JP2006500942A5 - - Google Patents
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- Publication number
- JP2006500942A5 JP2006500942A5 JP2004541126A JP2004541126A JP2006500942A5 JP 2006500942 A5 JP2006500942 A5 JP 2006500942A5 JP 2004541126 A JP2004541126 A JP 2004541126A JP 2004541126 A JP2004541126 A JP 2004541126A JP 2006500942 A5 JP2006500942 A5 JP 2006500942A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- polypeptide
- isolated
- terpenoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims description 52
- 108020004707 nucleic acids Proteins 0.000 claims description 51
- 102000039446 nucleic acids Human genes 0.000 claims description 51
- 229920001184 polypeptide Polymers 0.000 claims description 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 27
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 15
- 101710093888 Pentalenene synthase Proteins 0.000 claims description 10
- 101710115850 Sesquiterpene synthase Proteins 0.000 claims description 10
- 239000002773 nucleotide Substances 0.000 claims description 9
- 125000003729 nucleotide group Chemical group 0.000 claims description 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000012258 culturing Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 6
- 150000003505 terpenes Chemical class 0.000 claims 5
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 claims 2
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 claims 2
- -1 acyclic pyrophosphate terpene Chemical class 0.000 claims 2
- 229930004725 sesquiterpene Natural products 0.000 claims 2
- 150000004354 sesquiterpene derivatives Chemical class 0.000 claims 2
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 claims 2
- VPDZRSSKICPUEY-GQRSATBHSA-N (+)-Bicyclogermacrene Natural products CC1(C)[C@@H]/2[C@H]1CC/C(/C)=C\CC/C(/C)=C\2 VPDZRSSKICPUEY-GQRSATBHSA-N 0.000 claims 1
- KONGRWVLXLWGDV-BYGOPZEFSA-N (-)-cubebol Chemical compound CC(C)[C@@H]([C@H]12)CC[C@@H](C)[C@]32[C@@H]1[C@@](C)(O)CC3 KONGRWVLXLWGDV-BYGOPZEFSA-N 0.000 claims 1
- 241000207199 Citrus Species 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- VPDZRSSKICPUEY-JEPMYXAXSA-N bicyclogermacrene Chemical compound C1CC(/C)=C/CC\C(C)=C\[C@@H]2C(C)(C)[C@H]12 VPDZRSSKICPUEY-JEPMYXAXSA-N 0.000 claims 1
- RXARZHLXLNWPFG-UHFFFAOYSA-N bicyclogermacrene Natural products CC1=C2C3C(CCC2=CCC1)C3(C)C RXARZHLXLNWPFG-UHFFFAOYSA-N 0.000 claims 1
- 235000020971 citrus fruits Nutrition 0.000 claims 1
- KONGRWVLXLWGDV-UHFFFAOYSA-N cubebol Natural products C12C(C(C)C)CCC(C)C32C1C(C)(O)CC3 KONGRWVLXLWGDV-UHFFFAOYSA-N 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 235000007586 terpenes Nutrition 0.000 claims 1
- 108020003215 DNA Probes Proteins 0.000 description 4
- 239000003298 DNA probe Substances 0.000 description 4
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 4
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 4
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 4
- 239000013612 plasmid Substances 0.000 description 4
- 108091081024 Start codon Proteins 0.000 description 3
- 239000002299 complementary DNA Substances 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 238000001952 enzyme assay Methods 0.000 description 2
- 239000013613 expression plasmid Substances 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102100036263 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial Human genes 0.000 description 1
- 101001001786 Homo sapiens Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41576502P | 2002-10-04 | 2002-10-04 | |
| IB0205070 | 2002-12-02 | ||
| PCT/IB2003/005072 WO2004031376A2 (en) | 2002-10-04 | 2003-10-02 | Sesquiterpene synthases and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006500942A JP2006500942A (ja) | 2006-01-12 |
| JP2006500942A5 true JP2006500942A5 (https=) | 2006-11-24 |
| JP4571862B2 JP4571862B2 (ja) | 2010-10-27 |
Family
ID=34590004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004541126A Expired - Fee Related JP4571862B2 (ja) | 2002-10-04 | 2003-10-02 | セスキテルペン合成及び使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (3) | EP2365070B1 (https=) |
| JP (1) | JP4571862B2 (https=) |
| CN (3) | CN1703507B (https=) |
| AU (1) | AU2003278478A1 (https=) |
| BR (1) | BR0314979A (https=) |
| IL (1) | IL167832A (https=) |
| RU (1) | RU2005113300A (https=) |
| WO (1) | WO2004031376A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8106260B2 (en) | 1996-04-12 | 2012-01-31 | The Board Of Trustees Of The University Of Kentucky | Chimeric isoprenoid synthases and uses thereof |
| US7442785B2 (en) | 2003-07-24 | 2008-10-28 | The University Of Kentucky Research Foundation | Sesquiterpene synthase gene and protein |
| CA2537505A1 (en) * | 2003-09-02 | 2005-03-10 | Yoram Eyal | Citrus sesquiterpene synthase, methods of production and uses thereof |
| WO2006111924A2 (en) | 2005-04-19 | 2006-10-26 | University Of Kentucky Research Foundation | Transformed plants accumulating terpenes |
| JP5430929B2 (ja) | 2005-06-17 | 2014-03-05 | フイルメニツヒ ソシエテ アノニム | 新規セスキテルペン合成酵素ならびにその使用方法 |
| JP5135215B2 (ja) | 2005-07-01 | 2013-02-06 | ユニバーシティー オブ ケンタッキー リサーチ ファンデーション | モノテルペン及び／又はセスキテルペンを蓄積する形質転換植物 |
| WO2008100251A1 (en) * | 2007-02-13 | 2008-08-21 | Ls9, Inc. | Modified microorganism uses therefor |
| CN101384719B (zh) * | 2006-02-14 | 2012-10-03 | 弗门尼舍有限公司 | 用于生成萜的方法和用于该方法的mep转化后的微生物 |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| PL2252691T3 (pl) | 2008-03-06 | 2013-08-30 | Firmenich & Cie | Sposób otrzymywania alfa-santalenu |
| WO2010019696A2 (en) | 2008-08-12 | 2010-02-18 | Allylix, Inc. | Method for production of isoprenoids |
| ES2535722T3 (es) * | 2008-12-05 | 2015-05-14 | Keygene N.V. | Farneseno sintasa |
| CN111808892A (zh) | 2009-04-27 | 2020-10-23 | 基因组股份公司 | 脂肪酸酯的产生 |
| EP2449107B1 (en) | 2009-06-29 | 2015-04-08 | The University Of Western Australia | Terpene synthases from santalum |
| PT2493318T (pt) | 2009-10-28 | 2016-12-23 | Fundo De Defesa Da Citricultura - Fundecitrus | Composições repelentes e abordagens genéticas para controlo de huanglongbing |
| PL2569427T3 (pl) * | 2010-05-10 | 2018-02-28 | Firmenich Sa | Sposób wytwarzania alkoholu paczulowego i 7-epi-alfa-selinenu |
| CN103282492A (zh) | 2010-10-29 | 2013-09-04 | 奥利里克斯股份有限公司 | 修饰的瓦伦烯合酶多肽、编码核酸分子及其用途 |
| EP2537926A1 (en) * | 2011-06-21 | 2012-12-26 | Isobionics B.V. | Valencene synthase |
| EP2768955A1 (en) * | 2011-10-19 | 2014-08-27 | Keygene N.V. | Methods and compositions for producing drimenol |
| US9550815B2 (en) | 2012-01-23 | 2017-01-24 | University Of British Columbia | ABC terpenoid transporters and methods of using the same |
| CN103243083B (zh) * | 2012-02-06 | 2015-06-03 | 中国科学院上海生命科学研究院 | 一种新的倍半萜合成酶及其用途 |
| US10000749B2 (en) | 2013-03-14 | 2018-06-19 | Evolva, Inc. | Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof |
| ES2540791B1 (es) * | 2013-12-13 | 2016-05-09 | Consejo Superior De Investigaciones Científicas (Csic) | Nuevas sesquiterpeno sintasas aisladas de la piel de naranja. |
| SG11201701278RA (en) * | 2014-08-21 | 2017-03-30 | Manus Biosynthesis Inc | Methods for production of oxygenated terpenes |
| WO2017077125A1 (en) * | 2015-11-05 | 2017-05-11 | Firmenich S.A | Drimenol synthases iii |
| CN105524908B (zh) * | 2016-02-04 | 2018-12-28 | 中国农业科学院植物保护研究所 | 一种与(E)-β-石竹烯和(E)-a-律草烯合成相关的蛋白及其应用 |
| CN110093329B (zh) * | 2018-01-30 | 2023-07-04 | 深圳艾格鑫科技有限公司 | 萜类合酶及其应用 |
| CN108977426B (zh) * | 2018-06-29 | 2020-08-14 | 中国林业科学研究院热带林业研究所 | 一种油楠倍半萜合成酶及其编码基因和应用 |
| CN109852600B (zh) * | 2018-12-25 | 2021-12-31 | 天津大学 | 一种小萼苔倍半萜合成酶MTb及其基因序列 |
| CN109666668B (zh) * | 2019-01-24 | 2022-04-15 | 天津大学 | 一种小萼苔倍半萜合成酶MTa及其基因序列 |
| CN109837266B (zh) * | 2019-01-24 | 2021-12-31 | 天津大学 | 一种小萼苔倍半萜合成酶MTc及其基因序列 |
| CN109929828A (zh) * | 2019-01-30 | 2019-06-25 | 天津大学 | 一种苦皮藤倍半萜合成酶CaTPS1及其基因序列 |
| CN111004763B (zh) * | 2019-12-26 | 2022-06-03 | 中国科学院青岛生物能源与过程研究所 | 一种生产β-石竹烯的工程菌及其构建方法与应用 |
| CN115404228B (zh) * | 2021-05-28 | 2024-03-08 | 中国中医科学院中药研究所 | 山沉香倍半萜合酶蛋白tps1及其编码基因和应用 |
| CN116004490A (zh) * | 2022-07-12 | 2023-04-25 | 华东理工大学 | 一种生物合成右旋-双环吉玛烯的重组大肠杆菌、构建方法及应用 |
| CN116555238B (zh) * | 2023-06-09 | 2023-10-20 | 中国中医科学院中药研究所 | SoSTPS1在作为倍半萜合酶中的应用 |
| CN117126835B (zh) * | 2023-08-11 | 2025-04-25 | 武汉合生科技有限公司 | 瓦伦烯合成酶及其应用 |
| CN119899828B (zh) * | 2025-01-17 | 2026-01-30 | 中国药科大学 | 利用SsDMS突变体高效生产新颖drimane型倍半萜化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| ES2272209T3 (es) * | 1999-03-31 | 2007-05-01 | Firmenich Sa | Utilizacion de cubebol como ingrediente aromatizante. |
-
2003
- 2003-10-02 EP EP10177152.5A patent/EP2365070B1/en not_active Expired - Lifetime
- 2003-10-02 CN CN2003801009412A patent/CN1703507B/zh not_active Expired - Fee Related
- 2003-10-02 CN CN2010102392305A patent/CN101914559B/zh not_active Expired - Fee Related
- 2003-10-02 AU AU2003278478A patent/AU2003278478A1/en not_active Abandoned
- 2003-10-02 EP EP03769780A patent/EP1554379B1/en not_active Expired - Lifetime
- 2003-10-02 WO PCT/IB2003/005072 patent/WO2004031376A2/en not_active Ceased
- 2003-10-02 CN CN2010102391730A patent/CN101914558B/zh not_active Expired - Fee Related
- 2003-10-02 EP EP16182020.4A patent/EP3109319A1/en not_active Withdrawn
- 2003-10-02 RU RU2005113300/13A patent/RU2005113300A/ru not_active Application Discontinuation
- 2003-10-02 JP JP2004541126A patent/JP4571862B2/ja not_active Expired - Fee Related
- 2003-10-02 BR BR0314979-0A patent/BR0314979A/pt active IP Right Grant
-
2005
- 2005-04-03 IL IL167832A patent/IL167832A/en unknown
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