JP2006503862A5 - - Google Patents
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- Publication number
- JP2006503862A5 JP2006503862A5 JP2004541383A JP2004541383A JP2006503862A5 JP 2006503862 A5 JP2006503862 A5 JP 2006503862A5 JP 2004541383 A JP2004541383 A JP 2004541383A JP 2004541383 A JP2004541383 A JP 2004541383A JP 2006503862 A5 JP2006503862 A5 JP 2006503862A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- difluorophenyl
- phenyl
- acetyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0202929A SE0202929D0 (sv) | 2002-10-03 | 2002-10-03 | Novel benzothiazepines and uses thereof |
| SE0203829A SE0203829D0 (sv) | 2002-12-18 | 2002-12-18 | Novel lactams and uses thereof |
| PCT/SE2003/001534 WO2004031154A1 (en) | 2002-10-03 | 2003-10-02 | Novel lactams and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010136105A Division JP2010248216A (ja) | 2002-10-03 | 2010-06-15 | 新規なラクタムおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503862A JP2006503862A (ja) | 2006-02-02 |
| JP2006503862A5 true JP2006503862A5 (enExample) | 2006-11-16 |
| JP4637584B2 JP4637584B2 (ja) | 2011-02-23 |
Family
ID=32072595
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004541383A Expired - Fee Related JP4637584B2 (ja) | 2002-10-03 | 2003-10-02 | 新規なラクタムおよびその使用 |
| JP2010136105A Pending JP2010248216A (ja) | 2002-10-03 | 2010-06-15 | 新規なラクタムおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010136105A Pending JP2010248216A (ja) | 2002-10-03 | 2010-06-15 | 新規なラクタムおよびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7294622B2 (enExample) |
| EP (2) | EP1554250B1 (enExample) |
| JP (2) | JP4637584B2 (enExample) |
| AR (1) | AR041440A1 (enExample) |
| AT (1) | ATE374187T1 (enExample) |
| AU (1) | AU2003265202A1 (enExample) |
| DE (1) | DE60316588T2 (enExample) |
| DK (1) | DK1554250T3 (enExample) |
| ES (1) | ES2291743T3 (enExample) |
| PT (1) | PT1554250E (enExample) |
| TW (1) | TW200502221A (enExample) |
| WO (1) | WO2004031154A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006520396A (ja) | 2003-03-14 | 2006-09-07 | アストラゼネカ・アクチエボラーグ | 新規なラクタム及びその使用 |
| US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
| US20080311609A1 (en) * | 2004-12-14 | 2008-12-18 | Astrazeneca Ab | Novel Molecular Probes |
| GB2423085C (en) * | 2005-02-11 | 2011-11-09 | Cambridge Entpr Ltd | Ligands for G-protein coupled receptors |
| ES2537898T3 (es) | 2005-10-25 | 2015-06-15 | Shionogi & Co., Ltd. | Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1 |
| US20090054398A1 (en) * | 2006-03-10 | 2009-02-26 | Astrazeneca Ab | Chemical compounds |
| WO2007110335A1 (en) * | 2006-03-27 | 2007-10-04 | F. Hoffmann-La Roche Ag | Malonamide derivatives as gamma secretase inhibitors |
| EP2032539A4 (en) * | 2006-06-09 | 2011-03-16 | Merck Sharp & Dohme | BENZAZEPINONE AS SODIUM CHANNEL BLOCKER |
| TW200831104A (en) * | 2006-10-04 | 2008-08-01 | Pharmacopeia Inc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| AU2008245082B8 (en) | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
| KR101136260B1 (ko) | 2007-08-14 | 2012-04-19 | 일라이 릴리 앤드 캄파니 | 감마-세크레타제 억제제로서의 아제핀 유도체 |
| US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
| WO2010047372A1 (ja) | 2008-10-22 | 2010-04-29 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体 |
| CN101735211B (zh) * | 2008-11-04 | 2012-11-14 | 复旦大学 | 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途 |
| US9023767B2 (en) * | 2009-05-07 | 2015-05-05 | Memorial Sloan-Kettering Cancer Center | γ-Secretase substrates and methods of use |
| UY32799A (es) * | 2009-07-24 | 2011-02-28 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos |
| RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
| CN103502466A (zh) | 2010-09-07 | 2014-01-08 | 斯隆－凯特林纪念癌症中心 | 用于γ-分泌酶测定的方法和组合物 |
| JP2014001142A (ja) * | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
