JP2006510716A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006510716A5 JP2006510716A5 JP2004563615A JP2004563615A JP2006510716A5 JP 2006510716 A5 JP2006510716 A5 JP 2006510716A5 JP 2004563615 A JP2004563615 A JP 2004563615A JP 2004563615 A JP2004563615 A JP 2004563615A JP 2006510716 A5 JP2006510716 A5 JP 2006510716A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- chlorophenyl
- aryl
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(*)(*)*)N(*)C(*)=O Chemical compound *C(C(*)(*)*)N(*)C(*)=O 0.000 description 1
- KHAHHCRELJSXME-WFFHQLTOSA-N C[C@@H](C(Cc(cc1)ccc1Cl)(c1cc(C#N)ccc1)O)NC(C(C)(C)Oc1ccc(C(F)(F)F)cn1)=O Chemical compound C[C@@H](C(Cc(cc1)ccc1Cl)(c1cc(C#N)ccc1)O)NC(C(C)(C)Oc1ccc(C(F)(F)F)cn1)=O KHAHHCRELJSXME-WFFHQLTOSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43543602P | 2002-12-19 | 2002-12-19 | |
| US60/435,436 | 2002-12-19 | ||
| PCT/US2003/040040 WO2004058145A2 (en) | 2002-12-19 | 2003-12-15 | Substituted amides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006510716A JP2006510716A (ja) | 2006-03-30 |
| JP2006510716A5 true JP2006510716A5 (https=) | 2007-01-11 |
| JP4719469B2 JP4719469B2 (ja) | 2011-07-06 |
Family
ID=32682242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004563615A Expired - Fee Related JP4719469B2 (ja) | 2002-12-19 | 2003-12-15 | 置換アミド類 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7348456B2 (https=) |
| EP (1) | EP1575901B1 (https=) |
| JP (1) | JP4719469B2 (https=) |
| KR (1) | KR20050088194A (https=) |
| CN (1) | CN1747926A (https=) |
| AU (1) | AU2003300967B2 (https=) |
| CA (1) | CA2510785C (https=) |
| MX (1) | MXPA05006728A (https=) |
| WO (1) | WO2004058145A2 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3813152B2 (ja) | 2002-03-12 | 2006-08-23 | メルク エンド カムパニー インコーポレーテッド | 置換アミド類 |
| AU2003215024B2 (en) * | 2002-03-26 | 2008-02-21 | Merck Sharp & Dohme Corp. | Spirocyclic amides as cannabinoid receptor modulators |
| EP1558252B1 (en) | 2002-08-02 | 2007-10-10 | Merck & Co., Inc. | Substituted furo [2,3-b]pyridine derivatives |
| EP1575901B1 (en) * | 2002-12-19 | 2012-10-10 | Merck Sharp & Dohme Corp. | Substituted amides |
| JP2007527389A (ja) | 2003-06-30 | 2007-09-27 | メルク エンド カムパニー インコーポレーテッド | 放射性カンナビノイド−1受容体修飾因子 |
| EP1682494A4 (en) * | 2003-10-30 | 2006-11-08 | Merck & Co Inc | ARALKYLAMINES AS MODULATORS OF CANNABINOID RECEPTORS |
| US20100222316A1 (en) * | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US8415354B2 (en) * | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US7880001B2 (en) * | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| MX2007008238A (es) | 2005-01-05 | 2007-08-17 | Abbott Lab | Derivados de adamantilo como inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo 1. |
| US8198331B2 (en) * | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| CN101142172A (zh) * | 2005-01-05 | 2008-03-12 | 艾博特公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
| EP1879582A4 (en) * | 2005-05-02 | 2009-05-13 | Merck & Co Inc | COMBINATION OF A DIPEPTIDYLPEPTIDASE IV HEMMER AND A CANNABINOID CB1 RECEPTOR ANTAGONIST FOR THE TREATMENT OF DIABETES AND ADIPOSITAS |
| US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| CA2613678A1 (en) | 2005-06-02 | 2006-12-07 | Glenmark Pharmaceuticals S.A. | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| MX2007016508A (es) | 2005-06-30 | 2008-03-04 | Prosidion Ltd | Agonistas del receptor acoplado a la proteina g. |
| EP2061767B1 (de) | 2006-08-08 | 2014-12-17 | Sanofi | Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung |
| PE20081849A1 (es) | 2007-01-04 | 2009-01-26 | Prosidion Ltd | Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr |
| US20100048632A1 (en) | 2007-01-04 | 2010-02-25 | Matthew Colin Thor Fyfe | Piperidine GPCR Agonists |
| US20100048625A1 (en) | 2007-01-04 | 2010-02-25 | Matthew Colin Thor Fyfe | Piperidine gpcr agonists |
| PE20081659A1 (es) | 2007-01-04 | 2008-10-24 | Prosidion Ltd | Agonistas de gpcr |
| GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP5736098B2 (ja) * | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| KR20120060207A (ko) | 2009-08-26 | 2012-06-11 | 사노피 | 신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도 |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1223388B (de) | 1958-06-12 | 1966-08-25 | Hoechst Ag | Verfahren zur Herstellung von neuen Isonicotinsaeureamiden |
| DE1096883B (de) * | 1959-09-25 | 1961-01-12 | Basf Ag | Verfahren zur Herstellung von festem Alkalisulfit |
| US3555093A (en) | 1967-05-26 | 1971-01-12 | Parke Davis & Co | 2,alpha-dimenthyl-beta-ethyl-beta-(p-fluorophenyl)-ethylamines and the salts thereof |
| IE50355B1 (en) * | 1979-10-20 | 1986-04-02 | Wyeth John & Brother Ltd | Morpholine derivatives |
| ZA852439B (en) * | 1984-04-02 | 1986-04-30 | Merck & Co Inc | N-alkenyl-3-hydroxybenzo(b)thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors |
| US5281611A (en) * | 1990-12-19 | 1994-01-25 | Board Of Trustees Operating Michigan State University | Euthanasia compositions |
| JPH07173120A (ja) * | 1993-10-08 | 1995-07-11 | Banyu Pharmaceut Co Ltd | 置換芳香族カルボン酸誘導体 |
| FR2758723B1 (fr) | 1997-01-28 | 1999-04-23 | Sanofi Sa | Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments |
| US6251947B1 (en) | 1997-02-04 | 2001-06-26 | Board Of Trustees Of The University Of Arkansas | Fungicidal carboxamides |
| FR2764602B1 (fr) | 1997-06-11 | 1999-07-30 | Oreal | Composition cosmetique comprenant un amide et nouveaux amides |
| US6503905B1 (en) * | 1998-12-29 | 2003-01-07 | Pfizer Inc | 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives |
| WO2001009120A1 (en) | 1999-07-28 | 2001-02-08 | Ortho-Mcneil Pharmaceutical, Inc. | Amine and amide derivatives as ligands for the neuropeptide y y5 receptor useful in the treatment of obesity and other disorders |
| FR2804604B1 (fr) | 2000-02-09 | 2005-05-27 | Sanofi Synthelabo | Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles pour faciliter l'arret de la consommation de tabac |
| GB2381313B (en) | 2001-07-18 | 2005-01-05 | Westerngeco Ltd | A method of processing geophysical data |
| AU2002319627A1 (en) | 2001-07-20 | 2003-03-03 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| AU2003209388A1 (en) | 2002-01-29 | 2003-09-02 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| EP1482794A1 (en) | 2002-03-06 | 2004-12-08 | Merck & Co., Inc. | Method of treatment or prevention of obesity |
| JP3813152B2 (ja) | 2002-03-12 | 2006-08-23 | メルク エンド カムパニー インコーポレーテッド | 置換アミド類 |
| AU2003215024B2 (en) * | 2002-03-26 | 2008-02-21 | Merck Sharp & Dohme Corp. | Spirocyclic amides as cannabinoid receptor modulators |
| ES2192494B1 (es) | 2002-03-27 | 2005-02-16 | Consejo Superior De Investigaciones Cientificas | Derivados de 1,2,4-triazol con propiedades cannabinoides. |
| FR2837706A1 (fr) | 2002-03-28 | 2003-10-03 | Sanofi Synthelabo | Utilisation d'un antagoniste des recepteurs aux cannabinoides cb1 pour la preparation de medicaments utiles pour traiter les dysfonctionnements sexuels et/ou ameliorer les performances sexuelles |
| EP1492784A4 (en) | 2002-03-28 | 2006-03-29 | Merck & Co Inc | SUBSTITUTED 2,3-DIPHENYLPYRIDINES |
| US20050154202A1 (en) | 2002-04-05 | 2005-07-14 | Hagmann William K. | Substituted aryl amides |
| AU2003223510B2 (en) | 2002-04-12 | 2008-05-08 | Merck Sharp & Dohme Corp. | Bicyclic amides |
| DE60320784D1 (de) | 2002-06-06 | 2008-06-19 | Yissum Res Dev Co | Stände zur modulierung des knochenwachstums |
