JP2006510347A5 - - Google Patents
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- JP2006510347A5 JP2006510347A5 JP2004520607A JP2004520607A JP2006510347A5 JP 2006510347 A5 JP2006510347 A5 JP 2006510347A5 JP 2004520607 A JP2004520607 A JP 2004520607A JP 2004520607 A JP2004520607 A JP 2004520607A JP 2006510347 A5 JP2006510347 A5 JP 2006510347A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- ige
- antibodies
- protein
- recombinant protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 description 10
- 239000013566 allergen Substances 0.000 description 8
- 206010020751 Hypersensitivity Diseases 0.000 description 6
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 6
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 6
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 210000002443 helper t lymphocyte Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 230000036755 cellular response Effects 0.000 description 3
- 210000003630 histaminocyte Anatomy 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 244000036975 Ambrosia artemisiifolia Species 0.000 description 1
- 235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 235000003484 annual ragweed Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 235000006263 bur ragweed Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000003488 common ragweed Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000009736 ragweed Nutrition 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39612602P | 2002-07-17 | 2002-07-17 | |
| US60/396,126 | 2002-07-17 | ||
| PCT/EP2003/007572 WO2004007538A2 (en) | 2002-07-17 | 2003-07-14 | Molecular antigen arrays using a virus like particle derived from the ap205 coat protein |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009267660A Division JP2010075196A (ja) | 2002-07-17 | 2009-11-25 | 分子抗原アレイ |
| JP2010248015A Division JP2011087580A (ja) | 2002-07-17 | 2010-11-05 | 分子抗原アレイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006510347A JP2006510347A (ja) | 2006-03-30 |
| JP2006510347A5 true JP2006510347A5 (enExample) | 2011-01-20 |
| JP4726483B2 JP4726483B2 (ja) | 2011-07-20 |
Family
ID=30115977
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520607A Expired - Fee Related JP4726483B2 (ja) | 2002-07-17 | 2003-07-14 | 分子抗原アレイ |
| JP2009267660A Pending JP2010075196A (ja) | 2002-07-17 | 2009-11-25 | 分子抗原アレイ |
| JP2010248015A Pending JP2011087580A (ja) | 2002-07-17 | 2010-11-05 | 分子抗原アレイ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009267660A Pending JP2010075196A (ja) | 2002-07-17 | 2009-11-25 | 分子抗原アレイ |
| JP2010248015A Pending JP2011087580A (ja) | 2002-07-17 | 2010-11-05 | 分子抗原アレイ |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7138252B2 (enExample) |
| EP (2) | EP2351770A1 (enExample) |
| JP (3) | JP4726483B2 (enExample) |
| CN (2) | CN1668637B (enExample) |
| AT (1) | ATE542828T1 (enExample) |
| AU (1) | AU2003246690B2 (enExample) |
| BR (1) | BR0312935A (enExample) |
| CA (1) | CA2489410C (enExample) |
| IL (1) | IL165605A0 (enExample) |
| MX (1) | MXPA05000277A (enExample) |
| NZ (1) | NZ538083A (enExample) |
| RU (2) | RU2324704C2 (enExample) |
| WO (1) | WO2004007538A2 (enExample) |
| ZA (1) | ZA200410046B (enExample) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001252458A1 (en) * | 2000-05-05 | 2001-11-20 | Martin Bachmann | Molecular antigen arrays and vaccines |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| ATE447967T1 (de) | 2001-09-14 | 2009-11-15 | Cytos Biotechnology Ag | Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| ATE489969T1 (de) * | 2002-06-20 | 2010-12-15 | Cytos Biotechnology Ag | Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung |
| RU2324704C2 (ru) * | 2002-07-17 | 2008-05-20 | Цитос Байотекнолоджи Аг | Молекулярные массивы антигенов |
| EP2392345A3 (en) * | 2002-07-18 | 2012-03-07 | Cytos Biotechnology AG | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| RU2450827C2 (ru) * | 2002-07-19 | 2012-05-20 | Цитос Биотехнологи Аг | Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6 |
| JP5022028B2 (ja) | 2003-03-26 | 2012-09-12 | サイトス・バイオテクノロジー・アクチェンゲゼルシャフト | メラン−ａペプチドアナログ−ウイルス様粒子コンジュゲート |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| US20090028886A1 (en) * | 2004-08-04 | 2009-01-29 | Cytos Biotechnology Ag | Carrier conjugates of gnrh-peptides |
| BRPI0516953A (pt) * | 2004-09-21 | 2008-09-30 | Cytos Biotechnology Ag | partìculas do tipo vìrus compreendendo uma proteìna de fusão da proteìna de revestimento de ap205 e um polipeptìdeo antigênico |
