JP2006514946A5 - - Google Patents
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- JP2006514946A5 JP2006514946A5 JP2004559325A JP2004559325A JP2006514946A5 JP 2006514946 A5 JP2006514946 A5 JP 2006514946A5 JP 2004559325 A JP2004559325 A JP 2004559325A JP 2004559325 A JP2004559325 A JP 2004559325A JP 2006514946 A5 JP2006514946 A5 JP 2006514946A5
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- Prior art keywords
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- disease
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- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 19
- 229910052757 nitrogen Inorganic materials 0.000 claims 18
- 239000000064 cholinergic agonist Substances 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 206010040047 Sepsis Diseases 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- AUBPMADJYNSPOA-UHFFFAOYSA-N Anabaseine Chemical compound C1CCCC(C=2C=NC=CC=2)=N1 AUBPMADJYNSPOA-UHFFFAOYSA-N 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- -1 CO 2 R 1 Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 229910052717 sulfur Chemical group 0.000 claims 6
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 5
- 206010033645 Pancreatitis Diseases 0.000 claims 5
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 5
- 206010040070 Septic Shock Diseases 0.000 claims 5
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 5
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 206010034674 peritonitis Diseases 0.000 claims 5
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 5
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 4
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 4
- 206010019280 Heart failures Diseases 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 206010025135 lupus erythematosus Diseases 0.000 claims 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 206010000228 Abortion infected Diseases 0.000 claims 3
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 claims 3
- 206010002199 Anaphylactic shock Diseases 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 3
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 3
- 206010028851 Necrosis Diseases 0.000 claims 3
- 206010033799 Paralysis Diseases 0.000 claims 3
- 208000002359 Septic Abortion Diseases 0.000 claims 3
- 208000007107 Stomach Ulcer Diseases 0.000 claims 3
- 208000026935 allergic disease Diseases 0.000 claims 3
- 230000007815 allergy Effects 0.000 claims 3
- 208000003455 anaphylaxis Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000000718 duodenal ulcer Diseases 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 208000024908 graft versus host disease Diseases 0.000 claims 3
- 208000006454 hepatitis Diseases 0.000 claims 3
- 231100000283 hepatitis Toxicity 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 230000017074 necrotic cell death Effects 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000020431 spinal cord injury Diseases 0.000 claims 3
- 210000002784 stomach Anatomy 0.000 claims 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
- 206010003011 Appendicitis Diseases 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- RPYWXZCFYPVCNQ-RVDMUPIBSA-N DMXB-A Chemical compound COC1=CC(OC)=CC=C1\C=C/1C(C=2C=NC=CC=2)=NCCC\1 RPYWXZCFYPVCNQ-RVDMUPIBSA-N 0.000 claims 2
- 206010014824 Endotoxic shock Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 201000005917 gastric ulcer Diseases 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 235000015220 hamburgers Nutrition 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 239000011593 sulfur Chemical group 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- MTXSIJUGVMTTMU-JTQLQIEISA-N (S)-anabasine Chemical compound N1CCCC[C@H]1C1=CC=CN=C1 MTXSIJUGVMTTMU-JTQLQIEISA-N 0.000 claims 1
- HQYLURGLNKLOQJ-UHFFFAOYSA-N 1-(2-fluorophenyl)ethyl n-(1-azabicyclo[2.2.2]octan-3-yl)carbamate Chemical compound C1N(CC2)CCC2C1NC(=O)OC(C)C1=CC=CC=C1F HQYLURGLNKLOQJ-UHFFFAOYSA-N 0.000 claims 1
- OJIVTDGHABSTCR-NTCAYCPXSA-N 3-[(5e)-5-[(4-methoxyphenyl)methylidene]-3,4-dihydro-2h-pyridin-6-yl]pyridine Chemical compound C1=CC(OC)=CC=C1\C=C/1C(C=2C=NC=CC=2)=NCCC\1 OJIVTDGHABSTCR-NTCAYCPXSA-N 0.000 claims 1
- PDVZKLQPQUIDDW-NRFANRHFSA-N 4-(4-acetamidophenoxy)-n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Chemical compound C1=CC(NC(=O)C)=CC=C1OC1=CC=C(C(=O)N[C@@H]2C3CCN(CC3)C2)C=C1 PDVZKLQPQUIDDW-NRFANRHFSA-N 0.000 claims 1
- WKIKOLZQZBUNSZ-SDNWHVSQSA-N 4-[(e)-(6-pyridin-3-yl-3,4-dihydro-2h-pyridin-5-ylidene)methyl]aniline Chemical compound C1=CC(N)=CC=C1\C=C/1C(C=2C=NC=CC=2)=NCCC\1 WKIKOLZQZBUNSZ-SDNWHVSQSA-N 0.000 claims 1
- GIRLVGYIIVFTLI-UHFFFAOYSA-N 5'-phenylspiro[1-azabicyclo[2.2.2]octane-3,2'-3h-furo[2,3-b]pyridine] Chemical group C=1N=C2OC3(C4CCN(CC4)C3)CC2=CC=1C1=CC=CC=C1 GIRLVGYIIVFTLI-UHFFFAOYSA-N 0.000 claims 1
- 206010001889 Alveolitis Diseases 0.000 claims 1
- 208000004881 Amebiasis Diseases 0.000 claims 1
- 206010001980 Amoebiasis Diseases 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000031729 Bacteremia Diseases 0.000 claims 1
- 208000027496 Behcet disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 206010006448 Bronchiolitis Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 206010007134 Candida infections Diseases 0.000 claims 1
- 206010008088 Cerebral artery embolism Diseases 0.000 claims 1
- 208000001490 Dengue Diseases 0.000 claims 1
- 206010012310 Dengue fever Diseases 0.000 claims 1
- 206010014096 Echinococciasis Diseases 0.000 claims 1
- 208000009366 Echinococcosis Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 208000000289 Esophageal Achalasia Diseases 0.000 claims 1
- 206010016228 Fasciitis Diseases 0.000 claims 1
- 201000006353 Filariasis Diseases 0.000 claims 1
- 206010061459 Gastrointestinal ulcer Diseases 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010018691 Granuloma Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 206010019973 Herpes virus infection Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000024781 Immune Complex disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 208000009525 Myocarditis Diseases 0.000 claims 1
- 206010029240 Neuritis Diseases 0.000 claims 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims 1
- 206010030136 Oesophageal achalasia Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 201000007100 Pharyngitis Diseases 0.000 claims 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 201000008100 Vaginitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000027207 Whipple disease Diseases 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
- 201000000621 achalasia Diseases 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 201000003984 candidiasis Diseases 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- KXAAIPFSUGPVMQ-GXDHUFHOSA-N chembl1162395 Chemical compound COC1=CC(O)=CC=C1\C=C/1C(C=2C=NC=CC=2)=NCCC\1 KXAAIPFSUGPVMQ-GXDHUFHOSA-N 0.000 claims 1
- JWWQXOCTMDBZHM-SDNWHVSQSA-N chembl1164116 Chemical compound C1=CC(O)=CC=C1\C=C/1C(C=2C=NC=CC=2)=NCCC\1 JWWQXOCTMDBZHM-SDNWHVSQSA-N 0.000 claims 1
- 208000003167 cholangitis Diseases 0.000 claims 1
- 201000001352 cholecystitis Diseases 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 208000025729 dengue disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 210000000918 epididymis Anatomy 0.000 claims 1
- 201000010063 epididymitis Diseases 0.000 claims 1
- 208000001606 epiglottitis Diseases 0.000 claims 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
