ES2431963T3 - Partícula viral adyuvante - Google Patents
Partícula viral adyuvante Download PDFInfo
- Publication number
- ES2431963T3 ES2431963T3 ES03739913T ES03739913T ES2431963T3 ES 2431963 T3 ES2431963 T3 ES 2431963T3 ES 03739913 T ES03739913 T ES 03739913T ES 03739913 T ES03739913 T ES 03739913T ES 2431963 T3 ES2431963 T3 ES 2431963T3
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- papmv
- virus
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- protein
- immune response
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
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- A61K39/385—Haptens or antigens, bound to carriers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/26011—Flexiviridae
- C12N2770/26023—Virus like particles [VLP]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
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| US39365902P | 2002-07-05 | 2002-07-05 | |
| US393659P | 2002-07-05 | ||
| PCT/CA2003/000985 WO2004004761A2 (en) | 2002-07-05 | 2003-06-30 | Adjuvant viral particle |
Publications (1)
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| ES2431963T3 true ES2431963T3 (es) | 2013-11-28 |
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Family Applications (1)
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| ES03739913T Expired - Lifetime ES2431963T3 (es) | 2002-07-05 | 2003-06-30 | Partícula viral adyuvante |
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| EP (2) | EP1523329B1 (enExample) |
| JP (1) | JP4953570B2 (enExample) |
| KR (1) | KR20050044886A (enExample) |
| CN (1) | CN1665528B (enExample) |
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| ES (1) | ES2431963T3 (enExample) |
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| NO (1) | NO20050396L (enExample) |
| PT (1) | PT1523329E (enExample) |
| WO (1) | WO2004004761A2 (enExample) |
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| MXPA05000287A (es) * | 2002-07-05 | 2005-09-08 | Leclerc Denis | Particula viral adyuvante. |
| US8101189B2 (en) | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
| NZ554387A (en) * | 2004-09-21 | 2009-09-25 | Cytos Biotechnology Ag | Virus-like particles comprising a fusion protein of the coat protein of AP205 and an antigenic polypeptide |
| NZ554386A (en) | 2004-10-25 | 2009-12-24 | Cytos Biotechnology Ag | Gastric inhibtory polypeptide (GIP) antigen arrays with VLPs and uses thereof |
| KR100688522B1 (ko) * | 2005-01-18 | 2007-03-02 | 삼성전자주식회사 | 영상데이터 압축기 및 압축방법 |
| CA2608515A1 (en) | 2005-06-01 | 2007-05-10 | Dow Global Technolgies Inc. | Production of multivalent virus like particles |
| AT503690A1 (de) | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| US20100111996A1 (en) * | 2006-11-15 | 2010-05-06 | Denis Leclerc | Papaya Mosaic Virus-Based Vaccines for Influenza |
| WO2008058369A1 (en) | 2006-11-15 | 2008-05-22 | Folia Biotech Inc. | Immunogenic affinity-conjugated antigen systems based on papaya mosaic virus and uses thereof |
| EP2082042A4 (en) * | 2007-01-26 | 2010-08-18 | Folia Biotech Inc | VACCINE VACCINE FROM PAPAYA MOSAIC AGAINST SALMONELLA TYPHI AND OTHER ENTEROBACTERIAL PATHOGENS |
| AU2008279584A1 (en) * | 2007-04-27 | 2009-01-29 | Dow Global Technologies Inc. | Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles |
| JP2010538619A (ja) * | 2007-09-11 | 2010-12-16 | ユニベルシテ ラヴァル | Ｍａｌｖａモザイクウイルスおよびウイルス様粒子およびこれらの使用 |
| WO2010003219A1 (en) * | 2008-06-17 | 2010-01-14 | Universite Laval | Compositions comprising salmonella porins and uses thereof as adjuvants and vaccines |
| WO2010012069A1 (en) * | 2008-07-30 | 2010-02-04 | Folio Biotech Inc. | Multivalent vaccines based on papaya mosaic virus and uses thereof |
