JP2006501863A5 - - Google Patents
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- Publication number
- JP2006501863A5 JP2006501863A5 JP2005500990A JP2005500990A JP2006501863A5 JP 2006501863 A5 JP2006501863 A5 JP 2006501863A5 JP 2005500990 A JP2005500990 A JP 2005500990A JP 2005500990 A JP2005500990 A JP 2005500990A JP 2006501863 A5 JP2006501863 A5 JP 2006501863A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- sequence
- polypeptide
- seq
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- ACTOXUHEUCPTEW-BWHGAVFKSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2s,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-BWHGAVFKSA-N 0.000 claims description 5
- 239000004187 Spiramycin Substances 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 229960001294 spiramycin Drugs 0.000 claims description 5
- 229930191512 spiramycin Natural products 0.000 claims description 5
- 235000019372 spiramycin Nutrition 0.000 claims description 5
- 108091033319 polynucleotide Proteins 0.000 claims 13
- 102000040430 polynucleotide Human genes 0.000 claims 13
- 239000002157 polynucleotide Substances 0.000 claims 13
- 229920001184 polypeptide Polymers 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 244000005700 microbiome Species 0.000 claims 8
- 239000002609 medium Substances 0.000 claims 6
- 239000003636 conditioned culture medium Substances 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 230000014509 gene expression Effects 0.000 claims 3
- 230000002068 genetic effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 108020004511 Recombinant DNA Proteins 0.000 claims 2
- 241000187758 Streptomyces ambofaciens Species 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000012239 gene modification Methods 0.000 claims 2
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000187747 Streptomyces Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 229940041033 macrolides Drugs 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 6
- 102000034356 gene-regulatory proteins Human genes 0.000 description 3
- 108091006104 gene-regulatory proteins Proteins 0.000 description 3
- 229930188120 Carbomycin Natural products 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 241000187438 Streptomyces fradiae Species 0.000 description 1
- 241001600136 Streptomyces thermotolerans Species 0.000 description 1
- FQVHOULQCKDUCY-OGHXVOSASA-N [(2s,3s,4r,6s)-6-[(2r,3s,4r,5r,6s)-6-[[(1s,3r,7r,8s,9s,10r,12r,14e,16s)-7-acetyloxy-8-methoxy-3,12-dimethyl-5,13-dioxo-10-(2-oxoethyl)-4,17-dioxabicyclo[14.1.0]heptadec-14-en-9-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimeth Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@H]1[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@@H]2O[C@H]2C[C@@H](C)OC(=O)C[C@H]([C@@H]1OC)OC(C)=O)[C@H]1C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O1 FQVHOULQCKDUCY-OGHXVOSASA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 229950005779 carbomycin Drugs 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0212489A FR2845394A1 (fr) | 2002-10-08 | 2002-10-08 | Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications |
| FR0212489 | 2002-10-08 | ||
| FR0302439 | 2003-02-27 | ||
| FR0302439A FR2851773A1 (fr) | 2003-02-27 | 2003-02-27 | Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications |
| US49349003P | 2003-08-07 | 2003-08-07 | |
| US60/493,490 | 2003-08-07 | ||
| PCT/FR2003/002962 WO2004033689A2 (fr) | 2002-10-08 | 2003-10-08 | Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006501863A JP2006501863A (ja) | 2006-01-19 |
| JP2006501863A5 true JP2006501863A5 (https=) | 2010-02-18 |
| JP5042497B2 JP5042497B2 (ja) | 2012-10-03 |
Family
ID=32096598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005500990A Expired - Lifetime JP5042497B2 (ja) | 2002-10-08 | 2003-10-08 | スピラマイシンの生合成に関与するポリペプチド、これらポリペプチドをコードするヌクレオチド配列、および、その使用 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1551975A2 (https=) |
| JP (1) | JP5042497B2 (https=) |
| KR (1) | KR101110175B1 (https=) |
| AU (1) | AU2003300479B2 (https=) |
| BR (1) | BRPI0314543B8 (https=) |
| CA (1) | CA2501445C (https=) |
| IL (1) | IL167854A (https=) |
| MX (1) | MXPA05002852A (https=) |
| NO (1) | NO335995B1 (https=) |
| WO (1) | WO2004033689A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105505954B (zh) * | 2015-12-31 | 2019-01-22 | 沈阳福洋医药科技有限公司 | 可利霉素生物合成基因簇 |
| CN111349595A (zh) * | 2018-12-20 | 2020-06-30 | 沈阳福洋医药科技有限公司 | 一种螺旋霉素产生菌、可利霉素产生菌、构建方法、应用及提高产物产量的方法 |
| PY2380365A (es) * | 2022-10-07 | 2024-04-22 | Syngenta Crop Protection Ag | Mezcla fungicida |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5068189A (en) * | 1988-05-13 | 1991-11-26 | Eli Lilly And Company | Recombinant dna vectors encoding a 4"-o-isovaleryl acylase derived from a carbomycin biosynthetic gene, designated care, for use in streptomyces and other organisms |
| JP2749616B2 (ja) * | 1988-05-24 | 1998-05-13 | メルシャン株式会社 | マクロライド抗生物質の４”位アシル化酵素をコードする遺伝子 |
| US5098837A (en) * | 1988-06-07 | 1992-03-24 | Eli Lilly And Company | Macrolide biosynthetic genes for use in streptomyces and other organisms |
| US5322937A (en) * | 1990-06-01 | 1994-06-21 | Mercian Corporation | Genes encoding a 3-acylation enzyme for macrolide antibiotics |
| US5514544A (en) * | 1991-07-26 | 1996-05-07 | Eli Lilly And Company | Activator gene for macrolide biosynthesis |
| JPH0638750A (ja) * | 1991-08-09 | 1994-02-15 | Meiji Seika Kaisha Ltd | マクロライド抗生物質の３位アシル化酵素およびそれをコードする遺伝子 |
| JPH06121677A (ja) * | 1992-01-23 | 1994-05-06 | Mercian Corp | マクロライド抗生物質のアシル化酵素遺伝子の高発現方法 |
| CA2197160C (en) * | 1996-02-22 | 2007-05-01 | Stanley Gene Burgett | Platenolide synthase gene |
| CA2197524A1 (en) * | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
| JP2001511349A (ja) * | 1997-07-25 | 2001-08-14 | ヘキスト・マリオン・ルセル | Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａｅｒｙｔｈｒａｅａ及びＳｔｒｅｐｔｏｍｙｃｅｓａｎｔｉｂｉｏｔｉｃｕｓにおける６−デオキシヘキソースの生合成及び移送のための遺伝子 |
| AU2002355157A1 (en) * | 2001-07-26 | 2003-02-17 | Ecopia Biosciences Inc. | Genes and proteins for the biosynthesis of rosaramicin |
-
2003
- 2003-10-08 JP JP2005500990A patent/JP5042497B2/ja not_active Expired - Lifetime
- 2003-10-08 MX MXPA05002852A patent/MXPA05002852A/es active IP Right Grant
- 2003-10-08 AU AU2003300479A patent/AU2003300479B2/en not_active Expired
- 2003-10-08 WO PCT/FR2003/002962 patent/WO2004033689A2/fr not_active Ceased
- 2003-10-08 CA CA2501445A patent/CA2501445C/fr not_active Expired - Lifetime
- 2003-10-08 BR BRPI0314543A patent/BRPI0314543B8/pt not_active IP Right Cessation
- 2003-10-08 KR KR1020057006111A patent/KR101110175B1/ko not_active Expired - Lifetime
- 2003-10-08 EP EP03807883A patent/EP1551975A2/fr not_active Withdrawn
-
2005
- 2005-04-04 IL IL167854A patent/IL167854A/en active IP Right Grant
- 2005-05-02 NO NO20052160A patent/NO335995B1/no not_active IP Right Cessation
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