JP2006504644A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006504644A5 JP2006504644A5 JP2004518318A JP2004518318A JP2006504644A5 JP 2006504644 A5 JP2006504644 A5 JP 2006504644A5 JP 2004518318 A JP2004518318 A JP 2004518318A JP 2004518318 A JP2004518318 A JP 2004518318A JP 2006504644 A5 JP2006504644 A5 JP 2006504644A5
- Authority
- JP
- Japan
- Prior art keywords
- adjuvant
- coat protein
- immune response
- animal
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002671 adjuvant Substances 0.000 claims description 25
- 230000028993 immune response Effects 0.000 claims description 19
- 241001465754 Metazoa Species 0.000 claims description 17
- 241000709995 Papaya mosaic virus Species 0.000 claims description 10
- 230000002163 immunogen Effects 0.000 claims description 10
- 241000700605 Viruses Species 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 101710132601 Capsid protein Proteins 0.000 claims description 4
- 101710094648 Coat protein Proteins 0.000 claims description 4
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims description 4
- 101710125418 Major capsid protein Proteins 0.000 claims description 4
- 101710141454 Nucleoprotein Proteins 0.000 claims description 4
- 101710083689 Probable capsid protein Proteins 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 2
- 108700030444 papaya mosiac virus coat Proteins 0.000 claims 20
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000000890 antigenic effect Effects 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 244000045947 parasite Species 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 241000251468 Actinopterygii Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000024932 T cell mediated immunity Effects 0.000 claims 2
- 239000013566 allergen Substances 0.000 claims 2
- 230000028996 humoral immune response Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108090000565 Capsid Proteins Proteins 0.000 description 1
- 102100023321 Ceruloplasmin Human genes 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108010013381 Porins Proteins 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 102100021696 Syncytin-1 Human genes 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000002434 immunopotentiative effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 102000007739 porin activity proteins Human genes 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39365902P | 2002-07-05 | 2002-07-05 | |
| US60/393,659 | 2002-07-05 | ||
| PCT/CA2003/000985 WO2004004761A2 (en) | 2002-07-05 | 2003-06-30 | Adjuvant viral particle |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006504644A JP2006504644A (ja) | 2006-02-09 |
| JP2006504644A5 true JP2006504644A5 (enExample) | 2006-08-31 |
| JP4953570B2 JP4953570B2 (ja) | 2012-06-13 |
Family
ID=30115621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004518318A Expired - Fee Related JP4953570B2 (ja) | 2002-07-05 | 2003-06-30 | アジュバントウィルス粒子 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7641896B2 (enExample) |
| EP (2) | EP1523329B1 (enExample) |
| JP (1) | JP4953570B2 (enExample) |
| KR (1) | KR20050044886A (enExample) |
| CN (1) | CN1665528B (enExample) |
| AU (1) | AU2003281246A1 (enExample) |
| BR (1) | BR0312474A (enExample) |
| CA (1) | CA2434000C (enExample) |
| DK (1) | DK1523329T3 (enExample) |
| ES (1) | ES2431963T3 (enExample) |
| MX (1) | MXPA05000287A (enExample) |
| NO (1) | NO20050396L (enExample) |
| PT (1) | PT1523329E (enExample) |
