JP2006514012A5 - - Google Patents
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- Publication number
- JP2006514012A5 JP2006514012A5 JP2004555329A JP2004555329A JP2006514012A5 JP 2006514012 A5 JP2006514012 A5 JP 2006514012A5 JP 2004555329 A JP2004555329 A JP 2004555329A JP 2004555329 A JP2004555329 A JP 2004555329A JP 2006514012 A5 JP2006514012 A5 JP 2006514012A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- formula
- compound according
- acceptable salt
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrugs Drugs 0.000 claims 1
Claims (3)
- 式ＩＩ：
で示される化合物またはその製薬的に許容される塩。 - 請求項１記載の化合物またはその製薬的に許容される塩、エステルもしくはプロドラッグを、製薬的に許容される担体、希釈剤または賦形剤とともに含む、医薬製剤。
- 請求項１記載の化合物を一つ以上の製薬的な担体、希釈剤または賦形剤とともに含む、癌の治療用医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42889302P | 2002-11-22 | 2002-11-22 | |
| PCT/US2003/032747 WO2004048382A1 (en) | 2002-11-22 | 2003-11-10 | Quinolinyl-pyrrolopyrazoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514012A JP2006514012A (ja) | 2006-04-27 |
| JP2006514012A5 true JP2006514012A5 (ja) | 2006-12-14 |
| JP4542906B2 JP4542906B2 (ja) | 2010-09-15 |
Family
ID=32393478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004555329A Expired - Fee Related JP4542906B2 (ja) | 2002-11-22 | 2003-11-10 | キノリニル−ピロロピラゾール類 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7265225B2 (ja) |
| EP (1) | EP1565471B1 (ja) |
| JP (1) | JP4542906B2 (ja) |
| KR (1) | KR101057282B1 (ja) |
| CN (1) | CN100345852C (ja) |
| AT (1) | ATE341550T1 (ja) |
| AU (1) | AU2003291643B2 (ja) |
| BR (1) | BR0315337A (ja) |
| CA (1) | CA2501322C (ja) |
| CO (1) | CO5570677A2 (ja) |
| CR (1) | CR7830A (ja) |
| CY (1) | CY1106283T1 (ja) |
| DE (1) | DE60308893T2 (ja) |
| DK (1) | DK1565471T3 (ja) |
| EA (1) | EA008387B1 (ja) |
| EC (1) | ECSP055807A (ja) |
| EG (1) | EG25822A (ja) |
| ES (1) | ES2273046T3 (ja) |
| HK (1) | HK1081948A1 (ja) |
| HR (1) | HRP20050436B1 (ja) |
| IL (1) | IL168190A (ja) |
| MX (1) | MXPA05005432A (ja) |
| NO (1) | NO331403B1 (ja) |
| NZ (1) | NZ538942A (ja) |
| PL (1) | PL227840B1 (ja) |
| PT (1) | PT1565471E (ja) |
| UA (1) | UA80571C2 (ja) |
| WO (1) | WO2004048382A1 (ja) |
| ZA (1) | ZA200503121B (ja) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004050659A1 (en) * | 2002-11-27 | 2004-06-17 | Eli Lilly And Company | Novel compounds as pharmaceutical agents |
| DK1910370T3 (en) * | 2005-07-22 | 2015-06-08 | Lilly Co Eli | PYRIDINQUINOLINE SUBSTITUTED PYRROLO [1,2-B] PYRAZOLE MONOHYDRATE AS TGF-BETA INHIBITOR |
| WO2007039151A1 (en) * | 2005-09-28 | 2007-04-12 | Universität Zürich | Blockers of transforming growth factor beta and its receptors for the treatment of infectious diseases |
| MX2009003518A (es) | 2006-10-03 | 2009-08-25 | Genzyme Corp | Uso de antagonistas de tgf-beta para tratar a los infantes en riesgo de desarrollar displasia brocopulmonar. |
