JP2006502143A - 向代謝型グルタミン酸受容体のアセトフェノン増強因子 - Google Patents

向代謝型グルタミン酸受容体のアセトフェノン増強因子 Download PDF

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Publication number
JP2006502143A
JP2006502143A JP2004529871A JP2004529871A JP2006502143A JP 2006502143 A JP2006502143 A JP 2006502143A JP 2004529871 A JP2004529871 A JP 2004529871A JP 2004529871 A JP2004529871 A JP 2004529871A JP 2006502143 A JP2006502143 A JP 2006502143A
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Japan
Prior art keywords
compound
phenyl
mmol
alkyl
hydroxy
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JP2004529871A
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English (en)
Japanese (ja)
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JP2006502143A5 (enExample
Inventor
キユーブ，ロウイーナ・ブイ
ピンカートン，アンソニー・ビー
バーニア，ジーン−ミシエル
チヤオ，シオウミン
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Merck and Co Inc
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Merck and Co Inc
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Publication of JP2006502143A publication Critical patent/JP2006502143A/ja
Publication of JP2006502143A5 publication Critical patent/JP2006502143A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2004529871A 2002-08-26 2003-08-22 向代謝型グルタミン酸受容体のアセトフェノン増強因子 Withdrawn JP2006502143A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40590802P 2002-08-26 2002-08-26
PCT/US2003/026377 WO2004018386A2 (en) 2002-08-26 2003-08-22 Acetophenone potentiators of metabotropic glutamate receptors

Publications (2)

Publication Number Publication Date
JP2006502143A true JP2006502143A (ja) 2006-01-19
JP2006502143A5 JP2006502143A5 (enExample) 2006-10-05

Family

ID=31946942

Family Applications (1)

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JP2004529871A Withdrawn JP2006502143A (ja) 2002-08-26 2003-08-22 向代謝型グルタミン酸受容体のアセトフェノン増強因子

Country Status (6)

Country Link
US (1) US20050288346A1 (enExample)
EP (1) EP1556038A2 (enExample)
JP (1) JP2006502143A (enExample)
AU (1) AU2003262805A1 (enExample)
CA (1) CA2495756A1 (enExample)
WO (1) WO2004018386A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520680A (ja) * 2004-11-22 2008-06-19 イーライ リリー アンド カンパニー グルタミン酸受容体の増強剤
JP2010520264A (ja) * 2007-03-07 2010-06-10 オルソ−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド １，４−ジ置換３−シアノピリドン誘導体とそれらのポジティブｍＧｌｕＲ２−受容体モジュレーター
JP2010520263A (ja) * 2007-03-07 2010-06-10 オルソ−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド ３−シアノ−４−（４−フェニル−ピペリジン−１−イル）−ピリジン−２−オン誘導体
JP2010520265A (ja) * 2007-03-07 2010-06-10 オルソ−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド ３−シアノ−４−（４−テトラヒドロピラン−フェニル）−ピリジン−２−オン誘導体
JP2010539120A (ja) * 2007-09-14 2010-12-16 オルソー−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド． １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン

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AP2006003700A0 (en) 2004-02-13 2006-08-31 Warner Lambert Co Androgen receptor modulators
WO2005100305A1 (en) 2004-04-13 2005-10-27 Warner-Lambert Company Llc Androgen modulators
CA2562672C (en) * 2004-04-22 2009-09-29 Warner-Lambert Company Llc 4-cyano-phenoxy derivatives as androgen modulators
JP4874965B2 (ja) 2004-07-08 2012-02-15 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アンドロゲン調節剤
CA2574956A1 (en) * 2004-07-30 2006-02-09 Merck & Co., Inc. Heterocyclic acetophenone potentiators of metabotropic glutamate receptors
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AU2011226942B2 (en) * 2004-11-22 2012-06-28 Eli Lilly And Company Potentiators of glutamate receptors
WO2006091496A2 (en) * 2005-02-24 2006-08-31 Merck & Co., Inc. Benzazole potentiators of metabotropic glutamate receptors
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
AR059898A1 (es) * 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
CA2697399C (en) 2007-09-14 2016-01-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
MX2010002536A (es) 2007-09-14 2010-08-10 Ortho Mcneil Janssen Pharm 4-fenil-3,4,5,6-tetrahidro-2h, 1'h-[1,4]bipiridinil-2'-onas 1',3'-disubstituidas.
TW201006801A (en) * 2008-07-18 2010-02-16 Lilly Co Eli Imidazole carboxamides
BRPI0918055A2 (pt) 2008-09-02 2015-12-01 Addex Pharmaceuticals Sa derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato.
JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
CA2744138C (en) 2008-11-28 2015-08-11 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
ES2409006T3 (es) 2009-05-12 2013-06-24 Janssen Pharmaceuticals Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2
SG176021A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CA2804593C (en) 2010-07-09 2015-11-24 Pfizer Limited Biphenyloxybenzensulphonamide derivatives useful as sodium channel inhibitors
CA2804877A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Sulfonamide derivatives as nav1.7 inhibitors for the treatment of pain
JP2013532186A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 化合物
WO2012007869A2 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
EP2593432B1 (en) 2010-07-12 2014-10-22 Pfizer Limited N-sulfonylbenzamide derivatives useful as voltage gated sodium channel inhibitors
CA2804716A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
US9012448B2 (en) 2010-11-08 2015-04-21 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
WO2012062759A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
PT3096790T (pt) 2014-01-21 2019-10-15 Janssen Pharmaceutica Nv Combinações compreendendo moduladores alostéricos positivos ou agonistas ortostéricos do recetor glutamatérgico metabotrópico do subtipo 2 e seu uso
EA202192105A3 (ru) 2014-02-04 2022-02-28 Янссен Фармацевтика Нв Комбинации, содержащие положительные аллостерические модуляторы или ортостерические агонисты метаботропного глутаматергического рецептора 2 подтипа, и их применение
US10099993B2 (en) 2014-04-06 2018-10-16 Sanford-Burnham Medical Research Institute Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof
MX2021007377A (es) * 2018-12-17 2021-11-25 6Th Wave Innovations Corp Extraccion de litio con eteres de corona.
US20250179000A1 (en) * 2021-12-23 2025-06-05 Sanford Burnham Prebys Medical Discovery Institute Metabotropic glutamate receptor positive allosteric modulators (pams) and uses thereof
EP4299124A1 (en) 2022-06-30 2024-01-03 Universite De Montpellier Anti-mglur2 nanobodies for use as biomolecule transporter

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ES8505199A1 (es) * 1982-10-21 1985-05-16 Lilly Industries Ltd Un procedimiento para la preparacion de derivados de difenilalquilenicos.
US4820867A (en) * 1983-04-21 1989-04-11 Merck Frosst Canada, Inc. Phenoxypropoxy halophenylacetic acids as leukotriene antagonists
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520680A (ja) * 2004-11-22 2008-06-19 イーライ リリー アンド カンパニー グルタミン酸受容体の増強剤
JP2008520676A (ja) * 2004-11-22 2008-06-19 イーライ リリー アンド カンパニー グルタミン酸受容体の増強剤
JP2010520264A (ja) * 2007-03-07 2010-06-10 オルソ−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド １，４−ジ置換３−シアノピリドン誘導体とそれらのポジティブｍＧｌｕＲ２−受容体モジュレーター
JP2010520263A (ja) * 2007-03-07 2010-06-10 オルソ−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド ３−シアノ−４−（４−フェニル−ピペリジン−１−イル）−ピリジン−２−オン誘導体
JP2010520265A (ja) * 2007-03-07 2010-06-10 オルソ−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド ３−シアノ−４−（４−テトラヒドロピラン−フェニル）−ピリジン−２−オン誘導体
JP2010539120A (ja) * 2007-09-14 2010-12-16 オルソー−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド． １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン

Also Published As

Publication number Publication date
EP1556038A2 (en) 2005-07-27
AU2003262805A1 (en) 2004-03-11
WO2004018386A2 (en) 2004-03-04
US20050288346A1 (en) 2005-12-29
CA2495756A1 (en) 2004-03-04
WO2004018386A3 (en) 2004-11-25

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