JP2006515373A5 - - Google Patents
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- Publication number
- JP2006515373A5 JP2006515373A5 JP2006500749A JP2006500749A JP2006515373A5 JP 2006515373 A5 JP2006515373 A5 JP 2006515373A5 JP 2006500749 A JP2006500749 A JP 2006500749A JP 2006500749 A JP2006500749 A JP 2006500749A JP 2006515373 A5 JP2006515373 A5 JP 2006515373A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- formula
- pyridazin
- thieno
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 20
- -1 cyano, hydroxymethyl Chemical group 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 11
- DWHIRSWNWDXFMQ-UHFFFAOYSA-N 4h-pyridazin-5-one Chemical compound O=C1CC=NN=C1 DWHIRSWNWDXFMQ-UHFFFAOYSA-N 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 5
- MHCVCKDNQYMGEX-UHFFFAOYSA-N 1,1'-biphenyl;phenoxybenzene Chemical group C1=CC=CC=C1C1=CC=CC=C1.C=1C=CC=CC=1OC1=CC=CC=C1 MHCVCKDNQYMGEX-UHFFFAOYSA-N 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 229910052717 sulfur Chemical group 0.000 claims 4
- 239000011593 sulfur Chemical group 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 125000000464 thioxo group Chemical group S=* 0.000 claims 2
- OIWSCNLIZBUBKU-VWLOTQADSA-N 2-[(3,5-dimethyl-1-pyridin-2-ylpyrazol-4-yl)methyl]-7-ethyl-3-[(4s)-4-hydroxy-4-methyl-1,2-oxazolidine-2-carbonyl]-5-methylthieno[2,3-d]pyridazin-4-one Chemical compound CC1=NN(C=2N=CC=CC=2)C(C)=C1CC=1SC=2C(CC)=NN(C)C(=O)C=2C=1C(=O)N1C[C@](C)(O)CO1 OIWSCNLIZBUBKU-VWLOTQADSA-N 0.000 claims 1
- LIGIZFGWSFQIKC-ZDUSSCGKSA-N 2-[(3,5-dimethyl-1h-pyrazol-4-yl)methyl]-3-[(4s)-4-hydroxy-1,2-oxazolidine-2-carbonyl]-5-methyl-7-(2-methylpropyl)thieno[2,3-d]pyridazin-4-one Chemical compound CC1=NNC(C)=C1CC=1SC=2C(CC(C)C)=NN(C)C(=O)C=2C=1C(=O)N1C[C@H](O)CO1 LIGIZFGWSFQIKC-ZDUSSCGKSA-N 0.000 claims 1
- GQUIXLOQPRBJNH-NSHDSACASA-N 2-[(3,5-dimethyl-1h-pyrazol-4-yl)methyl]-7-ethyl-3-[(4s)-4-hydroxy-1,2-oxazolidine-2-carbonyl]-5-methylthieno[2,3-d]pyridazin-4-one Chemical compound CC1=NNC(C)=C1CC=1SC=2C(CC)=NN(C)C(=O)C=2C=1C(=O)N1C[C@H](O)CO1 GQUIXLOQPRBJNH-NSHDSACASA-N 0.000 claims 1
- HOIOIQPTCHIVDJ-FQEVSTJZSA-N 2-[(3,5-dimethyl-1h-pyrazol-4-yl)methyl]-7-ethyl-3-[(4s)-4-hydroxy-4-methyl-1,2-oxazolidine-2-carbonyl]-5-methylthieno[2,3-d]pyridazin-4-one Chemical compound CC1=NNC(C)=C1CC=1SC=2C(CC)=NN(C)C(=O)C=2C=1C(=O)N1C[C@](C)(O)CO1 HOIOIQPTCHIVDJ-FQEVSTJZSA-N 0.000 claims 1
- JJFADIPQVDQFNB-LBPRGKRZSA-N 7-cyclopropyl-2-[(3,5-dimethyl-1h-pyrazol-4-yl)methyl]-3-[(4s)-4-hydroxy-1,2-oxazolidine-2-carbonyl]-5-methylthieno[2,3-d]pyridazin-4-one Chemical compound CC1=NNC(C)=C1CC1=C(C(=O)N2OC[C@@H](O)C2)C(C(=O)N(C)N=C2C3CC3)=C2S1 JJFADIPQVDQFNB-LBPRGKRZSA-N 0.000 claims 1
- FACVQJBQWNITOR-NRFANRHFSA-N 7-cyclopropyl-2-[(3,5-dimethyl-1h-pyrazol-4-yl)methyl]-3-[(4s)-4-hydroxy-4-methyl-1,2-oxazolidine-2-carbonyl]-5-methylthieno[2,3-d]pyridazin-4-one Chemical compound CC1=NNC(C)=C1CC1=C(C(=O)N2OC[C@@](C)(O)C2)C(C(=O)N(C)N=C2C3CC3)=C2S1 FACVQJBQWNITOR-NRFANRHFSA-N 0.000 claims 1
- FLXIPFUVHRVGHE-ZDUSSCGKSA-N 7-cyclopropyl-2-[(3,5-dimethyl-1h-pyrazol-4-yl)methyl]-5-ethyl-3-[(4s)-4-hydroxy-1,2-oxazolidine-2-carbonyl]thieno[2,3-d]pyridazin-4-one Chemical compound C1=2SC(CC3=C(NN=C3C)C)=C(C(=O)N3OC[C@@H](O)C3)C=2C(=O)N(CC)N=C1C1CC1 FLXIPFUVHRVGHE-ZDUSSCGKSA-N 0.000 claims 1
