JP2009522368A5 - - Google Patents
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- Publication number
- JP2009522368A5 JP2009522368A5 JP2008549583A JP2008549583A JP2009522368A5 JP 2009522368 A5 JP2009522368 A5 JP 2009522368A5 JP 2008549583 A JP2008549583 A JP 2008549583A JP 2008549583 A JP2008549583 A JP 2008549583A JP 2009522368 A5 JP2009522368 A5 JP 2009522368A5
- Authority
- JP
- Japan
- Prior art keywords
- hcv
- agent
- composition
- complex
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000711549 Hepacivirus C Species 0.000 claims 69
- 239000000203 mixture Substances 0.000 claims 57
- 239000003795 chemical substances by application Substances 0.000 claims 56
- 150000001413 amino acids Chemical group 0.000 claims 50
- 235000001014 amino acid Nutrition 0.000 claims 34
- 108020004707 nucleic acids Proteins 0.000 claims 28
- 102000039446 nucleic acids Human genes 0.000 claims 28
- 150000007523 nucleic acids Chemical class 0.000 claims 28
- 235000018102 proteins Nutrition 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 26
- 102000004169 proteins and genes Human genes 0.000 claims 26
- 239000013603 viral vector Substances 0.000 claims 25
- 239000003814 drug Substances 0.000 claims 23
- 210000001744 T-lymphocyte Anatomy 0.000 claims 18
- 108010076039 Polyproteins Proteins 0.000 claims 16
- 241000710929 Alphavirus Species 0.000 claims 10
- 230000028993 immune response Effects 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 9
- 239000007764 o/w emulsion Substances 0.000 claims 9
- 239000002671 adjuvant Substances 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 239000013598 vector Substances 0.000 claims 7
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 5
- 230000005867 T cell response Effects 0.000 claims 5
- 230000005875 antibody response Effects 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 239000004475 Arginine Substances 0.000 claims 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 4
- 239000004472 Lysine Substances 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 230000003213 activating effect Effects 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 4
- 230000002950 deficient Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229930182817 methionine Natural products 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 3
- -1 amino-carboxy sequence Chemical group 0.000 claims 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 3
- 230000028996 humoral immune response Effects 0.000 claims 3
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 230000003472 neutralizing effect Effects 0.000 claims 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 3
- 229920000053 polysorbate 80 Polymers 0.000 claims 3
- 229940031439 squalene Drugs 0.000 claims 3
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 3
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 101710165845 CD81 protein Proteins 0.000 claims 1
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- SHFKGANKURXVMY-LCWPZEQJSA-N hcv e2 protein Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)CC1=CC=CC=C1 SHFKGANKURXVMY-LCWPZEQJSA-N 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75635406P | 2006-01-04 | 2006-01-04 | |
| US60/756,354 | 2006-01-04 | ||
| US79984006P | 2006-05-11 | 2006-05-11 | |
| US60/799,840 | 2006-05-11 | ||
| US84008206P | 2006-08-25 | 2006-08-25 | |
| US60/840,082 | 2006-08-25 | ||
| PCT/US2007/000362 WO2007081848A2 (en) | 2006-01-04 | 2007-01-04 | Activation of hcv-specific t cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009522368A JP2009522368A (ja) | 2009-06-11 |
| JP2009522368A5 true JP2009522368A5 (enExample) | 2011-02-10 |
| JP5405832B2 JP5405832B2 (ja) | 2014-02-05 |
Family
ID=38256946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008549583A Expired - Fee Related JP5405832B2 (ja) | 2006-01-04 | 2007-01-04 | Ｈｃｖ特異的なｔ細胞の活性化 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8178086B2 (enExample) |
| EP (1) | EP1981537B1 (enExample) |
| JP (1) | JP5405832B2 (enExample) |
| CA (1) | CA2636032C (enExample) |
| ES (1) | ES2551113T3 (enExample) |
| WO (1) | WO2007081848A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101578520B (zh) | 2006-10-18 | 2015-09-16 | 哈佛学院院长等 | 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法 |
| CN102016596B (zh) | 2008-03-27 | 2014-09-17 | 哈佛学院院长等 | 纸基微流体系统 |
| CA2719322C (en) | 2008-03-27 | 2018-11-27 | President And Fellows Of Harvard College | Cotton thread as a low-cost multi-assay diagnostic platform |
| US8628729B2 (en) | 2008-03-27 | 2014-01-14 | President And Fellows Of Harvard College | Three-dimensional microfluidic devices |
| US9829488B2 (en) | 2008-03-27 | 2017-11-28 | President And Fellows Of Havard College | Paper-based cellular arrays |
| PL2403645T3 (pl) | 2009-03-06 | 2017-05-31 | President And Fellows Of Harvard College | Mikroprzepływowe, elektrochemiczne urządzenia |
| CU24112B1 (es) * | 2012-11-05 | 2015-08-27 | Ct De Ingeniería Genética Y Biotecnología | Antígenos vacunales quiméricos contra el virus de la hepatitis c |
| RU2675108C2 (ru) * | 2015-06-15 | 2018-12-17 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича" (ИБМХ) | Композиция на основе синтетических пептидов и липидов для вакцины против гепатита с |
| US10300131B2 (en) | 2015-07-07 | 2019-05-28 | The Governors Of The University Of Alberta | Hepatitis C virus immunogenic compositions and methods of use thereof |
| WO2018055535A2 (en) * | 2016-09-21 | 2018-03-29 | The Governors Of The University Of Alberta | Hepatitis c virus immunogenic compositions and methods of use thereof |
| JP2024525578A (ja) * | 2021-07-06 | 2024-07-12 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Ｃ型肝炎ウイルスのためのＰ７含有ヌクレオシド－改変されたｍＲＮＡ－脂質ナノ粒子系統ワクチン |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
| US6054424A (en) | 1998-04-15 | 2000-04-25 | Church & Dwight Co., Inc. | Process for the production of a liquid laundry detergent composition of desired viscosity containing nonionic and anionic surfactants |
| US20050074465A1 (en) | 1999-11-24 | 2005-04-07 | Michael Houghton | HCV fusion proteins with modified NS3 domains |
| DE60040755D1 (de) * | 1999-12-01 | 2008-12-18 | Novartis Vaccines & Diagnostic | Hervorrufen von antikörpern spezifisch für hepatitis c virus (hcv) |
| CA2448066A1 (en) | 2001-05-31 | 2002-12-12 | Chiron Corporation | Chimeric alphavirus replicon particles |
| US20030232324A1 (en) | 2001-05-31 | 2003-12-18 | Chiron Corporation | Chimeric alphavirus replicon particles |
| GB0226722D0 (en) * | 2002-11-15 | 2002-12-24 | Glaxo Group Ltd | Vaccine |
| RU2006144714A (ru) * | 2004-05-17 | 2008-06-27 | Чирон Корпорейшн (Us) | Усеченный ns5 домен вируса гепатита с и содержащие его слитые белки |
-
2007
- 2007-01-04 ES ES07709585.9T patent/ES2551113T3/es active Active
- 2007-01-04 US US12/087,330 patent/US8178086B2/en not_active Expired - Fee Related
- 2007-01-04 EP EP07709585.9A patent/EP1981537B1/en not_active Not-in-force
- 2007-01-04 WO PCT/US2007/000362 patent/WO2007081848A2/en not_active Ceased
- 2007-01-04 CA CA2636032A patent/CA2636032C/en not_active Expired - Fee Related
- 2007-01-04 JP JP2008549583A patent/JP5405832B2/ja not_active Expired - Fee Related
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