| CA2763795A1 (en) * | 2010-10-14 | 2012-03-20 | Folia Biotech Inc. | Affinity-conjugated nucleoprotein-papaya mosaic virus-like particles and uses thereof |
| WO2012078069A1 (en) * | 2010-12-09 | 2012-06-14 | Iosif Grigorievich Atabekov | Spherical nano- and microparticles derived from plant viruses for the display of foreign proteins or epitopes |
| DK2707480T3 (da) * | 2011-05-13 | 2017-11-13 | Folia Biotech Inc | Viruslignende partikler og fremgangsmåde til fremstilling heraf |
| PT2717910T (pt) | 2011-06-09 | 2019-05-22 | Biomay Ag | Proteínas de fusão transportadoras de péptido como vacinas para alergia |
| WO2013149334A1 (en) * | 2012-04-02 | 2013-10-10 | Folia Biotech Inc. | Recombinant papaya mosaic virus coat proteins and uses thereof in influenza vaccines |
| WO2015039255A1 (en) * | 2013-09-19 | 2015-03-26 | Folia Biotech Inc. | Papaya mosaic virus and virus-like particles in cancer therapy |
| WO2016176558A1 (en) * | 2015-04-30 | 2016-11-03 | The Regents Of The University Of California | Adjuvant particles comprising adenosine receptor antagonists |
| WO2021198963A1 (en) * | 2020-03-31 | 2021-10-07 | Mediphage Bioceuticals, Inc. | Vectors for producing virus-like particles and uses thereof |
| AU2022208435A1 (en) | 2021-01-18 | 2023-08-10 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
| CN118684781A (zh) * | 2023-03-21 | 2024-09-24 | 深圳赫兹生命科学技术有限公司 | GnRH-VLP重组去势疫苗及其制备方法 |
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| IL79880A0 (en) | 1985-08-29 | 1986-11-30 | Inst Medical W & E Hall | Recombinant virus |
| US5977438A (en) * | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
| DE4006630A1 (de) | 1990-03-03 | 1991-09-12 | Behringwerke Ag | Humane monoklonale antikoerper gegen tollwutviren, ihre herstellung und verwendung |
| DE69128898T2 (de) * | 1990-08-15 | 1998-05-28 | Therion Biolog Corp | Selbstständig zusammenfügende replikationsdefekte hybride viruspartikel |
| US5443969A (en) * | 1992-10-29 | 1995-08-22 | Rutgers University | RNA packaging system |
| GB9414118D0 (en) * | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
| CA2202761A1 (en) | 1994-10-18 | 1996-04-25 | Sean Nicholas Chapman | Method of producing a chimeric protein |
| GB9607899D0 (en) | 1996-04-17 | 1996-06-19 | Scottish Crop Research Inst | Virus-like particle |
| US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| AU750702B2 (en) * | 1997-05-01 | 2002-07-25 | Chiron Corporation | Use of virus-like particles as adjuvants |
| US6228368B1 (en) | 1997-10-06 | 2001-05-08 | Loyola University Of Chicago | Papilloma virus capsomere formulations and method of use |
| DE19752855C2 (de) | 1997-11-28 | 2003-04-03 | Bundesrepublik Deutschland Let | Retrovirale Pseudotyp-Vektoren mit modifizierten Oberflächen-Hüllproteinen und Verpackungszelle zu ihrer Herstellung für den selektiven Gentransfer |
| GB9806666D0 (en) | 1998-03-27 | 1998-05-27 | Stanley Margaret | Antigen preparation and use |
| WO2000006717A2 (en) | 1998-07-27 | 2000-02-10 | Genentech, Inc. | Improved transformation efficiency in phage display through modification of a coat protein |
| FR2786773B1 (fr) | 1998-12-03 | 2002-03-08 | Univ Paris Curie | Proteines d'enveloppe, methodes et utilisations |
| DK1135408T3 (da) * | 1998-12-04 | 2012-01-23 | Biogen Idec Inc | HBV-kerneantigenpartikler med multipelle immunogene komponenter, som er bundne via peptidligander |
| DE19904800C1 (de) | 1999-02-05 | 2001-02-08 | Eberhard Hildt | Partikel zur Gentherapie |
| GB9921337D0 (en) * | 1999-09-09 | 1999-11-10 | Axis Genetics Plc | Modified plant viruses |