- FILIGAJYNUCMJI-QFIPXVFZSA-N 7-ethyl-3-[(4s)-4-hydroxy-4-methyl-1,2-oxazolidine-2-carbonyl]-5-methyl-2-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)thieno[2,3-d]pyridazin-4-one Chemical compound C=1NC2=NC=CC=C2C=1CC=1SC=2C(CC)=NN(C)C(=O)C=2C=1C(=O)N1C[C@](C)(O)CO1 FILIGAJYNUCMJI-QFIPXVFZSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- AFABGHUZZDYHJO-UHFFFAOYSA-N 2-Methylpentane Chemical compound CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0300120A SE0300120D0 (sv) | 2003-01-17 | 2003-01-17 | Novel compounds |
| PCT/SE2004/000051 WO2004065393A1 (en) | 2003-01-17 | 2004-01-15 | Novel compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515373A JP2006515373A (ja) | 2006-05-25 |
| JP2006515373A5 true JP2006515373A5 (enExample) | 2007-03-01 |
| JP4589298B2 JP4589298B2 (ja) | 2010-12-01 |
Family
ID=20290155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500749A Expired - Fee Related JP4589298B2 (ja) | 2003-01-17 | 2004-01-15 | 新規化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7064126B2 (enExample) |
| EP (1) | EP1587809B1 (enExample) |
| JP (1) | JP4589298B2 (enExample) |
| KR (1) | KR20050092759A (enExample) |
| CN (1) | CN100358900C (enExample) |
| AT (1) | ATE375352T1 (enExample) |
| AU (1) | AU2004205617B2 (enExample) |
| BR (1) | BRPI0406780A (enExample) |
| CA (1) | CA2512736A1 (enExample) |
| DE (1) | DE602004009407T2 (enExample) |
| ES (1) | ES2293208T3 (enExample) |
| IL (1) | IL169363A (enExample) |
| IS (1) | IS2503B (enExample) |
| MX (1) | MXPA05007494A (enExample) |
| NO (1) | NO20053827L (enExample) |
| NZ (1) | NZ541216A (enExample) |
| PL (1) | PL378223A1 (enExample) |
| RU (1) | RU2331646C2 (enExample) |
| SE (1) | SE0300120D0 (enExample) |
| UA (1) | UA80175C2 (enExample) |
| WO (1) | WO2004065393A1 (enExample) |
| ZA (1) | ZA200505273B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117583D0 (en) * | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
| GB0118479D0 (en) * | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
| EP1587811A1 (en) * | 2003-01-17 | 2005-10-26 | AstraZeneca AB | Thienopyridazinones and their use in modulation of autoimmune disease |
| SE0300119D0 (sv) | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
| SE0300120D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
| ES2527118T3 (es) | 2003-12-19 | 2015-01-20 | Plexxikon Inc. | Compuestos y procedimientos de desarrollo de moduladores de Ret |
| US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| NZ563444A (en) | 2005-05-17 | 2011-04-29 | Plexxikon Inc | Pyrrolo(2,3-b)pyridine derivatives as protein kinase inhibitors |
| UA95244C2 (ru) | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
| CA2666603C (en) * | 2006-10-16 | 2013-08-06 | Pfizer Products Inc. | Therapeutic pyrazolyl thienopyridines and uses thereof for treating tgf.beta. mediated conditions |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| RU2009122670A (ru) | 2006-12-21 | 2011-01-27 | Плекссикон, Инк. (Us) | Соединения и способы для модуляции киназ и показания к их применению |
| PE20081581A1 (es) | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| SG183036A1 (en) | 2007-07-17 | 2012-08-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| EA022924B1 (ru) | 2009-04-03 | 2016-03-31 | Ф.Хоффманн-Ля Рош Аг | ТВЁРДАЯ ФОРМА {3-[5-(4-ХЛОРФЕНИЛ)-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ И ЕЁ ПРИМЕНЕНИЕ |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| MA33975B1 (fr) | 2009-11-06 | 2013-02-01 | Plexxikon Inc | Composés et méthodes de modulation des kinases et leurs indications d'emploi |