| EP2625170A1 (en) * | 2010-10-07 | 2013-08-14 | Takeda Pharmaceutical Company Limited | 1,4-oxazepane derivatives |
| CA2816285A1 (en) | 2010-10-29 | 2012-05-03 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
| WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤 |
| RU2015105561A (ru) * | 2012-08-09 | 2016-09-27 | Ф. Хоффманн-Ля Рош Аг | Замещенные гетероазепиноны |
| JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2045578A1 (en) | 1989-01-31 | 1990-08-01 | Megumi Kawai | Anaphylatoxin-receptor ligands |
| US5936065A (en) * | 1993-12-06 | 1999-08-10 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| WO1997024339A1 (en) | 1995-12-27 | 1997-07-10 | Ono Pharmaceutical Co., Ltd. | Tetrazole derivatives and drugs containing the same as the active ingredient |
| GB9621836D0 (en) | 1996-10-19 | 1996-12-11 | Zeneca Ltd | Peptide compounds |
| ZA9711537B (en) * | 1996-12-23 | 1998-06-25 | Athena Neurosciences Inc Eli L | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ß-amyloid peptide release and/or its synthesis by use of such compounds. |
| AU4707999A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| JP2002518482A (ja) * | 1998-06-22 | 2002-06-25 | エラン ファーマシューティカルズ，インコーポレイテッド | β−アミロイドペプチド放出および／またはその合成を阻害する化合物 |
| AU4710199A (en) | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| AU1915399A (en) | 1998-07-10 | 2000-02-01 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| AU6278099A (en) | 1998-09-30 | 2000-04-17 | Elan Pharmaceuticals, Inc. | Biological reagents and methods for determining the mechanism in the generation of beta-amyloid peptide |
| CN1636011A (zh) * | 1998-12-24 | 2005-07-06 | 杜邦药品公司 | 作为Aβ蛋白产生抑制剂的琥珀酰氨基苯并二氮杂䓬 |
| JP2001030342A (ja) | 1999-07-23 | 2001-02-06 | Japan Polychem Corp | ポリオレフィン製延伸ブロー成形用インモールドラベル及びそのラベルを熱融着させた成形体 |
| AU783914B2 (en) * | 1999-09-13 | 2005-12-22 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoyl aminolactams and related structures as inhibitors of a beta protein production |
| AU2001243601A1 (en) | 2000-03-10 | 2001-09-24 | Ariad Pharmaceuticals, Inc. | Caprolactam derivatives and uses thereof |
| WO2001072324A1 (en) * | 2000-03-28 | 2001-10-04 | Bristol-Myers Squibb Pharma Company | Lactams as inhibitors of a-beta protein production |
| JP2006520396A (ja) * | 2003-03-14 | 2006-09-07 | アストラゼネカ・アクチエボラーグ | 新規なラクタム及びその使用 |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| US20080311609A1 (en) * | 2004-12-14 | 2008-12-18 | Astrazeneca Ab | Novel Molecular Probes |
-
2003
- 2003-09-29 TW TW092126851A patent/TW200502221A/zh unknown
- 2003-09-30 AR ARP030103560A patent/AR041440A1/es not_active Application Discontinuation
- 2003-10-02 EP EP03799234A patent/EP1554250B1/en not_active Expired - Lifetime
- 2003-10-02 JP JP2004541383A patent/JP4637584B2/ja not_active Expired - Fee Related
- 2003-10-02 DE DE60316588T patent/DE60316588T2/de not_active Expired - Lifetime
- 2003-10-02 ES ES03799234T patent/ES2291743T3/es not_active Expired - Lifetime
- 2003-10-02 PT PT03799234T patent/PT1554250E/pt unknown
- 2003-10-02 AU AU2003265202A patent/AU2003265202A1/en not_active Abandoned
- 2003-10-02 AT AT03799234T patent/ATE374187T1/de not_active IP Right Cessation
- 2003-10-02 WO PCT/SE2003/001534 patent/WO2004031154A1/en not_active Ceased
- 2003-10-02 DK DK03799234T patent/DK1554250T3/da active
- 2003-10-02 US US10/528,640 patent/US7294622B2/en not_active Expired - Fee Related
- 2003-10-02 EP EP07012660A patent/EP1845089A1/en not_active Withdrawn
-
2007
- 2007-08-24 US US11/844,451 patent/US20080076752A1/en not_active Abandoned
-
2009
- 2009-01-26 US US12/359,465 patent/US7858776B2/en not_active Expired - Fee Related
-
2010
- 2010-06-15 JP JP2010136105A patent/JP2010248216A/ja active Pending
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