JP2006500949A5 - - Google Patents
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- JP2006500949A5 JP2006500949A5 JP2004541231A JP2004541231A JP2006500949A5 JP 2006500949 A5 JP2006500949 A5 JP 2006500949A5 JP 2004541231 A JP2004541231 A JP 2004541231A JP 2004541231 A JP2004541231 A JP 2004541231A JP 2006500949 A5 JP2006500949 A5 JP 2006500949A5
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- nsc
- lung cancer
- small cell
- cell lung
- polypeptide
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- 210000001178 Neural Stem Cells Anatomy 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 17
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 12
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 8
- 210000004027 cells Anatomy 0.000 claims 7
- 230000002265 prevention Effects 0.000 claims 7
- 229920000023 polynucleotide Polymers 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 230000000692 anti-sense Effects 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 108020004459 Small Interfering RNA Proteins 0.000 claims 2
- 230000000259 anti-tumor Effects 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 201000005244 lung non-small cell carcinoma Diseases 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000001105 regulatory Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 239000002924 silencing RNA Substances 0.000 claims 2
- 230000002103 transcriptional Effects 0.000 claims 2
- 210000000612 Antigen-Presenting Cells Anatomy 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- 108020004999 Messenger RNA Proteins 0.000 claims 1
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 229920001985 Small interfering RNA Polymers 0.000 claims 1
- 210000003802 Sputum Anatomy 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229920002106 messenger RNA Polymers 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Claims (24)
- 対象由来の生物試料におけるNSC 810の発現レベルを決定する段階を含む、対象における非小細胞肺癌または非小細胞肺癌を発症する素因の診断方法であって、該レベルの、該遺伝子の正常対照レベルと比較した増加により、対象が非小細胞肺癌に罹患していること、または非小細胞肺癌を発症するリスクを有することが示される方法。
- 前記増加が該正常対照レベルを少なくとも10％上回る、請求項1記載の方法。
- 前記レベルが以下の段階からなる群より選択されるいずれか1つの方法によって決定される、請求項1記載の方法：
(1)NSC 810のmRNAを検出すること；
(2)NSC 810によってコードされるタンパク質を検出すること；および
(3)NSC 810によってコードされるタンパク質の生物学的活性を検出すること。 - 前記レベルが、NSC 810プローブと患者由来組織試料の遺伝子転写物とのハイブリダイゼーションによって検出することで決定される、請求項1記載の方法。
- ハイブリダイゼーションの段階がDNAアレイ上で行われる、請求項4記載の方法。
- 生物試料が痰または血液を含む、請求項1記載の方法。
- 以下の段階を含む、NSC 810の発現または活性を阻害する化合物の同定方法：
(1)NSC 810を発現する被験細胞を被験化合物と接触させる段階；
(2)NSC 810の発現レベルを検出する段階；および
(3)該発現レベルを該遺伝子の正常対照レベルと比較して抑制する化合物を、該NSC 810の阻害因子として決定する段階。 - 被験細胞がNSCLC細胞である、請求項7記載の方法。
- 以下の段階を含む、非小細胞肺癌の治療または予防のための化合物に関するスクリーニングの方法：
（1）被験化合物を、NSC 810によってコードされるポリペプチドと接触させる段階；
（2）ポリペプチドと被験化合物との結合活性を検出する段階；および
（3）ポリペプチドと結合する化合物を選択する段階。 - 以下の段階を含む、非小細胞肺癌の治療または予防のための化合物に関するスクリーニングの方法：
（a）被験化合物を、NSC 810によってコードされるポリペプチドと接触させる段階；
（b）段階（a）のポリペプチドの生物学的活性を検出する段階；および
（c）NSC 810によってコードされるポリペプチドの生物学的活性を被験化合物の非存在下で検出される生物学的活性と比較して抑制する化合物を選択する段階。 - 生物学的活性が細胞増殖活性である、請求項10記載の方法。
- 以下の段階を含む、非小細胞肺癌の治療または予防のための化合物に関するスクリーニングの方法：
（1）被験化合物をNSC 810を発現する細胞と接触させる段階；および
（2）NSC 810の発現レベルを低下させる化合物を選択する段階。 - 細胞がNSCLC細胞である、請求項12記載の方法。
- 以下の段階を含む、非小細胞肺癌の治療または予防のための化合物に関するスクリーニングの方法：
（1）被験化合物を、NSC 810の転写調節領域およびその転写調節領域の制御下で発現されるレポーター遺伝子を含むベクターが導入された細胞と接触させる段階；
（2）該レポーター遺伝子の活性を測定する段階；および
（3）対照と比較して、該レポーター遺伝子の発現レベルを低下させる化合物を選択する段階。 - NSC 810、またはNSC 810がコードするポリペプチドと結合するNSC検出用試薬を含むキット。
- NSC 810と結合するポリヌクレオチドを含むNSC検出用アレイ。
- NSC 810に対するアンチセンスポリヌクレオチドまたはsiRNAの薬学的有効量を含む、非小細胞肺癌の治療または予防のための組成物。
- NSC 810によってコードされるポリペプチドと結合する抗体またはその断片の薬学的有効量を含む、非小細胞肺癌の治療または予防のための組成物。
- 配列番号：423を含むアンチセンスポリヌクレオチド。
- 配列番号： 534のヌクレオチド配列を標的配列として含むsiRNA。
- 請求項19記載のアンチセンスポリヌクレオチドの薬学的有効量を含む、非小細胞肺癌の治療または予防のための組成物。
- 請求項20記載のsiRNAの薬学的有効量を含む、非小細胞肺癌の治療または予防のための組成物。
- 抗腫瘍免疫を誘導するための方法であって、NSC 810によってコードされるポリペプチド、または該ポリペプチドの免疫活性断片、またはこのポリペプチドもしくは断片をコードするポリヌクレオチドを投与する段階を含む方法。
- 抗原提示細胞を対象に投与する段階をさらに含む、請求項23記載の抗腫瘍免疫を誘導するための方法。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41467302P | 2002-09-30 | 2002-09-30 | |
| US45137403P | 2003-02-28 | 2003-02-28 | |
| US46610003P | 2003-04-28 | 2003-04-28 | |
| PCT/JP2003/012072 WO2004031413A2 (en) | 2002-09-30 | 2003-09-22 | Method for diagnosing non-small cell lung cancers |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009138122A Division JP4921522B2 (ja) | 2002-09-30 | 2009-06-09 | 非小細胞肺癌の診断のための方法 |
| JP2009231138A Division JP2010042016A (ja) | 2002-09-30 | 2009-10-05 | 非小細胞肺癌の診断のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006500949A JP2006500949A (ja) | 2006-01-12 |
| JP2006500949A5 true JP2006500949A5 (ja) | 2006-11-02 |
| JP4425141B2 JP4425141B2 (ja) | 2010-03-03 |
Family
ID=32074369
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004541231A Expired - Fee Related JP4425141B2 (ja) | 2002-09-30 | 2003-09-22 | 非小細胞肺癌の診断のための方法 |
| JP2009138122A Expired - Fee Related JP4921522B2 (ja) | 2002-09-30 | 2009-06-09 | 非小細胞肺癌の診断のための方法 |
| JP2009231138A Pending JP2010042016A (ja) | 2002-09-30 | 2009-10-05 | 非小細胞肺癌の診断のための方法 |
| JP2012003039A Pending JP2012125247A (ja) | 2002-09-30 | 2012-01-11 | 非小細胞肺癌の診断のための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009138122A Expired - Fee Related JP4921522B2 (ja) | 2002-09-30 | 2009-06-09 | 非小細胞肺癌の診断のための方法 |
| JP2009231138A Pending JP2010042016A (ja) | 2002-09-30 | 2009-10-05 | 非小細胞肺癌の診断のための方法 |
| JP2012003039A Pending JP2012125247A (ja) | 2002-09-30 | 2012-01-11 | 非小細胞肺癌の診断のための方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (30) | EP2270214A3 (ja) |
| JP (4) | JP4425141B2 (ja) |
| KR (2) | KR20110020953A (ja) |
| AT (1) | ATE541053T1 (ja) |
| AU (1) | AU2003272088A1 (ja) |
| CA (1) | CA2500151A1 (ja) |
| TW (1) | TW200413725A (ja) |
| WO (1) | WO2004031413A2 (ja) |
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