrition 0.000 claims 7
- 239000012737 fresh medium Substances 0.000 claims 6
- 239000001963 growth medium Substances 0.000 claims 5
- 108090000395 Cysteine Endopeptidases Proteins 0.000 claims 4
- 102000003950 Cysteine Endopeptidases Human genes 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 4
- 230000001143 conditioned effect Effects 0.000 claims 4
- 230000001419 dependent effect Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000007935 neutral effect Effects 0.000 claims 4
- ZHQQRIUYLMXDPP-SSDOTTSWSA-N Actinidine Natural products C1=NC=C(C)C2=C1[C@H](C)CC2 ZHQQRIUYLMXDPP-SSDOTTSWSA-N 0.000 claims 2
- 108090000270 Ficain Proteins 0.000 claims 2
- 101001013208 Homo sapiens Mediator of RNA polymerase II transcription subunit 15 Proteins 0.000 claims 2
- 102100027612 Kallikrein-11 Human genes 0.000 claims 2
- 102100029663 Mediator of RNA polymerase II transcription subunit 15 Human genes 0.000 claims 2
- 102000012479 Serine Proteases Human genes 0.000 claims 2
- 108010022999 Serine Proteases Proteins 0.000 claims 2
- 101710152431 Trypsin-like protease Proteins 0.000 claims 2
- ZHQQRIUYLMXDPP-ZETCQYMHSA-N actinidine Chemical compound C1=NC=C(C)C2=C1[C@@H](C)CC2 ZHQQRIUYLMXDPP-ZETCQYMHSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 239000006285 cell suspension Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 235000019836 ficin Nutrition 0.000 claims 2
- POTUGHMKJGOKRI-UHFFFAOYSA-N ficin Chemical compound FI=CI=N POTUGHMKJGOKRI-UHFFFAOYSA-N 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 238000010899 nucleation Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000003531 protein hydrolysate Substances 0.000 claims 2
- 108090000346 stem bromelain Proteins 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000711386 Mumps virus Species 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 101710180012 Protease 7 Proteins 0.000 claims 1
- 241000710799 Rubella virus Species 0.000 claims 1
- 241000209140 Triticum Species 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 230000021164 cell adhesion Effects 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 229960004854 viral vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0304799.0A GB0304799D0 (en) | 2003-03-03 | 2003-03-03 | Novel method |
| GB0304799.0 | 2003-03-03 | ||
| PCT/EP2004/002067 WO2004078955A1 (en) | 2003-03-03 | 2004-03-01 | Animal-free cell culture method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010157682A Division JP2010273683A (ja) | 2003-03-03 | 2010-07-12 | 動物を含まない細胞培養方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006519023A JP2006519023A (ja) | 2006-08-24 |
| JP2006519023A5 true JP2006519023A5 (https=) | 2007-04-19 |
| JP4787739B2 JP4787739B2 (ja) | 2011-10-05 |
Family
ID=9953995
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006504501A Expired - Fee Related JP4787739B2 (ja) | 2003-03-03 | 2004-03-01 | 動物を含まない細胞培養方法 |
| JP2010157682A Pending JP2010273683A (ja) | 2003-03-03 | 2010-07-12 | 動物を含まない細胞培養方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010157682A Pending JP2010273683A (ja) | 2003-03-03 | 2010-07-12 | 動物を含まない細胞培養方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8034617B2 (https=) |
| EP (3) | EP2186885A1 (https=) |
| JP (2) | JP4787739B2 (https=) |
| KR (1) | KR101242090B1 (https=) |
| CN (2) | CN1756837B (https=) |
| AU (1) | AU2004217807B2 (https=) |
| BR (1) | BRPI0407636A (https=) |
| CA (1) | CA2517327A1 (https=) |
| CO (1) | CO5601047A2 (https=) |
| GB (1) | GB0304799D0 (https=) |
| IS (1) | IS7992A (https=) |
| MA (1) | MA27631A1 (https=) |
| MX (1) | MXPA05009096A (https=) |
| NO (1) | NO20054124L (https=) |
| NZ (1) | NZ541908A (https=) |
| RU (1) | RU2369634C2 (https=) |
| WO (1) | WO2004078955A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2396689T3 (es) | 2003-12-11 | 2013-02-25 | Isto Technologies Inc. | Sistema de cartílago particulado |
| JP4650798B2 (ja) | 2004-04-19 | 2011-03-16 | デンカ生研株式会社 | ウイルスの生産方法 |