- 208000021760 high fever Diseases 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 201000010849 intracranial embolism Diseases 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- NUJUJJCMBQWIFW-JRJWNBDDSA-M methyl (1s,3s,4r,5r)-3-benzoyloxy-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane-4-carboxylate;iodide Chemical group [I-].O([C@H]1C[C@@H]2CC[C@@H]([N+]2(C)C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 NUJUJJCMBQWIFW-JRJWNBDDSA-M 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000008494 pericarditis Diseases 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 208000008423 pleurisy Diseases 0.000 claims 1
- 201000006292 polyarteritis nodosa Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 230000010410 reperfusion Effects 0.000 claims 1
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000004595 synovitis Diseases 0.000 claims 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 claims 1
- 201000005060 thrombophlebitis Diseases 0.000 claims 1
- 206010043778 thyroiditis Diseases 0.000 claims 1
- 208000000143 urethritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43165002P | 2002-12-06 | 2002-12-06 | |
| US60/431,650 | 2002-12-06 | ||
| PCT/US2003/038708 WO2004052365A2 (en) | 2002-12-06 | 2003-12-05 | Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011014401A Division JP2011105745A (ja) | 2002-12-06 | 2011-01-26 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514946A JP2006514946A (ja) | 2006-05-18 |
| JP2006514946A5 true JP2006514946A5 (enExample) | 2007-02-01 |
| JP4750421B2 JP4750421B2 (ja) | 2011-08-17 |
Family
ID=32507772
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559325A Expired - Fee Related JP4750421B2 (ja) | 2002-12-06 | 2003-12-05 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2011014401A Withdrawn JP2011105745A (ja) | 2002-12-06 | 2011-01-26 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2013257181A Expired - Fee Related JP5925178B2 (ja) | 2002-12-06 | 2013-12-12 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2016007291A Pending JP2016084355A (ja) | 2002-12-06 | 2016-01-18 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011014401A Withdrawn JP2011105745A (ja) | 2002-12-06 | 2011-01-26 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2013257181A Expired - Fee Related JP5925178B2 (ja) | 2002-12-06 | 2013-12-12 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| JP2016007291A Pending JP2016084355A (ja) | 2002-12-06 | 2016-01-18 | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7273872B2 (enExample) |
| EP (3) | EP2062595A1 (enExample) |
| JP (4) | JP4750421B2 (enExample) |
| CN (2) | CN1735414A (enExample) |
| AT (1) | ATE378048T1 (enExample) |
| AU (1) | AU2003298939B2 (enExample) |
| CA (1) | CA2507502C (enExample) |
| DE (1) | DE60317564T2 (enExample) |
| DK (1) | DK1949901T3 (enExample) |
| ES (2) | ES2462545T3 (enExample) |
| IL (2) | IL168787A (enExample) |
| PT (1) | PT1949901E (enExample) |
| SI (1) | SI1949901T1 (enExample) |
| WO (1) | WO2004052365A2 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8188043B2 (en) * | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US7045534B2 (en) * | 2002-02-12 | 2006-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of reducing angiogenesis |
| US7273872B2 (en) * | 2002-12-06 | 2007-09-25 | The Feinstein Institute For Medical Research | Inhibition of inflammation using α 7 receptor-binding cholinergic agonists |
| US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
| EP1603585A2 (en) | 2003-03-14 | 2005-12-14 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| AU2005225458B2 (en) | 2004-03-25 | 2008-12-04 | The Feinstein Institutes For Medical Research | Neural tourniquet |