| JP5941069B2 (ja) | 2011-02-07 | 2016-06-29 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼ調節のための化合物および方法、ならびにそれに対する適応症 |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| US9200005B2 (en) * | 2013-03-13 | 2015-12-01 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
| ES2890552T3 (es) * | 2013-10-21 | 2022-01-20 | Genosco | Compuestos de pirimidina sustituidos y su uso como inhibidores de SYK |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3620860A1 (de) * | 1986-06-21 | 1987-12-23 | Basf Ag | Substituierte acrylsaeureester und fungizide, die diese verbindungen enthalten |
| SE9702001D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
| US6469014B1 (en) * | 1997-05-28 | 2002-10-22 | Astrazeneca Ab | Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy |
| DE69807741T2 (de) * | 1997-12-05 | 2004-07-15 | Astrazeneca Uk Ltd. | Neuartige verbindungen |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| ATE253580T1 (de) * | 1998-08-28 | 2003-11-15 | Astrazeneca Ab | Neue thieno(2,3-d)pyrimidindione, verfahren für ihre herstellung und ihre verwendung in der therapie |
| GB0117583D0 (en) * | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
| GB0118479D0 (en) | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
| SE0300120D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
| SE0300119D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
| EP1587811A1 (en) * | 2003-01-17 | 2005-10-26 | AstraZeneca AB | Thienopyridazinones and their use in modulation of autoimmune disease |
-
2003
- 2003-01-17 SE SE0300120A patent/SE0300120D0/xx unknown
-
2004
- 2004-01-15 AU AU2004205617A patent/AU2004205617B2/en not_active Ceased
- 2004-01-15 CN CNB2004800071016A patent/CN100358900C/zh not_active Expired - Fee Related
- 2004-01-15 UA UAA200506375A patent/UA80175C2/uk unknown
- 2004-01-15 CA CA002512736A patent/CA2512736A1/en not_active Abandoned
- 2004-01-15 RU RU2005121493/04A patent/RU2331646C2/ru not_active IP Right Cessation
- 2004-01-15 EP EP04702471A patent/EP1587809B1/en not_active Expired - Lifetime
- 2004-01-15 PL PL378223A patent/PL378223A1/pl unknown
- 2004-01-15 ES ES04702471T patent/ES2293208T3/es not_active Expired - Lifetime
- 2004-01-15 AT AT04702471T patent/ATE375352T1/de not_active IP Right Cessation
- 2004-01-15 US US10/542,194 patent/US7064126B2/en not_active Expired - Fee Related
- 2004-01-15 NZ NZ541216A patent/NZ541216A/en not_active IP Right Cessation
- 2004-01-15 BR BR0406780-0A patent/BRPI0406780A/pt not_active IP Right Cessation
- 2004-01-15 WO PCT/SE2004/000051 patent/WO2004065393A1/en not_active Ceased
- 2004-01-15 MX MXPA05007494A patent/MXPA05007494A/es active IP Right Grant
- 2004-01-15 DE DE602004009407T patent/DE602004009407T2/de not_active Expired - Lifetime
- 2004-01-15 JP JP2006500749A patent/JP4589298B2/ja not_active Expired - Fee Related
- 2004-01-15 KR KR1020057013124A patent/KR20050092759A/ko not_active Abandoned
-
2005
- 2005-06-23 IL IL169363A patent/IL169363A/en not_active IP Right Cessation
- 2005-06-29 ZA ZA200505273A patent/ZA200505273B/xx unknown
- 2005-08-15 NO NO20053827A patent/NO20053827L/no not_active Application Discontinuation
- 2005-08-15 IS IS7982A patent/IS2503B/is unknown
-
2006
- 2006-06-06 US US11/447,343 patent/US20060223809A1/en not_active Abandoned
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