| JP5443988B2 (ja) * | 2006-10-16 | 2014-03-19 | メディシス・ファーマシューティカル・コーポレーション | 治療用のピラゾリルチエノピリジン |
| AP2013006706A0 (en) | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | Napht-2-ylacetic acid derivatives to treat AIDS |
| CN103209963A (zh) | 2010-07-02 | 2013-07-17 | 吉里德科学公司 | 作为hiv抗病毒化合物的2-喹啉基-乙酸衍生物 |
| US8871744B2 (en) | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
| ES2707997T3 (es) | 2011-04-21 | 2019-04-08 | Gilead Sciences Inc | Compuestos de benzotiazol y su uso farmacéutico |
| US20140308275A1 (en) | 2011-07-27 | 2014-10-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale | Methods for diagnosing and treating myhre syndrome |
| US9468612B2 (en) | 2011-10-26 | 2016-10-18 | Seattle Children's Hospital | Cysteamine in the treatment of fibrotic disease |
| US9782452B2 (en) | 2011-11-22 | 2017-10-10 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| JP5911638B2 (ja) | 2012-04-20 | 2016-04-27 | ギリアード サイエンシーズ， インコーポレイテッド | ベンゾチアゾール−６−イル酢酸誘導体およびｈｉｖ感染を処置するためのそれらの使用 |
| EA039595B1 (ru) | 2012-10-05 | 2022-02-15 | Кадмон Корпорейшн, Ллк | Нуклеиновые кислоты, кодирующие человеческие анти-vegfr-2/kdr-антитела |
| US20150289795A1 (en) | 2012-11-12 | 2015-10-15 | Institució Catalana De Recerca I Estudis Avançats | Methods and kits for the prognosis of colorectal cancer |
| TWI582083B (zh) | 2014-10-07 | 2017-05-11 | 美國禮來大藥廠 | 胺基吡啶基氧基吡唑化合物 |
| TWI704151B (zh) | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Ｅｒｋ抑制劑 |
| WO2016160881A1 (en) | 2015-04-01 | 2016-10-06 | Rigel Pharmaceuticals, Inc. | TGF-β INHIBITORS |
| CN108602829A (zh) | 2015-12-15 | 2018-09-28 | 百时美施贵宝公司 | Cxcr4受体拮抗剂 |
| CN109548403A (zh) * | 2016-07-07 | 2019-03-29 | 苏州科睿思制药有限公司 | Galunisertib的晶型及其制备方法和用途 |
| WO2018165979A1 (zh) * | 2017-03-17 | 2018-09-20 | 杭州领业医药科技有限公司 | 2-(6-甲基-吡啶-2-基)-3-基-[6-酰胺基-喹啉-4-基]-5,6-二氢-4H-吡咯并[1,2-b]吡唑的晶型及其制备方法和药物组合物 |
| WO2018170724A1 (zh) * | 2017-03-21 | 2018-09-27 | 杭州领业医药科技有限公司 | 2-(6-甲基-吡啶-2-基)-3-基-[6-酰胺基-喹啉-4-基]-5,6-二氢-4H-吡咯并[1,2-b]吡唑的共晶，其制备方法和药物组合物 |
| WO2019042383A1 (zh) * | 2017-08-31 | 2019-03-07 | 苏州科睿思制药有限公司 | Galunisertib的晶型及其制备方法和用途 |
| WO2019105082A1 (zh) * | 2017-11-30 | 2019-06-06 | 苏州科睿思制药有限公司 | Galunisertib的晶型及其制备方法和用途 |
| WO2019137027A1 (zh) * | 2018-01-12 | 2019-07-18 | 苏州科睿思制药有限公司 | Galunisertib的晶型及其制备方法和用途 |
| US20210309679A1 (en) | 2018-07-23 | 2021-10-07 | Guangzhou Othrotx Co., Ltd. | Bisphosphonate drug conjugates |
| US20220054465A1 (en) | 2018-12-27 | 2022-02-24 | Nexys Therapeutics, Inc. | (pyridin-2-yl)amine derivatives as tgf-beta r1 (alk5) inhibitors for the treatment of cancer |
| WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| WO2020248908A1 (zh) * | 2019-06-10 | 2020-12-17 | 中国科学院广州生物医药与健康研究院 | 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 |