| US11207518B2 (en) * | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| ATE489132T1 (de) * | 2004-12-27 | 2010-12-15 | The Feinstein Inst Medical Res | Behandlung von entzündlichen erkrankungen durch elektrische stimulation des vagus-nervs |
| US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| BRPI0620080A2 (pt) * | 2005-12-19 | 2011-11-01 | Comentis Inc | formulações tópicas de mecamilamina para adminstração ocular e usos das mesma |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| WO2009029614A1 (en) | 2007-08-27 | 2009-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
| WO2009066107A1 (en) * | 2007-11-21 | 2009-05-28 | Astrazeneca Ab | Use of a nicotinic receptor agonist |
| US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
| US9211409B2 (en) | 2008-03-31 | 2015-12-15 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of T-cell activity |
| US8722630B2 (en) * | 2008-06-13 | 2014-05-13 | The General Hospital Corporation | Use of apolipoproteins to decrease inflammation |
| CN102171564B (zh) * | 2008-10-03 | 2013-03-20 | 圣保罗大学 | 药物组合物、药物筛选方法和用于治疗疟疾的方法 |
| ES2452484T3 (es) | 2008-11-18 | 2014-04-01 | Setpoint Medical Corporation | Dispositivos para optimizar la colocación de electrodos para la estimulación antiinflamatoria |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| US8788034B2 (en) | 2011-05-09 | 2014-07-22 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
| CN102573986B (zh) | 2009-06-09 | 2016-01-20 | 赛博恩特医疗器械公司 | 用于无导线刺激器的具有袋部的神经封套 |
| WO2014169145A1 (en) | 2013-04-10 | 2014-10-16 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
| EP2515996B1 (en) | 2009-12-23 | 2019-09-18 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
| US9096669B2 (en) * | 2010-09-30 | 2015-08-04 | Chengdu Kanghong Biotechnologies Co., Ltd. | Humanized anti-TNF-α antibody and antigen-binding fragment (Fab) thereof and use of the same |
| EP2640378A4 (en) * | 2010-11-18 | 2014-05-21 | Envivo Pharmaceuticals Inc | INFLAMMATION TREATMENT WITH CERTAIN NICOTINIC ACID ALPHA-7 RECEPTOR AGONISTS IN COMBINATION WITH ACETYLCHOLINESTERASE INHIBITORS |
| LT3673906T (lt) * | 2011-03-18 | 2025-08-11 | Genzyme Corporation | Gliukozilceramido sintazės inhibitoriai |
| BR112013025682A2 (pt) * | 2011-04-29 | 2017-01-03 | Chiesi Farm Spa | Compostos, composição farmacêutica, uso de um composto, combinação e dispositivo |
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| US8865641B2 (en) | 2011-06-16 | 2014-10-21 | The Feinstein Institute For Medical Research | Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways |
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- 2003-12-05 US US10/729,427 patent/US7273872B2/en not_active Expired - Fee Related
- 2003-12-05 ES ES07020473.0T patent/ES2462545T3/es not_active Expired - Lifetime
- 2003-12-05 EP EP09001425A patent/EP2062595A1/en not_active Withdrawn
- 2003-12-05 PT PT70204730T patent/PT1949901E/pt unknown
- 2003-12-05 EP EP07020473.0A patent/EP1949901B1/en not_active Expired - Lifetime
- 2003-12-05 DK DK07020473.0T patent/DK1949901T3/da active
- 2003-12-05 JP JP2004559325A patent/JP4750421B2/ja not_active Expired - Fee Related
- 2003-12-05 WO PCT/US2003/038708 patent/WO2004052365A2/en not_active Ceased
- 2003-12-05 ES ES03796701T patent/ES2293086T3/es not_active Expired - Lifetime
- 2003-12-05 AT AT03796701T patent/ATE378048T1/de not_active IP Right Cessation
- 2003-12-05 SI SI200332349T patent/SI1949901T1/sl unknown
- 2003-12-05 EP EP03796701.5A patent/EP1581223B2/en not_active Expired - Lifetime
- 2003-12-05 DE DE60317564T patent/DE60317564T2/de not_active Expired - Lifetime
- 2003-12-05 CN CNA2003801082615A patent/CN1735414A/zh active Pending
- 2003-12-05 AU AU2003298939A patent/AU2003298939B2/en not_active Ceased
- 2003-12-05 CN CN2012100243080A patent/CN102657651A/zh active Pending
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