ATE374187T1 - Neue lactame und deren verwendungen - Google Patents
Neue lactame und deren verwendungenInfo
- Publication number
- ATE374187T1 ATE374187T1 AT03799234T AT03799234T ATE374187T1 AT E374187 T1 ATE374187 T1 AT E374187T1 AT 03799234 T AT03799234 T AT 03799234T AT 03799234 T AT03799234 T AT 03799234T AT E374187 T1 ATE374187 T1 AT E374187T1
- Authority
- AT
- Austria
- Prior art keywords
- lactames
- new
- new lactames
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0202929A SE0202929D0 (sv) | 2002-10-03 | 2002-10-03 | Novel benzothiazepines and uses thereof |
| SE0203829A SE0203829D0 (sv) | 2002-12-18 | 2002-12-18 | Novel lactams and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE374187T1 true ATE374187T1 (de) | 2007-10-15 |
Family
ID=32072595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03799234T ATE374187T1 (de) | 2002-10-03 | 2003-10-02 | Neue lactame und deren verwendungen |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7294622B2 (de) |
| EP (2) | EP1845089A1 (de) |
| JP (2) | JP4637584B2 (de) |
| AR (1) | AR041440A1 (de) |
| AT (1) | ATE374187T1 (de) |
| AU (1) | AU2003265202A1 (de) |
| DE (1) | DE60316588T2 (de) |
| DK (1) | DK1554250T3 (de) |
| ES (1) | ES2291743T3 (de) |
| PT (1) | PT1554250E (de) |
| TW (1) | TW200502221A (de) |
| WO (1) | WO2004031154A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1636196A1 (de) | 2003-03-14 | 2006-03-22 | AstraZeneca AB | Neue lactame und ihre verwendung |
| US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
| EP1831187A1 (de) * | 2004-12-14 | 2007-09-12 | AstraZeneca AB | Neue molekulare sonden |
| GB2423085C (en) | 2005-02-11 | 2011-11-09 | Cambridge Entpr Ltd | Ligands for G-protein coupled receptors |
| EP2597087B1 (de) | 2005-10-25 | 2016-03-30 | Shionogi&Co., Ltd. | Dihydrooxazin- und Tetrahydropyrimidin-Derivate als BACE 1-Inhibitoren |
| WO2007104933A1 (en) * | 2006-03-10 | 2007-09-20 | Astrazeneca Ab | Chemical compounds |
| AU2007229550B2 (en) * | 2006-03-27 | 2012-03-08 | F. Hoffmann-La Roche Ag | Malonamide derivatives as gamma secretase inhibitors |
| EP2032539A4 (de) * | 2006-06-09 | 2011-03-16 | Merck Sharp & Dohme | Benzazepinone als natrium-kanal-blocker |
| US7919490B2 (en) * | 2006-10-04 | 2011-04-05 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
| EP2147914B1 (de) | 2007-04-24 | 2014-06-04 | Shionogi&Co., Ltd. | Mit zyklischen gruppen substituierte aminodihydrothiazin-derivate |
| WO2009023453A1 (en) * | 2007-08-14 | 2009-02-19 | Eli Lilly And Company | Azepine derivatives as gamma-secretase inhibitors |
| CA2727859C (en) | 2008-06-13 | 2016-11-01 | Shionogi & Co., Ltd. | SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ß-SECRETASE-INHIBITING ACTIVITY |
| JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体 |
| CN101735211B (zh) * | 2008-11-04 | 2012-11-14 | 复旦大学 | 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途 |
| US9023767B2 (en) * | 2009-05-07 | 2015-05-05 | Memorial Sloan-Kettering Cancer Center | γ-Secretase substrates and methods of use |
| UY32799A (es) * | 2009-07-24 | 2011-02-28 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos |
| ES2590038T5 (es) | 2009-12-11 | 2021-10-19 | Shionogi & Co | Derivado de oxazina |