| AU2005302516A1 (en) * | 2004-10-29 | 2006-05-11 | Centocor, Inc. | Chemically defined media compositions |
| JP4693839B2 (ja) * | 2005-03-10 | 2011-06-01 | 共立製薬株式会社 | 動物由来の成分なしで培養可能である細胞株及びその作出方法、これを用いたウイルスの生産方法、及びワクチンの生産方法 |
| JP2008541746A (ja) * | 2005-06-03 | 2008-11-27 | ビオヴィトルム・アクチボラゲット（プブリクト） | 新規プロセス |
| EP1916964A4 (en) | 2005-08-26 | 2015-11-04 | Zimmer Inc | IMPLANTS AND METHODS FOR THE REPAIR, REPLACEMENT AND TREATMENT OF JOINT DISEASES |
| EP1764117A1 (en) | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implant for the repair of a cartilage defect and method for manufacturing the implant |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| AU2008240191B2 (en) | 2007-04-12 | 2013-09-19 | Zimmer, Inc. | Compositions and methods for tissue repair |
| FI20075417A0 (fi) * | 2007-06-05 | 2007-06-05 | Marjo-Riitta Suuronen | Koostumuksia ja menetelmiä alkion kantasolujen kasvatukseen |
| KR101594046B1 (ko) | 2008-01-09 | 2016-02-15 | 첼카 게엠베하 | 개선된 배양 배지 첨가제 및 이를 이용한 방법 |
| PE20110992A1 (es) | 2009-02-17 | 2012-02-12 | Glaxosmithkline Biolog Sa | Composicion inmunogenica que comprende un antigeno del virus del dengue |
| CA2797356C (en) * | 2010-04-26 | 2020-12-29 | Novartis Ag | Improved cell culture medium |
| CN101831415B (zh) * | 2010-05-12 | 2012-05-30 | 江苏博立生物制品有限公司 | 一种提高糖化酶发酵水平的方法 |
| DK2681306T3 (en) * | 2011-02-28 | 2019-04-23 | Harvard College | CELL CULTURE SYSTEM |
| PT2788009T (pt) | 2011-12-08 | 2016-08-31 | Yeda Res & Dev | Células pulmonares fetais de mamíferos e uso terapêutico das mesmas |
| US9493744B2 (en) * | 2012-06-20 | 2016-11-15 | Genentech, Inc. | Methods for viral inactivation and other adventitious agents |
| US20130281355A1 (en) * | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
| JP6041199B2 (ja) * | 2012-09-14 | 2016-12-07 | 国立大学法人大阪大学 | 三次元細胞培養体の製造方法 |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| EP4026563B1 (en) | 2015-06-18 | 2025-10-29 | Yeda Research and Development Co. Ltd | Conditioning protocols and use of same for tissue regeneration |
| US10004795B2 (en) * | 2015-09-08 | 2018-06-26 | Fundacao Butantan | Process for preparing an attenuated tetravalent dengue vaccine |
| BE1024160B9 (fr) | 2015-12-22 | 2017-12-06 | Glaxosmithkline Biologicals Sa | Formulation immunogène |
| CN105567628B (zh) * | 2016-01-30 | 2019-07-12 | 令世鑫 | 一种全悬浮培养mdck细胞的低血清培养基 |
| CN105779376B (zh) * | 2016-03-24 | 2019-08-30 | 友康恒业生物科技（北京）有限公司 | 一种流感病毒分离无血清培养基及其用途和制备 |
| CN105695393B (zh) * | 2016-03-24 | 2019-09-10 | 友康恒业生物科技（北京）有限公司 | 一种mdck细胞无血清培养基及其用途和制备 |
| KR101925079B1 (ko) * | 2017-05-24 | 2018-12-04 | 가천대학교 산학협력단 | Dna 정제-증폭을 위한 통합형 마이크로 디바이스 및 이를 이용한 dna 정제-증폭 방법 |
| CN107432931B (zh) * | 2017-08-03 | 2018-04-13 | 长春祈健生物制品有限公司 | 一种微载体培养水痘病毒制备疫苗的方法 |
| MX2021006115A (es) | 2019-01-17 | 2021-07-07 | Boehringer Ingelheim Animal Health Usa Inc | Medio libre de suero para produccion de vacuna aviar y usos del mismo. |
| KR20220123019A (ko) | 2019-12-31 | 2022-09-05 | 에어 프로틴 인코포레이티드 | 고단백질 식품 조성물 |
| EP4093848A4 (en) * | 2020-01-24 | 2024-08-07 | Air Protein, Inc. | Microorganism-derived protein hydrolysates, and methods of preparation and use thereof |
| CN113373107B (zh) * | 2021-01-29 | 2022-12-30 | 上海生物制品研究所有限责任公司 | 一种大规模制备传代鸡胚细胞生产病毒的方法 |
| WO2024039216A1 (ko) * | 2022-08-19 | 2024-02-22 | 셀미트주식회사 | 동물세포 또는 동물 세포주의 배양방법 |
| CN115627255B (zh) * | 2022-12-01 | 2023-04-07 | 天信和(苏州)生物科技有限公司 | 一种采用低血清培养基培养人二倍体细胞的方法 |
| KR102926380B1 (ko) * | 2025-02-19 | 2026-02-12 | (주)엑셀세라퓨틱스 | 줄기세포 유래 엑소좀의 제조방법, 엑소좀 및 이를 포함하는 조성물 |
| CN119979445B (zh) * | 2025-04-10 | 2025-09-09 | 四川大学 | 一种培养基、口腔黏膜上皮细胞模型，及其制备方法和用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94611A (en) * | 1989-06-05 | 1994-12-29 | Organogenesis Inc | Medium for cell cultures containing insulin or growth factor similar to insulin, transferrin or iron ion, triiodothyronine or thyroxine and method of use |