| AU2005291231B2 (en) * | 2004-10-05 | 2010-12-23 | Cytos Biotechnology Ag | VLP-antigen conjugates and their uses as vaccines |
| CA2580919A1 (en) | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof |
| WO2006045849A1 (en) * | 2004-10-29 | 2006-05-04 | Cytos Biotechnology Ag | T-cadherin antigen arrays and uses thereof |
| GB0424563D0 (en) * | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| JP2008523132A (ja) * | 2004-12-13 | 2008-07-03 | サイトス バイオテクノロジー アーゲー | Ｉｌ−１５抗原アレイとその使用法 |
| KR20070112225A (ko) * | 2005-03-18 | 2007-11-22 | 사이토스 바이오테크놀로지 아게 | 고양이 알레르겐 컨쥬게이트 및 그의 용도 |
| EP1746165A1 (en) | 2005-07-21 | 2007-01-24 | Cytos Biotechnology AG | Scalable fermentation process |
| JP5442251B2 (ja) | 2005-05-26 | 2014-03-12 | サイトス バイオテクノロジー アーゲー | 拡張可能な発酵方法 |
| CN101193654A (zh) * | 2005-06-14 | 2008-06-04 | 赛托斯生物技术公司 | 抗原偶联物及其用途 |
| EP1736538A1 (en) * | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| ES2310062B1 (es) | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| KR20080047564A (ko) * | 2005-09-28 | 2008-05-29 | 사이토스 바이오테크놀로지 아게 | 인터루킨-1 컨쥬게이트 및 그의 용도 |
| CA2632662A1 (en) * | 2005-12-08 | 2007-06-14 | South Dakota State University | Methods of in vitro propagation and detection of infectious prion |
| EP1973608A1 (en) | 2005-12-14 | 2008-10-01 | Cytos Biotechnology AG | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| NZ573622A (en) | 2006-06-12 | 2011-12-22 | Cytos Biotechnology Ag | Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages |
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| EP2066347A1 (en) * | 2006-09-28 | 2009-06-10 | Cytos Biotechnology AG | Interleukin-1 muteins linked to virus-like particles to treat il-1 associated diseases |
| US7998487B2 (en) * | 2007-02-16 | 2011-08-16 | The Salk Institute For Biological Studies | Antitoxin and vaccine platform based on nodavirus VLPs |
| JPWO2008133141A1 (ja) * | 2007-04-24 | 2010-07-22 | 東洋紡績株式会社 | オスモチン組換えタンパク質およびその製造方法、並びにその利用 |
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| US12218609B2 (en) * | 2012-05-11 | 2025-02-04 | The Regents Of The University Of California | Virus-based piezoelectric energy generation |
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| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
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| CN114634578B (zh) * | 2020-12-15 | 2024-04-02 | 榕森生物科技(北京)有限公司 | 针对新型冠状病毒感染的疫苗组合物 |
| CN114632148B (zh) * | 2020-12-15 | 2024-08-09 | 榕森生物科技(北京)有限公司 | 病原样抗原疫苗及其制备方法 |
| CN112480245B (zh) * | 2020-12-19 | 2023-08-18 | 上海佰君生物科技有限公司 | 一种疏水性环状肽配基纯化人免疫球蛋白g的应用 |
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| WO2025000310A1 (zh) * | 2023-06-29 | 2025-01-02 | 深圳赫兹生命科学技术有限公司 | 去势ap205病毒样颗粒亚单位疫苗的制备方法 |
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-
2003
- 2003-07-14 RU RU2005104235/13A patent/RU2324704C2/ru not_active IP Right Cessation
- 2003-07-14 AU AU2003246690A patent/AU2003246690B2/en not_active Ceased
- 2003-07-14 US US10/617,876 patent/US7138252B2/en not_active Expired - Fee Related
- 2003-07-14 WO PCT/EP2003/007572 patent/WO2004007538A2/en not_active Ceased
- 2003-07-14 CN CN038168626A patent/CN1668637B/zh not_active Expired - Fee Related
- 2003-07-14 CN CN2010101587965A patent/CN102061288A/zh active Pending
- 2003-07-14 MX MXPA05000277A patent/MXPA05000277A/es active IP Right Grant
- 2003-07-14 CA CA2489410A patent/CA2489410C/en not_active Expired - Fee Related
- 2003-07-14 JP JP2004520607A patent/JP4726483B2/ja not_active Expired - Fee Related
- 2003-07-14 EP EP10011277A patent/EP2351770A1/en not_active Withdrawn
- 2003-07-14 NZ NZ538083A patent/NZ538083A/en not_active IP Right Cessation
- 2003-07-14 EP EP03763829A patent/EP1532167B1/en not_active Expired - Lifetime
- 2003-07-14 BR BR0312935-7A patent/BR0312935A/pt not_active IP Right Cessation
- 2003-07-14 AT AT03763829T patent/ATE542828T1/de active
-
2004
- 2004-12-07 IL IL16560504A patent/IL165605A0/xx unknown
- 2004-12-13 ZA ZA200410046A patent/ZA200410046B/en unknown
-
2006
- 2006-11-20 US US11/601,687 patent/US7494656B2/en not_active Expired - Fee Related
-
2007
- 2007-12-03 RU RU2007144895/13A patent/RU2007144895A/ru not_active Application Discontinuation
-
2008
- 2008-12-22 US US12/341,763 patent/US20100092508A1/en not_active Abandoned
-
2009
- 2009-11-25 JP JP2009267660A patent/JP2010075196A/ja active Pending
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2010
- 2010-11-05 JP JP2010248015A patent/JP2011087580A/ja active Pending
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