| WO2012033831A2 (en) | 2010-09-07 | 2012-03-15 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for gamma-secretase assay |
| JP2014001142A (ja) * | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
| PE20140239A1 (es) * | 2010-10-07 | 2014-03-07 | Takeda Pharmaceutical | Derivados de 1,4-oxazepano |
| AU2011321427A1 (en) | 2010-10-29 | 2013-05-02 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| TW201247635A (en) | 2011-04-26 | 2012-12-01 | Shionogi & Co | Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them |
| CA2877048A1 (en) * | 2012-08-09 | 2014-02-13 | F. Hoffmann-La Roche Ag | Substituted hetero-azepinones |
| US9540359B2 (en) | 2012-10-24 | 2017-01-10 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04503073A (ja) | 1989-01-31 | 1992-06-04 | アボツト・ラボラトリーズ | アナフィラトキシン受容体リガンド |
| US5936065A (en) | 1993-12-06 | 1999-08-10 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| US6136834A (en) | 1995-12-27 | 2000-10-24 | Ono Pharmaceutical Co., Ltd. | Tetrazole compounds and pharmaceutical agents containing such derivative |
| GB9621836D0 (en) | 1996-10-19 | 1996-12-11 | Zeneca Ltd | Peptide compounds |
| WO1998028268A2 (en) * | 1996-12-23 | 1998-07-02 | Elan Pharmaceuticals, Inc. | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AS β-AMYLOID PEPTIDE RELEASE INHIBITORS |
| CA2325388A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| WO1999067219A1 (en) | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| WO1999067221A1 (en) | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| WO2000002903A1 (en) | 1998-07-10 | 2000-01-20 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| EP1131634A2 (de) | 1998-09-30 | 2001-09-12 | Elan Pharmaceuticals, Inc. | Bestimmung des mechanismus der beta-amyloid-peptid-erzeugung |
| WO2000038618A2 (en) * | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| JP2001030342A (ja) | 1999-07-23 | 2001-02-06 | Japan Polychem Corp | ポリオレフィン製延伸ブロー成形用インモールドラベル及びそのラベルを熱融着させた成形体 |
| MXPA02001813A (es) * | 1999-09-13 | 2004-03-19 | Bristol Myers Squibb Pharma Co | Hidroxialcanoilaminolactamas y estructuras relacionas como inhibidores de la produccion de la proteina abeta. |
| WO2001068655A2 (en) | 2000-03-10 | 2001-09-20 | Ariad Pharmaceuticals, Inc. | Caprolactam derivatives and uses thereof |
| EP1267906A1 (de) * | 2000-03-28 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | A-beta protein-produktion inhibierende lactame |
| EP1636196A1 (de) | 2003-03-14 | 2006-03-22 | AstraZeneca AB | Neue lactame und ihre verwendung |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| EP1831187A1 (de) | 2004-12-14 | 2007-09-12 | AstraZeneca AB | Neue molekulare sonden |
-
2003
- 2003-09-29 TW TW092126851A patent/TW200502221A/zh unknown
- 2003-09-30 AR ARP030103560A patent/AR041440A1/es not_active Application Discontinuation
- 2003-10-02 AT AT03799234T patent/ATE374187T1/de not_active IP Right Cessation
- 2003-10-02 PT PT03799234T patent/PT1554250E/pt unknown
- 2003-10-02 WO PCT/SE2003/001534 patent/WO2004031154A1/en active IP Right Grant
- 2003-10-02 EP EP07012660A patent/EP1845089A1/de not_active Withdrawn
- 2003-10-02 EP EP03799234A patent/EP1554250B1/de not_active Expired - Lifetime