| GB9924352D0 (en) | 1999-10-14 | 1999-12-15 | Hellendoorn Koen | Methods,compositions and applications relating to the generation of novel plant viral particles |
| GB9924351D0 (en) * | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| US6730306B1 (en) | 2000-03-08 | 2004-05-04 | Large Scale Biology Corporation | Parvovirus vaccine as viral coat protein fusions |
| AUPQ661600A0 (en) | 2000-03-31 | 2000-05-04 | Macfarlane Burnet Centre For Medical Research Limited, The | A nucleic acid construct and methods related thereto |
| IT1317046B1 (it) | 2000-06-16 | 2003-05-26 | Ist Superiore Sanita | Proteina di fusione, particelle virali chimeriche che la espongono sulcapside, piante infettate con tali particelle, loro usi e composizioni |
| AU2001270164A1 (en) | 2000-06-26 | 2002-01-08 | The United States Of America As Represented By The Secretary Of Agriculture | Production of vaccines using transgenic plants |
| ATE418997T1 (de) | 2000-07-06 | 2009-01-15 | Univ Georgetown | Stabile (fixierte) formen von viralen l1 capsidproteinen, deren fusionsproteinen, und deren verwendungen |
| GB0028319D0 (en) * | 2000-11-20 | 2001-01-03 | Univ Southampton | Materials and methods relating to fusion proteins for inducing an immune response |
| ITRM20010332A1 (it) * | 2001-06-11 | 2002-12-11 | Ist Superiore Sanita | Vaccini a subunita' e procedimenti per la loro produzione. |
| US8101189B2 (en) * | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
| MXPA05000287A (es) * | 2002-07-05 | 2005-09-08 | Leclerc Denis | Particula viral adyuvante. |
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2003
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- 2003-06-30 EP EP03739913.6A patent/EP1523329B1/en not_active Expired - Lifetime
- 2003-06-30 BR BR0312474-6A patent/BR0312474A/pt not_active Application Discontinuation
- 2003-06-30 KR KR1020057000114A patent/KR20050044886A/ko not_active Withdrawn
- 2003-06-30 EP EP10179379A patent/EP2272525A3/en not_active Withdrawn
- 2003-06-30 DK DK03739913.6T patent/DK1523329T3/da active
- 2003-06-30 CA CA2434000A patent/CA2434000C/en not_active Expired - Fee Related
- 2003-06-30 AU AU2003281246A patent/AU2003281246A1/en not_active Abandoned
- 2003-06-30 ES ES03739913T patent/ES2431963T3/es not_active Expired - Lifetime
- 2003-06-30 PT PT37399136T patent/PT1523329E/pt unknown
- 2003-06-30 CN CN03815935XA patent/CN1665528B/zh not_active Expired - Fee Related
- 2003-06-30 WO PCT/CA2003/000985 patent/WO2004004761A2/en not_active Ceased
- 2003-06-30 JP JP2004518318A patent/JP4953570B2/ja not_active Expired - Fee Related
- 2003-07-01 US US10/609,417 patent/US7641896B2/en not_active Expired - Fee Related
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2005
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2009
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| US7641896B2 (en) | 2010-01-05 |
| WO2004004761A2 (en) | 2004-01-15 |
| HK1075214A1 (en) | 2005-12-09 |
| PT1523329E (pt) | 2013-10-08 |
| US20090280145A1 (en) | 2009-11-12 |
| CN1665528B (zh) | 2013-05-15 |
| WO2004004761A3 (en) | 2004-05-06 |
| EP1523329B1 (en) | 2013-07-24 |
| DK1523329T3 (da) | 2013-10-14 |
| US20050048082A1 (en) | 2005-03-03 |
| US8282940B2 (en) | 2012-10-09 |
| NO20050396L (no) | 2005-01-25 |
| BR0312474A (pt) | 2005-04-26 |
| MXPA05000287A (es) | 2005-09-08 |
| EP2272525A3 (en) | 2011-11-16 |
| CA2434000C (en) | 2012-07-17 |
| JP2006504644A (ja) | 2006-02-09 |
| JP4953570B2 (ja) | 2012-06-13 |
| CN1665528A (zh) | 2005-09-07 |
| AU2003281246A1 (en) | 2004-01-23 |
| KR20050044886A (ko) | 2005-05-13 |
| EP1523329A2 (en) | 2005-04-20 |
| CA2434000A1 (en) | 2004-01-05 |
| EP2272525A2 (en) | 2011-01-12 |
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