| WO (1) | WO2004004761A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05000287A (es) * | 2002-07-05 | 2005-09-08 | Leclerc Denis | Particula viral adyuvante. |
| US8101189B2 (en) | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
| NZ554387A (en) * | 2004-09-21 | 2009-09-25 | Cytos Biotechnology Ag | Virus-like particles comprising a fusion protein of the coat protein of AP205 and an antigenic polypeptide |
| NZ554386A (en) | 2004-10-25 | 2009-12-24 | Cytos Biotechnology Ag | Gastric inhibtory polypeptide (GIP) antigen arrays with VLPs and uses thereof |
| KR100688522B1 (ko) * | 2005-01-18 | 2007-03-02 | 삼성전자주식회사 | 영상데이터 압축기 및 압축방법 |
| CA2608515A1 (en) | 2005-06-01 | 2007-05-10 | Dow Global Technolgies Inc. | Production of multivalent virus like particles |
| AT503690A1 (de) | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| US20100111996A1 (en) * | 2006-11-15 | 2010-05-06 | Denis Leclerc | Papaya Mosaic Virus-Based Vaccines for Influenza |
| WO2008058369A1 (en) | 2006-11-15 | 2008-05-22 | Folia Biotech Inc. | Immunogenic affinity-conjugated antigen systems based on papaya mosaic virus and uses thereof |
| EP2082042A4 (en) * | 2007-01-26 | 2010-08-18 | Folia Biotech Inc | VACCINE VACCINE FROM PAPAYA MOSAIC AGAINST SALMONELLA TYPHI AND OTHER ENTEROBACTERIAL PATHOGENS |
| AU2008279584A1 (en) * | 2007-04-27 | 2009-01-29 | Dow Global Technologies Inc. | Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles |
| JP2010538619A (ja) * | 2007-09-11 | 2010-12-16 | ユニベルシテ ラヴァル | Ｍａｌｖａモザイクウイルスおよびウイルス様粒子およびこれらの使用 |
| WO2010003219A1 (en) * | 2008-06-17 | 2010-01-14 | Universite Laval | Compositions comprising salmonella porins and uses thereof as adjuvants and vaccines |
| WO2010012069A1 (en) * | 2008-07-30 | 2010-02-04 | Folio Biotech Inc. | Multivalent vaccines based on papaya mosaic virus and uses thereof |
| CA2763795A1 (en) * | 2010-10-14 | 2012-03-20 | Folia Biotech Inc. | Affinity-conjugated nucleoprotein-papaya mosaic virus-like particles and uses thereof |
| WO2012078069A1 (en) * | 2010-12-09 | 2012-06-14 | Iosif Grigorievich Atabekov | Spherical nano- and microparticles derived from plant viruses for the display of foreign proteins or epitopes |
| DK2707480T3 (da) * | 2011-05-13 | 2017-11-13 | Folia Biotech Inc | Viruslignende partikler og fremgangsmåde til fremstilling heraf |
| PT2717910T (pt) | 2011-06-09 | 2019-05-22 | Biomay Ag | Proteínas de fusão transportadoras de péptido como vacinas para alergia |
| WO2013149334A1 (en) * | 2012-04-02 | 2013-10-10 | Folia Biotech Inc. | Recombinant papaya mosaic virus coat proteins and uses thereof in influenza vaccines |
| WO2015039255A1 (en) * | 2013-09-19 | 2015-03-26 | Folia Biotech Inc. | Papaya mosaic virus and virus-like particles in cancer therapy |
| WO2016176558A1 (en) * | 2015-04-30 | 2016-11-03 | The Regents Of The University Of California | Adjuvant particles comprising adenosine receptor antagonists |
| WO2021198963A1 (en) * | 2020-03-31 | 2021-10-07 | Mediphage Bioceuticals, Inc. | Vectors for producing virus-like particles and uses thereof |
| AU2022208435A1 (en) | 2021-01-18 | 2023-08-10 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
| CN118684781A (zh) * | 2023-03-21 | 2024-09-24 | 深圳赫兹生命科学技术有限公司 | GnRH-VLP重组去势疫苗及其制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL79880A0 (en) | 1985-08-29 | 1986-11-30 | Inst Medical W & E Hall | Recombinant virus |
| US5977438A (en) * | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
| DE4006630A1 (de) | 1990-03-03 | 1991-09-12 | Behringwerke Ag | Humane monoklonale antikoerper gegen tollwutviren, ihre herstellung und verwendung |
| DE69128898T2 (de) * | 1990-08-15 | 1998-05-28 | Therion Biolog Corp | Selbstständig zusammenfügende replikationsdefekte hybride viruspartikel |
| US5443969A (en) * | 1992-10-29 | 1995-08-22 | Rutgers University | RNA packaging system |
| GB9414118D0 (en) * | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
| CA2202761A1 (en) | 1994-10-18 | 1996-04-25 | Sean Nicholas Chapman | Method of producing a chimeric protein |
| GB9607899D0 (en) | 1996-04-17 | 1996-06-19 | Scottish Crop Research Inst | Virus-like particle |
| US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| AU750702B2 (en) * | 1997-05-01 | 2002-07-25 | Chiron Corporation | Use of virus-like particles as adjuvants |
| US6228368B1 (en) | 1997-10-06 | 2001-05-08 | Loyola University Of Chicago | Papilloma virus capsomere formulations and method of use |
| DE19752855C2 (de) | 1997-11-28 | 2003-04-03 | Bundesrepublik Deutschland Let | Retrovirale Pseudotyp-Vektoren mit modifizierten Oberflächen-Hüllproteinen und Verpackungszelle zu ihrer Herstellung für den selektiven Gentransfer |
| GB9806666D0 (en) | 1998-03-27 | 1998-05-27 | Stanley Margaret | Antigen preparation and use |
| WO2000006717A2 (en) | 1998-07-27 | 2000-02-10 | Genentech, Inc. | Improved transformation efficiency in phage display through modification of a coat protein |
| FR2786773B1 (fr) | 1998-12-03 | 2002-03-08 | Univ Paris Curie | Proteines d'enveloppe, methodes et utilisations |
| DK1135408T3 (da) * | 1998-12-04 | 2012-01-23 | Biogen Idec Inc | HBV-kerneantigenpartikler med multipelle immunogene komponenter, som er bundne via peptidligander |
| DE19904800C1 (de) | 1999-02-05 | 2001-02-08 | Eberhard Hildt | Partikel zur Gentherapie |
| GB9921337D0 (en) * | 1999-09-09 | 1999-11-10 | Axis Genetics Plc | Modified plant viruses |
| GB9924352D0 (en) | 1999-10-14 | 1999-12-15 | Hellendoorn Koen | Methods,compositions and applications relating to the generation of novel plant viral particles |
| GB9924351D0 (en) * | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| US6730306B1 (en) | 2000-03-08 | 2004-05-04 | Large Scale Biology Corporation | Parvovirus vaccine as viral coat protein fusions |
| AUPQ661600A0 (en) | 2000-03-31 | 2000-05-04 | Macfarlane Burnet Centre For Medical Research Limited, The | A nucleic acid construct and methods related thereto |
| IT1317046B1 (it) | 2000-06-16 | 2003-05-26 | Ist Superiore Sanita | Proteina di fusione, particelle virali chimeriche che la espongono sulcapside, piante infettate con tali particelle, loro usi e composizioni |
| AU2001270164A1 (en) | 2000-06-26 | 2002-01-08 | The United States Of America As Represented By The Secretary Of Agriculture | Production of vaccines using transgenic plants |
| ATE418997T1 (de) | 2000-07-06 | 2009-01-15 | Univ Georgetown | Stabile (fixierte) formen von viralen l1 capsidproteinen, deren fusionsproteinen, und deren verwendungen |
| GB0028319D0 (en) * | 2000-11-20 | 2001-01-03 | Univ Southampton | Materials and methods relating to fusion proteins for inducing an immune response |
| ITRM20010332A1 (it) * | 2001-06-11 | 2002-12-11 | Ist Superiore Sanita | Vaccini a subunita' e procedimenti per la loro produzione. |
| US8101189B2 (en) * | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
| MXPA05000287A (es) * | 2002-07-05 | 2005-09-08 | Leclerc Denis | Particula viral adyuvante. |
-
2003
- 2003-06-30 MX MXPA05000287A patent/MXPA05000287A/es active IP Right Grant
- 2003-06-30 EP EP03739913.6A patent/EP1523329B1/en not_active Expired - Lifetime
- 2003-06-30 BR BR0312474-6A patent/BR0312474A/pt not_active Application Discontinuation
- 2003-06-30 KR KR1020057000114A patent/KR20050044886A/ko not_active Withdrawn
- 2003-06-30 EP EP10179379A patent/EP2272525A3/en not_active Withdrawn
- 2003-06-30 DK DK03739913.6T patent/DK1523329T3/da active
- 2003-06-30 CA CA2434000A patent/CA2434000C/en not_active Expired - Fee Related
- 2003-06-30 AU AU2003281246A patent/AU2003281246A1/en not_active Abandoned
- 2003-06-30 ES ES03739913T patent/ES2431963T3/es not_active Expired - Lifetime
- 2003-06-30 PT PT37399136T patent/PT1523329E/pt unknown
- 2003-06-30 CN CN03815935XA patent/CN1665528B/zh not_active Expired - Fee Related
- 2003-06-30 WO PCT/CA2003/000985 patent/WO2004004761A2/en not_active Ceased
- 2003-06-30 JP JP2004518318A patent/JP4953570B2/ja not_active Expired - Fee Related
- 2003-07-01 US US10/609,417 patent/US7641896B2/en not_active Expired - Fee Related
-
2005
- 2005-01-25 NO NO20050396A patent/NO20050396L/no not_active Application Discontinuation
-
2009
- 2009-04-03 US US12/384,476 patent/US8282940B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Syomin et al. | Virus-like particles as an instrument of vaccine production | |
| Qiao et al. | Recombinant lactic acid bacteria as promising vectors for mucosal vaccination | |
| Cox | Recombinant protein vaccines produced in insect cells | |
| JP4953570B2 (ja) | アジュバントウィルス粒子 | |
| TWI481717B (zh) | 免疫原性組合物及其用途 | |
| RU2005104824A (ru) | Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6 | |
| Shoja et al. | Rotavirus VP6: involvement in immunogenicity, adjuvant activity, and use as a vector for heterologous peptides, drug delivery, and production of nano-biomaterials: Z. Shoja et al. | |
| JP2009526780A5 (enExample) | ||
| JP2010516713A5 (enExample) | ||
| Pumpens et al. | Construction of novel vaccines on the basis of the virus-like particles: Hepatitis B virus proteins as vaccine carriers | |
| JP2019195328A (ja) | デングウイルスワクチンのための方法および組成物 | |
| Huo et al. | Hepatitis B virus core particles containing multiple epitopes confer protection against enterovirus 71 and coxsackievirus A16 infection in mice | |
| Narayanan et al. | Recombinant helical plant virus-based nanoparticles for vaccination and immunotherapy | |
| JP2010508857A5 (enExample) | ||
| EP1136077B1 (en) | Preparations containing virus-like particles as immunopotentiators administered through the mucosa | |
| Chen et al. | Recombinant bacteriophage T4 displaying key epitopes of the foot-and-mouth disease virus as a novel nanoparticle vaccine | |
| CN101880647B (zh) | 重组猪霍乱沙门氏菌及二价基因工程疫苗与应用 | |
| Badri Narayanan et al. | Genetic modifications of icosahedral plant virus-based nanoparticles for vaccine and immunotherapy applications | |
| JP2009522368A5 (enExample) | ||
| US8691234B2 (en) | Vaccine formulation potentiated by the combination of DNA and an antigen | |
| CN102464721A (zh) | 针对人肠道病毒71型的重组广谱性疫苗 | |
| CN115850398B (zh) | 新型冠状病毒奥密克戎系列变异株的多肽组合物及其应用 | |
| CA3044582C (en) | Vaccine composition comprising hepatitis b virus-like particles as adjuvant | |
| Melhem et al. | The current status of Norovirus vaccine development | |
| RU2007112117A (ru) | Вакцинная композиция против вируса гепатита с |