JP2006512906A5 - - Google Patents
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- JP2006512906A5 JP2006512906A5 JP2004540017A JP2004540017A JP2006512906A5 JP 2006512906 A5 JP2006512906 A5 JP 2006512906A5 JP 2004540017 A JP2004540017 A JP 2004540017A JP 2004540017 A JP2004540017 A JP 2004540017A JP 2006512906 A5 JP2006512906 A5 JP 2006512906A5
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- Prior art keywords
- composition
- sirna
- shrna
- seq
- transcript
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020004459 Small interfering RNA Proteins 0.000 claims description 144
- 210000004027 cell Anatomy 0.000 claims description 61
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- 108091027967 Small hairpin RNA Proteins 0.000 claims description 53
- 239000004055 small Interfering RNA Substances 0.000 claims description 51
- 241000712461 unidentified influenza virus Species 0.000 claims description 51
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- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 5
- 206010022000 influenza Diseases 0.000 claims description 5
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- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
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- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 claims 1
- 101710159080 Aconitate hydratase A Proteins 0.000 claims 1
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- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims 1
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- 108010011110 polyarginine Proteins 0.000 claims 1
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
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- 108010048367 enhanced green fluorescent protein Proteins 0.000 description 2
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41445702P | 2002-09-28 | 2002-09-28 | |
| US44637703P | 2003-02-10 | 2003-02-10 | |
| PCT/US2003/030502 WO2004028471A2 (en) | 2002-09-28 | 2003-09-29 | Influenza therapeutic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006512906A JP2006512906A (ja) | 2006-04-20 |
| JP2006512906A5 true JP2006512906A5 (https=) | 2009-07-30 |
Family
ID=32045286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004540017A Pending JP2006512906A (ja) | 2002-09-28 | 2003-09-29 | インフルエンザ治療剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050008617A1 (https=) |
| EP (1) | EP1658304A4 (https=) |
| JP (1) | JP2006512906A (https=) |
| KR (1) | KR20050084607A (https=) |
| AU (3) | AU2003279010A1 (https=) |
| CA (1) | CA2500468A1 (https=) |
| MX (1) | MXPA05003287A (https=) |
| NO (1) | NO20052058L (https=) |
| WO (2) | WO2004029213A2 (https=) |
Families Citing this family (132)
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|---|---|---|---|---|
| US8541548B2 (en) * | 1999-06-07 | 2013-09-24 | Arrowhead Madison Inc. | Compounds and methods for reversible modification of biologically active molecules |
| US20080281041A1 (en) * | 1999-06-07 | 2008-11-13 | Rozema David B | Reversibly Masked Polymers |
| US8008355B2 (en) * | 2002-03-11 | 2011-08-30 | Roche Madison Inc. | Endosomolytic poly(vinyl ether) polymers |
| US8138383B2 (en) * | 2002-03-11 | 2012-03-20 | Arrowhead Madison Inc. | Membrane active heteropolymers |
| DE10214983A1 (de) * | 2002-04-04 | 2004-04-08 | TransMIT Gesellschaft für Technologietransfer mbH | Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen |
| US20080214437A1 (en) * | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
| WO2004022003A2 (en) | 2002-09-06 | 2004-03-18 | University Of South Florida | Materials and methods for treatment of allergic diseases |
| US20060160759A1 (en) * | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
| US20050136430A1 (en) * | 2003-07-15 | 2005-06-23 | California Institute Of Technology | Inhibitor nucleic acids |
| US8145436B2 (en) | 2003-07-15 | 2012-03-27 | The Trustees Of The University Of Pennsylvania | Method and systems for identifying micro-RNA targets and synthesizing novel micro-RNAs and uses of the same |
| US20050256071A1 (en) * | 2003-07-15 | 2005-11-17 | California Institute Of Technology | Inhibitor nucleic acids |
| US20050060771A1 (en) * | 2003-09-11 | 2005-03-17 | Farmer Andrew Alan | siRNA encoding constructs and methods for using the same |
| AU2005227870A1 (en) * | 2004-02-17 | 2005-10-13 | University Of South Florida | Materials and methods for treatment of inflammatory and cell proliferation disorders |
| WO2005080410A1 (en) * | 2004-02-20 | 2005-09-01 | Genesis Research And Development Corporation Limited | Targeted delivery of rna interference molecules for the treatment of ige-mediated disorders |
| WO2005110438A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
| US20050265927A1 (en) * | 2004-05-17 | 2005-12-01 | Yale University | Intranasal delivery of nucleic acid molecules |
| US7297786B2 (en) * | 2004-07-09 | 2007-11-20 | University Of Iowa Research Foundation | RNA interference in respiratory epitheial cells |
| US20080222743A1 (en) * | 2004-08-25 | 2008-09-11 | Avigenics, Inc. | RNA interference and disease resistance in avians |
| US20090313712A1 (en) * | 2004-08-25 | 2009-12-17 | Leandro Christmann | RNA interference and disease resistance in avians |
| DE602005027479D1 (de) * | 2004-09-24 | 2011-05-26 | Alnylam Pharmaceuticals Inc | Targeting von zwischenprodukten zur gegenstrangreplikation von einzelstrangigen viren durch rnai |
| US7790878B2 (en) | 2004-10-22 | 2010-09-07 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
| US20060089324A1 (en) * | 2004-10-22 | 2006-04-27 | Sailen Barik | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
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| US20070248535A1 (en) * | 2005-02-07 | 2007-10-25 | The Trustees Of Columbia University In The City Of New York | Methods to treat or prevent hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity |
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| US20070213293A1 (en) * | 2005-04-08 | 2007-09-13 | Nastech Pharmaceutical Company Inc. | Rnai therapeutic for respiratory virus infection |
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| CA2605068A1 (en) | 2005-04-15 | 2006-10-26 | The Board Of Regents Of The University Of Texas System | Delivery of sirna by neutral lipid compositions |
| NZ562661A (en) * | 2005-04-21 | 2010-04-30 | Univ Florida | Materials and methods for respiratory disease control in canines |
| WO2006116756A1 (en) * | 2005-04-28 | 2006-11-02 | Benitec, Limited. | Multiple-rnai expression cassettes for simultaneous delivery of rnai agents related to heterozygotic expression patterns |
| US7199109B2 (en) * | 2005-06-03 | 2007-04-03 | Cal Poly Pomona Foundation | Potent inhibition of influenza virus by specifically designed short interfering RNA |
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| US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
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| WO2007053696A2 (en) * | 2005-11-01 | 2007-05-10 | Alnylam Pharmaceuticals, Inc. | Rnai inhibition of influenza virus replication |
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| WO2007127487A2 (en) * | 2006-04-28 | 2007-11-08 | University Of South Florida | Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor |
| EP2295045A1 (en) * | 2006-07-07 | 2011-03-16 | Aarhus Universitet | Nanoparticles for nucleic acid delivery |
| GB0613753D0 (en) * | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
| WO2008014404A2 (en) * | 2006-07-26 | 2008-01-31 | The University Of Chicago | Receptor-mediated delivery : compositions and methods |
| CN101500548A (zh) * | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
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| CA2661093A1 (en) * | 2006-08-18 | 2008-02-21 | Nastech Pharmaceutical Company Inc. | Dicer substrate rna peptide conjugates and methods for rna therapeutics |
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| EP2057179A4 (en) * | 2006-08-24 | 2010-11-10 | British Columbia Cancer Agency | COMPOSITION AND METHOD FOR THE TREATMENT OF MYELOSUPPRESSION |
| KR100817024B1 (ko) * | 2006-11-09 | 2008-03-26 | 재단법인 목암생명공학연구소 | 핵산 또는 약물을 간에 특이적으로 전달하는 복합체 및이를 포함하는 약학적 조성물 |
| WO2008098139A2 (en) | 2007-02-07 | 2008-08-14 | The Regents Of The University Of Colorado | Axl tyrosine kinase inhibitors and methods of making and using the same |
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