JP2006504644A5 - - Google Patents
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- Publication number
- JP2006504644A5 JP2006504644A5 JP2004518318A JP2004518318A JP2006504644A5 JP 2006504644 A5 JP2006504644 A5 JP 2006504644A5 JP 2004518318 A JP2004518318 A JP 2004518318A JP 2004518318 A JP2004518318 A JP 2004518318A JP 2006504644 A5 JP2006504644 A5 JP 2006504644A5
- Authority
- JP
- Japan
- Prior art keywords
- adjuvant
- coat protein
- immune response
- animal
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002671 adjuvant Substances 0.000 claims description 25
- 230000028993 immune response Effects 0.000 claims description 19
- 241001465754 Metazoa Species 0.000 claims description 17
- 241000709995 Papaya mosaic virus Species 0.000 claims description 10
- 230000002163 immunogen Effects 0.000 claims description 10
- 241000700605 Viruses Species 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 101710132601 Capsid protein Proteins 0.000 claims description 4
- 101710094648 Coat protein Proteins 0.000 claims description 4
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims description 4
- 101710125418 Major capsid protein Proteins 0.000 claims description 4
- 101710141454 Nucleoprotein Proteins 0.000 claims description 4
- 101710083689 Probable capsid protein Proteins 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 2
- 108700030444 papaya mosiac virus coat Proteins 0.000 claims 20
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000000890 antigenic effect Effects 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 244000045947 parasite Species 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 241000251468 Actinopterygii Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000024932 T cell mediated immunity Effects 0.000 claims 2
- 239000013566 allergen Substances 0.000 claims 2
- 230000028996 humoral immune response Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108090000565 Capsid Proteins Proteins 0.000 description 1
- 102100023321 Ceruloplasmin Human genes 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108010013381 Porins Proteins 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 102100021696 Syncytin-1 Human genes 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000002434 immunopotentiative effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 102000007739 porin activity proteins Human genes 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39365902P | 2002-07-05 | 2002-07-05 | |
| US60/393,659 | 2002-07-05 | ||
| PCT/CA2003/000985 WO2004004761A2 (en) | 2002-07-05 | 2003-06-30 | Adjuvant viral particle |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006504644A JP2006504644A (ja) | 2006-02-09 |
| JP2006504644A5 true JP2006504644A5 (enExample) | 2006-08-31 |
| JP4953570B2 JP4953570B2 (ja) | 2012-06-13 |
Family
ID=30115621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004518318A Expired - Fee Related JP4953570B2 (ja) | 2002-07-05 | 2003-06-30 | アジュバントウィルス粒子 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7641896B2 (enExample) |
| EP (2) | EP1523329B1 (enExample) |
| JP (1) | JP4953570B2 (enExample) |
| KR (1) | KR20050044886A (enExample) |
| CN (1) | CN1665528B (enExample) |
| AU (1) | AU2003281246A1 (enExample) |
| BR (1) | BR0312474A (enExample) |
| CA (1) | CA2434000C (enExample) |
| DK (1) | DK1523329T3 (enExample) |
| ES (1) | ES2431963T3 (enExample) |
| MX (1) | MXPA05000287A (enExample) |
| NO (1) | NO20050396L (enExample) |
| PT (1) | PT1523329E (enExample) |
| WO (1) | WO2004004761A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8101189B2 (en) | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
| MXPA05000287A (es) * | 2002-07-05 | 2005-09-08 | Leclerc Denis | Particula viral adyuvante. |
| JP2008513035A (ja) * | 2004-09-21 | 2008-05-01 | サイトス バイオテクノロジー アーゲー | Ａｐ２０５のコートタンパク質と抗原性ポリペプチドとの融合タンパク質を含んでなるウイルス粒子 |
| ZA200701792B (en) | 2004-10-25 | 2008-12-31 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof |
| KR100688522B1 (ko) * | 2005-01-18 | 2007-03-02 | 삼성전자주식회사 | 영상데이터 압축기 및 압축방법 |
| KR20080018176A (ko) * | 2005-06-01 | 2008-02-27 | 다우 글로벌 테크놀로지스 인크. | 다가 바이러스 유사 입자 생산 방법 |
| AT503690A1 (de) | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| WO2012048430A1 (en) * | 2010-10-14 | 2012-04-19 | Folia Biotech Inc. | Affinity-conjugated nucleoprotein-papaya mosaic virus-like particles and uses thereof |
| JP2010508857A (ja) * | 2006-11-15 | 2010-03-25 | フォリア バイオテック インコーポレイテッド | パパイヤモザイクウイルスに基づく免疫原性の親和性で複合体化された抗原系及びその使用 |
| ES2562774T3 (es) * | 2006-11-15 | 2016-03-08 | Folia Biotech Inc. | Vacunas para la gripe basadas en el virus del mosaico de la papaya |
| WO2008089569A1 (en) * | 2007-01-26 | 2008-07-31 | Folia Biotech Inc. | Papaya mosaic virus-based vaccines against salmonella typhi and other enterobacterial pathogens |
| AU2008279584A1 (en) * | 2007-04-27 | 2009-01-29 | Dow Global Technologies Inc. | Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles |
| JP2010538619A (ja) * | 2007-09-11 | 2010-12-16 | ユニベルシテ ラヴァル | Ｍａｌｖａモザイクウイルスおよびウイルス様粒子およびこれらの使用 |
| US20110189231A1 (en) * | 2008-06-17 | 2011-08-04 | Denis Leclerc | Compositions Comprising Salmonella Porins and Uses Thereof as Adjuvants and Vaccines |
| CA2742288A1 (en) * | 2008-07-30 | 2010-02-04 | Folia Biotech Inc. | Multivalent vaccines based on papaya mosaic virus and uses thereof |
| WO2012078069A1 (en) * | 2010-12-09 | 2012-06-14 | Iosif Grigorievich Atabekov | Spherical nano- and microparticles derived from plant viruses for the display of foreign proteins or epitopes |
| CN103687942A (zh) * | 2011-05-13 | 2014-03-26 | 弗利亚生物技术公司 | 病毒样颗粒及其制备方法 |
| WO2012168487A1 (en) | 2011-06-09 | 2012-12-13 | Biomay Ag | Peptide carrier fusion proteins as allergy vaccines |
| HK1203983A1 (en) * | 2012-04-02 | 2015-11-06 | Folia Biotech Inc. | Recombinant papaya mosaic virus coat proteins and uses thereof in influenza vaccines |
| JP2016531927A (ja) * | 2013-09-19 | 2016-10-13 | フォリア バイオテック インコーポレイテッド | 癌治療でのパパイヤモザイクウイルス及びウイルス様粒子 |
| US20180153984A1 (en) * | 2015-04-30 | 2018-06-07 | The Regents Of The University Of California | Adjuvant particles comprising adenosine receptor antagonists |
| CN115956125A (zh) * | 2020-03-31 | 2023-04-11 | 医学噬菌体生物制药公司 | 用于产生病毒样颗粒的载体及其用途 |
| AU2022208435A1 (en) | 2021-01-18 | 2023-08-10 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
| CN118684781A (zh) * | 2023-03-21 | 2024-09-24 | 深圳赫兹生命科学技术有限公司 | GnRH-VLP重组去势疫苗及其制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL79880A0 (en) | 1985-08-29 | 1986-11-30 | Inst Medical W & E Hall | Recombinant virus |
| US5977438A (en) * | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
| DE4006630A1 (de) | 1990-03-03 | 1991-09-12 | Behringwerke Ag | Humane monoklonale antikoerper gegen tollwutviren, ihre herstellung und verwendung |
| WO1992003537A1 (en) | 1990-08-15 | 1992-03-05 | Therion Biologics Corporation | Self-assembling replication defective hybrid virus particles |
| US5443969A (en) * | 1992-10-29 | 1995-08-22 | Rutgers University | RNA packaging system |
| GB9414118D0 (en) * | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
| CA2202761A1 (en) | 1994-10-18 | 1996-04-25 | Sean Nicholas Chapman | Method of producing a chimeric protein |
| GB9607899D0 (en) | 1996-04-17 | 1996-06-19 | Scottish Crop Research Inst | Virus-like particle |
| US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| AU750702B2 (en) * | 1997-05-01 | 2002-07-25 | Chiron Corporation | Use of virus-like particles as adjuvants |
| US6228368B1 (en) | 1997-10-06 | 2001-05-08 | Loyola University Of Chicago | Papilloma virus capsomere formulations and method of use |
