JP2006508036A5 - - Google Patents
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- JP2006508036A5 JP2006508036A5 JP2004512756A JP2004512756A JP2006508036A5 JP 2006508036 A5 JP2006508036 A5 JP 2006508036A5 JP 2004512756 A JP2004512756 A JP 2004512756A JP 2004512756 A JP2004512756 A JP 2004512756A JP 2006508036 A5 JP2006508036 A5 JP 2006508036A5
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- JP
- Japan
- Prior art keywords
- group
- independently selected
- haloalkyl
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45371102P | 2002-06-12 | 2002-06-12 | |
| US60/453,711 | 2002-06-12 | ||
| PCT/US2003/018660 WO2003105853A1 (en) | 2002-06-12 | 2003-06-11 | 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006508036A JP2006508036A (ja) | 2006-03-09 |
| JP2006508036A5 true JP2006508036A5 (https=) | 2006-08-03 |
| JP4723242B2 JP4723242B2 (ja) | 2011-07-13 |
Family
ID=29736828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004512756A Expired - Lifetime JP4723242B2 (ja) | 2002-06-12 | 2003-06-11 | 炎症および免疫障害治療用ｃｃｒ１アンタゴニストとして使用するための１−アリール−４−置換ピペラジン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7157464B2 (https=) |
| EP (1) | EP1531822B1 (https=) |
| JP (1) | JP4723242B2 (https=) |
| KR (1) | KR101255356B1 (https=) |
| CN (1) | CN1867336B (https=) |
| AT (1) | ATE438401T1 (https=) |
| AU (1) | AU2003236500B9 (https=) |
| CA (1) | CA2488202C (https=) |
| DE (1) | DE60328690D1 (https=) |
| DK (1) | DK1531822T3 (https=) |
| ES (1) | ES2329356T3 (https=) |
| MX (1) | MXPA04012393A (https=) |
| WO (1) | WO2003105853A1 (https=) |
Families Citing this family (66)
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| PT1906965E (pt) * | 2005-06-22 | 2015-09-03 | Chemocentryx Inc | Compostos de azaindazol e métodos de utilização |
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| PL2044043T5 (pl) | 2006-06-16 | 2022-05-02 | H. Lundbeck A/S | Bromowodorek 1-[2-(2,4-dimetylofenylosulfanylo)fenylo]piperazyny jako związek o połączonym działaniu wychwytu zwrotnego serotoniny i działaniu na 5-ht3 i 5-ht1a do leczenia upośledzenia funckji poznawczych |
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| AU2009291749B2 (en) | 2007-05-22 | 2015-05-21 | Chemocentryx, Inc. | 4-amino-3-(imidazolyl)-pyrazolo[3,4-d]pyrimidines |
| HUE032273T2 (en) | 2007-05-22 | 2017-09-28 | Chemocentryx Inc | 3-Imidazolyl-pyrazolo [3,4-b] pyridines |
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| WO2012087782A1 (en) | 2010-12-23 | 2012-06-28 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
| US20140329809A1 (en) | 2011-10-28 | 2014-11-06 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
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| US8741892B2 (en) | 2011-12-05 | 2014-06-03 | Boehringer Ingelheim International Gmbh | Compounds |
| US8642774B2 (en) | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
| US8796467B2 (en) | 2011-12-13 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Compounds |
| US8846948B2 (en) | 2011-12-13 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Compounds |
| US8716277B2 (en) | 2011-12-14 | 2014-05-06 | Boehringer Ingelheim International Gmbh | Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity |
| US8883789B2 (en) | 2011-12-14 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
| US8937176B2 (en) | 2011-12-14 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Compounds |
| US8889677B2 (en) | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
| JP6330040B2 (ja) | 2013-07-22 | 2018-05-23 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | １−（ピペラジン−１−イル）−２−（［１，２，４］トリアゾール−１−イル）−エタノン誘導体 |
| AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| PL3245203T3 (pl) | 2015-01-15 | 2019-05-31 | Idorsia Pharmaceuticals Ltd | Pochodne hydroksyalkilopiperazyny jako modulatory receptora cxcr3 |
| SG11201811023UA (en) | 2016-06-23 | 2019-01-30 | St Jude Childrens Res Hospital | Small molecule modulators of pantothenate kinases |
| WO2019133635A1 (en) | 2017-12-27 | 2019-07-04 | St. Jude Children's Research Hospital | Small molecule modulators of pantothenate kinases |
| JP7527967B2 (ja) | 2017-12-27 | 2024-08-05 | セント ジュード チルドレンズ リサーチ ホスピタル，インコーポレイティド | Ｃａｓｔｏｒに関連する障害を治療する方法 |
| BR112021025888A2 (pt) | 2019-07-10 | 2022-04-26 | Chemocentryx Inc | Indanos como inibidores de pd-l1 |
| WO2021039961A1 (ja) * | 2019-08-30 | 2021-03-04 | 大日本住友製薬株式会社 | 縮環ピラゾール誘導体 |
| ES3064674T3 (en) | 2019-10-16 | 2026-04-28 | Chemocentryx Inc | Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases |
| JP7736678B2 (ja) | 2019-10-16 | 2025-09-09 | ケモセントリックス，インコーポレイティド | Ｐｄ－ｌ１疾患の処置のためのヘテロアリール－ビフェニルアミド |
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| ATE402704T1 (de) | 2000-03-27 | 2008-08-15 | Abbott Gmbh & Co Kg | Dopamin-d3-rezeptor-liganden zur behandlung von sucht |
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| US20020045613A1 (en) | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
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2003
- 2003-06-11 EP EP03737057A patent/EP1531822B1/en not_active Expired - Lifetime
- 2003-06-11 DE DE60328690T patent/DE60328690D1/de not_active Expired - Lifetime
- 2003-06-11 DK DK03737057T patent/DK1531822T3/da active
- 2003-06-11 CN CN038193027A patent/CN1867336B/zh not_active Expired - Fee Related
- 2003-06-11 AU AU2003236500A patent/AU2003236500B9/en not_active Ceased
- 2003-06-11 WO PCT/US2003/018660 patent/WO2003105853A1/en not_active Ceased
- 2003-06-11 MX MXPA04012393A patent/MXPA04012393A/es active IP Right Grant
- 2003-06-11 KR KR1020047020177A patent/KR101255356B1/ko not_active Expired - Fee Related
- 2003-06-11 JP JP2004512756A patent/JP4723242B2/ja not_active Expired - Lifetime
- 2003-06-11 US US10/460,752 patent/US7157464B2/en not_active Expired - Lifetime
- 2003-06-11 ES ES03737057T patent/ES2329356T3/es not_active Expired - Lifetime
- 2003-06-11 CA CA2488202A patent/CA2488202C/en not_active Expired - Fee Related
- 2003-06-11 AT AT03737057T patent/ATE438401T1/de active
-
2006
- 2006-07-21 US US11/491,540 patent/US7449576B1/en not_active Expired - Lifetime
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