- 2003-10-02 DK DK03799234T patent/DK1554250T3/da active
- 2003-10-02 JP JP2004541383A patent/JP4637584B2/ja not_active Expired - Fee Related
- 2003-10-02 DE DE60316588T patent/DE60316588T2/de not_active Expired - Lifetime
- 2003-10-02 ES ES03799234T patent/ES2291743T3/es not_active Expired - Lifetime
- 2003-10-02 AU AU2003265202A patent/AU2003265202A1/en not_active Abandoned
- 2003-10-02 US US10/528,640 patent/US7294622B2/en not_active Expired - Fee Related
-
2007
- 2007-08-24 US US11/844,451 patent/US20080076752A1/en not_active Abandoned
-
2009
- 2009-01-26 US US12/359,465 patent/US7858776B2/en not_active Expired - Fee Related
-
2010
- 2010-06-15 JP JP2010136105A patent/JP2010248216A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003265202A1 (en) | 2004-04-23 |
| US20060089346A1 (en) | 2006-04-27 |
| US7858776B2 (en) | 2010-12-28 |
| WO2004031154A1 (en) | 2004-04-15 |
| US20080076752A1 (en) | 2008-03-27 |
| EP1554250B1 (de) | 2007-09-26 |
| US7294622B2 (en) | 2007-11-13 |
| DE60316588T2 (de) | 2008-07-31 |
| DE60316588D1 (de) | 2007-11-08 |
| JP2006503862A (ja) | 2006-02-02 |
| DK1554250T3 (da) | 2007-12-17 |
| PT1554250E (pt) | 2007-11-15 |
| JP2010248216A (ja) | 2010-11-04 |
| JP4637584B2 (ja) | 2011-02-23 |
| AR041440A1 (es) | 2005-05-18 |
| TW200502221A (en) | 2005-01-16 |
| US20100160627A1 (en) | 2010-06-24 |
| EP1554250A1 (de) | 2005-07-20 |
| EP1845089A1 (de) | 2007-10-17 |
| ES2291743T3 (es) | 2008-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE374187T1 (de) | Neue lactame und deren verwendungen | |
| ATE470675T1 (de) | Immunoglobulinvarianten und deren verwendungen | |
| DE602004021904D1 (de) | Gyraseinhibitoren und deren verwendungen | |
| DE60226865D1 (de) | Thermoplastische elastomerzusammensetzung | |
| DE60207627D1 (de) | Überzug und Überzugszusammensetzung | |
| DE60207663D1 (de) | Bürstendichtung und Bürstendichtungsanordnung | |
| DE60326611D1 (de) | N und dergleichen | |
| DE60325255D1 (de) | Duftzusammensetzung | |
| DE60327611D1 (de) | Gesichertes Mehrfachsenden | |
| ATE324387T1 (de) | Durchsichtige und flexible polypropenzusammensetzungen | |
| IS6915A (is) | Lyfjablanda | |
| BR0210619A (pt) | composição | |
| DE60336306D1 (de) | Photoinitiator, neue verbindung und photohärtbare zusammensetzung | |
| DE60314077D1 (de) | Polyamid und daraus hergestellte Harzzusammensetzung | |
| IS7081A (is) | Lyfjablanda | |
| ATE476500T1 (de) | Neue phospholipasen und deren verwendungen | |
| DE60230245D1 (de) | Wabenkonstruktion und deren zusammenbau | |
| DE602004003809D1 (de) | Neue 14- und 15-gliedrige ringverbindungen | |
| DE60216283D1 (de) | Thermoplastische elastomerzusammensetzung | |
| DE60323517D1 (de) | Hybridisierungsnachweisverfahren und bioassay-vorr | |
| ATE433448T1 (de) | Kondensierte heterocyclen und deren verwendungen | |
| DE60228380D1 (de) | Polyamidharzzusammensetzung | |
| DE602004029488D1 (de) | Leuchtstoffschirm und abbildungsbaugruppe | |
| DE60231613D1 (de) | Neue expressionsvektoren und deren verwendungen | |
| DE602004002696D1 (de) | Neue 14- und 15-gliedrige ringverbindungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1554250 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |