BRPI0314543B8 - células hospedeiras, dna recombinante, utilização dos mesmos, processos de produção de um polipeptídeo implicado na biossíntese das espiramicinas, de produção de macrolídeos e de produção de espiramicina(s), e micro-organismo transgênico mutante produtor de macrolídeo - Google Patents

células hospedeiras, dna recombinante, utilização dos mesmos, processos de produção de um polipeptídeo implicado na biossíntese das espiramicinas, de produção de macrolídeos e de produção de espiramicina(s), e micro-organismo transgênico mutante produtor de macrolídeo

Info

Publication number
BRPI0314543B8
BRPI0314543B8 BRPI0314543A BR0314543A BRPI0314543B8 BR PI0314543 B8 BRPI0314543 B8 BR PI0314543B8 BR PI0314543 A BRPI0314543 A BR PI0314543A BR 0314543 A BR0314543 A BR 0314543A BR PI0314543 B8 BRPI0314543 B8 BR PI0314543B8
Authority
BR
Brazil
Prior art keywords
production
spiramycin
biosynthesis
spiramycins
genes
Prior art date
Application number
BRPI0314543A
Other languages
English (en)
Portuguese (pt)
Other versions
BRPI0314543B1 (pt
BR0314543A (pt
Inventor
Gondran Anne
Gerbaud Claude
Darbon-Rongere Emmanuelle
Karray Fatma
Dominguez Hélène
Pernodet Jean-Luc
Tuphile Karine
Blondelet-Rouault Marie-Hélène
Oestreicher-Mermet-Bouvier Nathalie
Lacroix Patricia
Original Assignee
Aventis Pharma Sa
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0212489A external-priority patent/FR2845394A1/fr
Priority claimed from FR0302439A external-priority patent/FR2851773A1/fr
Application filed by Aventis Pharma Sa, Centre Nat Rech Scient filed Critical Aventis Pharma Sa
Publication of BR0314543A publication Critical patent/BR0314543A/pt
Publication of BRPI0314543B1 publication Critical patent/BRPI0314543B1/pt
Publication of BRPI0314543B8 publication Critical patent/BRPI0314543B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0314543A 2002-10-08 2003-10-08 células hospedeiras, dna recombinante, utilização dos mesmos, processos de produção de um polipeptídeo implicado na biossíntese das espiramicinas, de produção de macrolídeos e de produção de espiramicina(s), e micro-organismo transgênico mutante produtor de macrolídeo BRPI0314543B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0212489A FR2845394A1 (fr) 2002-10-08 2002-10-08 Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications
FR0302439A FR2851773A1 (fr) 2003-02-27 2003-02-27 Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications
US49349003P 2003-08-07 2003-08-07
PCT/FR2003/002962 WO2004033689A2 (fr) 2002-10-08 2003-10-08 Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications.

Publications (3)

Publication Number Publication Date
BR0314543A BR0314543A (pt) 2005-08-09
BRPI0314543B1 BRPI0314543B1 (pt) 2016-06-14
BRPI0314543B8 true BRPI0314543B8 (pt) 2021-05-25

Family

ID=32096598

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0314543A BRPI0314543B8 (pt) 2002-10-08 2003-10-08 células hospedeiras, dna recombinante, utilização dos mesmos, processos de produção de um polipeptídeo implicado na biossíntese das espiramicinas, de produção de macrolídeos e de produção de espiramicina(s), e micro-organismo transgênico mutante produtor de macrolídeo

Country Status (10)

Country Link
EP (1) EP1551975A2 (https=)
JP (1) JP5042497B2 (https=)
KR (1) KR101110175B1 (https=)
AU (1) AU2003300479B2 (https=)
BR (1) BRPI0314543B8 (https=)
CA (1) CA2501445C (https=)
IL (1) IL167854A (https=)
MX (1) MXPA05002852A (https=)
NO (1) NO335995B1 (https=)
WO (1) WO2004033689A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105505954B (zh) * 2015-12-31 2019-01-22 沈阳福洋医药科技有限公司 可利霉素生物合成基因簇
CN111349595A (zh) * 2018-12-20 2020-06-30 沈阳福洋医药科技有限公司 一种螺旋霉素产生菌、可利霉素产生菌、构建方法、应用及提高产物产量的方法
PY2380365A (es) * 2022-10-07 2024-04-22 Syngenta Crop Protection Ag Mezcla fungicida

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5068189A (en) * 1988-05-13 1991-11-26 Eli Lilly And Company Recombinant dna vectors encoding a 4"-o-isovaleryl acylase derived from a carbomycin biosynthetic gene, designated care, for use in streptomyces and other organisms
JP2749616B2 (ja) * 1988-05-24 1998-05-13 メルシャン株式会社 マクロライド抗生物質の４”位アシル化酵素をコードする遺伝子
US5098837A (en) * 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms
US5322937A (en) * 1990-06-01 1994-06-21 Mercian Corporation Genes encoding a 3-acylation enzyme for macrolide antibiotics
US5514544A (en) * 1991-07-26 1996-05-07 Eli Lilly And Company Activator gene for macrolide biosynthesis
JPH0638750A (ja) * 1991-08-09 1994-02-15 Meiji Seika Kaisha Ltd マクロライド抗生物質の３位アシル化酵素およびそれをコードする遺伝子
JPH06121677A (ja) * 1992-01-23 1994-05-06 Mercian Corp マクロライド抗生物質のアシル化酵素遺伝子の高発現方法
CA2197160C (en) * 1996-02-22 2007-05-01 Stanley Gene Burgett Platenolide synthase gene
CA2197524A1 (en) * 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
JP2001511349A (ja) * 1997-07-25 2001-08-14 ヘキスト・マリオン・ルセル Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａｅｒｙｔｈｒａｅａ及びＳｔｒｅｐｔｏｍｙｃｅｓａｎｔｉｂｉｏｔｉｃｕｓにおける６−デオキシヘキソースの生合成及び移送のための遺伝子
AU2002355157A1 (en) * 2001-07-26 2003-02-17 Ecopia Biosciences Inc. Genes and proteins for the biosynthesis of rosaramicin

Also Published As

Publication number Publication date
AU2003300479A1 (en) 2004-05-04
BRPI0314543B1 (pt) 2016-06-14
JP2006501863A (ja) 2006-01-19
KR101110175B1 (ko) 2012-07-18
CA2501445A1 (fr) 2004-04-22
WO2004033689A2 (fr) 2004-04-22
NO20052160L (no) 2005-06-02
AU2003300479B2 (en) 2009-12-10
EP1551975A2 (fr) 2005-07-13
KR20050084843A (ko) 2005-08-29
JP5042497B2 (ja) 2012-10-03
IL167854A (en) 2011-06-30
MXPA05002852A (es) 2005-10-05
BR0314543A (pt) 2005-08-09
NO335995B1 (no) 2015-04-13
CA2501445C (fr) 2016-01-26
WO2004033689A3 (fr) 2004-08-26

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12N 15/52 , C12N 9/00 , C12N 15/63 , C12N 1/21 , C07K 14/36 , C12P 19/62

Ipc: C12N 15/52 (2006.01), C07K 14/36 (2006.01), C12P 1

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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