| EP1558252B1 (en) | 2002-08-02 | 2007-10-10 | Merck & Co., Inc. | Substituted furo [2,3-b]pyridine derivatives |
| JP2006510597A (ja) | 2002-09-27 | 2006-03-30 | メルク エンド カムパニー インコーポレーテッド | 置換ピリミジン類 |
| MY134457A (en) | 2002-11-22 | 2007-12-31 | Merck & Co Inc | Substituted amides |
| EP1575901B1 (en) | 2002-12-19 | 2012-10-10 | Merck Sharp & Dohme Corp. | Substituted amides |
| US20040224962A1 (en) | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| US20040224963A1 (en) | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| CN1802351A (zh) | 2003-06-11 | 2006-07-12 | 麦克公司 | 被取代的3-烷基和3-链烯基氮杂环丁烷衍生物 |
| RU2344132C2 (ru) | 2003-06-20 | 2009-01-20 | Ф.Хоффманн-Ля Рош Аг | 2-аминобензотиазолы в качестве обратных агонистов рецепторов cb1 |
| JP2007527389A (ja) | 2003-06-30 | 2007-09-27 | メルク エンド カムパニー インコーポレーテッド | 放射性カンナビノイド−1受容体修飾因子 |
| TW200511990A (en) | 2003-09-02 | 2005-04-01 | Solvay Pharm Gmbh | Novel medical uses of 4, 5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity |
| EP1663215A1 (en) | 2003-09-02 | 2006-06-07 | Solvay Pharmaceuticals GmbH | Novel medical use of selective cb1- receptor antagonists |
| EP1663113A4 (en) | 2003-09-18 | 2007-06-13 | Merck & Co Inc | SUBSTITUTED SULFONAMIDE |
| MXPA06004434A (es) | 2003-10-24 | 2006-06-20 | Solvay Pharm Gmbh | Usos medicos novedosos de compuestos que muestran actividad antagonista cb1 y tratamiento de combinacion que involucra tales compuestos. |
| US8166053B2 (en) | 2003-10-30 | 2012-04-24 | Ntt Docomo, Inc. | Method and apparatus for schema-driven XML parsing optimization |
-
2003
- 2003-12-15 EP EP03814048A patent/EP1575901B1/en not_active Expired - Lifetime
- 2003-12-15 JP JP2004563615A patent/JP4719469B2/ja not_active Expired - Fee Related
- 2003-12-15 AU AU2003300967A patent/AU2003300967B2/en not_active Ceased
- 2003-12-15 CN CNA2003801097502A patent/CN1747926A/zh active Pending
- 2003-12-15 WO PCT/US2003/040040 patent/WO2004058145A2/en not_active Ceased
- 2003-12-15 US US10/538,395 patent/US7348456B2/en not_active Expired - Fee Related
- 2003-12-15 CA CA2510785A patent/CA2510785C/en not_active Expired - Fee Related
- 2003-12-15 MX MXPA05006728A patent/MXPA05006728A/es active IP Right Grant
- 2003-12-15 KR KR1020057011407A patent/KR20050088194A/ko not_active Ceased
-
2008
- 2008-01-14 US US12/008,728 patent/US7576239B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006510716A5 (https=) | ||
| AU2023201399B2 (en) | Modulators of the integrated stress pathway | |
| TWI518080B (zh) | 布魯頓氏酪胺酸激酶抑制劑 | |
| EP3704096B1 (en) | Modulators of the integrated stress pathway | |
| KR20190041471A (ko) | 케모카인 수용체 조절제 및 이의 용도 | |
| RU2459806C2 (ru) | Замещенные гетероарильные производные | |
| RU2412934C2 (ru) | Применение антагонистов crth2 в терапии | |
| CN101611013B (zh) | 作为5-ht2a血清素受体调节剂用于治疗与其相关病症的吡唑衍生物 | |
| DK2928474T3 (en) | Diazollactamer | |
| JP2023522250A (ja) | 免疫活性化のためのdgkzeta阻害剤としての置換アミノチアゾール類 | |
| CN1152870A (zh) | 杂环化合物作为多巴胺d3配位体的用途 | |
| JP2008513498A5 (https=) | ||
| JP2015529224A5 (https=) | ||
| JP2020523330A (ja) | シクロプロピルウレアホルミルペプチド2受容体およびホルミルペプチド1受容体アゴニスト | |
| US9750722B2 (en) | Diazole amides | |
| TW200306837A (en) | Adenosine A2a receptor antagonists | |
| WO2007146761A2 (en) | Diaryl pyrimidinones and related compounds | |
| TW200900060A (en) | Chemical compounds | |
| AU2013364038A1 (en) | Diazole amides | |
| BRPI0411095B1 (pt) | Derivados de imidazol, seus usos e seus processos de preparação, e medicamentos | |
| TW200413369A (en) | New compounds | |
| CN119585256A (zh) | 趋化因子受体调节剂及其用途 | |
| JP5101639B2 (ja) | アミド誘導体及びそれを含有する医薬組成物 | |
| JP2009513513A (ja) | Orl−1受容体リガンドとしての置換インドール | |
| JP2001520225A (ja) | セロトニン再摂取阻害物質および5−HT1Dα拮抗薬としてのアリールピペラジン |