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| DE4115722A1 (de) | 1991-05-14 | 1992-11-19 | Boehringer Mannheim Gmbh | Serumfreies medium zur kultivierung von saeugerzellen |
| RU2057176C1 (ru) * | 1992-05-20 | 1996-03-27 | Институт генетики АН Республики Молдова | Питательная среда для культивирования клеток человека и животных |
| DZ1706A1 (fr) * | 1992-08-07 | 2002-02-17 | Merck & Co Inc | Vaccin contre le virus de l'hepatite a. |
| EP0666751B1 (en) | 1992-09-18 | 2001-09-12 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Mutants of hepatitis a virus strain hm-175 for use as hepatitis a vaccines |
| CN1088984A (zh) * | 1993-11-11 | 1994-07-06 | 江西省医学科学研究所 | 一种用于造血祖细胞培养的无血清培养基 |
| HRP950097A2 (en) | 1994-03-08 | 1997-06-30 | Merck & Co Inc | Hepatitis a virus culture process |
| CA2205015C (en) | 1994-11-10 | 2003-04-08 | Otfried Kistner | Method for producing biologicals in protein-free culture |
| WO1998000521A1 (fr) * | 1996-06-28 | 1998-01-08 | The Green Cross Corporation | Milieux exempts de serum, methode de culture de cellules d'origine animale, et procede de production de substances physiologiquement actives |
| WO1998004680A1 (en) * | 1996-07-26 | 1998-02-05 | University Of Manitoba | Serum-free medium for growth of anchorage-dependant mammalian cells |
| US6103529A (en) * | 1996-10-10 | 2000-08-15 | Life Technologies, Inc. | Animal cell culture media comprising peptides derived from rice |
| WO1998059035A2 (en) * | 1997-06-25 | 1998-12-30 | The Goverment Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services, National Institutes Of Health | Serum-free cell growth medium |
| US6656719B1 (en) * | 1997-10-27 | 2003-12-02 | Merck & Co., Inc. | Serum-free, low-protein media for rotavirus vaccine production |
| FR2775983B1 (fr) | 1998-03-13 | 2000-11-10 | Pasteur Merieux Serums Vacc | Milieu et procede de propagation et de multiplication virales |
| WO1999057246A1 (en) * | 1998-05-01 | 1999-11-11 | Life Technologies, Inc. | Animal cell culture media comprising non-animal or plant-derived nutrients |
| US6406909B1 (en) | 1998-07-10 | 2002-06-18 | Chugai Seiyaku Kabushiki Kaisha | Serum-free medium for culturing animal cells |
| US6623959B2 (en) * | 2001-06-13 | 2003-09-23 | Ethicon, Inc. | Devices and methods for cell harvesting |
-
2003
- 2003-03-03 GB GBGB0304799.0A patent/GB0304799D0/en not_active Ceased
-
2004
- 2004-03-01 CN CN2004800058488A patent/CN1756837B/zh not_active Expired - Fee Related
- 2004-03-01 EP EP10151350A patent/EP2186885A1/en not_active Withdrawn
- 2004-03-01 AU AU2004217807A patent/AU2004217807B2/en not_active Ceased
- 2004-03-01 CN CNA2007101866779A patent/CN101200705A/zh active Pending
- 2004-03-01 MX MXPA05009096A patent/MXPA05009096A/es active IP Right Grant
- 2004-03-01 JP JP2006504501A patent/JP4787739B2/ja not_active Expired - Fee Related
- 2004-03-01 EP EP10151351A patent/EP2192175A1/en not_active Ceased
- 2004-03-01 NZ NZ541908A patent/NZ541908A/en unknown
- 2004-03-01 CA CA002517327A patent/CA2517327A1/en not_active Abandoned
- 2004-03-01 KR KR1020057016385A patent/KR101242090B1/ko not_active Expired - Fee Related
- 2004-03-01 WO PCT/EP2004/002067 patent/WO2004078955A1/en not_active Ceased
- 2004-03-01 BR BRPI0407636-2A patent/BRPI0407636A/pt not_active IP Right Cessation
- 2004-03-01 EP EP04715891A patent/EP1599580A1/en not_active Ceased
- 2004-03-01 RU RU2005125606/13A patent/RU2369634C2/ru not_active IP Right Cessation
- 2004-03-01 US US10/547,804 patent/US8034617B2/en not_active Expired - Fee Related
-
2005
- 2005-08-18 IS IS7992A patent/IS7992A/is unknown
- 2005-08-31 CO CO05087280A patent/CO5601047A2/es not_active Application Discontinuation
- 2005-09-05 NO NO20054124A patent/NO20054124L/no not_active Application Discontinuation
- 2005-09-09 MA MA28488A patent/MA27631A1/fr unknown
-
2010
- 2010-07-12 JP JP2010157682A patent/JP2010273683A/ja active Pending
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