| DE19752855C2 (de) | 1997-11-28 | 2003-04-03 | Bundesrepublik Deutschland Let | Retrovirale Pseudotyp-Vektoren mit modifizierten Oberflächen-Hüllproteinen und Verpackungszelle zu ihrer Herstellung für den selektiven Gentransfer |
| GB9806666D0 (en) | 1998-03-27 | 1998-05-27 | Stanley Margaret | Antigen preparation and use |
| CA2334170A1 (en) | 1998-07-27 | 2000-02-10 | Genentech, Inc. | Improved transformation efficiency in phage display through modification of a coat protein |
| FR2786773B1 (fr) | 1998-12-03 | 2002-03-08 | Univ Paris Curie | Proteines d'enveloppe, methodes et utilisations |
| BR9915942A (pt) * | 1998-12-04 | 2001-08-21 | Biogen Inc | Patìculas de antìgeno de núcleo de hbv com componentes imunogênicos múltiplos ligados através de ligantes de peptìdeo |
| DE19904800C1 (de) | 1999-02-05 | 2001-02-08 | Eberhard Hildt | Partikel zur Gentherapie |
| GB9921337D0 (en) * | 1999-09-09 | 1999-11-10 | Axis Genetics Plc | Modified plant viruses |
| GB9924351D0 (en) * | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| GB9924352D0 (en) | 1999-10-14 | 1999-12-15 | Hellendoorn Koen | Methods,compositions and applications relating to the generation of novel plant viral particles |
| US6730306B1 (en) | 2000-03-08 | 2004-05-04 | Large Scale Biology Corporation | Parvovirus vaccine as viral coat protein fusions |
| AUPQ661600A0 (en) | 2000-03-31 | 2000-05-04 | Macfarlane Burnet Centre For Medical Research Limited, The | A nucleic acid construct and methods related thereto |
| IT1317046B1 (it) * | 2000-06-16 | 2003-05-26 | Ist Superiore Sanita | Proteina di fusione, particelle virali chimeriche che la espongono sulcapside, piante infettate con tali particelle, loro usi e composizioni |
| CA2414396A1 (en) | 2000-06-26 | 2002-01-03 | The United States Of America, As Represented By The Secretary Of Agricul Ture | Production of vaccines using transgenic plants |
| ES2317910T3 (es) | 2000-07-06 | 2009-05-01 | Georgetown University | Formas (fijas) estables e proteinas de capside l1 virales, proteinas de fusion y sus utilizaciones. |
| GB0028319D0 (en) * | 2000-11-20 | 2001-01-03 | Univ Southampton | Materials and methods relating to fusion proteins for inducing an immune response |
| ITRM20010332A1 (it) * | 2001-06-11 | 2002-12-11 | Ist Superiore Sanita | Vaccini a subunita' e procedimenti per la loro produzione. |
| MXPA05000287A (es) * | 2002-07-05 | 2005-09-08 | Leclerc Denis | Particula viral adyuvante. |
| US8101189B2 (en) * | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
-
2003
- 2003-06-30 MX MXPA05000287A patent/MXPA05000287A/es active IP Right Grant
- 2003-06-30 EP EP03739913.6A patent/EP1523329B1/en not_active Expired - Lifetime
- 2003-06-30 BR BR0312474-6A patent/BR0312474A/pt not_active Application Discontinuation
- 2003-06-30 CA CA2434000A patent/CA2434000C/en not_active Expired - Fee Related
- 2003-06-30 DK DK03739913.6T patent/DK1523329T3/da active
- 2003-06-30 ES ES03739913T patent/ES2431963T3/es not_active Expired - Lifetime
- 2003-06-30 KR KR1020057000114A patent/KR20050044886A/ko not_active Withdrawn
- 2003-06-30 AU AU2003281246A patent/AU2003281246A1/en not_active Abandoned
- 2003-06-30 CN CN03815935XA patent/CN1665528B/zh not_active Expired - Fee Related
- 2003-06-30 PT PT37399136T patent/PT1523329E/pt unknown
- 2003-06-30 JP JP2004518318A patent/JP4953570B2/ja not_active Expired - Fee Related
- 2003-06-30 WO PCT/CA2003/000985 patent/WO2004004761A2/en not_active Ceased
- 2003-06-30 EP EP10179379A patent/EP2272525A3/en not_active Withdrawn
- 2003-07-01 US US10/609,417 patent/US7641896B2/en not_active Expired - Fee Related
-
2005
- 2005-01-25 NO NO20050396A patent/NO20050396L/no not_active Application Discontinuation
-
2009
- 2009-04-03 US US12/384,476 patent/US8282940B2/en not_active Expired - Fee Related
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