| WO2021142086A1 (en) | 2020-01-08 | 2021-07-15 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| CN115243724A (zh) | 2020-02-19 | 2022-10-25 | 纳米医疗有限公司 | 可用于治疗癌症的经调配和/或共调配的含有TFGβ拮抗剂前药的脂质体组合物和其方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
| MXPA02002111A (es) * | 1999-08-27 | 2002-10-31 | Abbott Lab | Compuestos de sulfonilfenilpirazol utiles como inhibidores de cox-2. |
| CN1951939A (zh) * | 2001-05-24 | 2007-04-25 | 伊莱利利公司 | 作为药物的新的吡唑衍生物 |
| WO2004048383A1 (en) | 2002-11-21 | 2004-06-10 | Eli Lilly And Company | Mixed lineage kinase modulators |
-
2003
- 2003-10-11 UA UAA200504767A patent/UA80571C2/uk unknown
- 2003-11-10 ES ES03768531T patent/ES2273046T3/es not_active Expired - Lifetime
- 2003-11-10 AT AT03768531T patent/ATE341550T1/de active
- 2003-11-10 PT PT03768531T patent/PT1565471E/pt unknown
- 2003-11-10 KR KR1020057009199A patent/KR101057282B1/ko not_active IP Right Cessation
- 2003-11-10 EA EA200500859A patent/EA008387B1/ru not_active IP Right Cessation
- 2003-11-10 AU AU2003291643A patent/AU2003291643B2/en not_active Ceased
- 2003-11-10 DE DE60308893T patent/DE60308893T2/de not_active Expired - Lifetime
- 2003-11-10 WO PCT/US2003/032747 patent/WO2004048382A1/en active IP Right Grant
- 2003-11-10 CN CNB2003801038400A patent/CN100345852C/zh not_active Expired - Fee Related
- 2003-11-10 BR BR0315337-1A patent/BR0315337A/pt active Pending
- 2003-11-10 CA CA2501322A patent/CA2501322C/en not_active Expired - Fee Related
- 2003-11-10 US US10/531,237 patent/US7265225B2/en not_active Expired - Fee Related
- 2003-11-10 JP JP2004555329A patent/JP4542906B2/ja not_active Expired - Fee Related
- 2003-11-10 MX MXPA05005432A patent/MXPA05005432A/es active IP Right Grant
- 2003-11-10 EP EP03768531A patent/EP1565471B1/en not_active Expired - Lifetime
- 2003-11-10 NZ NZ538942A patent/NZ538942A/en not_active IP Right Cessation
- 2003-11-10 PL PL376797A patent/PL227840B1/pl unknown
- 2003-11-10 DK DK03768531T patent/DK1565471T3/da active
-
2005
- 2005-04-18 ZA ZA200503121A patent/ZA200503121B/en unknown
- 2005-04-21 IL IL168190A patent/IL168190A/en active IP Right Grant
- 2005-05-06 CR CR7830A patent/CR7830A/es unknown
- 2005-05-16 HR HRP20050436AA patent/HRP20050436B1/hr not_active IP Right Cessation
- 2005-05-18 CO CO05048136A patent/CO5570677A2/es active IP Right Grant
- 2005-05-18 EG EGNA2005000237 patent/EG25822A/xx active
- 2005-05-19 EC EC2005005807A patent/ECSP055807A/es unknown
- 2005-06-21 NO NO20053045A patent/NO331403B1/no not_active IP Right Cessation
-
2006
- 2006-02-16 HK HK06102038A patent/HK1081948A1/xx not_active IP Right Cessation
- 2006-12-08 CY CY20061101769T patent/CY1106283T1/el unknown
-
2007
- 2007-07-25 US US11/782,659 patent/US7834029B2/en not_active Expired - Fee Related
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